ACR Meeting Abstracts

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Abstracts tagged "Lupus nephritis"

  • Abstract Number: 0636 • ACR Convergence 2022

    Serum Soluble Mediator Signatures of Lupus Nephritis Histological Features and Response to Treatment

    Andrea Fava1, Carla J. Guthridge2, Joseph Kheir2, Catriona Wagner3, Michelle Petri4, Jill Buyon5, Betty Diamond6, the Accelerating Medicines Partnership (AMP) RA/SLE7, Joel Guthridge2 and Judith James2, 1Johns Hopkins University, Baltimore, MD, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma, 4Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, 5NYU Grossman School of Medicine, New York, NY, 6Feinstein Institutes for Medical Research, Manhasset, NY, 7Multiple Insitutions

    Background/Purpose: There is a pressing need to identify novel therapeutic approaches and noninvasive biomarkers in lupus nephritis (LN). In this study, we quantified serum soluble…
  • Abstract Number: 1282 • ACR Convergence 2022

    Practice Patterns for Pneumocystis Jiroveci Pneumonia (PJP) Prophylaxis Among Nephrologists and Rheumatologists – an International Survey Study

    Swati Arora1, Brad Rovin2 and Tanmayee Bichile3, 1Allegheny Health Network, Pittsburgh, 2The Ohio State University, Columbus, OH, 3Allegheny Health Network, Gibsonia, PA

    Background/Purpose: Patients with autoimmune disorders such as systemic lupus erythematosus (SLE), lupus nephritis (LN) and granulomatosis with polyangiitis (GPA) frequently require treatment with immunosuppressive drugs.…
  • Abstract Number: 1666 • ACR Convergence 2022

    Differentiation of Injury-associated Macrophages in Lupus Kidneys Is Conserved in Humans and Lupus Mouse Models

    Paul Hoover1, David Lieb2, Stephen Li2, Chirag Raparia3, Accelerating Medicines Partnership SLE/RA4, Arnon Arazi5, Nir Hacohen2 and Anne Davidson6, 1Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Cambridge, MA, 3Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Shoreham, NY, 4NIH, Bethesda, MD, 5Feinstein Institutes for Medical Research, Melrose, MA, 6Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Infiltrating monocytes acquire functions that support kidney remodeling in response to tissue damage in lupus nephritis. This process of monocyte differentiation has been difficult…
  • Abstract Number: 2097 • ACR Convergence 2022

    Association of Renal Biopsy NIH Activity and Chronicity Scores with Clinical Outcomes in a Cohort of Patients with Lupus Nephritis

    David Kellner1, Jonathan Zuckerman1, Jennifer Grossman2 and Maureen McMahon2, 1UCLA David Geffen School of Medicine, Los Angeles, CA, 2University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Renal biopsy has long been the gold standard for diagnosis of lupus nephritis (LN), and pathologic features on biopsy are commonly used to guide…
  • Abstract Number: 0353 • ACR Convergence 2022

    Steroid-Induced Diabetes in Lupus Nephritis Patients: Classic Risk Factors or a Different Type of Diabetes?

    Cristian Alejandro Dimas Ramírez1, André Fortanell-Meza1, Diego San Agustin-Morales1, Eduardo Brenner Muslera2, Juan Mejia-Vilet3, Paloma Almeda-Valdes4, Paola Vázquez Cárdenas5, F. Javier Merayo-Chalico6 and Ana Barrera-Vargas1, 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico, 2School of Medicine of Universidad Panamericana, Ciudad de México, Mexico, 3National Autonomous University of Mexico, Ciudad de México, Mexico, 4Department of Endocrinology and Metabolism, and the Research Unit of Metabolic Diseases. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico, 5Hospital General Dr. Manuel Gea González, Ciudad de México, Mexico, 6Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirn", Ciudad de México, Mexico

    Background/Purpose: Glucocorticoids are frequently employed in the treatment of systemic lupus erythematosus (SLE) patients and play a critical role in the induction therapy of lupus…
  • Abstract Number: 0640 • ACR Convergence 2022

    Immune Cell Heterogeneity in Lupus Nephritis Kidneys and Its Relation to Histopathological Features

    Arnon Arazi1, Joseph Mears2, Thomas Eisenhaure3, Qian Xiao4, Paul Hoover4, Deepak Rao4, Celine Berthier5, Andrea Fava6, Siddarth Gurajala4, Michael Peters3, Tony Jones3, William Apruzzese4, Jennifer Barnas7, Richard Furie8, Anne Davidson9, David Hildeman10, Judith James11, Joel Guthridge11, Maria Dall'Era12, David Wofsy13, Peter Izmirly14, H Michael Belmont15, Robert Clancy14, Diane Kamen16, Chaim Putterman17, Thomas Tuschl18, Maureen McMahon19, Jennifer Grossman19, Kenneth Kalunian20, Michael Weisman21, Matthias Kretzler5, Michael Brenner22, Jennifer Anolik23, Michelle Petri24, Jill Buyon14, Soumya Raychaudhuri4, Nir Hacohen3, Betty Diamond9 and the Accelerating Medicines Partnership RA/SLE Network3, 1Feinstein Institutes for Medical Research, Melrose, MA, 2Michigan University, Ann Arbor, MI, 3Broad Institute, Cambridge, MA, 4Brigham and Women's Hospital, Boston, MA, 5University of Michigan, Ann Arbor, MI, 6Johns Hopkins University, Baltimore, MD, 7University of Rochester, Rochester, NY, 8Northwell Health, Great Neck, NY, 9Feinstein Institutes for Medical Research, Manhasset, NY, 10Cincinnati Children's Hospital, Cincinnati, OH, 11Oklahoma Medical Research Foundation, Oklahoma City, OK, 12University of California, Division of Rheumatology, San Francisco, CA, 13University of California San Francisco, SF, CA, 14NYU Grossman School of Medicine, New York, NY, 15NYU School of Medicine, New York, NY, 16Medical University of South Carolina, Charleston, SC, 17Albert Einstein College of Medicine, Bronx, NY, 18Rockefeller University, New York, NY, 19University of California Los Angeles, Los Angeles, CA, 20University of California San Diego, La Jolla, CA, 21Adjunct Professor of Medicine, Stanford University; Distinguished Professor of Medicine Emeritus, David Geffen School of Medicine at UCLA, Los Angeles, CA, 22Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 23University of Rochester Medical Center, Rochester, NY, 24Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD

    Background/Purpose: Lupus nephritis (LN) is characterized by considerable variability in its clinical manifestations and histopathological findings. Understanding the cellular and molecular mechanisms underlying this heterogeneity…
  • Abstract Number: 1334 • ACR Convergence 2022

    Exploring Canadian Patient Experiences of Living with Lupus Nephritis (LN)

    Francesca S Cardwell1, Sydney George2, Adrian Boucher2, Megan R W Barber3, Kim Cheema4, Susan J Elliott5 and Ann E Clarke3, 1University of Waterloo, Department of Geography & Environmental Management, Burlington, ON, Canada, 2GlaxoSmithKline, Health Outcomes and Economics, Mississauga, ON, Canada, 3University of Calgary, Division of Rheumatology, Cumming School of Medicine, Calgary, AB, Canada, 4University of Calgary, Division of Nephrology, Cumming School of Medicine, Calgary, AB, Canada, 5University of Waterloo, Department of Geography & Environmental Management, Waterloo, ON, Canada

    Background/Purpose: LN is one of the most severe manifestations of SLE; however, the patient experience remains understudied. This research investigates patient experiences and perspectives of…
  • Abstract Number: 1694 • ACR Convergence 2022

    Skin Exposure to UV Light Triggers Podocyte and Distal Tubular Injury, in the Presence of CD177+ Neutrophil Cell Cluster

    Angelique Cortez1, Lindsay Mendyka1, Fred Kolling2 and Sladjana Skopelja-Gardner1, 1Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: Sensitivity to ultraviolet (UV) light affects ~ 80% of systemic lupus erythematosus (SLE) patients. UV light exposure of lupus skin leads to local and…
  • Abstract Number: 2099 • ACR Convergence 2022

    Drug Repurposing for Treating Lupus Nephritis Based on Transcriptome Profiling and Autoimmunity-Related Serological Markers

    Ioannis Parodis1, Julius Lindblom1, Daniel Toro-Domínguez2, Elena Carnero-Montoro2, Maria Orietta Borghi3, Jessica Castillo4, Yvonne Enman5, Chandra Mohan4, Marta Alarcon-Riquelme2 and Guillermo Barturen2, 1Karolinska Institutet, Stockholm, Sweden, 2Center for Genomics and Oncological Research (GENYO), Granada, Spain, 3Università degli Studi di Milano and Istituto Auxologico Italiano, Milano, Italy, 4University of Houston, Houston, TX, 5Karolinska Institutet, Sundbyberg, Sweden

    Background/Purpose: LN is one of the most severe organ manifestations of SLE and constitutes an important cause of morbidity and death among patients with SLE…
  • Abstract Number: 0355 • ACR Convergence 2022

    Long-term Use of Voclosporin in Patients with Class V Lupus Nephritis: Results from the AURORA 2 Continuation Study

    Amit Saxena1, Dawn Caster2, Salem Almaani3, Amber Rosales4 and Henry Leher5, 1NYU School of Medicine, New York, NY, 2University of Louisville, Louisville, KY, 3The Ohio State University Medical Center, Columbus, OH, 4Aurinia Pharmaceuticals Inc., Rockville, MD, 5Aurinia Pharmaceuticals Inc, Rockville, MD

    Background/Purpose: Persistent proteinuria increases the risk of comorbidities in lupus nephritis, and rapid reductions in protein have shown to be predictive of improved long-term renal…
  • Abstract Number: 0647 • ACR Convergence 2022

    Transcriptomic Analysis of Lupus Nephritis Kidneys Identifies Molecular Endotypes

    Kathryn Kingsmore Allison1, Sneha Shrotri1, Prathyusha Bachali2, Nan Shen3, Amrie Grammer4 and Peter Lipsky1, 1AMPEL BioSolutions, Charlottesville, VA, 2AMPEL BioSolutions, Redmond, WA, 3Shanghai Jiang Tong University School of Medicine, Shanghai, China, 4AMPEL LLC, Charlottesville, VA

    Background/Purpose: Predicting the course or response to treatment of lupus nephritis (LN) from standard renal biopsies is problematic. We, therefore sought to understand the molecular…
  • Abstract Number: 1347 • ACR Convergence 2022

    Poor Health-Related Quality of Life in Patients with Lupus Nephritis

    Cristina Arriens1, Janice Ma2, Konrad Pisarczyk2, Richard Leff3, Kiruthi Palaniswamy4 and Li Long4, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Maple Health Group, LLC, New York, NY, 3Kezar Life Sciences, South San Francisco, CA, 4Kezar Life Sciences, Inc., South San Francisco, CA

    Background/Purpose: Lupus nephritis (LN) is one of the most serious manifestations of systemic lupus erythematosus (SLE) associated with considerable morbidity that has a devastating impact…
  • Abstract Number: 1697 • ACR Convergence 2022

    Measurements of Specific Activation Through the Lectin -or Classical Pathway of Complement in Patients with SLE

    Anne Troldborg1, Mads Lamm Larsen1, Erik J.M. Toonen2, Lisa Hurler3, Zoltan Prohaszka3, László Cervenak3, Annette Gudmann Hansen4 and Steffen Thiel4, 1Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 2Hycult Biotech, Arnhem-Nijmegen, Netherlands, 3Semmelweis University, Budapest, Hungary, 4Aarhus University, Aarhus, Denmark

    Background/Purpose: In systemic lupus erythematosus (SLE), the complement system is activated and commonly thought to occur through the classical pathway (CP) [1]. However, our previous…
  • Abstract Number: 2222 • ACR Convergence 2022

    Lupus Clinical Flares in Patients with Gut Pathobiont Blooms Share a Novel Peripheral Blood Transcriptomic Immune Activation Profile

    Gregg Silverman1, Macintosh Cornwell1, Peter Izmirly1, Mala Masson1, Jill Buyon1, Doua Azzouz2 and Kelly Ruggles1, 1NYU Grossman School of Medicine, New York, NY, 2NYU Gross School of Medicine, New York, NY

    Background/Purpose: SLE is an inflammatory condition associated with hyperactivation of the immune system, with mounting evidence that imbalances in the gut microbiota communities are common.…
  • Abstract Number: 0356 • ACR Convergence 2022

    Early Reductions in Proteinuria with Voclosporin Treatment Across Lupus Nephritis Biopsy Classes: Pooled Data from the AURA-LV and AURORA 1 Trials

    Anca Askanase1, Lucy Hodge2, Vanessa Birardi3 and Henry Leher3, 1Columbia University Medical Center, New York, NY, 2Aurinia Pharmaceuticals, Seattle, WA, 3Aurinia Pharmaceuticals Inc, Rockville, MD

    Background/Purpose: Voclosporin, a novel calcineurin inhibitor, is approved for the treatment of adults with lupus nephritis in combination with background immunotherapy and was successfully tested…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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