ACR Meeting Abstracts

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Abstracts tagged "Lupus nephritis"

  • Abstract Number: 287 • 2012 ACR/ARHP Annual Meeting

    Variation in Healthcare Utilization by Region and Number of Rheumatologists Per State Among Pediatric Medicaid Patients with Lupus Nephritis Prior to End-Stage Renal Disease in the United States, 2000-2004

    Linda T. Hiraki1, Candace H. Feldman2, Graciela S. Alarcon3, Jun Liu4, Michael A. Fischer5, Wolfgang C. Winkelmayer6 and Karen H. Costenbader7, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard School of Public Health, Boston, MA, 2Rheumatology, Brigham and Women's Hospital, Boston, MA, 3Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 4Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Boston, MA, 5Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, 6Division of Nephrology, Stanford University School of Medicine, Stanford, CA, 7Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Unequal healthcare access and utilization may contribute to the striking sociodemographic disparities seen in outcomes for children with lupus nephritis. Medicaid is the U.S.…
  • Abstract Number: 2249 • 2012 ACR/ARHP Annual Meeting

    Comparison of Mycophenolate Mofetil and Intravenous Cyclophosphamide As Induction Therapy in Korean Patients with Lupus Nephritis

    Dong-Jin Park1, Kyung-Eun Lee1, Tae-Jong Kim1, Yong-Wook Park1 and Shin-Seok Lee2, 1Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 2Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea

    Background/Purpose: Although intravenous cyclophosphamide (IVC) pulses are generally accepted as standard therapy for induction treatment of active proliferative lupus nephritis (LN), several clinical trials have…
  • Abstract Number: 315 • 2012 ACR/ARHP Annual Meeting

    Pediatric Lupus Nephritis: Micrornas – Macro Inflammation

    Patrícia Costa Reis1, Pierre Russo2 and Kathleen E. Sullivan3, 1Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, 2Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA, 3Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: New biomarkers to guide clinical management of lupus nephritis (LN) patients are highly desirable, since the histopathologic classification currently in use is an unreliable…
  • Abstract Number: 632 • 2012 ACR/ARHP Annual Meeting

    The Effects of Co-Existing Proliferative Histopathology On Membranous Lupus Nephritis

    Jennifer L. Graybill1, Catarina Vila-Inda1, Chaim Putterman2 and Irene Blanco1, 1Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 2Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Lupus nephritis (LN) affects up to 60% of SLE patients and is worse in minority communities. Traditionally membranous LN confers a better prognosis than…
  • Abstract Number: 668 • 2012 ACR/ARHP Annual Meeting

    Markers of Nitric Oxide and Hydroxyl Radical Formation Are Increased in Proliferative Lupus Nephritis and May Emanate From Increased Nitric Oxide Synthase and NADPH Oxidase Production and Reduced Endothelial Nitric Oxide Synthase-Derived NO Scavenging

    Jim Oates1, Ahmad Mashmoushi1, Thomas Fleury1, Ann Hofbauer1 and Gary S. Gilkeson2, 1Medicine, Medical University of South Carolina, Charleston, SC, 2Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: The role of redox regulation of cell function in the different International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of lupus nephritis (LN) is…
  • Abstract Number: 684 • 2012 ACR/ARHP Annual Meeting

    Correlation of Signal Transducers and Activators of Transcription-1 and Microrna-146a with Anaemia and Other Clinical Features in Systemic Lupus Erythematosus Patients

    Paul R. Dominguez-Gutierrez1, Angela Ceribelli1, Minoru Satoh2, Eric S. Sobel3, Yi Li2, Westley H. Reeves4 and Edward K.L. Chan1, 1Oral Biology, University of Florida, Gainesville, FL, 2Medicine, University of Florida, Gainesville, FL, 3Medicine/Div of Rheumatology, University of Florida, Gainesville, FL, 4Rheumatology & Clinical Imm, University of Florida, Gainesville, FL

    Background/Purpose: Anaemia is one of the most common haematological manifestations in SLE patients, occurring in about 50% of active cases. STAT1 is a critical signalling…
  • Abstract Number: 837 • 2012 ACR/ARHP Annual Meeting

    Response to MMF Therapy for Lupus Nephritis Is Independent of Genetic Variation of Inosine Monophosphate Dehydrogenase

    Noa Schwartz1, Tejaskumar Patel1, Ellen M. Ginzler2, Neil Solomons3, Jill P. Buyon4 and Robert M. Clancy1, 1Medicine, New York University School of Medicine, New York, NY, 2Rheumatology, SUNY-Downstate Medical Center, Brooklyn, NY, 3Vifor Pharma, New York, NY, 4Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose: The Aspreva Lupus Management Study (ALMS) demonstrated the efficacy of mycophenolate mofetil (MMF-a prodrug of MFA, mycophenolic acid) for both induction and maintenance of…
  • Abstract Number: 931 • 2012 ACR/ARHP Annual Meeting

    Health Care Utilization Among Medicaid Enrollees with Systemic Lupus Erythematosus Preceding the Development of End-Stage Renal Disease: Sociodemographic Variation

    Candace H. Feldman1, Linda T. Hiraki2, Graciela S. Alarcon3, Jinoos Yazdany4, Jun Liu5, Michael A. Fischer6, Wolfgang C. Winkelmayer7 and Karen H. Costenbader8, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital/ Harvard School of Public Health, Boston, MA, 3Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 4Medicine, University of California, San Francisco, San Francisco, CA, 5Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Boston, MA, 6Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, 7Division of Nephrology, Stanford University School of Medicine, Stanford, CA, 8Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Extreme sociodemographic disparities exist among systemic lupus erythematosus (SLE) patients in the development of end-stage renal disease (ESRD) from lupus nephritis. Better resource allocation…
  • Abstract Number: 1392 • 2012 ACR/ARHP Annual Meeting

    Clinical Correlation with Anti Double Stranded Deoxyribonucleic Acid Via Enzyme Linked Immunoassay Versus Multiplex Immunoassay

    Megan L. Krause1, Melissa R. Snyder2, Cynthia S. Crowson3, Abigail B. Green3 and Kevin G. Moder4, 1Internal Medicine, Mayo Clinic, Rochester, MN, 22Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 3Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 4Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose: In systemic lupus erythematosus (SLE), antibodies to double-stranded DNA (dsDNA) are utilized for disease classification and assessment of activity. Enzyme immunoassays (EIAs) and multiplex…
  • Abstract Number: 1414 • 2012 ACR/ARHP Annual Meeting

    Combination of Mycophenolate Mofetil and Tacrolimus for Refractory Lupus Nephritis: A 12-Month Open-Labeled Trial

    Chi Chiu Mok, Pak To Chan, Ling Yin Ho and Ka Lung Yu, Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong

    Background/Purpose: To evaluate the efficacy and tolerability of a combination of mycophenolate mofetil (MMF) and tacrolimus (Tac) for refractory lupus nephritis Methods: Patients with refractory…
  • Abstract Number: 1415 • 2012 ACR/ARHP Annual Meeting

    Effect of Renal Disease On Survival of Patients with Systemic Lupus Erythematosus: A Prospective Cohort Study of 694 Patients

    Chi Chiu Mok1, Raymond Kwok2 and Paul Yip2, 1Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, 2Social Work and Social Administration, University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: To study the effect of renal disease on survival and life expectancy of patients with systemic lupus erythematosus (SLE). Methods: Patients who fulfilled >=4…
  • Abstract Number: 1413 • 2012 ACR/ARHP Annual Meeting

    Clinical Presentation, Treatment and Outcome of Membranous Nephropathy in SLE: A Comparison with Proliferative Lupus Glomerulonephritis in 141 Patients

    Chi Chiu Mok, Ling Yin Ho and Ka Lung Yu, Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong

    Background/Purpose: To study the presentation and outcome of membranous nephropathy in SLE in comparison with proliferative lupus glomerulonephritis. Methods: Patients with biopsy firmed active lupus nephritis…
  • Abstract Number: 1433 • 2012 ACR/ARHP Annual Meeting

    Persistent Dyslipidemia Is a Risk Factor of Progression to Chronic Kidney Disease in Patients with Lupus Nephritis

    Dong-Jin Park1, Kyung-Eun Lee1, Tae-Jong Kim1, Yong-Wook Park1 and Shin-Seok Lee2, 1Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 2Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea

    Background/Purpose: To investigate the effect of dyslipidemia at baseline and during follow-up period on the progression to chronic kidney disease (CKD) in patients with biopsy-proven…
  • Abstract Number: 1444 • 2012 ACR/ARHP Annual Meeting

    HLA-DR3 Controls Autoantibody Response to Sm in NZM2328.DR3+.AE0 Transgenic Mice

    Vaidehi R. Chowdhary1, Chao Dai2, Shu Man Fu2 and Chella S. David3, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Medicine/CIIR/Rheumatology, University of Virginia Health System, Charlottesville, VA, 3Departement of Immunology, Mayo Clinic, Rochester, MN

    Background/Purpose: Large genome wide scans have confirmed the strong association of HLA -DR3 with risk of developing SLE and antibody response to Sm which is specific…
  • Abstract Number: 1650 • 2012 ACR/ARHP Annual Meeting

    Abnormal Serologies in the Absence of Clinical Activity Do Not Predict New or Recurrent Lupus Nephritis During Pregnancy

    Jill P. Buyon1, Aanam Aslam2, Marta M. Guerra2, Michael D. Lockshin3, Carl A. Laskin4, Ware Branch5, Lisa R. Sammaritano6, Michelle Petri7, Joan T. Merrill8, Allen D. Sawitzke9 and Jane E. Salmon6, 1Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 2Rheumatology 3rd Fl Rsrch, Hospital for Special Surgery, New York, NY, 3Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, 4University of Toronto and LifeQuest Centre for Reproductive Medicine, Toronto, ON, Canada, 5Obsterics and Gynecology, Univ of Utah, Salt Lake City, UT, 6Rheumatology, Hospital for Special Surgery, New York, NY, 7Johns Hopkins University School of Medicine, Baltimore, MD, 8Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 9Rheumatology, University of Utah Medical Ctr, Salt Lake City, UT

    Background/Purpose: Renal disease is a critical concern of physicians counseling lupus patients regarding pregnancy. In patients without a history of kidney disease, does pregnancy increase…
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