Abstracts tagged "Knee"

Abstract Number: 423 • 2018 ACR/ARHP Annual Meeting
Accelerated Knee Osteoarthritis Is Characterized By Pre-Radiographic Degeneration of the Extensor Mechanism and Cruciate Ligaments: Data from the Osteoarthritis Initiative
Julie Davis¹, Matthew Harkey¹, Robert J. Ward², James MacKay³, Lori Lyn Price^4,5, Charles B. Eaton⁶, Grace H. Lo⁷, Mary Barbe⁸, Timothy E. McAlindon⁹ and Jeffrey B. Driban¹⁰, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Radiology, Tufts Medical Center, Boston, MA, ³Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁶Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁷Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ⁸Temple University School of Medicine, Philadelphia, PA, ⁹Division of Rheumatology, Tufts Medical Center, Boston, MA, ¹⁰Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Degeneration of knee ligaments and tendons, which may be signs of joint instability and abnormal joint loading, may antedate the onset of radiographic accelerated…
Abstract Number: 957 • 2018 ACR/ARHP Annual Meeting
Biomechanical Therapy for Osteoarthritis of the Knee: A Randomized Controlled Trial
Stephan Reichenbach^1,2, Sarah Heldner¹, Armando Lenz³, David T. Felson⁴ and Peter Jüni⁵, ¹Institute for Social and Preventive Medicine, Bern, Bern, Switzerland, ²Department of Rheumatology, Immunology and Allergology, Bern, Bern, Switzerland, ³CTU Bern, University of Bern, Bern, Switzerland, ⁴Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁵Applied Health Research Centre (AHRC), Toronto, Toronto, ON, Canada
Background/Purpose: Biomechanics plays an important role in knee osteoarthritis (OA). A new biomechanical footwear system aims at altering knee loading patterns and retraining neuromuscular control…
Abstract Number: 1948 • 2018 ACR/ARHP Annual Meeting
Beliefs and Preferences for Reducing Sedentary Time in Those with Current or Past Knee Symptoms
Christine Pellegrini^1,2, Sara Powell², Chelsea Larsen² and Siobhan Phillips³, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Exercise Science, University of South Carolina, Columbia, SC, ³Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Physical activity is beneficial for those with current or previous knee symptoms, yet few meet federal physical activity guidelines. Reducing sedentary time, which has…
Abstract Number: 426 • 2018 ACR/ARHP Annual Meeting
The Association of Dietary Patterns with Knee Symptoms and MRI Detected Structures in Patients with Knee Osteoarthritis (OA)
Shuang Zheng¹, Feitong Wu¹, Flavia Cicuttini², Anita E Wluka², Dawn Aitken¹, Tania Winzeberg^1,3, Leigh Blizzard¹, Graeme Jones⁴ and Changhai Ding^1,5, ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ³Faculty of Health, University of Tasmania, Hobart, Australia, ⁴Menzies Institute for Medical Research, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ⁵Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China
The association of dietary patterns with knee symptoms and MRI detected structures in patients with knee osteoarthritis (OA)Abstract Background/Purpose: This study aimed to examine the…
Abstract Number: 1133 • 2018 ACR/ARHP Annual Meeting
Factors for Opioids Use in the Early Treatment Options for the Knee Osteoarthritis Patients
Soo-Kyung Cho¹, Seongmi Choi², Seul Gi Im², Hyoungyoung Kim¹, Sun-Young Jung³, Eun Jin Jang⁴ and Yoon-Kyoung Sung⁵, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Statistics, Kyungpook National University, Daegu, Korea, Republic of (South), ³College of Pharmacy, Chung-Ang University, Seoul, Korea, Republic of (South), ⁴Information Statistics, Andong National University, Andong-si, Korea, Republic of (South), ⁵Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South)
Background/Purpose: Current guidelines for osteoarthritis (OA) treatment recommend a range of nonpharmacological and pharmacological interventions to alleviate pain, improve function and quality of life. Most…
Abstract Number: 1954 • 2018 ACR/ARHP Annual Meeting
Factors Associated with Overweight or Obesity in Athletes 5 Years after Anterior Cruciate Ligament Injury
Louise Thoma¹, Jessica Johnson², Daniel White³, May Arna Risberg^4,5 and Lynn Snyder-Mackler², ¹Physical Therapy, University of Delaware, Newark, DE, ²Physical Therapy; Biomechanics and Movement Science, University of Delaware, Newark, DE, ³Department of Physical Therapy, University of Delaware, Newark, DE, ⁴Norwegian Research Center for Active Rehabilitation, Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway, ⁵Division of Orthopedic Surgery, Oslo University Hospital, Oslo, Norway
Background/Purpose: Obesity and knee injury, including anterior cruciate ligament (ACL) rupture, are strong risk factors for the development of knee osteoarthritis. Identifying participant and post-injury…
Abstract Number: 427 • 2018 ACR/ARHP Annual Meeting
One Year Efficacy and Safety of One or Three Injections of Hylan G-F 20 for Knee Osteoarthritis: A Systematic Literature Review and Meta-Analysis
Orazio De Lucia¹, Georgios Filippou², Joerg Jerosch³, Sophie Yoon⁴, Jean-Francois Bitsch⁴, Tobias Sayre⁴ and Wilson Ngai⁵, ¹Division of Clinical Rheumatology, G. Pini Hospital, Milan, Italy, ²Section of Rheumatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy, ³Department of Orthopedic Surgery, Johanna-Etienne Krankenhaus, Neuss, Germany, ⁴Doctor Evidence, Santa Monica, CA, ⁵Global Medical Affairs, General Medicines and Emerging Markets, Sanofi, Bridgewater, NJ
Background/Purpose: Hylan G-F 20 is indicated for the treatment of pain in knee osteoarthritis (OA) in patients who failed to respond adequately to conservative nonpharmacologic…
Abstract Number: 1134 • 2018 ACR/ARHP Annual Meeting
Some Is Better Than None: Minimum Physical Activity Threshold to Prevent Disability in Older Adults with Lower Extremity Joint Symptoms
Dorothy D. Dunlop¹, Jing Song¹, Jennifer M. Hootman², Julia (Jungwha) Lee³, Michael C. Nevitt⁴, Leena Sharma⁵, Pamela Semanik⁶, Charles B. Eaton⁷, C. Kent Kwoh⁸, Marc C. Hochberg⁹, Rebecca D. Jackson¹⁰ and Rowland W. Chang¹¹, ¹Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ³Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶College of Nursing, Rush University, Chicago, IL, ⁷Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁸Medicine, Division of Rheumatology, University of Arizona School of Medicine, University of Arizona Arthritis Center, Tucson, AZ, ⁹University of Maryland School of Medicine, Baltimore, MD, ¹⁰Ohio State University, Columbus, OH, ¹¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: This study evaluated physical activity and sedentary times to identify an evidence-based threshold related to remaining free of disability over 4 years among adults…
Abstract Number: 1955 • 2018 ACR/ARHP Annual Meeting
Race Is Associated with Discharge Disposition after Total Knee Arthroplasty (TKA), Which Is Associated with 90-Day Readmission Rate
Jasvinder A. Singh¹, Michael Kallan² and Said Ibrahim³, ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²University of Pennsylvania, Philadelphia, PA, ³Cornell University, New York, NY
Background/Purpose: To assess whether race/ethnicity is associated with differences in discharge disposition after elective primary total knee arthroplasty (TKA), and if discharge disposition is associated…
Abstract Number: 1L • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Intra-Articular Sprifermin in Symptomatic Radiographic Knee Osteoarthritis: Results of the 2-Year Primary Analysis from a 5-Year Randomised, Placebo-Controlled, Phase II Study
Marc C. Hochberg¹, Ali Guermazi², Hans Guehring³, Aida Aydemir⁴, Stephen Wax⁵, Patricia Fleuranceau-Morel⁴, Asger Reinstrup Bihlet⁶, Inger Byrjalsen⁶, Jeppe Ragnar Andersen⁶ and Felix Eckstein⁷, ¹University of Maryland School of Medicine, Baltimore, MD, ²Boston Imaging Core Lab, LLC, and Boston University School of Medicine, Boston, MA, ³Merck KGaA, Darmstadt, Germany, ⁴EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁵EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, ⁶Nordic Bioscience, Herlev, Denmark, ⁷Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria

Background/Purpose: Sprifermin, a novel recombinant human fibroblast growth factor-18 is currently investigated as a potential disease-modifying osteoarthritis (OA) drug. Two-year primary data from a 5-year…
Abstract Number: 13L • 2017 ACR/ARHP Annual Meeting
Significant, Sustained Improvement in Knee Function after Intra-Articular TPX-100: A Double-Blind, Randomized, Multi-Center, Placebo-Controlled Phase 2 Trial
Dawn McGuire¹, Nancy E Lane², Neil Segal³, Samy Metyas⁴, Hans Richard Barthel⁵, Meghan Miller¹, David Rosen¹ and Yoshi Kumagai¹, ¹OrthoTrophix, Inc, Oakland, CA, ²UC Davis Medical Center, Sacramento, CA, ³University of Kansas, Shawnee, KS, ⁴Medvin Clinical Research, Covina, CA, ⁵Barthel Clinic, Santa Barbara, CA

Background/Purpose: The current Phase 2 study was designed to evaluate safety, tolerability and preliminary efficacy of TPX-100 by IA administration in subjects with mild to…
Abstract Number: 936 • 2017 ACR/ARHP Annual Meeting
Knee Confidence Trajectories over 8 Years and Factors Associated with Poor Trajectories: Data from the Osteoarthritis Initiative
Alison H. Chang, Julia (Jungwha) Lee, Orit Almagor, Joan S. Chmiel, Kirsten C. Moisio, Karen W. Hayes, Julie Szymaszek and Leena Sharma, Northwestern University, Chicago, IL
Background/Purpose: Lack of knee confidence, a frequent complaint, has been associated with function decline in knee OA. Given its key role in weight-bearing activities, a…
Abstract Number: 1207 • 2017 ACR/ARHP Annual Meeting
Clinical Relevance of Structural Measures in Knee Osteoarthritis: Baseline Values and Change from Baseline Discriminate Patients Subsequently Receiving Knee Replacement
C. Kent Kwoh¹, Hans Guehring², Michael J Hannon³ and Aida Aydemir⁴, ¹University of Arizona Arthritis Center, Tuscan, AZ, ²Merck KGaA, Darmstadt, Germany, ³Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA
Background/Purpose: Structural measures of knee OA (KOA) progression include assessment of radiographic joint space width (JSW) and quantitative MRI (qMRI) measurement of cartilage thickness, both…
Abstract Number: 2251 • 2017 ACR/ARHP Annual Meeting
Preferences for Physical Activity: A Discrete Choice Experiment in People with Chronic Knee Pain
Daniel Pinto¹, Ulf Bockenholt², Rowland W. Chang^3,4, Julia (Jungwha) Lee⁵, Jane Holl⁶, Daniel Finn⁶, Leena Sharma⁷, Allen Heinemann⁸ and Paul Hansen⁹, ¹Department of Physical Therapy & Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Marketing, Kellogg School of Management, Northwestern University, Evanston, IL, ³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Preventive Medicine, Medicine, and Physical Medicine & Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Center for Rehabilitation Outcomes Research, Shirley Ryan Ability Lab, Chicago, IL, ⁹Economics, University of Otago, Dundin, New Zealand
Preferences For Physical Activity: A Discrete Choice Experiment In People With Chronic Knee Pain Background/Purpose: Understanding preferences for physical activity (PA) can help guide patient…
Abstract Number: 977 • 2017 ACR/ARHP Annual Meeting
Association of Leisure-Time Physical Activity with Late-Life Mobility Limitation Among Women with Total Joint Replacement for Hip or Knee Osteoarthritis
Aladdin Shadyab¹, Wenjun Li², Charles Eaton³ and Andrea LaCroix⁴, ¹Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, ⁴Family Medicine and Public Health, University of California, San Diego School of Medicine, La Jolla, CA
Background/Purpose: Maintaining mobility in old age is an important public health goal for patients with hip or knee osteoarthritis (OA), who are vulnerable to functional…

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