Abstracts tagged "Knee"

Abstract Number: 2753 • 2013 ACR/ARHP Annual Meeting
Relationship Of Pre-Radiographic MRI Lesions With Prevalent Frequent Knee Symptoms and Incident Persistent Knee Symptoms In Persons At Higher Risk For Knee Osteoarthritis
Leena Sharma¹, Joan S. Chmiel¹, Orit Almagor¹, Dorothy D. Dunlop², Marc C. Hochberg³, Charles Eaton⁴, C. Kent Kwoh⁵, Rebecca D. Jackson⁶, Joan M. Bathon⁷, Ali Guermazi⁸, Frank Roemer⁹, Michel Crema⁸, W. Jerry Mysiw⁶ and Michael C. Nevitt¹⁰, ¹Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine, University of Maryland School of Medicine, Baltimore, MD, ⁴Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁵School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Ohio State University, Columbus, OH, ⁷Columbia University, New York, NY, ⁸Boston University, Boston, MA, ⁹Klinikum Augsburg, Augsburg, Germany, ¹⁰Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA
Background/Purpose: The clinical significance of pre-radiographic MRI lesions in persons at risk for knee OA is unclear. Understanding whether such lesions are inconsequential or early…
Abstract Number: 2146 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On Brain Response To Painful Stimulation In Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Jordi Monfort¹, Jesús Pujol², O Contreras-Rodriguez², Jone Llorente-Onaindia², M López-Solà², Laura Blanco-Hinojo², J Deus², H Ortiz², Francisco Montañés³, M Campillo², Pere Benito², Laura Sánchez⁴, Marta Herrero⁵ and Josep Vergés⁶, ¹Reumatologia, Hospital del Mar, Barcelona, Spain, ²Hospital del Mar, Barcelona, Spain, ³Rhaumatology, Hospital del Mar, Barcelona, Spain, ⁴Bioiberica, Barcelona, Spain, ⁵Pharmascience Division, Bioiberica S.A., Barcelona, Spain, ⁶Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Knee osteoarthritis (OA) is a degenerative joint disease causing symptoms in 12% of people over the age of 65 . A variety of treatments…
Abstract Number: 265 • 2013 ACR/ARHP Annual Meeting
All-Cause Mortality and Incident Cardiovascular Disease In Knee Osteoarthritis: The Framingham Study
Devyani Misra¹, David T. Felson², Ida K. Haugen³, Martin Englund⁴ and Tuhina Neogi¹, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose: Studies examining the relation of osteoarthritis (OA) to mortality or cardiovascular disease (CVD) have reported conflicting results, raising the question of whether OA itself…
Abstract Number: 2754 • 2013 ACR/ARHP Annual Meeting
Trajectory Of Cartilage Thickness Change During The Years Prior To Knee Replacement: Data From The Osteoarthritis Initiative
Felix Eckstein¹, Robert M. Boudreau², Zhijie Wang³, Michael J. Hannon³, Wolfgang Wirth¹, Sebastian Cotofana⁴, Ali Guermazi⁵, Frank Roemer⁶, Michael C. Nevitt⁷, Markus John⁸, Christoph Ladel⁹, David J. Hunter¹⁰ and C. Kent Kwoh¹¹, ¹Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ²Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Musculoskeletal Anatomy, Paracelsus Medical University, Salzburg, Austria, ⁵Boston University, Boston, MA, ⁶Klinikum Augsburg, Augsburg, Germany, ⁷Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Merck KG, Darmstadt, Germany, ¹⁰Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ¹¹School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Knee replacement (KR) represents a clinically important and cost-effective endpoint of knee osteoarthritis (OA). We have shown previously that, in a year prior to…
Abstract Number: 2148 • 2013 ACR/ARHP Annual Meeting
Use Of Low Dose Aspirin Is Associated With Reduced Medial Tibial Cartilage Loss In Symptomatic Osteoarthritis: DATA From A Cohort Study
Anita Wluka¹, Changhai Ding², Yuanyuan Wang³, Graeme Jones⁴, Andrew Teichtahl⁵ and Flavia Cicuttini¹, ¹Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Monash University, Melbourne, Australia, ⁴Menzies Research Institute Tasmania, University of Tasmania, HOBART, Australia, ⁵Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Inflammation and vascular disease have recently been shown to play a role in the pathogenesis of osteoarthritis (OA). Low dose aspirin is commonly used…
Abstract Number: 266 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Disease In Osteoarthritis: Hip Versus Knee and The Influence Of Multiple Symptomatic Joint Involvement
Anthony V. Perruccio¹, Rita A. Kandel² and Aileen M. Davis³, ¹Toronto Western Hospital, Toronto Western Research Institute, and University of Toronto, Toronto, ON, Canada, ²Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ³Health Care and Outcomes Research, Toronto Western Research Institute; Departments of Rehabilitation Science and Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
Background/Purpose: The strength of association between obesity and osteoarthritis (OA) is reported to vary by joint (e.g. stronger association with knee than hip). As well,…
Abstract Number: 2755 • 2013 ACR/ARHP Annual Meeting
The Clinical Significance and Natural History Of Knee Bone Marrow Lesions Over 8 Years
Yi Chao Foong¹, Hussain Ijaz Khan¹, Dawn Aitken¹, Changhai Ding², Flavia Cicuttini³ and Graeme Jones², ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Department of Epidemiology and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, Australia
Background/Purpose: There is increasing evidence to suggest that bone marrow lesions (BMLs) play a key role in the pathogenesis of OA. Whilst many studies have…
Abstract Number: 2111 • 2013 ACR/ARHP Annual Meeting
The Impact Of Centralized Pain On Long-Term Analgesic Response To Lower Extremity Joint Arthroplasty: A Prospective, Observational Cohort Study
Chad M. Brummett¹, Andrew Urquhart², Brian Hallstrom², Alex Tsodikov³, David A. Williams⁴ and Daniel J. Clauw⁵, ¹Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, ²Orthopedics, University of Michigan Health System, Ann Arbor, MI, ³Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, ⁴Chronic Pain & Fatigue Rsch Ctr, Univ of MI Hlth System-Lobby M, Ann Arbor, MI, ⁵Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI
Background/Purpose : In cross-sectional studies, depression and pain in other locations have been reported as predicting poorer outcomes following total knee and hip arthroplasty. These…
Abstract Number: 244 • 2013 ACR/ARHP Annual Meeting
Association Between Serum Adipokine Levels and Extent Of Symptomatic Joint Involvement In Hip and Knee Osteoarthritis
Anthony V. Perruccio¹, Vinod Chandran², Nizar N. Mahomed³ and Rajiv Gandhi⁴, ¹Toronto Western Hospital, Toronto Western Research Institute, and University of Toronto, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Orthopaedic Surgery, University Health Network and University of Toronto, Toronto, ON, Canada, ⁴University Health Network, Arthritis Program, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) has not traditionally been considered a systemic joint disease. However, a growing body of evidence suggests that OA cannot solely be accounted…
Abstract Number: 2668 • 2013 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Dose Ranging Study Comparing FX006, An Intra-Articular (IA) Sustained-Release Formulation Of Triamcinolone Acetonide (TCA), To An Approved Injectable Suspension Of TCA In Patients With Osteoarthritis (OA) Of The Knee
Neil Bodick¹, Joelle Lufkin¹, Christina Willwerth¹, Pierre Lachance², Gregory Jasey³, Anil Gupta⁴, Anthony Chris⁵, Marc Russo⁶, Michael O'Mahony⁷, Sam Henein⁸, Louise Murdoch⁹, Ferdinandus de Looze¹⁰, David Hunter¹¹ and Michael Clayman¹, ¹Flexion Therapeutics, Burlington, MA, ²Clinique St-Louis (Recherche) Inc, Quebec, QC, Canada, ³North Walkerville Orthopaedic Associates, Windsor, ON, Canada, ⁴Anil K. Gupta Medicine Professional Corporation, Toronto, ON, Canada, ⁵Aim Health Group, Waterloo, ON, Canada, ⁶Hunter Clinical Research, Broadmeadow, Australia, ⁷London Road Diagnostic Clinic and Medical Centre, Sarnia, ON, Canada, ⁸SKDS Research Inc., Newmarket, ON, Canada, ⁹Emeritus Research, Malvern East, Australia, ¹⁰AusTrials Pty Limited, Sherwood, Australia, ¹¹Royal North Shore Hospital, St. Leonards, Australia
Background/Purpose: FX006 is a novel sustained-release formulation of TCA in poly(lactic-co-glycolic) acid microspheres intended to maintain therapeutic concentrations in the joint up to 3 months…
Abstract Number: 2112 • 2013 ACR/ARHP Annual Meeting
Hip and Knee Arthroplasty In Patients With Rheumatoid Arthritis: Results From The Australian Orthopaedic Association National Joint Replacement Registry: 2003 To 2011
Andrew Lim¹, Stephen Graves², Yen Liu², Lionel Schachna¹ and Russell R. Buchanan¹, ¹Rheumatology, Austin Health, Melbourne, Australia, ²Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, Australia
Background/Purpose: Total Joint Replacement in rheumatoid arthritis (RA) patients is a marker of disease severity. Whilst the rate of total hip (THA) and total knee…
Abstract Number: 247 • 2013 ACR/ARHP Annual Meeting
Associations Between Levels Of Urinary C-Telopeptide Fragments Of Type II Collagen and Knee Structure In Asymptomatic Middle-Aged Women
Binghui Wang¹, Hans Kurniawan Pramono², Flavia Cicuttini³, Anita Wluka³, Fahad Hanna², Susan Davis², Robin Bell², Andrew Teichtahl¹ and Yuanyuan Wang², ¹Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ²Monash University, Melbourne, Australia, ³Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: There is evidence for an association between levels of urinary C-telopeptide fragments of type II collagen (uCTX-II) and the risk of knee osteoarthritis. The…
Abstract Number: 2669 • 2013 ACR/ARHP Annual Meeting
Treatment Of Knee Osteoarthritis Patients With Strontium Ranelate Reduces The Loss Of Cartilage Volume and Bone Marrow Lesions As Assessed By Magnetic Resonance Imaging: Data From The Phase III Strontium Ranelate Efficacy In Knee Osteoarthrtis Trial
Johanne Martel-Pelletier¹, Camille Roubille¹, Jean-Pierre Raynauld¹, François Abram², Marc Dorais³, Philippe Delorme¹ and Jean-Pierre Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada
Background/Purpose: This study aimed to evaluate in a subpopulation of osteoarthritis (OA) patients from the SEKOIA Phase III trial the disease-modifying (DMOAD) effect of strontium…
Abstract Number: 2119 • 2013 ACR/ARHP Annual Meeting
Higher Mortality In Males Compared To Females Undergoing Total Knee Or Total Hip Arthroplasty: A Study Of National Time Trends, 2003-2010
Jasvinder A. Singh^1,2 and Rekha Ramachandaran³, ¹Rheumatology, Birmingham VA, Birmingham, AL, ²Department of Medicine, University of Alabama, Tuscaloosa, AL, ³University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: To assess the time-trends in gender differences in mortality after primary total knee and total hip arthroplasty (TKA and THA) by rural or urban…
Abstract Number: 250 • 2013 ACR/ARHP Annual Meeting
Synovial Inflammation In Meniscal Tear Patients: CCL19 mRNA Expression Is Independently Associated With Knee Related Disability
Anjali Nair¹, Charles Bush-Joseph², Nikhil Verma², Matthew Tetreault², Kanta Saha³, Arkady Margulis⁴, Louis F. Fogg⁵ and Carla R. Scanzello³, ¹Section of Rheumatology, Rush University Medical Center, Chicago, IL, ²Orthopedics, Rush University Medical Center, Chicago, IL, ³Rheumatology, Rush University Medical Center, Chicago, IL, ⁴Rush University Medical Center, Chicago, IL, ⁵Department of Nursing, Rush University Medical Center, Chicago, IL
Background/Purpose: In patients with knee osteoarthritis (OA), synovitis is associated with severity of knee symptoms. Previously, we demonstrated that in patients undergoing partial meniscectomy without…

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