Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose: History of knee joint injury is a strong risk factor for the development of knee osteoarthritis (OA) but it’s not clear how different structures comprising the knee joint are affected by injury. The aim of this study was to describe the association between history of knee injury and knee structural changes on MRI in middle aged and older adults.
Methods: This study included two population based samples. (I)the Offspring Study comprised of middle aged adults (n=372; mean age 45.0 years, range 26-61 years; 57.5% female). Approximately half were adult offspring of subjects who had a knee replacement performed for knee OA and the remaining were randomly selected controls that were initially matched by age and sex.(II) the Tasmanian Older Adult Cohort (TASOAC) Study comprised of older adults(n=430; mean age 63.0 years, range 51 – 79 years; 51% female) which were selected from the electoral roll using sex-stratified simple random sampling without replacement. 1.5 T MRI scans of the right knee at baseline was performed in both studies to measure bone marrow lesions (BMLs), cartilage volume, tibial bone area, cartilage defects, and meniscal pathology. History of knee injury was assessed using a self-administered questionnaire. The association between knee injury and knee structures was determined using multiple linear and log binomial regression models.
Results: In middle aged adults, only BML prevalence (Prevalence Ratio (PR)=1.6 (1.2, 2.0)) was significantly higher in those with knee injury in adjusted analysis (Table 1). In older adults, cartilage defects (PR=1.3 (1.0,1.7), total tibial cartilage volume (Difference of Means (df)= -323 (-616,-32)) and BMLs (PR=1.4 (1.0,1.9)) showed significant associations with knee injury in adjusted analysis. Meniscal tears and extrusions showed no significant associations in either of the two cohorts and tears were very common.
Conclusion: In terms of specific structural abnormalities, history of knee injury is weakly and inconsistently associated with knee structural changes in either middle age or later life suggesting most structural change in the knee is atraumatic.
Table 1: Association between injury and bone marrow lesions in the knee
|
BMLs Absent/Present(site) |
Injury
|
No Injury
|
Unadjusted
|
Adjusted*
|
|
OFFSPRING
|
||||
|
%
|
%
|
PR (95%CI)
|
PR (95%CI)
|
|
|
Medial Tibial |
33(13/39)
|
16(25/159)
|
2.1 (1.2,3.8)
|
1.9 (1.0,3.4)
|
|
Lateral Tibial |
31(12/39)
|
25(40/161)
|
1.2 (0.7,2.1)
|
1.3 (0.8,2.3)
|
|
Medial Femoral |
31(12/39)
|
11(17/160)
|
2.9 (1.5,5.6)
|
2.7 (1.3,5.3)
|
|
Lateral Femoral |
21(8/39)
|
14(23/159)
|
1.4 (0.7,2.9)
|
1.5 (0.7,3.2)
|
|
Total |
72(28/39)
|
49(82/158)
|
1.5 (1.1,1.9)
|
1.6 (1.2,2.0)
|
|
TASOAC
|
||||
|
Medial Tibial |
33(15/46)
|
18(63/346)
|
1.9 (1.1,3.1)
|
1.8 (1.1,3.1)
|
|
Lateral Tibial |
17(8/46)
|
15(51/346)
|
1.5 (0.8,3.0)
|
1.6 (0.8,3.2)
|
|
Medial Femoral |
17(8/46)
|
12(40/346)
|
2.0 (1.0,3.9)
|
1.9 (1.0,3.5)
|
|
Lateral Femoral |
30(14/46)
|
17(58/346)
|
1.7 (0.9,3.0)
|
1.7 (0.9,3.0)
|
|
Total |
52(24/46)
|
41(143/346)
|
1.4 (1.1,1.9)
|
1.4 (1.0,1.9)
|
PR-Prevalence Ratio
CI-Confidence Interval
*Adjusted for age, sex and bmi
Disclosure:
H. I. Khan,
None;
D. Aitken,
None;
C. Ding,
None;
L. Blizzard,
None;
J. P. Pelletier,
None;
J. M. Pelletier,
ArthroLab,
4;
F. Cicuttini,
None;
G. Jones,
None.
« Back to 2013 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/history-of-knee-injury-is-weakly-associated-with-knee-structural-change-in-middle-or-older-aged-adults/