Abstracts tagged "Juvenile idiopathic arthritis"

Abstract Number: 1620 • ACR Convergence 2021
Pediatric Onset (< 16 Years) Non-infectious Uveitis: Results from Spanish National Registry
Pablo Mesa-del-Castillo B.¹, Ines Yago Ugarte¹, jose Miguel Bolarin², Berta Lopez Montesinos³, Honorio Barranco Gonzalez³, Daniel Clemente⁴, Isabel Valls Ferran⁴, Juan Carlos Lopez Robledillo⁴, Beatriz Bravo⁵, Marina Rubio Prats⁵, Carmen Alba Linero⁶, Laura Martin Pedraz⁶, Esmeralda Nuñez Cuadros⁶, Maria Concepción Mir Perelló⁷, Noelia Druetta⁷, Mari Carmen Pinedo Gago⁸, Alex Fonollosa Calduch⁸, Alex Souto⁹, Fernando Lopez Lopez¹⁰, Cristina Zarallo Reales¹¹, Maria Jerez Fidalgo¹¹, Jorge Solana Fajardo¹¹, NATALIA PALMOU FONTANA¹², Rosalía Demetrio-Pablo¹³, Maria Vega Jovani Casano¹⁴, Jose Juan Mondejar Garcia¹⁵, Anahy Maria Brandy-Garcia¹⁶, Alba Garcia Lopez¹⁷, Belen Sevilla¹⁸, Jose Luis Garcia Serrano¹⁹, Alfredo Tagarro²⁰, Mar Esteban²⁰, Joan Calzada²¹, Jesus Diaz Carrascosa²¹, Cesar Gavilan Martin²², Encarna Mengual Verdu²², Ester Carreño Salas²³, Sheila Recuero Diaz²³, Neus Quilis Marti²⁴, Mari Carmen Alvarado Valero²⁵, José Rosas²⁶, Juan Luis Sanchez Sevilla²⁷, Juan Carlos Nieto²⁸, Lucia Ibares²⁸, Jaime De Inocencio²⁹, Pilar Tejada²⁹ and Almudena Roman Pascual³⁰, ¹Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, ²CENTIC (Centro tecnológico de las TICs de Murcia), Murcia, Spain, ³Hospital Universitari i Politècnic La Fe, Valencia, Spain, ⁴Hospital Infantil Universitario Niño Jesús, Madrid, Spain, ⁵Hospital Universitario Virgen de las Nieves, Granada, Spain, ⁶Hospital Universitario Regional de Málaga, Malaga, Spain, ⁷Hospital Universitari Son Espases, Palma de Mallorca, Spain, ⁸Hospital Universitario de Cruces, Bilbao, Spain, ⁹Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, ¹⁰Hospital Clínico Universitario de Santiago, Santiago de Compostela, South Georgia & South Sandwich Islands, ¹¹Hospital Universitario de Badajoz, Badajoz, Spain, ¹²UNIVERSITARY HOSPITAL MARQUES VALDECILLA, Santander, Spain, ¹³Hospital Universitario de Marqués de Valdecilla, Santander, Spain, ¹⁴National Health system, Alicante, Spain, ¹⁵Hospital General Universitario de Alicante, Alicante, Spain, ¹⁶Hospital Germans Trias i Pujol, Badalona, Spain, ¹⁷Hospital Universitario de Cabueñes, Gijón, Spain, ¹⁸Division of Paediatrics, Hospital Universitario San Cecilio, Granada, Spain, ¹⁹Hospital Universitario Clínico San Cecilio, Granada, ²⁰Hospital Universitario Infanta Sofía, Madrid, Spain, ²¹Hospital maternoinfantil Sant Joan de Déu, Barcelona, Spain, ²²Hospital Universitario San Juan de Alicante, Alicante, Spain, ²³Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ²⁴Hospital del Vinalopó, Elche, Spain, ²⁵Hospital del Vinalopó, Elche, ²⁶Hospital Marina Baixa, Villajoyosa, ²⁷Hospital Marina Baixa, Villajoyosa, Spain, ²⁸Hospital General Universitario Gregorio Marañón, Madrid, Spain, ²⁹Hospital Universitario 12 de Octubre, Madrid, Spain, ³⁰Hospital Universitario Rey Juan Carlos, Madrid, Spain
Background/Purpose: Pediatric noninfectious uveitis is a major clinical challenge for Pediatric ophthalmologists and rheumatologists. The burden of disease is considerable and etiological diagnosis elusive in…
Abstract Number: 0195 • ACR Convergence 2021
JAK Inhibitors in Refractory Adult and Childhood-Onset Still’s Disease
Louise GILLARD¹, Stéphane Mitrovic², Jacques Pouchot³, Fleur Cohen¹, Martin Michaud⁴, Heloise Reumaux⁵, Isabelle Kone-Paut⁶ and Bruno Fautrel⁷, ¹Pitié Salpêtrière Hospital, Paris, France, ²Pitié Salpêtrière Hospital - Institut Mutaliste Montsouris, Paris, France, ³AP-HP, RUEIL-MALMAISON, France, ⁴Joseph Ducuing Hospital, Toulouse, France, ⁵Jeanne de Flandre Hospital, Lille, France, ⁶APHP, Bicetre hospital, Le Kremlin bictre, France, ⁷Pitié Salpêtrière Hospital, APHP, Sorbonne Université, Paris, France
Background/Purpose: Excessive and inappropriate production of pro-inflammatory cytokines such as interleukin IL-1, IL-6 or IL-18, is a pathogenic cornerstone in adult and childhood onset Still’s…
Abstract Number: 0260 • ACR Convergence 2021
Impact on Caregivers of Patients with Juvenile Idiopathic Arthritis: A Hospital-based Study from India
Nikhil Gowda¹, Abhishek Samuel¹, Akash Yadav¹, Amita Aggarwal² and Anu Balakrishnan¹, ¹Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Juvenile idiopathic arthritis is a chronic disease that impacts patient's physical and mental health. Caregivers act as a bridge between physicians and patients, by…
Abstract Number: 1621 • ACR Convergence 2021
Self-reported Transition Readiness of Adolescent Patients with Rheumatologic Disease: Do the Parents Agree?
Christina Ma¹, Molly Dushnicky¹, Habeba Talaat¹, Steffy Thomas¹, Karen Beattie¹, Tania Cellucci², Stephanie Garner¹, Liane Heale¹, Mark Matsos¹ and Michelle Batthish¹, ¹McMaster University, Hamilton, ON, Canada, ²McMaster Children's Hospital, Hamilton, ON, Canada
Background/Purpose: The transition from pediatric to adult rheumatology care is associated with increased disease activity and morbidity. The parent-child relationship is a significant relationship in…
Abstract Number: 0241 • ACR Convergence 2021
Psoriasis Rate Is Increased by the Exposure to TNF Inhibition in Children with JIA
yongdong Zhao¹, Erin Sullivan², Mary Beth Son³ and Timothy Beukelman⁴, ¹University of Washington, Redmond, WA, ²Seattle Children's Research Institute, Seattle, WA, ³Boston Children's Hospital, Brookline, MA, ⁴University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Paradoxical psoriasis has been increasingly reported in adults after exposure to tumor necrosis factor inhibitors (TNFi). Systematic studies in the pediatric population are lacking.…
Abstract Number: 0261 • ACR Convergence 2021
Methotrexate Withdrawal and Outcomes in Participants with Well-controlled Non-systemic JIA Within the CARRA Registry
Marinka Twilt¹, Kevin Baszis², Sarah Ringold³, Timothy Beukelman⁴, Anne Dennos⁵, Peter Shrader⁶ and Daniel Horton⁷, ¹Alberta Children's Hospital, Calgary, AB, Canada, ²Washington University School of Medicine, St Louis, MO, ³Seattle Children's Hospital, Seattle, WA, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Duke University, Durham, NC, ⁶Duke Clinical Research Institute, Durham, NC, ⁷Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
Background/Purpose: Methotrexate (MTX) is currently the recommended first-line conventional DMARD for the treatment of JIA with oligo- or polyarthritis. There are limited data on how…
Abstract Number: 1622 • ACR Convergence 2021
Mind the Gap: The Experience of Adolescents in a Rheumatology Transition Clinic
Claire Fine¹, Karen Beattie¹, Tania Cellucci², Liane Heale¹, Mark Matsos¹, Stephanie Garner¹ and Michelle Batthish¹, ¹McMaster University, Hamilton, ON, Canada, ²McMaster Children's Hospital, Hamilton, ON, Canada
Background/Purpose: The transition from pediatric to adult healthcare is a critical time for the wellbeing of patients with chronic illness including rheumatologic disease. Low patient…
Abstract Number: 0242 • ACR Convergence 2021
FiRst Line Options for Systemic JIA Treatment (FROST): Results from a Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry Consensus Treatment Plan Observational Study
Timothy Beukelman¹, George Tomlinson², Peter Nigrovic³, Anne Dennos⁴, Vincent Del Gaizo⁵, Mary Ellen Riordan⁶, Laura Schanberg⁷, Shalini Mohan⁸, Erin Pfeifer⁹ and Yukiko Kimura¹⁰, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Toronto, Toronto, ON, Canada, ³Boston Children's Hospital, Brookline, MA, ⁴Duke University, Durham, NC, ⁵Childhood Arthritis & Rheumatology Research Alliance (CARRA), Whitehouse Station, NJ, ⁶Hackensack University Medical Center, Westwood, NJ, ⁷Duke University Medical Center, Durham, NC, ⁸Genentech, Inc., South San Francisco, CA, ⁹Genentech, Inc., Englewood, CO, ¹⁰Hackensack University Medical Center, New York, NY
Background/Purpose: The optimal initial treatment for systemic juvenile idiopathic arthritis (sJIA) is unclear. To further study the initial treatment of sJIA, the Childhood Arthritis and…
Abstract Number: 0262 • ACR Convergence 2021
High Degree of Inter-patient Heterogeneity in Synoviocyte Hyperplasia and Immune Cells Infiltration in the Synovium of Juvenile Idiopathic Arthritis Patients
Clément TRIAILLE¹, Cécile BOULANGER², Tatiana SOKOLOVA¹, Laurent MERIC de BELLEFON³, Adrien NZEUSSEU TOUKAP⁴, Christine GALANT⁵, Nisha LIMAYE⁶, Bernard LAUWERYS⁷ and Patrick DUREZ⁸, ¹Pôle de pathologies rhumatismales systémiques et inflammatoires, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ²Service d’Hématologie, Oncologie et Rhumatologie pédiatrique, Cliniques Universitaires Saint-Luc, Brussels, Belgium, ³Service de Rhumatologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium, ⁴Rheumatology department, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium, ⁵Service d’Anatomie Pathologique, Cliniques Universitaires Saint-Luc, Brussels, Belgium, ⁶Genetics of Autoimmune Diseases and Cancer, de Duve Institute, Université catholique de Louvain, Brussels, Belgium, ⁷UCB Pharma, Brussels, Belgium, ⁸Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium
Background/Purpose: Increasing evidence indicates that synovial tissue analysis can deliver pathophysiological insights but also individual clinically-relevant information in adult-onset inflammatory arthritides. Little is known about…
Abstract Number: 1626 • ACR Convergence 2021
Use of Total Hip Arthroplasty in Patients Under 21 Years Old: A U.S. Population Analysis
J. Alex Gibbons¹, Cynthia Kahlenberg¹, Deanna Jannat-Khah¹, Susan Goodman¹, Lisa Mandl¹, Peter Sculco¹, Stuart Goodman², Mark Figgie¹ and Bella Mehta³, ¹Hospital for Special Surgery, New York, NY, ²Stanford University, Stanford, CA, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: Total hip arthroplasty (THA) is a treatment option for young patients with severe hip pathology due to congenital, developmental, rheumatologic, traumatic, and other acquired…
Abstract Number: 0243 • ACR Convergence 2021
Effectiveness of Abatacept in Patients with JIA, Classified by Category: Results from the PRCSG/PRINTO JIA Real-World Registry
Daniel Lovell¹, Nikolay Tzaribachev², Tracy Ting³, Ekaterina Alexeeva⁴, Teresa Giani⁵, Thomas Griffin⁶, John Bohnsack⁷, Andrew Zeft⁸, Richard Vehe⁹, Stacey Tarvin¹⁰, Gerd Horneff¹¹, Maria Trachana¹², Alyssa Dominique¹³, Lixian Dong¹³, Tzuyung Douglas Kou¹³, Robert Wong¹⁴, Alberto Martini¹⁵, Hermine Brunner³ and Nicolino Ruperto¹⁶, ¹Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, ²PRI Research, Bad Bramstedt, Germany, ³Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Scientific Center of Children Health of RAMS, Moscow, Russia, ⁵Università di Siena, Siena, Italy, ⁶Levine Children's Hospital, Charlotte, NC, ⁷University of Utah, Salt Lake City, UT, ⁸Cleveland Clinic, Cleveland, OH, ⁹University of Minnesota, Twin Cities, MN, ¹⁰Riley Hospital for Children at Indiana University, Indianapolis, IN, ¹¹Paediatric Rheumatology International Trials Organisation (PRINTO), Sankt Augustin, Germany, ¹²Aristotle University of Thessaloniki, Thessaloniki, Greece, ¹³Bristol Myers Squibb, Princeton, NJ, ¹⁴Bristol Myers Squibb, Basking Ridge, NJ, ¹⁵Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, ¹⁶IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy
Background/Purpose: Long-term treatment with abatacept, a selective T-cell co-stimulation modulator, is effective and well tolerated in patients with JIA.1–4 The objective of this analysis was…
Abstract Number: 0263 • ACR Convergence 2021
Patterns of Medication Switching in Juvenile Idiopathic Arthritis: A Retrospective Analysis of a National Administrative Claims Database
Mei-Sing Ong¹, Sarah Ringold², Melissa Mannion³, Marc Natter⁴, Laura Schanberg⁵ and Yukiko Kimura⁶, ¹Harvard Medical School & Harvard Pilgrim Healthcare Institute, Boston, MA, ²Seattle Children's Hospital, Seattle, WA, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Boston Children's Hospital, Boston, MA, ⁵Duke University Medical Center, Durham, NC, ⁶Hackensack University Medical Center, New York, NY
Background/Purpose: Although the increasing availability of biologic disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) has significantly improved outcomes for patients with Juvenile Idiopathic…
Abstract Number: 1631 • ACR Convergence 2021
Predictive Factors for Lack of Response to Treatment in a Long-term Cohort of Patients with Juvenile Idiopathic Arthritis-associated Uveitis
Francesca Minoia¹, Luca Marelli², Francesca Pregnolato³, Gisella Beatrice Beretta⁴, Chiara Mapelli⁴, Gaia Leone⁴, Gilberto Cincinelli³, Paolo Nucci⁵, Teresa Giani⁶, Elisabetta Miserocchi⁷ and Rolando Cimaz⁸, ¹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy, ²Ospedale San Giuseppe, IRCCS Multimedica, Milan, Italy, ³Università degli Studi di Milano, Milan, Italy, ⁴Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, ⁵Ospedale San Giuseppe, IRCCS Multimedica, Università degli Studi di Milano, Milan, Italy, ⁶Università di Siena, Siena, Italy, ⁷San Raffaele Scientific Institute, Milan, Italy, ⁸ASST Gaetano Pini-CTO, Università degli Studi di Milano, Milan, Italy
Background/Purpose: Uveitis is the main extraarticular complication of juvenile idiopathic arthritis (JIA) with still a significant impact on JIA morbidity, despite continuous improvement in systemic…
Abstract Number: 0245 • ACR Convergence 2021
Long-term Safety and Effectiveness of Abatacept Treatment in Patients with JIA: 5-year Results from the PRCSG/PRINTO JIA Real-World Registry
Hermine Brunner¹, Daniel Lovell², Michael Henrickson¹, Ruy Carrassco³, Kirsten Minden⁴, Lyudmila Grebenkina⁵, James Nocton⁶, Ingrid Louw⁷, Linda Wagner-Weiner⁸, Gabriel Vega Cornejo⁹, Sylvia Kamphuis¹⁰, Vyacheslav Chasnyk¹¹, Heather Walters¹², Simone Appenzeller¹³, Jordi Anton¹⁴, Alyssa Dominique¹⁵, Robert Wong¹⁶, Lixian Dong¹⁵, Tzuyung Douglas Kou¹⁵, Alberto Martini¹⁷ and Nicolino Ruperto¹⁸, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, ³Presbyterian Health Services, Albuquerque, NM, ⁴Charite University Hospital Berlin, Berlin, Germany, ⁵Togliatti City Clinical Hospital №5, Togliatti, Russia, ⁶Medical College of Wisconsin, Milwaukee, WI, ⁷Panorama Medical Centre, Cape Town, South Africa, ⁸University of Chicago (Comer Children's), Chicago, IL, ⁹Crea de Guadalajara/Hospital México Americano, Guadalajara, Mexico, ¹⁰Sophia Children’s Hospital, Erasmus University Medical Center, Rotterdam, Netherlands, ¹¹Saint-Petersburg State Pediatric Medical Academy, Saint Petersburg, Russia, ¹²Cohen Children's Hospital, New York, NY, ¹³Hospital das Clínicas da Universidade Estadual de Campinas, Campinas, Brazil, ¹⁴Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain, ¹⁵Bristol Myers Squibb, Princeton, NJ, ¹⁶Bristol Myers Squibb, Basking Ridge, NJ, ¹⁷Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, ¹⁸IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy
Background/Purpose: Abatacept (ABA) is well tolerated and effective in patients with JIA.1 The Pediatric Rheumatology Collaborative Study Group (PRCSG)/ Paediatric Rheumatology INternational Trials Organisation (PRINTO)…
Abstract Number: 0264 • ACR Convergence 2021
Joint Acoustic Emissions as a Biomarker to Differentiate Between Active and Inactive Juvenile Idiopathic Arthritis via 2-stage Machine Learning Classifier
Luis Rosa¹, Sevda Gharehbaghi¹, Omer Inan¹, Daniel Whittingslow², Lori Ponder³ and Sampath Prahalad⁴, ¹Georgia Institute of Technology, Atlanta, GA, ²Emory University School of Medicine, Atlanta, GA, ³Children's Healthcare of Atlanta, Atlanta, GA, ⁴Emory + Children's Pediatric Institute, Atlanta, GA
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is the most prevalent chronic rheumatic disease and can result in disability in children. JIA most commonly affects the knee.…

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