Abstracts tagged "Juvenile idiopathic arthritis"

Abstract Number: L20 • ACR Convergence 2021
Efficacy of Emapalumab, an Anti-IFNγ Antibody in Patients with Macrophage Activation Syndrome (MAS) Complicating Systemic Juvenile Idiopathic Arthritis (sJIA) Who Had Failed High-Dose Glucocorticoids (GCs)
Fabrizio De Benedetti¹, Alexei Grom², Paul Brogan³, Claudia Bracaglia¹, Manuela Pardeo¹, Giulia Marucci¹, Despina Eleftheriou³, Charalampia Papadopoulou³, Pierre Quartier⁴, Jordi Antón⁵, Rikke Frederiksen⁶, Veronica Asnaghi⁶ and Cristina De Min⁶, ¹Bambino Gesù Children's Hospital IRCCS, Rome, Italy, ²Cincinnati Children’s Hospital, Division of Rheumatology, Cincinnati, OH, ³UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, ⁴Université de Paris, IMAGINE Institute, RAISE reference centre, Pediatric Immuno-Hematology and Rheumatology Unit, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France, ⁵Hospital Sant Joan de Déu, Division of Pediatric Rheumatology, University of Barcelona, Barcelona, Spain, ⁶Swedish Orphan Biovitrum AG (Sobi), Basel, Switzerland
Background/Purpose: MAS is a life-threatening complication of rheumatic diseases, occurring most frequently in sJIA. The mainstay of MAS treatment is high dose GCs; however, GCs…
Abstract Number: 0257 • ACR Convergence 2021
Can We Assess Disability in Juvenile Idiopathic Arthritis with Two Simple Questions? Results from the CAPRI Registry
Meghan McPherson¹, Kristin Houghton², Nikola Surjanovic³, Thomas Loughin³, Roberta Berard⁴, Jean-Philippe Proulx-Gauthier⁵, Gaelle Chedeville⁶, Dax Rumsey⁷, Heinrike Schmeling⁸, Nadia Luca⁸, Nicole Johnson⁸, Tommy Gerschman², Paivi Miettunen⁸, Evelyn Rozenblyum⁹, Herman Tam¹⁰, Lilliam Lim⁷, Kimberly Morishita², Rosie Scuccimarri¹¹, Johannes Roth¹², Ciaran Duffy¹², Lori Tucker¹³, Brian Feldman¹⁴ and Jaime Guzman¹⁵, ¹University of Manitoba, Winnipeg, MB, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Simon Fraser University, Burnaby, BC, Canada, ⁴London Health Sciences Centre, London, ON, Canada, ⁵Laval University, Québec City, QC, Canada, ⁶The Montreal Children's Hospital, Montréal, QC, Canada, ⁷University of Alberta, Edmonton, AB, Canada, ⁸University of Calgary, Calgary, AB, Canada, ⁹Temerty School of Medicine and Unity Health, Toronto, ON, Canada, ¹⁰Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada, ¹¹MgGill University, Montréal, QC, Canada, ¹²University of Ottawa, Ottawa, ON, Canada, ¹³BC Children's Hospital, Vancouver, BC, Canada, ¹⁴The Hospital for Sick Children, Toronto, ON, Canada, ¹⁵University of British Columbia and BC Children's Hospital, Vancouver, BC, Canada
Background/Purpose: To assess if a combination of two questions (Functional Arthritis Screening with Two Questions - FAST index) can detect and roughly estimate the degree…
Abstract Number: 1424 • ACR Convergence 2021
Secukinumab Treatment in Children and Adolescents with Enthesitis-related Arthritis and Juvenile Psoriatic Arthritis: Efficacy and Safety Results from a Phase 3 Study
Hermine Brunner¹, Ivan Foeldvari², Ekaterina Alexeeva³, Nuray Ayaz⁴, Inmaculada Calvo Penads⁵, Ozgur Kasapcopur⁶, Vyacheslav Chasnyk⁷, Markus Hufnagel⁸, Zbigniew Zuber⁹, Grant Schulert¹, Seza Ozen¹⁰, Artem Popov¹¹, Athimalaipet Ramanan¹², Christiaan Scott¹³, Betul Sozeri¹⁴, Elena Zholobova¹⁵, Xuan Zhu¹⁶, Sarah Whelan¹⁷, Luminita Pricop¹⁸, Angelo Ravelli¹⁹, Alberto Martini²⁰, Daniel Lovell²¹ and Nicolino Ruperto²², ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Hamburger Zentrum fuer Kinder- und Jugendrheumatologie, Hamburg, Germany, ³Scientific Center of Children Health of RAMS, Moscow, Russia, ⁴Istanbul University, İstanbul, Turkey, ⁵Hospital Universitario y Politécnico La Fe, Valencia, Spain, ⁶Istanbul University-Cerrahpasa, İstanbul, Turkey, ⁷Saint-Petersburg State Pediatric Medical Academy, Saint Petersburg, Russia, ⁸Division of Pediatric Infectious Diseases and Rheumatology, Department of Pediatrics and Adolescent Medicine, University Hospital Medical Center Freiburg, Medical Faculty, University of Freiburg, Freiburg, Germany, ⁹Paediatric Rheumatology International Trials Organisation (PRINTO), Lodz, Poland, ¹⁰Hacettepe University Medical Faculty, Ankara, Turkey, ¹¹Ural State Medical University, Yekaterinburg, Russia, ¹²University of Bristol, Bristol, United Kingdom, ¹³Paediatric Rheumatology, University of Cape Town, Cape Town, South Africa, ¹⁴University of Health Sciences, Umraniye Tranining and Research Hospital Division of Pediatric Rheumatology, Istanbul, Turkey, ¹⁵First Moscow State Medical University n.a. I.M.Sechenov, Moscow, Russia, ¹⁶Novartis Pharmaceuticals Corporation, East Hanover, NJ, ¹⁷Novartis, Dublin, Ireland, ¹⁸Novartis Pharmaceutical Corporation, East Hanover, NJ, ¹⁹Istituto Giannina Gaslini, Genoa, Italy, ²⁰IRCCS Istituto G. Gaslini, Università di Genova Pediatria II, Genova, Italy, ²¹Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, ²²IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy
Background/Purpose: Enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) are two conditions that represent pediatric correlates of axial spondyloarthritis (axSpA) and adult psoriatic arthritis (PsA),…
Abstract Number: 0258 • ACR Convergence 2021
Developing Electronic Health Record Algorithms That Accurately Identify Patients with Juvenile Idiopathic Arthritis
Hannah Peterson¹, April Barnado² and Anna Patrick², ¹Lipscomb University College of Pharmacy, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Electronic Health Records (EHRs) store nearly all clinical data in one central location providing increased accessibility, accuracy, and security. At our institution, the Synthetic…
Abstract Number: 1615 • ACR Convergence 2021
Responsiveness of Quality of Life and Function Assessment to Changes in Topical Eye Medications in Children with Uveitis
Virginia Miraldi Utz¹, Amy Cassedy¹, Theresa Hennard¹, Najima Mwase² and Sheila Angeles-Han¹, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²University of Nevada, Las Vegas, Las Vegas, NV
Background/Purpose: Children with uveitis often require topical eye medications (eye drops) to control inflammation (glucocorticoids) and complications such as elevated intraocular pressure and synechiae (glaucoma…
Abstract Number: 0016 • ACR Convergence 2021
Structural and Functional Neurobiological Alterations of Salience and Sensorimotor Networks in Juvenile Idiopathic Arthritis
Hanne van der Heijden¹, Jordan Lemme², Mariesa Cay², Diana Sibai², Benjamin Goodlett³, Jeffrey Lo⁴, Peter Nigrovic⁵, Margaret Chang⁴, Esra Meidan⁴, Olha Halyabar⁴, Melissa Hazen⁶, Maria Taylor⁴, Kacie Hoyt⁴, Camilo Jaimes⁷, Lauren Henderson³, Kirsten Ecklund⁷, Rudy Schreiber⁸, Robert Sundel⁴ and Jaymin Upadhyay⁹, ¹Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA USA/ Faculty of Psychology and Neuroscience, Section Neuropsychology & Psychopharmacology Maastricht University, Maastricht, The Netherlands/ Faculty of Science, Biomedical Sciences Neurobiology, University of Amsterdam, Amsterdam, The Netherlands, Sittard, Netherlands, ²Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA USA, Boston, MA, ³Division of Genetics and Genomics, Boston Children’s Hospital, Harvard Medical School, Boston, MA, ⁴Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ⁵Boston Children's Hospital, Brookline, MA, ⁶Boston Children's Hospital, Boston, MA, ⁷Department of Radiology, Boston Children’s Hospital, Harvard Medical School, Boston, ⁸Faculty of Psychology and Neuroscience, Section Neuropsychology & Psychopharmacology Maastricht University, Maastricht, The Netherlands., Maastricht, Netherlands, ⁹Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA USA/ Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA USA, Boston, MA
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is a common childhood illness, characterized by inflammation of the joint, chronic pain and decreased physical functioning. To date, the…
Abstract Number: 0259 • ACR Convergence 2021
JIA Diagnoses and Trends from 2006-2019: Has the U.S. ICD-9-to-ICD-10 Transition Created Coding Artifacts?
Daniel Horton¹, Lauren Parlett², Cecilia Huang³, Stephen Crystal⁴, Amy Davidow⁵, Tobias Gerhard⁶, Carlos Rose⁷, Kevin Haynes² and Brian Strom⁸, ¹Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²HealthCore, Wilmington, DE, ³Rutgers Institute for Health, New Brunswick, NJ, ⁴Rutgers School of Social Work, New Brunswick, NJ, ⁵Rutgers School of Public Health, New Brunswick, NJ, ⁶Ernst Mario School of Pharmacy, New Brunswick, NJ, ⁷Thomas Jefferson University, Wilmington, DE, ⁸Rutgers Biomedical and Health Sciences, Newark, NJ
Background/Purpose: JIA is the most common rheumatic disease of childhood, but recent data on diagnostic trends in the US are lacking. Furthermore, the impact of…
Abstract Number: 1620 • ACR Convergence 2021
Pediatric Onset (< 16 Years) Non-infectious Uveitis: Results from Spanish National Registry
Pablo Mesa-del-Castillo B.¹, Ines Yago Ugarte¹, jose Miguel Bolarin², Berta Lopez Montesinos³, Honorio Barranco Gonzalez³, Daniel Clemente⁴, Isabel Valls Ferran⁴, Juan Carlos Lopez Robledillo⁴, Beatriz Bravo⁵, Marina Rubio Prats⁵, Carmen Alba Linero⁶, Laura Martin Pedraz⁶, Esmeralda Nuñez Cuadros⁶, Maria Concepción Mir Perelló⁷, Noelia Druetta⁷, Mari Carmen Pinedo Gago⁸, Alex Fonollosa Calduch⁸, Alex Souto⁹, Fernando Lopez Lopez¹⁰, Cristina Zarallo Reales¹¹, Maria Jerez Fidalgo¹¹, Jorge Solana Fajardo¹¹, NATALIA PALMOU FONTANA¹², Rosalía Demetrio-Pablo¹³, Maria Vega Jovani Casano¹⁴, Jose Juan Mondejar Garcia¹⁵, Anahy Maria Brandy-Garcia¹⁶, Alba Garcia Lopez¹⁷, Belen Sevilla¹⁸, Jose Luis Garcia Serrano¹⁹, Alfredo Tagarro²⁰, Mar Esteban²⁰, Joan Calzada²¹, Jesus Diaz Carrascosa²¹, Cesar Gavilan Martin²², Encarna Mengual Verdu²², Ester Carreño Salas²³, Sheila Recuero Diaz²³, Neus Quilis Marti²⁴, Mari Carmen Alvarado Valero²⁵, José Rosas²⁶, Juan Luis Sanchez Sevilla²⁷, Juan Carlos Nieto²⁸, Lucia Ibares²⁸, Jaime De Inocencio²⁹, Pilar Tejada²⁹ and Almudena Roman Pascual³⁰, ¹Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, ²CENTIC (Centro tecnológico de las TICs de Murcia), Murcia, Spain, ³Hospital Universitari i Politècnic La Fe, Valencia, Spain, ⁴Hospital Infantil Universitario Niño Jesús, Madrid, Spain, ⁵Hospital Universitario Virgen de las Nieves, Granada, Spain, ⁶Hospital Universitario Regional de Málaga, Malaga, Spain, ⁷Hospital Universitari Son Espases, Palma de Mallorca, Spain, ⁸Hospital Universitario de Cruces, Bilbao, Spain, ⁹Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, ¹⁰Hospital Clínico Universitario de Santiago, Santiago de Compostela, South Georgia & South Sandwich Islands, ¹¹Hospital Universitario de Badajoz, Badajoz, Spain, ¹²UNIVERSITARY HOSPITAL MARQUES VALDECILLA, Santander, Spain, ¹³Hospital Universitario de Marqués de Valdecilla, Santander, Spain, ¹⁴National Health system, Alicante, Spain, ¹⁵Hospital General Universitario de Alicante, Alicante, Spain, ¹⁶Hospital Germans Trias i Pujol, Badalona, Spain, ¹⁷Hospital Universitario de Cabueñes, Gijón, Spain, ¹⁸Division of Paediatrics, Hospital Universitario San Cecilio, Granada, Spain, ¹⁹Hospital Universitario Clínico San Cecilio, Granada, ²⁰Hospital Universitario Infanta Sofía, Madrid, Spain, ²¹Hospital maternoinfantil Sant Joan de Déu, Barcelona, Spain, ²²Hospital Universitario San Juan de Alicante, Alicante, Spain, ²³Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ²⁴Hospital del Vinalopó, Elche, Spain, ²⁵Hospital del Vinalopó, Elche, ²⁶Hospital Marina Baixa, Villajoyosa, ²⁷Hospital Marina Baixa, Villajoyosa, Spain, ²⁸Hospital General Universitario Gregorio Marañón, Madrid, Spain, ²⁹Hospital Universitario 12 de Octubre, Madrid, Spain, ³⁰Hospital Universitario Rey Juan Carlos, Madrid, Spain
Background/Purpose: Pediatric noninfectious uveitis is a major clinical challenge for Pediatric ophthalmologists and rheumatologists. The burden of disease is considerable and etiological diagnosis elusive in…
Abstract Number: 0195 • ACR Convergence 2021
JAK Inhibitors in Refractory Adult and Childhood-Onset Still’s Disease
Louise GILLARD¹, Stéphane Mitrovic², Jacques Pouchot³, Fleur Cohen¹, Martin Michaud⁴, Heloise Reumaux⁵, Isabelle Kone-Paut⁶ and Bruno Fautrel⁷, ¹Pitié Salpêtrière Hospital, Paris, France, ²Pitié Salpêtrière Hospital - Institut Mutaliste Montsouris, Paris, France, ³AP-HP, RUEIL-MALMAISON, France, ⁴Joseph Ducuing Hospital, Toulouse, France, ⁵Jeanne de Flandre Hospital, Lille, France, ⁶APHP, Bicetre hospital, Le Kremlin bictre, France, ⁷Pitié Salpêtrière Hospital, APHP, Sorbonne Université, Paris, France
Background/Purpose: Excessive and inappropriate production of pro-inflammatory cytokines such as interleukin IL-1, IL-6 or IL-18, is a pathogenic cornerstone in adult and childhood onset Still’s…
Abstract Number: 0260 • ACR Convergence 2021
Impact on Caregivers of Patients with Juvenile Idiopathic Arthritis: A Hospital-based Study from India
Nikhil Gowda¹, Abhishek Samuel¹, Akash Yadav¹, Amita Aggarwal² and Anu Balakrishnan¹, ¹Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Juvenile idiopathic arthritis is a chronic disease that impacts patient's physical and mental health. Caregivers act as a bridge between physicians and patients, by…
Abstract Number: 1621 • ACR Convergence 2021
Self-reported Transition Readiness of Adolescent Patients with Rheumatologic Disease: Do the Parents Agree?
Christina Ma¹, Molly Dushnicky¹, Habeba Talaat¹, Steffy Thomas¹, Karen Beattie¹, Tania Cellucci², Stephanie Garner¹, Liane Heale¹, Mark Matsos¹ and Michelle Batthish¹, ¹McMaster University, Hamilton, ON, Canada, ²McMaster Children's Hospital, Hamilton, ON, Canada
Background/Purpose: The transition from pediatric to adult rheumatology care is associated with increased disease activity and morbidity. The parent-child relationship is a significant relationship in…
Abstract Number: 0241 • ACR Convergence 2021
Psoriasis Rate Is Increased by the Exposure to TNF Inhibition in Children with JIA
yongdong Zhao¹, Erin Sullivan², Mary Beth Son³ and Timothy Beukelman⁴, ¹University of Washington, Redmond, WA, ²Seattle Children's Research Institute, Seattle, WA, ³Boston Children's Hospital, Brookline, MA, ⁴University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Paradoxical psoriasis has been increasingly reported in adults after exposure to tumor necrosis factor inhibitors (TNFi). Systematic studies in the pediatric population are lacking.…
Abstract Number: 0261 • ACR Convergence 2021
Methotrexate Withdrawal and Outcomes in Participants with Well-controlled Non-systemic JIA Within the CARRA Registry
Marinka Twilt¹, Kevin Baszis², Sarah Ringold³, Timothy Beukelman⁴, Anne Dennos⁵, Peter Shrader⁶ and Daniel Horton⁷, ¹Alberta Children's Hospital, Calgary, AB, Canada, ²Washington University School of Medicine, St Louis, MO, ³Seattle Children's Hospital, Seattle, WA, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Duke University, Durham, NC, ⁶Duke Clinical Research Institute, Durham, NC, ⁷Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
Background/Purpose: Methotrexate (MTX) is currently the recommended first-line conventional DMARD for the treatment of JIA with oligo- or polyarthritis. There are limited data on how…
Abstract Number: 1622 • ACR Convergence 2021
Mind the Gap: The Experience of Adolescents in a Rheumatology Transition Clinic
Claire Fine¹, Karen Beattie¹, Tania Cellucci², Liane Heale¹, Mark Matsos¹, Stephanie Garner¹ and Michelle Batthish¹, ¹McMaster University, Hamilton, ON, Canada, ²McMaster Children's Hospital, Hamilton, ON, Canada
Background/Purpose: The transition from pediatric to adult healthcare is a critical time for the wellbeing of patients with chronic illness including rheumatologic disease. Low patient…
Abstract Number: 0242 • ACR Convergence 2021
FiRst Line Options for Systemic JIA Treatment (FROST): Results from a Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry Consensus Treatment Plan Observational Study
Timothy Beukelman¹, George Tomlinson², Peter Nigrovic³, Anne Dennos⁴, Vincent Del Gaizo⁵, Mary Ellen Riordan⁶, Laura Schanberg⁷, Shalini Mohan⁸, Erin Pfeifer⁹ and Yukiko Kimura¹⁰, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Toronto, Toronto, ON, Canada, ³Boston Children's Hospital, Brookline, MA, ⁴Duke University, Durham, NC, ⁵Childhood Arthritis & Rheumatology Research Alliance (CARRA), Whitehouse Station, NJ, ⁶Hackensack University Medical Center, Westwood, NJ, ⁷Duke University Medical Center, Durham, NC, ⁸Genentech, Inc., South San Francisco, CA, ⁹Genentech, Inc., Englewood, CO, ¹⁰Hackensack University Medical Center, New York, NY
Background/Purpose: The optimal initial treatment for systemic juvenile idiopathic arthritis (sJIA) is unclear. To further study the initial treatment of sJIA, the Childhood Arthritis and…

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