Abstracts tagged "juvenile idiopathic arthritis (JIA)"

Abstract Number: 1925 • 2019 ACR/ARP Annual Meeting
Discriminant and Predictive Ability of the Parent Version of the Juvenile Arthritis Disease Activity Score in Two Large Multination Cohorts of Patients with Juvenile Idiopathic Arthritis
Francesca Ridella ¹, Giedre Januskeviciute ², Chiara Trincianti ³, Evert Hendrik Pieter Van Dijkhuizen ⁴, Gabriella Giancane ⁵, Serena Pastore ⁶, Kirsten Minden ⁷, Maria Ekelund ⁸, Patrizia Barone ⁹, Matilda Laday ¹⁰, Nicolino Ruperto ¹¹, Angelo Ravelli ¹² and Alessandro Consolaro¹³, ¹Università degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, Italy, Genova, Italy, ²Klaipeda Children's Hospital, Klaipeda, Lithuania, Klaipeda, Lithuania, ³Università degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, Italy, Genoa, Italy, ⁴Wilhelmina Children’s Hospital, Department of Pediatric Immunology and Rheumatology, Utrecht, The Netherlands, Utrecht, Netherlands, ⁵Università degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, Italy and IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, Genoa, Italy, Genoa, Italy, ⁶Institute for Maternal and Child Health IRCCS "Burlo Garofolo," Trieste, Italy, Trieste, Italy, ⁷German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany, Berlin, Germany, ⁸Ryhov County Hospital, Futurum - the Academy for health and care, Jonkoping, Sweden, Jonkoping, Sweden, ⁹Department of Pediatrics, University of Catania, Catania, Italy, Catania, Italy, ¹⁰Spitalul Clinic Județean De Urgenta, Tîrgu-Mures, Romania, Tîrgu-Mures, Romania, ¹¹Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, ¹²IRCCS Istituto Giannina Gaslini, Università degli Studi di Genova, Genova, Italy, ¹³Università degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, Italy and IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, Genoa, Italy, Genova, Italy
Background/Purpose: The assessment of disease activity plays a pivotal role in the management of children with juvenile idiopathic arthritis (JIA). Most recent recommendations require that…
Abstract Number: 2718 • 2019 ACR/ARP Annual Meeting
A Retrospective Study Comparing Refractoriness to Biologic Disease Modifying Anti-Rheumatic Drugs in Adults with Juvenile Idiopathic Arthritis as Compared to Those with Rheumatoid Arthritis
Kiana Taba¹ and Elizabeth Ortiz ², ¹University of Southern California, LAGUNA HILLS, CA, ²LAC+USC/Keck Medicine of USC, Los Angeles
Background/Purpose: The use of biologic DMARDs (bDMARDs) has vastly changed the treatment of autoimmune arthritis, both Rheumatoid Arthritis (RA) and polyarticular and oligoarticular Juvenile Idiopathic…
Abstract Number: 2703 • 2019 ACR/ARP Annual Meeting
The Childhood Arthritis and Rheumatology Research Alliance Start Time Optimization of Biologic Therapy in Polyarticular JIA Study: Patient Characteristics, Patient Reported Outcomes and Consensus Treatment Plan Choices
Sarah Ringold ¹, George Tomlinson ², Pamela Weiss ³, Laura Schanberg ⁴, Mary Ellen Riordan ⁵, Anne Dennos ⁶, Vincent Del Gaizo ⁷, Katherine Murphy ⁸, Brian Feldman ⁹ and Yukiko Kimura¹⁰, ¹Seattle Children's, Seattle, ²University of Toronto, Toronto, ON, Canada, ³Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Duke University Medical Center, Durham, NC, ⁵Joseph M Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, NJ, ⁶Duke Clinical Research Institute, Durham, NC, ⁷Childhood Arthritis & Rheumatology Research Alliance, Whitehouse Station, NJ, ⁸Louisiana Office of Public Health, New Orleans, LA, ⁹University of Toronto & The Hospital for Sick Children, Toronto, ON, Canada, ¹⁰Joseph M Sanzari Children's Hospital, Hackensack University Medical Center, Cincinnati, OH
Background/Purpose: There continues to be uncertainty regarding when to start biologic medications for polyarticular juvenile idiopathic arthritis (P-JIA). The Childhood Arthritis and Rheumatology Research Alliance…
Abstract Number: 786 • 2019 ACR/ARP Annual Meeting
Distinguishing S100 Proteins and Cytokine Levels Between Active and Inactive Uveitis in Children with Juvenile Idiopathic Arthritis
Jackeline Rodriguez-Smith¹, Virginia Utz ², Sherry Thornton ¹, Grant Schulert ¹, Adam Kauffman ³, Alyssa Sproles ¹, Najima Mwase ¹, Theresa Hennard ⁴, Alexei A. Grom ¹, Mekibib Altaye ⁵, Gary Holland ⁶ and Sheila Angeles-Han ⁷, ¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Cincinnati Eye Institute and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Rheumatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁵Divison of Biostatistics and Epidemiology and Department of Pediatrics, University of Cincinnati, Cincinnati, OH, ⁶UCLA Stein Eye Institute and David Geffen School of Medicine at University of California, Los Angeles, Ca, Los Angeles, CA, ⁷Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cinicinnati
Background/Purpose: Uveitis occurs in 10-20% of children with Juvenile Idiopathic Arthritis (JIA) and is typically asymptomatic. Ocular complications occur in 50% of children, (i.e. cataracts,…
Abstract Number: 2096 • 2019 ACR/ARP Annual Meeting
An Intervention Bundle Increases Uptake of Influenza Vaccine by Rheumatoid Arthritis Patients
Valeria Valerio¹, Maria Bazan ¹, Mianbo Wang ², Bruce Mazer ¹, Elizabeth M. Hazel ³, Christian Pineau ⁴, Sasha Bernatsky ⁵, Brian Ward ⁶ and Ines Colmegna ⁶, ¹The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada, ³McGill University Health Centre, Montreal, Canada, ⁴McGill University Health Centre, Montreal, QC, Canada, ⁵McGill University Health Center, Montreal, Canada, ⁶McGill University Health Center, Montreal, QC, Canada
Background/Purpose: Annual vaccination with inactivated influenza vaccine is recommended for adults with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). Despite this, influenza immunization coverage…
Abstract Number: 2724 • 2019 ACR/ARP Annual Meeting
Farber Disease (Acid Ceramidase Deficiency): The First Natural History Study of This Rare Disease Involving Symptoms Which Can Mimic JIA
Alexander Solyom¹, Erik Sundberg ², John Mitchell ³, Christina Grant ⁴, Carlos Ferreira ⁵, Paul Harmatz ⁶, Neslihan Mungan ⁷, Fatma Bulut ⁷, Christina Lampe ⁸, Andreas Hahn ⁸, Norberto Guelbert ⁹, Nur Arslan ¹⁰, Balahan Makay ¹⁰, Ratna Puri ¹¹, Sunita Bijarnia-Mahay ¹¹, Laila Selim ¹², Iman Gamal el Din ¹², Seema Kapoor ¹³, Maja DiRocco ¹⁴, Seza Ozen ¹⁵, Ezgi Batu ¹⁵, Gulden Gokcay ¹⁶, Marta Torcoletti ¹⁷, Alan Kimura ¹⁸ and Bo Magnusson ², ¹Enzyvant, Basel, Switzerland, ²Karolinska University Hospital, Stockholm, Sweden, ³Montreal Children's Hospital, Montreal, Canada, ⁴Children's National Medical Center, Washingotn, DC, ⁵Children's National Medical Center, Washington, DC, ⁶UCSF Benioff Children's Hospital Oakland, Oakland, CA, ⁷Cukurova University Hospital, Adana, Turkey, ⁸University Hospital Giessen, Giessen, Germany, ⁹Children's Hospital of Cordoba, Cordoba, Argentina, ¹⁰Dokuz Eylul University Hospital, Izmir, Turkey, ¹¹Sir Ganga Ram Hospital, Delhi, India, ¹²Cairo University Children's Hospital, Cairo, Egypt, ¹³13Lok Nayak Hospital and Maulana Azad Medical College, Delhi, India, ¹⁴Istituto Giannina Gaslini, Genoa, Italy, ¹⁵Hacettepe University Hospital, Ankara, Turkey, ¹⁶Istanbul University, Istanbul, Turkey, ¹⁷University of Milan, Milan, Italy, ¹⁸Enzyvant, Cambridge, MA
Background/Purpose: The cardinal clinical symptoms of Farber disease (arthritis/contractures, subcutaneous granulomatous nodules, dysphonia) may be misdiagnosed as JIA. Mutations in the ASAH1 gene and the…
Abstract Number: 787 • 2019 ACR/ARP Annual Meeting
Complement Protein Levels Reflect Disease Activity in Juvenile Idiopathic Arthritis
Mia Glerup¹, Steffen Thiel ², Veronika Rypdal ³, Ellen Dalen Arnstadt ⁴, Maria Ekelund ⁵, Suvi Peltoniemi ⁶, Kristiina Aalto ⁶, Marite Rygg ⁷, Susan Nielsen ⁸, Anders Fasth ⁹, Lillemor Berntson ¹⁰, Ellen Nordal ³ and Troels Herlin ¹¹, ¹Dept of Pediatrics, Aarhus University Hospital, Aarhus, Denmark, Aarhus, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, Aarhus, Denmark, ³Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway., Tromsø, Norway, ⁴Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Trondheim, Norway, ⁵Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden. Department of Pediatrics, Ryhov County Hospital, Jonkoping, Sweden., Jonkoping, Sweden, ⁶Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland., Helsinki, Finland, ⁷Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway., Tromsø, Norway, ⁸Department of Pediatrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Copenhavn, Denmark, ⁹Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Gothenburg, Sweden, ¹⁰Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden., Uppsala, Sweden, ¹¹Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark., Aarhus, Denmark
Background/Purpose: There is an increasing body of evidence that inadequately controlled activation of complement factors leading to either overactivity or deficiency may be involved in…
Abstract Number: 2258 • 2019 ACR/ARP Annual Meeting
Causes of Influenza Vaccine Hesitancy in Rheumatoid Arthritis and Adults with Juvenile Idiopathic Arthritis
Sandra Pelaez ¹, Vincent Gosselin Boucher ², Valeria Valerio ³, Elizabeth M. Hazel ⁴, Kim Lavoie ⁵, Brian Ward ⁶ and Ines Colmegna⁶, ¹Research Centre of the Sainte-Justine University Hospital, Montreal, Canada, ²Montreal Behavioural Medicine Centre, Centre Intégré Universitaire de santé et services sociaux du Nord-de-l’Ile-de-Montréal (CIUSSS-NIM), Hôpital du Sacré-Cœur de Montréal & Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada, ³The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁴McGill University Health Centre, Montreal, Canada, ⁵Montreal Behavioural Medicine Centre, Centre Intégré Universitaire de santé et services sociaux du Nord-de-l’Ile-de-Montréal (CIUSSS-NIM), Hôpital du Sacré-Cœur de Montréal & Department of Psychology, Université du Québec à Montréal, Montreal, Canada, ⁶McGill University Health Center, Montreal, QC, Canada
Background/Purpose: Vaccine hesitancy -the reluctance or refusal to vaccinate despite the availability of vaccines- is one of the threats to global health set by the…
Abstract Number: 790 • 2019 ACR/ARP Annual Meeting
Can High ANA Titre Combined with Clinical Features Predict Developing Autoimmune Conditions in Children?
Ovgu Kul Cinar¹, Charlene Foley ², Ali Al-Hussain ³, Kimberly Gilmour ⁴, Matthew Buckland ⁴ and Muthana Al-Obaidi ⁵, ¹Great Ormond Street Hospital, Lonodn, United Kingdom, ²Great Ormond Street Hospital, London, Ireland, ³Great Ormond Street Hospital, London, United Kingdom, ⁴Great Ormond Street Hospital NHS Trust, Camelia Botnar Laboratories, London, United Kingdom, ⁵Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom
Background/Purpose: Antinuclear antibodies (ANA) are autoantibodies that recognise cellular antigens found predominantly in the cell nucleus. They are associated with numerous autoimmune diseases such as…
Abstract Number: 2696 • 2019 ACR/ARP Annual Meeting
Long-Term Efficacy and Safety of Сanakinumab in Children with Systemic Juvenile Idiopathic Arthritis
Ekaterina Alexeeva¹, Rina Denisova ², Tatyana Dvoryakovskaya ², Ksenia Isaeva ², Ivan Kriulin ², Alina Alshevskaya ³ and Andrey Moskalev ³, ¹National Medical Research Center of Children`s Health, Moscow, Russia, ²NMRCCH, Moscow, Russia, ³Biostatistics and Clinical Trials Center, Novosibirsk, Russia
Background/Purpose: Canakinumab (CAN) is an efficacious option for treatment of systemic juvenile idiopathic arthritis (sJIA). However, it is still disputable whether long-term therapy is efficacious…
Abstract Number: 804 • 2019 ACR/ARP Annual Meeting
STING-associated Vasculopathy with Onset in Infancy (SAVI Syndrome) Can Mimic Juvenile Idiopathic Arthritis
Jose Luis Tandaipan¹, Mireia Lopez Corbeto ² and Estefania Moreno Ruzafa ³, ¹Hospital Universitari Mutua Terrassa, Terrassa, Spain, ²Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain, ³Hospital Universitari Vall d'Hebron, Barcelona, Spain
Background/Purpose: Gain-of-function mutations in TMEM173 encoding STING (Stimulator of Interferon Genes) underlie a novel type I INF termed SAVI syndrome. It is characterized by a…
Abstract Number: 2699 • 2019 ACR/ARP Annual Meeting
Systemic Therapy in Children with Juvenile Idiopathic Arthritis-Associated Uveitis Immediately Following Failure of Methotrexate, Adalimumab and Infliximab
Najima Mwase ¹, Theresa Hennard ², Joseph McDonald ³, Amy Cassedy ⁴, Onengiya Harry ³ and Sheila Angeles-Han⁵, ¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ³Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, ⁴Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, ⁵Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cinicinnati
Background/Purpose: Juvenile idiopathic arthritis-associated uveitis (JIA-U) is the most common extra-articular manifestation of JIA, leading to ocular complications and blindness when not adequately treated. First…
Abstract Number: 1849 • 2018 ACR/ARHP Annual Meeting
Remission Status after 18 Years of Follow-up in the Population-Based Nordic Juvenile Idiopathic Arthritis (JIA) Cohort
Mia Glerup¹, Veronika Rypdal^2,3, Ellen Dalen Arnstad^4,5, Maria Ekelund^6,7, Suvi Peltoniemi⁸, Kristiina Aalto⁸, Marite Rygg^9,10, Peter Toftedal¹¹, Susan Nielsen¹¹, Anders Fasth¹², Lillemor Berntson¹³, Ellen Nordal^14,15 and Troels Herlin¹⁶, ¹Department of Pediatrics, Dept. of Pediatrics, Aarhus University Hospital, Denmark, Aarhus, Denmark, ²Dept. of Clin. Med, UIT The Arctic University of Norway, Tromsø, Norway, ³Dept. of Pediatrics, University Hospital of North Norway, Tromsø, Norway, ⁴Dept. Clin. and Mol. Med., NTNU, Norway, Trondheim, Norway, ⁵Dept. of Pediatrics, Levanger Hospital, Nord-Trøndelag, Norway, Trondheim, Norway, ⁶Department of Pediatrics, Dept. of Pediatrics, Ryhov County Hospital, Jonkoping, Sweden, Jonkoping, Sweden, ⁷Uppsala University, Uppsala, Sweden, Jonkobing, Sweden, ⁸Hospital for Children and Adolescents, University of Helsinki, Finland, Helsinki, Finland, ⁹Dep. Clin. and Mol. Med., Dept. Clin. and Mol. Med., NTNU, Norway, Trondheim, Norway, ¹⁰Department of Pediatrics, Dept. of Pediatrics, St. Olavs Hospital, Norway, Trondheim, Norway, ¹¹Department of Pediatrics, Dept. of Pediatrics, Copenhagen University Hospital, Denmark, Copenhagen, Denmark, ¹²Sahlgrenska Academy, University of Gothenburg, Sweden, Gothenburg, Sweden, ¹³Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ¹⁴Departments of Pediatrics, Dept. of Pediatrics, University Hospital of North Norway, Tromsø, Norway, ¹⁵Department of Clinical Medicine, Dept. of Clin. Med, UIT The Arctic University of Norway, Tromsø, Norway, ¹⁶Dept. of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark
Background/Purpose: Innovative changes towards targeted treatment have improved the outcome dramatically for juvenile idiopathic arthritis (JIA) but the question remains how well these patients perform…
Abstract Number: 2916 • 2018 ACR/ARHP Annual Meeting
New JADAS10- and cJADAS10-Based Cutoffs for Juvenile Idiopathic Arthritis Disease Activity States: Validation in a Multinational Dataset of 4830 Patients
Alessandro Consolaro^1,2, Chiara Trincianti¹, Pieter van Dijkhuizen³, Giedre Januskeviciute⁴, Gabriella Giancane⁵, Alessandra Alongi¹, Joost Swart³, Nicola Ruperto^6,7 and Angelo Ravelli^2,8, ¹University of Genova, Genova, Italy, ²Clinica Pediatrica - Reumatologia, Istituto Giannina Gaslini, Genova, Italy, ³UMC Utrecht, Wilhelmina Children’s Hospital, Utrecht, Netherlands, ⁴Istituto Giannina Gaslini, Genova, Italy, ⁵Clinica Pediatrica - Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, ⁶Universita di Genova Pediatria II, Genova, Italy, ⁷Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, ⁸University of Genova, Genoa, Italy
Background/Purpose: The Juvenile Arthritis Disease Activity Score (JADAS) and its clinical version excluding the acute phase reactant (cJADAS) were developed for measuring disease activity in…
Abstract Number: 2017 • 2018 ACR/ARHP Annual Meeting
Oral Microbiota in New-Onset Juvenile Idiopathic Arthritis
Albert Chow^1,2,3, Sriharsha Grevich^1,2,3, Peggy Lee⁴, Jeffrey McLean⁴, Sarah Ringold^1,3,5, Roger Bumgarner⁶ and Anne Stevens^1,2,3, ¹Pediatrics, University of Washington, Seattle, WA, ²Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ³Pediatric Rheumatology, Seattle Children's Hospital, Seattle, WA, ⁴Dentistry, University of Washington, Seattle, WA, ⁵Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, ⁶Microbiology, University of Washington, Seattle, WA
Background/Purpose: Oral microbial dysbiosis of specific organisms such as Porphyromonas, Aggregatibacter, Tannerella, and Treponema in dental plaque has been implicated in the pathogenesis of adult…

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