Abstracts tagged "juvenile idiopathic arthritis (JIA)"

Abstract Number: 1921 • 2019 ACR/ARP Annual Meeting
Parent-Reported Medication Side-Effects and Their Impact on Health-Related Quality of Life in Children with Juvenile Idiopathic Arthritis: Results from the CAPRI Registry
Gaëlle Chédeville¹, Michelle Batthish ², Roberta Berard ³, Roxana Bolaria ⁴, Alessandra Bruns ⁵, David Cabral ⁶, Ciaran Duffy ⁷, Kerstin Gerhold ⁸, Tommy Gerschman ⁶, Jean-Philippe Proulx-Gauthier ⁹, Alan Rosenberg ¹⁰, Dax Rumsey ¹¹, Heinrike Schmeling ¹², Natalie Shiff ¹³, Gordon Soon ¹⁴, Lori Tucker ¹⁵ and Jaime Guzman ⁶, ¹The Montreal Children's Hospital, McGill University, Montreal, Canada, ²McMaster University, Hamilton, Canada, ³Children's Hospital, London Health Sciences Centre, London, Canada, ⁴University of British Columbia, Victoria, BC, Canada, ⁵Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶University of British Columbia, Vancouver, BC, Canada, ⁷University of Ottawa, Ottawa, ON, Canada, ⁸University of Manitoba, Winnipeg, MB, Canada, ⁹Université Laval, Québec, QC, Canada, ¹⁰University of Saskatchewan, Saskatoon, SK, Canada, ¹¹University of Alberta, Edmonton, AB, Canada, ¹²Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹³University of Florida, Gainesville, FL, ¹⁴University of Toronto, Toronto, ON, Canada, ¹⁵British Columbia Children’s Hospital, Vancouver, Canada
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and many medications are available to control the disease. While physician-reported adverse…
Abstract Number: 2715 • 2019 ACR/ARP Annual Meeting
Incidence of Juvenile Idiopathic Arthritis in the United Kingdom: Estimates from a National Primary Care Dataset
Ruth Costello¹, Janet McDonagh ², Will Dixon ¹, Kimme Hyrich ² and Jenny Humphreys ¹, ¹Versus Arthritis Centre for Epidemiology, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom, Manchester, United Kingdom, ²Versus Arthritis Centre for Epidemiology, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom / NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, Manchester, United Kingdom
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common childhood onset inflammatory arthritis. The last estimates of incidence of this disease in the United Kingdom…
Abstract Number: 782 • 2019 ACR/ARP Annual Meeting
Oligoarticular Juvenile Idiopathic Arthritis Displayed Increased Expression of Co-Inhibitory Receptors Without Signs of T-Cell Exhaustion
Erdal Sag¹, Selcan Demir ², Morten A. Nielsen ³, Malene Hvid ⁴, Egemen Turhan ⁵, Yelda Bilginer ², Seza Ozen ⁶ and Bent Deleuran ⁷, ¹Hacettepe University, Ankara, Turkey, ²Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Turkey, ³Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁴Department of Biomedicine; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁵Department of Orthopedics and Traumatology, Hacettepe University, Ankara, Turkey, ⁶Hacettepe University Hospital, Ankara, Turkey, ⁷Department of Biomedicine; Department of Rheumatology, Aarhus University, Aarhus, Denmark
Background/Purpose: Activated T cells are involved in the pathogenesis of the synovitis in oligoarticular Juvenile Idiopathic Arthritis (o-JIA). T cell activation is counter-balanced via co-inhibitory…
Abstract Number: 1923 • 2019 ACR/ARP Annual Meeting
Disability and Health-Related Quality of Life Outcomes in Patients with Systemic or Polyarticular Juvenile Idiopathic Arthritis Treated with Tocilizumab in Randomized Controlled Phase 3 Trials
Hermine Brunner¹, Chen Chen ¹, Alberto Martini ², Graciela Espada ², Rik Joos ², Jonathan Akikusa ², Jeffrey Chaitow ², Maria Luz Gámir Gámir ², Yukiko Kimura ³, Christoph Rietschel ², Daniel Siri ², Elzbieta Smolewska ², Heinrike Schmeling ¹, Diane Brown ¹, Fabrizio De Benedetti ⁴, Daniel J. Lovell ⁵, Bin Huang ¹ and Nicolino Ruperto ², ¹Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, ³Joseph M Sanzari Children's Hospital, Hackensack University Medical Center, Cincinnati, OH, ⁴Bambino Gesù Children’s Hospital, Rome, Italy, ⁵Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati
Background/Purpose: Tocilizumab (TCZ) was approved for the treatment of systemic juvenile idiopathic arthritis (sJIA) and polyarticular juvenile idiopathic arthritis (pJIA) based on the results of…
Abstract Number: 2716 • 2019 ACR/ARP Annual Meeting
Long Term Outcomes of Childhood Onset Rheumatoid Arthritis
Rebecca Overbury¹, Aimee Hersh ², CJ Inman ², Sara Stern ², Karen James ² and John Bohnsack ³, ¹Assisstant Professor, University of Utah, Salt Lake City, UT, ²University of Utah, Salt Lake City, UT, ³University of Utah School of Medicine, Salt Lake City, UT
Background/Purpose: Childhood onset rheumatoid arthritis (CORA) describes patients with juvenile idiopathic arthritis (JIA) who are rheumatoid factor (RF) or anti-cyclic citrullinated antibody (ACPA) positive. Phenotypically,…
Abstract Number: 785 • 2019 ACR/ARP Annual Meeting
Predictors of Response to Tumour Necrosis Factor – α Inhibitors (TNFi) in Juvenile Idiopathic Arthritis (JIA): A Single-center Experience
Muhammad Shipa¹, Anastasia-vasiliki Madenidou ², vera Choida ¹, Anna Radziszewska ³, corinne fisher ⁴, coziana ciurtin ¹, maria Leandro ¹ and Debajit Sen ¹, ¹Centre for Adolescent Rheumatology versus Arthritis at UCL, UCLH and GOSH, London, UK, London, United Kingdom, ²Centre for Adolescent Rheumatology, University College London London, UK, LOndon, ³University College London, London, United Kingdom, ⁴Centre for Adolescent Rheumatology versus Arthritis at UCL, UCLH and GOSH, London, UK, lonodn, United Kingdom
Background/Purpose: Biologics have transformed the treatment of Juvenile idiopathic arthritis (JIA) and escalation toTumour Necrosis Factor - α inhibitors (TNFi) after failure of methotrexate (MTX)…
Abstract Number: 1925 • 2019 ACR/ARP Annual Meeting
Discriminant and Predictive Ability of the Parent Version of the Juvenile Arthritis Disease Activity Score in Two Large Multination Cohorts of Patients with Juvenile Idiopathic Arthritis
Francesca Ridella ¹, Giedre Januskeviciute ², Chiara Trincianti ³, Evert Hendrik Pieter Van Dijkhuizen ⁴, Gabriella Giancane ⁵, Serena Pastore ⁶, Kirsten Minden ⁷, Maria Ekelund ⁸, Patrizia Barone ⁹, Matilda Laday ¹⁰, Nicolino Ruperto ¹¹, Angelo Ravelli ¹² and Alessandro Consolaro¹³, ¹Università degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, Italy, Genova, Italy, ²Klaipeda Children's Hospital, Klaipeda, Lithuania, Klaipeda, Lithuania, ³Università degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, Italy, Genoa, Italy, ⁴Wilhelmina Children’s Hospital, Department of Pediatric Immunology and Rheumatology, Utrecht, The Netherlands, Utrecht, Netherlands, ⁵Università degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, Italy and IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, Genoa, Italy, Genoa, Italy, ⁶Institute for Maternal and Child Health IRCCS "Burlo Garofolo," Trieste, Italy, Trieste, Italy, ⁷German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany, Berlin, Germany, ⁸Ryhov County Hospital, Futurum - the Academy for health and care, Jonkoping, Sweden, Jonkoping, Sweden, ⁹Department of Pediatrics, University of Catania, Catania, Italy, Catania, Italy, ¹⁰Spitalul Clinic Județean De Urgenta, Tîrgu-Mures, Romania, Tîrgu-Mures, Romania, ¹¹Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, ¹²IRCCS Istituto Giannina Gaslini, Università degli Studi di Genova, Genova, Italy, ¹³Università degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, Italy and IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, Genoa, Italy, Genova, Italy
Background/Purpose: The assessment of disease activity plays a pivotal role in the management of children with juvenile idiopathic arthritis (JIA). Most recent recommendations require that…
Abstract Number: 2718 • 2019 ACR/ARP Annual Meeting
A Retrospective Study Comparing Refractoriness to Biologic Disease Modifying Anti-Rheumatic Drugs in Adults with Juvenile Idiopathic Arthritis as Compared to Those with Rheumatoid Arthritis
Kiana Taba¹ and Elizabeth Ortiz ², ¹University of Southern California, LAGUNA HILLS, CA, ²LAC+USC/Keck Medicine of USC, Los Angeles
Background/Purpose: The use of biologic DMARDs (bDMARDs) has vastly changed the treatment of autoimmune arthritis, both Rheumatoid Arthritis (RA) and polyarticular and oligoarticular Juvenile Idiopathic…
Abstract Number: 2703 • 2019 ACR/ARP Annual Meeting
The Childhood Arthritis and Rheumatology Research Alliance Start Time Optimization of Biologic Therapy in Polyarticular JIA Study: Patient Characteristics, Patient Reported Outcomes and Consensus Treatment Plan Choices
Sarah Ringold ¹, George Tomlinson ², Pamela Weiss ³, Laura Schanberg ⁴, Mary Ellen Riordan ⁵, Anne Dennos ⁶, Vincent Del Gaizo ⁷, Katherine Murphy ⁸, Brian Feldman ⁹ and Yukiko Kimura¹⁰, ¹Seattle Children's, Seattle, ²University of Toronto, Toronto, ON, Canada, ³Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Duke University Medical Center, Durham, NC, ⁵Joseph M Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, NJ, ⁶Duke Clinical Research Institute, Durham, NC, ⁷Childhood Arthritis & Rheumatology Research Alliance, Whitehouse Station, NJ, ⁸Louisiana Office of Public Health, New Orleans, LA, ⁹University of Toronto & The Hospital for Sick Children, Toronto, ON, Canada, ¹⁰Joseph M Sanzari Children's Hospital, Hackensack University Medical Center, Cincinnati, OH
Background/Purpose: There continues to be uncertainty regarding when to start biologic medications for polyarticular juvenile idiopathic arthritis (P-JIA). The Childhood Arthritis and Rheumatology Research Alliance…
Abstract Number: 786 • 2019 ACR/ARP Annual Meeting
Distinguishing S100 Proteins and Cytokine Levels Between Active and Inactive Uveitis in Children with Juvenile Idiopathic Arthritis
Jackeline Rodriguez-Smith¹, Virginia Utz ², Sherry Thornton ¹, Grant Schulert ¹, Adam Kauffman ³, Alyssa Sproles ¹, Najima Mwase ¹, Theresa Hennard ⁴, Alexei A. Grom ¹, Mekibib Altaye ⁵, Gary Holland ⁶ and Sheila Angeles-Han ⁷, ¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Cincinnati Eye Institute and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Rheumatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ⁵Divison of Biostatistics and Epidemiology and Department of Pediatrics, University of Cincinnati, Cincinnati, OH, ⁶UCLA Stein Eye Institute and David Geffen School of Medicine at University of California, Los Angeles, Ca, Los Angeles, CA, ⁷Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cinicinnati
Background/Purpose: Uveitis occurs in 10-20% of children with Juvenile Idiopathic Arthritis (JIA) and is typically asymptomatic. Ocular complications occur in 50% of children, (i.e. cataracts,…
Abstract Number: 2096 • 2019 ACR/ARP Annual Meeting
An Intervention Bundle Increases Uptake of Influenza Vaccine by Rheumatoid Arthritis Patients
Valeria Valerio¹, Maria Bazan ¹, Mianbo Wang ², Bruce Mazer ¹, Elizabeth M. Hazel ³, Christian Pineau ⁴, Sasha Bernatsky ⁵, Brian Ward ⁶ and Ines Colmegna ⁶, ¹The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada, ³McGill University Health Centre, Montreal, Canada, ⁴McGill University Health Centre, Montreal, QC, Canada, ⁵McGill University Health Center, Montreal, Canada, ⁶McGill University Health Center, Montreal, QC, Canada
Background/Purpose: Annual vaccination with inactivated influenza vaccine is recommended for adults with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). Despite this, influenza immunization coverage…
Abstract Number: 2724 • 2019 ACR/ARP Annual Meeting
Farber Disease (Acid Ceramidase Deficiency): The First Natural History Study of This Rare Disease Involving Symptoms Which Can Mimic JIA
Alexander Solyom¹, Erik Sundberg ², John Mitchell ³, Christina Grant ⁴, Carlos Ferreira ⁵, Paul Harmatz ⁶, Neslihan Mungan ⁷, Fatma Bulut ⁷, Christina Lampe ⁸, Andreas Hahn ⁸, Norberto Guelbert ⁹, Nur Arslan ¹⁰, Balahan Makay ¹⁰, Ratna Puri ¹¹, Sunita Bijarnia-Mahay ¹¹, Laila Selim ¹², Iman Gamal el Din ¹², Seema Kapoor ¹³, Maja DiRocco ¹⁴, Seza Ozen ¹⁵, Ezgi Batu ¹⁵, Gulden Gokcay ¹⁶, Marta Torcoletti ¹⁷, Alan Kimura ¹⁸ and Bo Magnusson ², ¹Enzyvant, Basel, Switzerland, ²Karolinska University Hospital, Stockholm, Sweden, ³Montreal Children's Hospital, Montreal, Canada, ⁴Children's National Medical Center, Washingotn, DC, ⁵Children's National Medical Center, Washington, DC, ⁶UCSF Benioff Children's Hospital Oakland, Oakland, CA, ⁷Cukurova University Hospital, Adana, Turkey, ⁸University Hospital Giessen, Giessen, Germany, ⁹Children's Hospital of Cordoba, Cordoba, Argentina, ¹⁰Dokuz Eylul University Hospital, Izmir, Turkey, ¹¹Sir Ganga Ram Hospital, Delhi, India, ¹²Cairo University Children's Hospital, Cairo, Egypt, ¹³13Lok Nayak Hospital and Maulana Azad Medical College, Delhi, India, ¹⁴Istituto Giannina Gaslini, Genoa, Italy, ¹⁵Hacettepe University Hospital, Ankara, Turkey, ¹⁶Istanbul University, Istanbul, Turkey, ¹⁷University of Milan, Milan, Italy, ¹⁸Enzyvant, Cambridge, MA
Background/Purpose: The cardinal clinical symptoms of Farber disease (arthritis/contractures, subcutaneous granulomatous nodules, dysphonia) may be misdiagnosed as JIA. Mutations in the ASAH1 gene and the…
Abstract Number: 787 • 2019 ACR/ARP Annual Meeting
Complement Protein Levels Reflect Disease Activity in Juvenile Idiopathic Arthritis
Mia Glerup¹, Steffen Thiel ², Veronika Rypdal ³, Ellen Dalen Arnstadt ⁴, Maria Ekelund ⁵, Suvi Peltoniemi ⁶, Kristiina Aalto ⁶, Marite Rygg ⁷, Susan Nielsen ⁸, Anders Fasth ⁹, Lillemor Berntson ¹⁰, Ellen Nordal ³ and Troels Herlin ¹¹, ¹Dept of Pediatrics, Aarhus University Hospital, Aarhus, Denmark, Aarhus, Denmark, ²Department of Biomedicine, Aarhus University, Aarhus, Denmark, Aarhus, Denmark, ³Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway., Tromsø, Norway, ⁴Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Trondheim, Norway, ⁵Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden. Department of Pediatrics, Ryhov County Hospital, Jonkoping, Sweden., Jonkoping, Sweden, ⁶Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland., Helsinki, Finland, ⁷Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway., Tromsø, Norway, ⁸Department of Pediatrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Copenhavn, Denmark, ⁹Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Gothenburg, Sweden, ¹⁰Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden., Uppsala, Sweden, ¹¹Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark., Aarhus, Denmark
Background/Purpose: There is an increasing body of evidence that inadequately controlled activation of complement factors leading to either overactivity or deficiency may be involved in…
Abstract Number: 2258 • 2019 ACR/ARP Annual Meeting
Causes of Influenza Vaccine Hesitancy in Rheumatoid Arthritis and Adults with Juvenile Idiopathic Arthritis
Sandra Pelaez ¹, Vincent Gosselin Boucher ², Valeria Valerio ³, Elizabeth M. Hazel ⁴, Kim Lavoie ⁵, Brian Ward ⁶ and Ines Colmegna⁶, ¹Research Centre of the Sainte-Justine University Hospital, Montreal, Canada, ²Montreal Behavioural Medicine Centre, Centre Intégré Universitaire de santé et services sociaux du Nord-de-l’Ile-de-Montréal (CIUSSS-NIM), Hôpital du Sacré-Cœur de Montréal & Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada, ³The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁴McGill University Health Centre, Montreal, Canada, ⁵Montreal Behavioural Medicine Centre, Centre Intégré Universitaire de santé et services sociaux du Nord-de-l’Ile-de-Montréal (CIUSSS-NIM), Hôpital du Sacré-Cœur de Montréal & Department of Psychology, Université du Québec à Montréal, Montreal, Canada, ⁶McGill University Health Center, Montreal, QC, Canada
Background/Purpose: Vaccine hesitancy -the reluctance or refusal to vaccinate despite the availability of vaccines- is one of the threats to global health set by the…
Abstract Number: 790 • 2019 ACR/ARP Annual Meeting
Can High ANA Titre Combined with Clinical Features Predict Developing Autoimmune Conditions in Children?
Ovgu Kul Cinar¹, Charlene Foley ², Ali Al-Hussain ³, Kimberly Gilmour ⁴, Matthew Buckland ⁴ and Muthana Al-Obaidi ⁵, ¹Great Ormond Street Hospital, Lonodn, United Kingdom, ²Great Ormond Street Hospital, London, Ireland, ³Great Ormond Street Hospital, London, United Kingdom, ⁴Great Ormond Street Hospital NHS Trust, Camelia Botnar Laboratories, London, United Kingdom, ⁵Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom
Background/Purpose: Antinuclear antibodies (ANA) are autoantibodies that recognise cellular antigens found predominantly in the cell nucleus. They are associated with numerous autoimmune diseases such as…

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