ACR Meeting Abstracts

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Abstracts tagged "juvenile dermatomyositis"

  • Abstract Number: 092 • 2023 Pediatric Rheumatology Symposium

    Procalcitonin Levels in Patients with Juvenile Dermatomyositis Compared to Healthy Controls

    Christopher Costin1, Gabrielle Morgan2, Lutfiyya Muhammad3, Amer Khojah4, Marisa Klein-Gitelman1, Yvonne Lee5 and Lauren Pachman6, 1Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 2Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University Feinberg School of Medicine, Chicago, IL, 4Umm Al-Qura University, Makkah, Saudi Arabia, 5Northwestern University, Chicago, IL, 6Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL

    Background/Purpose: Patients with JDM are at increased risk of infection due to increased aspiration risk and immunosuppression. Procalcitonin (PCT) is a biomarker of infection, that…
  • Abstract Number: 049 • 2023 Pediatric Rheumatology Symposium

    What Happens After Juvenile Myositis Patients Screen Positive for Mental Health Comorbidities? Update from a Multicenter Juvenile Myositis Mental Health Screening Pilot Study

    Kaveh Ardalan1, Rebecca Fillipo1, Christina ZIgler2, Audrey Ward1, Jeffrey Dvergsten3, Ann Reed1, Alison Manning1, Gary Maslow1, Brian Feldman4, Ashley Danguecan5, Sarah Mossad5, Luana Flores Pereira5, Susan Shenoi6, Stacey Haynes7, Joanna Patten7 and Andrea Knight5, 1Duke University School of Medicine, Durham, NC, 2Duke, Durham, NC, 3Duke University Hospital, Durham, NC, 4Hospital for Sick Children / University of Toronto, Toronto, ON, Canada, 5The Hospital for Sick Children, Toronto, ON, Canada, 6Seattle Children's Hospital, Seattle, WA, 7Seattle Childrens Hospital and Research Center / University of Washington, Seattle, WA

    Background/Purpose: Juvenile myositis (JM) patients report high rates of emotional distress but qualitative studies suggest challenges accessing high quality mental health care. We present survey…
  • Abstract Number: 0775 • ACR Convergence 2021

    Decreased HDL Levels and Antioxidant Function in Juvenile Dermatomyositis

    Amer Khojah1, Arya Kadakia2, Christina Charles-Schoeman3, Jacob Spitznagle4, Jennifer Wang3, Ani Shahbazian3, Gabrielle Morgan5 and Lauren Pachman6, 1Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 2Ann and Robert H. Lurie Children’s Hospital, Chicago, IL, 3Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 4Hospital for Special Surgery, New York, NY, 5Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 6Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL

    Background/Purpose: Juvenile Dermatomyositis (JDM) is the most common inflammatory myopathy of childhood and is characterized by chronic inflammation targeting muscle and skin. Older patients who…
  • Abstract Number: 0978 • ACR Convergence 2021

    Immunological and Clinical Features of Untreated Juvenile Dermatomyositis Patients with Elevated Neopterin

    Amer Khojah1, Gabrielle Morgan2 and Lauren Pachman3, 1Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 2Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL

    Background/Purpose: Neopterin is a metabolic product of guanosine triphosphate, which is produced by macrophages upon stimulation with interferon-gamma from activated T helper cells. Despite the…
  • Abstract Number: 1907 • ACR Convergence 2021

    Increased Otoferlin Expression in B Cells Is Associated with Muscle Weakness in Untreated Juvenile Dermatomyositis: A Pilot Study

    Ameera Bukhari1, Amer Khojah2, Wilfredo Marin3, Gabrielle Morgan4 and Lauren Pachman5, 1Department of Microbiology and Immunology, Loyola University Chicago, Chicago, IL, 2Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 3Ann & Robert H. Lurie Children's Hospital, Chicago, IL, 4Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 5Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL

    Background/Purpose: Juvenile Dermatomyositis (JDM) is a rare pediatric inflammatory myopathy with a complex pathophysiology. Previously our group showed a significant increase in Otoferlin mRNA expression…
  • Abstract Number: 021 • 2020 Pediatric Rheumatology Symposium

    Myositis Autoantibodies in a Racially Diverse Population of Children with Idiopathic Inflammatory Myopathies

    Dawn Wahezi 1, Natalia Vasquez Canizares 2, Gabriel Tarshish 2 and Megan Colwell2, 1Children's Hospital at Montefiore, Bronx, 2Children's Hospital at Montefiore, new york

    Background/Purpose: The presence of myositis specific autoantibodies (MSA) and myositis associated antibodies (MAA) has been associated with specific clinical phenotypes, various organ involvement and disease…
  • Abstract Number: 044 • 2020 Pediatric Rheumatology Symposium

    Nailing Down Nailfold Capillaroscopy Practices: A Survey of Pediatric Rheumatologists Within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Network

    Sonia Savani1, Natasha Ruth 2, Paul Nietert 1, Gabrielle Morgan 3, Mileka Gilbert 1 and Lauren Pachman 4, 1Medical University of South Carolina, Charleston, South Carolina, 2Medical University South Carolina, Charleston, South Carolina, 3Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, Illinois, 4Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, 303 E Superior, Chicago

    Background/Purpose: Juvenile dermatomyositis (JDM) is a rare systemic autoimmune disease characterized by vasculopathy and rash. The Bohan-Peter criteria for dermatomyositis are not ideal. There is…
  • Abstract Number: 082 • 2020 Pediatric Rheumatology Symposium

    Anti-Mitochondrial Autoantibodies Are Associated with Dysphagia in Juvenile and Adult Myositis, and with Persistent Weakness and Cardiomyopathy in Adult Myositis

    Sara Sabbagh1, Iago Pinal-Fernandez 2, Maria Casal-Dominguez 3, Frederick W. Miller 4, Lisa G. Rider 5, Andrew Mammen 3 and Lisa Christopher-Stine 6, 1NIH/NIAMS, Bethesda, 2National Institutes of Health, Bethesda, 3NIH, Bethesda, 4Bethesda, 5NIEHS, NIH, Garrett Park, 6Johns Hopkins University, Baltimore

    Background/Purpose: We analyzed the prevalence of anti-mitochondrial autoantibodies (AMA) in both juvenile-(JM) and adult-onset myositis cohorts and investigated phenotype differences between juvenile and adult myositis…
  • Abstract Number: 105 • 2020 Pediatric Rheumatology Symposium

    Discovering the Implications of Adiposity in Juvenile Dermatomyositis

    Vy Do1, Chanhee Jo 2, Jaclyn Albin 1, Tracey Wright 1, Julie Fuller 3 and Una Makris 1, 1UT Southwestern Medical Center, Dallas, 2Texas Scottish Rite Hospital, Dallas, 3UT Southwestern Medical Center, Frisco

    Background/Purpose: Obesity and pro-inflammatory cytokines produced by adipocytes have been linked to many outcomes including disease severity, treatment response, and disease progression in several autoimmune…
  • Abstract Number: 120 • 2020 Pediatric Rheumatology Symposium

    Characteristics of the New Childhood Arthritis and Rheumatology Research Alliance Registry of Juvenile Myositis Patients Enrolled in the First Two Years

    Jessica Neely1, Adam Huber 2 and Susan Kim 3 for the CARRA investigators, 1University of California, San Francisco, San Francisco, California, 2IWK Health Centre & Dalhousie University, Halifax, Nova Scotia, Canada, 3University of California, San Francisco, San Francisco

    Background/Purpose: The New CARRA Registry of Juvenile Myositis (JM) was developed in 2017 to collect 10-year longitudinal data to increase knowledge of the course of…
  • Abstract Number: 125 • 2020 Pediatric Rheumatology Symposium

    Feasibility and Pilot Study of Mental Health Screening in Juvenile Myositis

    Kaveh Ardalan1, Alison Manning 1, Brian Feldman 2, Gary Maslow 1 and Andrea Knight 3, 1Duke University Medical Center, Durham, 2The Hospital for Sick Children, Toronto, Canada, 3SickKids Research Institute, Toronto, Canada

    Background/Purpose: Juvenile myositis (JM) negatively affects health-related quality of life due to chronic weakness, skin/muscle damage, multiorgan dysfunction, and side effects of immunosuppression. While JM’s…
  • Abstract Number: 156 • 2020 Pediatric Rheumatology Symposium

    Metabolic Profiling in Juvenile Dermatomyositis

    Jeffrey Dvergsten1, Olga Ilkayeva 2, Lawrence Landerman 2, Michael Muehlbauer 3, David Pisetsky 4, Ann Reed 3 and Kim Huffman 5, 1Duke University Hospital, Hillsborough, 2Duke University, Durham, NC, 3Duke University, Durham, 4Duke University Medical Center, Durham, 5Durham

    Background/Purpose: Investigators have made significant progress piecing together pathogenic mechanisms of juvenile dermatomyositis (DM).  However, this remains an incomplete puzzle, and optimal approaches to diagnosing,…
  • Abstract Number: 186 • 2020 Pediatric Rheumatology Symposium

    Anthropometric Assessment and Food Intake of Parents of Pediatric Patients with Chronic Rheumatic Diseases

    Lucila Pereira1, Agatha Nogueira Previdelli 2, Rosana Gomes de Torres Rossi 2, Wellington Douglas Rodrigues 3, Fernado Luiz Affonso Fonseca 3, Claudio Len 4, Roseli Oselka Saccardo Sarni 3 and Maria Teresa Terreri 4, 1Federal University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil, 2Sao Judas Tadeu University, Sao Paulo, Brazil, 3Federal University of Sao Paulo, Sao Paulo, Brazil, 4Sao Paulo, Brazil

    Background/Purpose: Chronic rheumatic diseases in children and adolescents increase cardiovascular risk. Thus, knowing the eating habits, biomarkers of lipid metabolism and the lifestyle of patients…
  • Abstract Number: 1924 • 2019 ACR/ARP Annual Meeting

    Assessing Psychosocial Needs in Juvenile Dermatomyositis Patients Across the United Kingdom

    Polly Livermore1 and Lucy Wedderburn 2, 1ICH/UCL, Arlesey, United Kingdom, 2ICH/UCL, London, United Kingdom

    Background/Purpose: Juvenile Dermatomyositis (JDM) is a rare, autoimmune inflammatory condition primarily affecting the muscles and skin. With a mean age of onset of 7 years…
  • Abstract Number: 2106 • 2019 ACR/ARP Annual Meeting

    Features of Pneumocystis Jirovecii Pneumonia in Juvenile Idiopathic Inflammatory Myopathy

    Sara Sabbagh1, Jessica Neely 2, Jamie Lai 3, Anjali Sura 4, Kelly Rouster-Stevens 5, Svetlana Lvovich 6, Tara McGrath 7, Lori Tucker 8, Heinrike Schmeling 9, Jordan Roberts 10, Lisa G. Rider 11 and Susan Kim 2, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH), Bethesda, MD, 2University of California, San Francisco, San Francisco, CA, 3Department of Pediatrics, University of Colorado School of Medicine, Division of Pediatric Rheumatology, Children’s Hospital Colorado, Aurora, CO, 4University of Michigan, Ann Arbor, MI, 5Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, 6Section of Rheumatology, Department of Pediatrics, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PA, 7Division of Rheumatology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, 8British Columbia Children’s Hospital, Vancouver, Canada, 9Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 10Boston Children’s Hospital, Harvard Medical School, Boston, MD, 11Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Bethesda, MD

    Background/Purpose: Approximately 6% of adults with idiopathic inflammatory myopathy (IIM) develop Pneumocystis jirovecii pneumonia (PJP), and PJP confers higher mortality in IIM patients compared to…
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