ACR Meeting Abstracts

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Abstracts tagged "interferons"

  • Abstract Number: 005 • 2020 Pediatric Rheumatology Symposium

    Single Cell Sequencing of the Skin to Define Cell Populations of Interest in Localized Scleroderma (LS)

    Emily Mirizio 1, Wei Chen 2, Tao Sun 2, Tracy Tabib 3, Kaila Schollaert-Fitch 1, Robert Lafyatis 4, Heidi Jacobe 5 and Kathryn Torok1, 1Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh, 2Research Computing Core at Children's Hospital of Pittsburgh, Pittsburgh, 3Univ of Pittsburgh Med Ctr, Pittsburgh, 4Univ of Pittsburgh Med Ctr, Pittsburgh, Pittsburgh, 5University of Texas Southwestern Medical Ctr, Dallas

    Background/Purpose: Scleroderma is an autoimmune disorder involving inflammatory driven fibrosis, which encompasses systemic sclerosis (SSc) and localized scleroderma (LS).  LS and SSc share histological characteristics,…
  • Abstract Number: 027 • 2020 Pediatric Rheumatology Symposium

    Clinical Features and Outcomes in Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature (CANDLE) Syndrome: Before and After JAK-inhibition

    Sofia Torreggiani1, Pascal Pillet 2, Fabiano de Oliveira Poswar 3, Anna Kozlova 4, Anna Shcherbina 4, Marietta De Guzman 5, Jacob Mitchell 6, Gina A. Montealegre Sanchez 7, Katherine Townsend 8, Kim Johnson 9, Adriana Almeida de Jesus 10 and Raphaela Goldbach-Mansky 11, 1National Institutes of Health, Bethesda, 2Bordeaux Cedex, France, 3Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil, 4Center for Pediatric Hematology, Oncology, Immunology, Moscow, Russia, 5Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, 6NIAID, NIH, Bethesda, 7NIH/ NIAID, Rockville, 8NIH, 9NIH, NIAID, Bethesda, 10NIAID, NIH, Silver Spring, 11NIH/NIAID, Potomac

    Background/Purpose: Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature (CANDLE) Syndrome is an autoinflammatory interferonopathy caused by mutations in the genes encoding for components…
  • Abstract Number: 079 • 2020 Pediatric Rheumatology Symposium

    Traditional Laboratory Parameters and New Biomarkers in Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis

    Arianna De Matteis 1, Denise Pires Marafon 2, Ivan Caiello 2, Manuela Pardeo 2, Giulia Marucci 2, Emanuela Sacco 2, Giusi Prencipe 2, Fabrizio De Benedetti 2 and Claudia Bracaglia2, 1Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesu', Rome, Lazio, Italy, 2Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesu', Rome, Italy

    Background/Purpose: Macrophage Activation Syndrome (MAS) and Secondary Hemophagocytic Lymphohistiocytosis (sHLH) are hyperinflammatory conditions caused by a cytokine storm. Prompt recognition and early treatment are essential…
  • Abstract Number: 080 • 2020 Pediatric Rheumatology Symposium

    Therapeutic Interferon Gamma Neutralization with Emapalumab in Patients with NRLC4- and CDC42-Associated Diseases Characterized by Recurrent and Severe Hemophagocytic Lymphohistiocytosis

    Claudia Bracaglia1, Antonella Insalaco 1, Giulia Marucci 1, Manuela Pardeo 1, Emanuela Sacco 1, Virginia Messia 1, Giusi Prencipe 1, Ivan Caiello 1, Sarka Fingerhutova 2, Pavla Dolezalova 2, Veronica Asnaghi 3, Maria Ballabio 3, Cristina de Min 3 and Fabrizio De Benedetti 1, 1Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesu', Rome, Italy, 2Paediatric Rheumatology and Autoinflammatory Diseases Unit, General University Hospital, Prague, Czech Republic, 3Swedish Orphan Biovitrum AG (Sobi), Basel, Switzerland

    Background/Purpose: Interferon gamma (IFNγ) is a pivotal mediator of HLH. Emapalumab (a fully human anti-IFNγ monoclonal antibody) is efficacious in patients with primary HLH. In…
  • Abstract Number: 140 • 2020 Pediatric Rheumatology Symposium

    Serum Biomarkers in a German Cohort of Patients with Systemic Juvenile Idiopathic Arthritis and Their Relationship to Response to Interleukin-1 Blockade

    Claas Hinze1, Tanja Hinze 2, Helmut Wittkowski 1, Christoph Kessel 1, Sabrina Fuehner 1 and Dirk Foell 1, 1University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany, 2Muenster, Nordrhein-Westfalen, Germany

    Background/Purpose: Most, but not all, patients with systemic juvenile idiopathic arthritis (systemic JIA) respond to therapy with interleukin (IL)-1 blocking agents but predictive factors have…
  • Abstract Number: 168 • 2020 Pediatric Rheumatology Symposium

    Examining the Role of IFN-I and Langerhans Cell ADAM17 in Lupus Photosensitivity

    Keila Veiga1, Noa Schwartz 2, William Shipman 1, Marvin Sandoval 3, Thomas Li 1, Yurii Chinenov 1, David Oliver 1, Ali Jabbari 4, James Krueger 5, Sarah Taber 1, Niroshana Anandasabapathy 6 and Theresa Lu 1, 1Hospital for Special Surgery, New York, 2Albert Einstein College of Medicine/Montefiore Medical Center, New York, 3Weill Cornell Graduate School of Medical Sciences, New York, 4University of Iowa, Iowa City, 5Rockefeller Center, New York, 6Weill Cornell Medicine, New York

    Background/Purpose: Photosensitivity resulting in inflammatory skin lesions is a hallmark of cutaneous lupus.  Lesions can be disfiguring and have a negative impact on quality of…
  • Abstract Number: L06 • 2019 ACR/ARP Annual Meeting

    Interferon-gamma (IFN-γ) Neutralization with Emapalumab and Time to Response in Patients with Macrophage Activation Syndrome (MAS) Complicating Systemic Juvenile Idiopathic Arthritis (s-JIA) who failed High-Dose Glucocorticoids

    Fabrizio De Benedetti1, Paul Brogan 2, Alexei A. Grom 3, Pierre Quartier 4, Rayfel Schneider 5, Jordi Antón 6, Claudia Bracaglia 7, Manuela Pardeo 8, Giulia Marucci 8, Emanuela Sacco 9, Despina Eleftheriou 10, Charalampia Papadopoulou 11, Philippe Jacqmin 12, maria ballabio 13 and Cristina de Min 13, 1Bambino Gesù Children's Hospital, Rome, Italy, 2Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 3Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Necker Hospital, Paris, France, 5Hospital for Sick Children, Toronto, ON, Canada, 6Hospital Sant Joan de Déu, Barcelona, Spain, 7Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, 8Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome, Italy, 9Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome, 10UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, Infection, Immunology, and Rheumatology section,, london, United Kingdom, 11UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, Infection, Immunology, and Rheumatology section, london, United Kingdom, 12MnS, Dinant, Belgium, 13Sobi AG, basel, Switzerland

    Background/Purpose: MAS is a severe complication of rheumatic diseases, most frequently sJIA and adult-onset Still’s disease. It is characterized by fever, hepatosplenomegaly, liver dysfunction, cytopenias,…
  • Abstract Number: 958 • 2019 ACR/ARP Annual Meeting

    Identification of IFN-γ-producing Effector B Cells in Humans: Their Relevance to the Pathogenesis of Systemic Lupus Erythematosus

    Kazuhiko Higashioka1, Masahiro Ayano 2, Yasutaka Kimoto 3, Hiroki Mitoma 2, Mitsuteru Akahoshi 2, Yojiro Arinobu 2, Koichi Akashi 1, Takahiko Horiuchi 4 and Hiroaki Niiro 5, 1Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Japan, 3Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 4Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, 5Clinical Education Centre, Kyushu University Hospital, Fukuoka, Japan, Fukuoka, Japan

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune, multi-systemic disease that potentially affects any organ in the body. Clinical efficacy of B cell-targeting therapy underscores…
  • Abstract Number: 2900 • 2019 ACR/ARP Annual Meeting

    Interferon Signature Predicts Response to Tofacitinib in Haploinsufficiency of A20

    Sarah Blackstone1, Daniella Schwartz 1, Natalia Sampaio Moura 1, Deborah Stone 1, Meryl Waldman 1, Patrycja Hoffmann 1, Anne Jones 1, Tina Romeo 1, Karyl Barron 1, Joshua Milner 1, Daniel Kastner 1 and Amanda Ombrello 1, 1National Institutes of Health, Bethesda, MD

    Background/Purpose: The protein A20, encoded by TNFAIP3, represses signaling upstream of the inflammatory transcription factor nuclear factor (NF)-kB by regulating ubiquitination. Heterozygous loss-of-function mutations in…
  • Abstract Number: 1026 • 2019 ACR/ARP Annual Meeting

    Interferon Lambda Promotes Age-Associated B Cells

    Jennifer Barnas1, Nida Meednu 1, Andrew McDavid 1, Jennifer Albrecht 1, Christopher Richardson 1, R. John Looney 2 and Jennifer Anolik 1, 1University of Rochester Medical Center, Rochester, NY, 2University of Rochester Medical Center, Rochester

    Background/Purpose: Age-associated B cells (ABC), defined as CD11c+ T-bet+ or CD11c+CD21-, represent a subset of B lymphocytes that are increased in systemic lupus erythematosus (SLE)…
  • Abstract Number: 2909 • 2019 ACR/ARP Annual Meeting

    Efficacy and Safety of the Selective Interleukin-1 Receptor Associated Kinase 4 Inhibitor, PF-06650833, in Patients with Active Rheumatoid Arthritis and Inadequate Response to Methotrexate

    Spencer I Danto1, Negin Shojaee 1, Ravi Shankar P Singh 1, Zorayr Manukyan 2, Jessica Mancuso 1, Elena Peeva 1, Michael Vincent 1 and Jean Beebe 1, 1Pfizer Worldwide Research & Development, Immunology, and Inflammation Research Unit, Cambridge, MA, 2Pfizer Worldwide Research & Development, Immunology, and Inflammation Research Unit, ..

    Background/Purpose: Adaptive and innate immune pathways are involved in inflammation and pathogenesis of rheumatoid arthritis (RA). Toll-like receptor (TLR) stimulation activates the innate immune system,…
  • Abstract Number: 1296 • 2019 ACR/ARP Annual Meeting

    Increased MxA Protein Expression and Dendritic Cells in Spongiotic Dermatitis Differentiates Dermatomyositis from Eczema

    Majid Zeidi1, Kristen Chen 1, Basil Patel 2, Rachel Lim 3 and Victoria Werth 1, 1Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA and Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, 2Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, 3Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA, Philadelphia

    Background/Purpose: Dermatomyositis (DM) is conventionally characterized by interface dermatitis (ID) on skin histopathology. A subset of patients with clinically diagnosed DM have skin biopsies showing…
  • Abstract Number: 1455 • 2019 ACR/ARP Annual Meeting

    B and T Cell Immunologic Features Associated with Higher Disease Activity Score and Focus Score in Primary Sjögren Syndrome

    Alice Mai1, Yuriy Baglaenko 2, Dario Ferri 3, Kieran Manion 4, Dennisse Bonilla 5, Arthur Bookman 6 and Joan Wither 7, 1University of British Columbia Department of Rheumatology, Vancouver, Canada, 2Brigham Woman's Hospital, Boston, 3University Health Network, Toronto, ON, Canada, 4Krembil Research Institute, Toronto, ON, Canada, 5University Health Network, University of Toronto, Toronto, ON, Canada, 6University Health Network, Toronto, Canada, 7University Health Network, Krembil Research Institute, Toronto, ON, Canada

    Background/Purpose: Primary Sjögren syndrome (pSS) is a systemic autoimmune disease with an incompletely understood pathogenesis and heterogenous disease manifestations. Identifying cellular immune changes that may…
  • Abstract Number: 1762 • 2019 ACR/ARP Annual Meeting

    UV Light Induces Acute Type I Interferon Production in the Skin and Blood Which Is cGAS Dependent

    Sladjana Skopelja-Gardner1, Jie An 2, Xizhang Sun 2, Lena Tanaka 2, Joyce Tai 2, Payton Hermanson 2, Masaoki Kawasumi 2 and Keith Elkon 2, 1University of Washington, Seattle, WA, 2University of Washington, Seattle

    Background/Purpose: Interferon response genes (ISG) are strongly expressed in the skin of many patients with systemic lupus erythematosus (SLE). Since plasmacytoid dendritic cells (pDC) are…
  • Abstract Number: 1866 • 2019 ACR/ARP Annual Meeting

    Gene Expression Meta-Analysis Reveals Commonalities in Gene Activation and Enrichment of Immune Pathways and Cell Types in Dermatomyositis Target Tissues

    Jessica Neely1, Dmitry Rychkov 1, Manish Paranjpe 1, Michael Waterfield 2, Susan Kim 1 and Marina Sirota 2, 1University of California, San Francisco, San Francisco, CA, 2University of California, San Francisco, San Francisco

    Background/Purpose: Dermatomyositis (DM) is a complex immune-mediated disease resulting in muscle and skin inflammation.  Prior studies of gene expression in DM have revealed a type…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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