ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "innate immunity"

  • Abstract Number: 127 • 2023 Pediatric Rheumatology Symposium

    What’s in a Name? A20 Protein Expression in an in Vitro Model of A20 Haploinsufficiency

    Patricia Pontes Aires1, DANIELA GERENT PETRY PIOTTO1, Andre Cunha1, Sandro Perazzio2 and Maria Teresa Terreri3, 1Universidade Federal de São Paulo, São Paulo, Brazil, 2Universidade de So Paulo; Fleury Laboratories, São Paulo, Brazil, 3UNIFESP, São Paulo, Brazil

    Background/Purpose: Tumor necrosis factor alpha (TNF-alpha) induced protein 3 gene, or TNFAIP3, encodes the A20 protein, an important regulator of the NF-κB pathway. Since its…
  • Abstract Number: 0148 • ACR Convergence 2022

    Dysferlin Associated Autoinflammatory Disease Causing Systemic Inflammation and Sterile Lung Abcesses Through Impaired Efferocytosis

    Farzana Bhuyan1, Adriana Almeida de Jesus2, Clinton Bradfield3, Mohammad Arif Rahman4, Andre Rastegar3, sundar ganesan3, Sachin Gaurav3, Sara Alehashemi3, Ronit Herzog5, Steven Holland3, Deborah Consilini6, Iain Fraser3 and Raphaela Goldbach-Mansky7, 1National Institutes of Health, Bethesda, MD, 2NIAID, NIH, Silver Spring, MD, 3NIAID, Bethesda, MD, 4NCI, Bethesda, MD, 5Langone Medical Center, New York, NY, 6Nemours Children's Hospital-Delaware, Wilmington, DE, 7NIAID, NIH, Rockville

    Background/Purpose: Using whole exome sequencing (WES), we identified a de novo mutation in DYSF encoding dysferlin in 2 unrelated patients with systemic inflammation and sterile…
  • Abstract Number: 1695 • ACR Convergence 2022

    Dermatomyositis (DM) Macrophages Upregulate Genes Involved in the Remodeling of the Extracellular Matrix and Activate Keratinocytes in a Novel 3D Tissue Model of DM Skin Disease

    Zoe Chafouleas1, Angelique Cortez1, James Whitley1, Dorothea Barton1, Lin Brown1, Michael Whitfield2, Patricia pioli3 and Sladjana Skopelja-Gardner1, 1Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Dartmouth Geisel School of Medicine, Department of Biomedical Data Science, Lebanon, NH, 3Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: With an incidence of 10 cases per million and lack of animal or ex vivo disease models, dermatomyositis (DM) remains a debilitating disease without…
  • Abstract Number: 0149 • ACR Convergence 2022

    Autoinflammatory Diseases Associated with NOD2 and Other Concurrent Genetic Mutations

    Hafsa Nomani, Brianne Navetta-Modrov, Mark Yun and QingPing Yao, Stony Brook University, Stony Brook, NY

    Background/Purpose: Systemic autoinflammatoy diseases (SAIDs) are primarily caused by abnormal innate immune response. NOD-like receptors (NLRs) are intracellular sensors to the immune process, including NOD2,…
  • Abstract Number: 1697 • ACR Convergence 2022

    Measurements of Specific Activation Through the Lectin -or Classical Pathway of Complement in Patients with SLE

    Anne Troldborg1, Mads Lamm Larsen1, Erik J.M. Toonen2, Lisa Hurler3, Zoltan Prohaszka3, László Cervenak3, Annette Gudmann Hansen4 and Steffen Thiel4, 1Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 2Hycult Biotech, Arnhem-Nijmegen, Netherlands, 3Semmelweis University, Budapest, Hungary, 4Aarhus University, Aarhus, Denmark

    Background/Purpose: In systemic lupus erythematosus (SLE), the complement system is activated and commonly thought to occur through the classical pathway (CP) [1]. However, our previous…
  • Abstract Number: 0554 • ACR Convergence 2022

    Loss of Synovial Tissue Macrophage Homeostasis Precedes Rheumatoid Arthritis Clinical Onset

    Megan Hanlon1, Mary Canavan2, conor Smith3, Achilleas Floudas4, Nuno Neto5, Qingxuan Song6, Phil Gallagher7, Ronan Mullan8, Conor Hurson9, Barry Moran5, Michael Monaghan5, Sunil Nagpal10, Douglas Veale11 and Ursula Fearon5, 1Molecular Rheumatology, Dublin, Ireland, 2Trinity College, Dublin, Ireland, 3bTrinity College Dublin, Dublin, Ireland, 4Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Ireland, 5Trinity College Dublin, Dublin, Ireland, 6Janssen Research and Development, LLC, Spring House, PA, 7St Vincent's University Hospital, Dublin, Ireland, 8Tallaght University Hospital, Dublin, Ireland, 9St Vincents University Hospital, Dublin, Ireland, 10Janssen Research, Collegeville, PA, 11St. Vincent's University Hospital, Blackrock, Dublin, Ireland

    Background/Purpose: Synovial-tissue macrophages significantly contribute to Rheumatoid Arthritis, yet the precise nature/function of macrophage subsets within the inflamed joint remains unexplored. Here we explore the…
  • Abstract Number: 1700 • ACR Convergence 2022

    IL-21/STAT3 Pathway Mediated Th2-like Vδ2 T Cells Promote Plasmablasts Differentiation in IgG4-Related Disease

    Jieqiong Li1 and Wen Zhang2, 1Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China, 2Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: To explore the phenotype and role of gamma delta (γδ) T cells in the pathogenesis of IgG4-related disease (IgG4-RD), focusing on the effect on…
  • Abstract Number: 0556 • ACR Convergence 2022

    Immune Checkpoint VISTA Regulates Type I Interferon (IFN-I) Production and Controls UV Light Triggered Skin IFN-I Response

    Zachary Peters1, Lindsay Mendyka1, Sicong Shan1, Angelique Cortez1, William Rigby2, Christopher Burns1, Randolph Noelle3 and Sladjana Skopelja-Gardner1, 1Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Dartmouth Hitchcock Medical Center, Lebanon, PA, 3Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: Most lupus patients chronically exhibit higher IFN-I scores in the skin, peripheral blood, and kidneys that is exacerbated by ultraviolet (UV) light. In normal…
  • Abstract Number: 1702 • ACR Convergence 2022

    Targeting CD6-CD318 Axis with UMCD6 (anti-CD6) Enhances in Vivo Killing of Cancer Cells Through Direct Activation of NK Cells

    Mikel Gurrea-Rubio1, Qi Wu1, Eliza Pei-Suen Tsou1, M. Asif Amin1, Phillip Campbell1, Peggy Randon1, Matthew Lind1, Sarah Ory1, Camila Amarista1, Sirapa Vichaikul2, Jeffrey Ruth1, Feng Ling3 and David Fox1, 1University of Michigan, Ann Arbor, MI, 2Michigan Medicine, Howell, MI, 3Cleveland Clinic, Cleveland, OH

    Background/Purpose: Immune checkpoint inhibitors represent a major advance in cancer treatment, but disease prognosis continues to be poor for most patients. Resistance of cancer cells…
  • Abstract Number: 0562 • ACR Convergence 2022

    Large-Scale Targeted Sequencing Study Links Systemic Juvenile Idiopathic Arthritis with Rare Variants of MEFV, LYST, STXBP2, UNC13D

    Mariana Correia Marques1, Danielle Rubin2, Emily Shuldiner2, Elizabeth Schmitz2, Elizabeth Baskin2, Andrew Patt3, Alexei Grom4, Dirk Foell5, Marco Gattorno6, John Bohnsack7, Rae Yeung8, Sampath Prahalad9, Elizabeth Mellins10, Jordi Antón11, Claudio Len12, Sheila Oliveira13, Patricia Woo14, Seza Ozen15, INCHARGE Consortium16 and Michael Ombrello17, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases / Children`s National Hospital, Bethesda, MD, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 3National Center for Advancing Translational Sciences, Bethesda, MD, 4Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 5University Hospital Münster, Münster, Germany, 6Pediatric Clinic and Rheumatology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy, 7University of Utah, Salt Lake City, UT, 8The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, 9Emory + Children's Pediatric Institute, Atlanta, GA, 10Stanford University, Stanford, CA, 11Pediatric Rheumatology Department. Hospital Sant Joan de Déu. Universitat de Barcelona, Esplugues de Llobregat, Spain, 12Universidade Federal de São Paulo, São Paulo, Brazil, 13Universidade Federal do Rio de Janeiro, Rio De Janeiro, Brazil, 14University College London, London, United Kingdom, 15Hacettepe University Faculty of Medicine, Ankara, Turkey, 16International Childhood Arthritis Genetics Consortium, Bethesda, MD, 17National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a genetically complex inflammatory condition. It can be marked by severe systemic inflammation that resembles the hereditary periodic…
  • Abstract Number: 1704 • ACR Convergence 2022

    Interaction of Macrophages and Natural Killer Cells in Pathogenesis of HIV-1-Associated Inflammatory Arthritis

    Can Sungur1, Gao Hongbo1, Li-ping Yang2, Liang Shan1 and Wayne Yokoyama3, 1Washington University, St. Louis, MO, 2Washington University in St. Louis, St. Louis, MO, 3Washington University School of Medicine, St. Louis, MO

    Background/Purpose: Human immunodeficiency virus (HIV) remains a significant life-threatening agent and burden on public health. Lesser studied and understood aspects of HIV infections include HIV-associated…
  • Abstract Number: 0621 • ACR Convergence 2022

    Altered Immunological Circadian Rhythms and the Effect of Treatment with Glucocorticoids on Circadian Rhythms of Immune Cells in Patients with Rheumatoid Arthritis: Bring Back the Rhythm

    Siska Wilantri1, Cindy Strehl1, Dimas Abdirama1, Timo Gaber1, Robert Biesen2 and Frank Buttgereit1, 1Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany, 2Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

    Background/Purpose: Clinical symptoms of rheumatoid arthritis (RA), including pain, joint stiffness, and swelling, exhibit a distinct circadian rhythm that exacerbates in the early morning in…
  • Abstract Number: 1711 • ACR Convergence 2022

    The Cellular Basis for Type I Interferon Production Following Ultraviolet Light Stimulated Cyclic-GMP-AMP Synthase Activation in the Skin

    Jie An, Xizhang Sun, Lena Tanaka and Keith Elkon, University of Washington, Seattle, WA

    Background/Purpose: SLE patients characteristically have a type I interferon (IFN-I) signature in peripheral blood cells and this same signature is prominent in lesional and non-lesional…
  • Abstract Number: 0661 • ACR Convergence 2022

    Cutaneous Type I IFN Responses in Systemic Lupus Erythematosus Are Associated with Inflammatory Phenotype and Altered Wound Healing Function of Lupus Fibroblasts from Non-Lesional Skin

    Lisa Abernathy-Close, Suzanne Shoffner-Beck, Annie Lu, Amanda Victory, Amy Hurst, Craig Dobry, Rachael Wasikowski, Johann Gudjonsson, Alex Tsoi and J. Michelle Kahlenberg, University of Michigan, Ann Arbor, MI

    Background/Purpose: Cutaneous lupus erythematosus (CLE) is a heterogenous, disfiguring, and difficult-to-treat manifestation of systemic lupus erythematosus (SLE) with scar formation in CLE subtypes such as…
  • Abstract Number: 1730 • ACR Convergence 2022

    T Cell-Macrophage Interactions Play a Critical Role in a Mouse Model of Histidyl-tRNA Synthetase-Induced Myositis

    Daniel Reay1, Ying Wang2, Wael Jarjour3, Paula Clemens1 and Dana Ascherman4, 1University of Pittsburgh School of Medicine, Pittsburgh, PA, 2University of Miami Miller School of Medicine, Miami, FL, 3The Ohio State University, Columbus, OH, 4University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Histidyl-tRNA synthetase (HRS) is a key target of antigen-specific B and T cell responses in the anti-synthetase syndrome. Despite a clear role for aberrant…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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