Abstract Number: 1026 • 2018 ACR/ARHP Annual Meeting
Autoinflammatory Diseases, Particularly SAVI and Candle, Are Driven By Chronically Active Type I Interferons
Background/Purpose: STING Associated Vasculopathy with onset in Infancy (SAVI)is caused by gain-of-function mutations in TMEM173/STING and Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature…Abstract Number: 1833 • 2018 ACR/ARHP Annual Meeting
The Vδ2 Subset of Γδt-Cells Are Present at Healthy Human Enthesis and Have Transcriptional and Functional Characteristics Consistent with a Capacity for IL- 17A Production in Response to IL-23
Background/Purpose: Recent mouse studies of SpA pathogenesis have suggested that γδT-cells accumulate at entheseal regions in an IL-23 overexpression model and that these cells are…Abstract Number: 2039 • 2018 ACR/ARHP Annual Meeting
A Survey of Blood and Synovial Tissue Myeloid Cells in RA Patients By Transcriptional Profiling
Background/Purpose: Myeloid cells – including dendritic cells (DCs), monocytes, and macrophages – are critical to the pathogenesis of rheumatoid arthritis (RA) through production of pro-inflammatory…Abstract Number: 2091 • 2018 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T (MAIT) Cells As a Potential Therapeutic Target for Systemic Lupus Erythematosus
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by the nonpolymorphic MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain:…Abstract Number: 2854 • 2018 ACR/ARHP Annual Meeting
Majeed Syndrome Causing LPIN2 mutations May Prevent Bone “Healing” By Rendering M2 Macrophage Proinflammatory
Background/Purpose: To study the mechanism that leads to bone inflammation in a 4-year old patient of mixed Puerto Rican and African-American background who presented with…Abstract Number: 33 • 2018 ACR/ARHP Annual Meeting
Card9 Is a Critical Regulator of Autoimmune Arthritis in SKG Mice
Background/Purpose: Caspase recruitment domain-containing protein 9 (Card9) is a C-type lectin receptor known for its function in protection against fungal infection and association with human diseases…Abstract Number: 94 • 2018 ACR/ARHP Annual Meeting
Circulating Soluble MICA Is Associated to Lupus Nephritis and to a TLR/IFN-I Signature in T Cells in a Cohort of Adult SLE Patients
Background/Purpose: The MHC class I-related chain A (MICA) is a major ligand for the NKG2D receptor of NK and CD8 T cells. MICA expression at…Abstract Number: 97 • 2018 ACR/ARHP Annual Meeting
Enhanced IFN-α Production By Plasmacytoid Dendritic Cells Is Associated with Increased Toll-like Receptor 7 Retention in the Lysosomes and Exosure to Type I IFN in Systemic Lupus Erythematosus
Background/Purpose: Type I interferon(IFN) appears to contribute to the development of systemic lupus erythematosus (SLE). Overexpression of type I IFN regulated genes has been reported…Abstract Number: 104 • 2018 ACR/ARHP Annual Meeting
Identification of a Gut Pathobiont Immunostimulatory Lipoglycan Antigen Linked to Lupus Nephritis
Background/Purpose: A transmissible agent has long been suspected in SLE. In a discovery cohort we found that,compared with healthy subjects, Lupus patients had a five-fold…Abstract Number: 152 • 2018 ACR/ARHP Annual Meeting
Polymorphonuclear Neutrophils and Regulatory T Lymphocytes (Treg) Cooperate to Sustain Treg Activity in Normal and Arthritic Contexts
Background/Purpose: Polymorphonuclear neutrophils (PMN) are abundant and activated in rheumatoid arthritis (RA) joints. In addition to their pro-inflammatory role, PMN exert immunoregulatory functions and may…Abstract Number: 366 • 2018 ACR/ARHP Annual Meeting
Infectious Complications of Immunosuppressive Therapy in Patients with Common Variable Immunodeficiency (CVID) and Inflammatory Arthritis
Background/Purpose: Common variable immunodeficiency (CVID) is one of the most common symptomatic primary immunodeficiency syndrome with an incidence of ~1 in 25,000 people. CVID is…Abstract Number: 1011 • 2018 ACR/ARHP Annual Meeting
Tissue Resident Macrophages Establish a Niche That Limits Monocyte to Macrophage Differentiation in Synovial Tissue during Homeostasis
Background/Purpose: Monocytes and Macrophages play critical roles in immune homeostasis and host defense. Recent studies identified that macrophages are highly heterogeneous in terms of location,…Abstract Number: 1015 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Peripheral CD14+ Monocytes Are Hyper-Inflammatory, Hyper-Glycolytic and Retain a Memory Bias Toward M1 Macrophages
Background/Purpose: Myeloid cells with a monocyte/macrophages phenotype are present in large numbers in the rheumatoid arthritis (RA) joint, significantly contributing to disease. This study aimed…Abstract Number: 1338 • 2017 ACR/ARHP Annual Meeting
Important Role of CD11c+ Dendtritic Cells in Inflammatory Arthritis
Background/Purpose: Dendritic cells (DCs) are important antigen presenting cells (APCs) and therefore they play an important role in bridging the innate and the adaptive immune…Abstract Number: 1663 • 2017 ACR/ARHP Annual Meeting
De Novo Mutation in ΑCΑCΒ in Childhood Onset SLE Highlights a Novel Role As Modulator of Nucleic Acid Sensor-Driven Type I Interferon Responses
Background/Purpose: Rare variants provide important opportunity for mechanistic insight as they carry substantial effect sizes and provide deep insight into disease etiopathogenesis. To date, several…
- 1
- 2
- 3
- …
- 5
- Next Page »