ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "innate immunity"

  • Abstract Number: 1472 • 2014 ACR/ARHP Annual Meeting

    Synovial Fluid from Rheumatoid Arthritis Patients Modulates the Immunophenotype and Viability of Monocytes

    Maria Sole Chimenti, Alberto Bergamini, Eleonora Baffari, Eleonora Ballanti, Alessia Musto, Paola Conigliaro and Roberto Perricone, Rheumatology, allergology and clinical immunology, Department of "Medicina dei Sistemi", University of Rome "Tor Vergata", Rome, Italy

    Background/Purpose Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by infiltration of the synovium by inflammatory cells that destroys the cartilage and the…
  • Abstract Number: 1196 • 2014 ACR/ARHP Annual Meeting

    Inflammation Develops in a Toll-like Receptor 9-Independent Manner in Experimental Arthritis and Rheumatoid Arthritis

    Julie Mussard1, Matthieu Ribon1, Gaelle Clavel2, Marie-Christophe Boissier3 and Patrice Decker1, 1INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, 2Fondation Ophtalmologique A. De Rothschild, Paris cedex 19, France, 3INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France

    Background/Purpose Rheumatoid arthritis (RA) is an inflammatory disease of unknown etiology. Toll-like receptor (TLR) 9 recognizes pathogen-derived DNA and even self DNA under certain circumstances.…
  • Abstract Number: 1199 • 2014 ACR/ARHP Annual Meeting

    Alarmins S100A8/S100A9 Aggravate Osteophyte Formation in Experimental Osteoarthritis and Predict Osteophyte Progression in EARLY Human Osteoarthritis in the Dutch Check Cohort

    Rik Schelbergen1, Wouter de Munter2, Martijn van den Bosch3, Floris Lafeber4, Annet Sloetjes3, Thomas Vogl5, Johannes Roth5, Peter M. van der Kraan6, Arjen B. Blom3, Wim B van den Berg3 and Peter L. van Lent3, 1Radboud university medical center, Nijmegen, Netherlands, 2Experimental rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Immunology, Institute of Immunology University of Muenster, Muenster, Germany, 6Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose The main pathological feature of osteoarthritis (OA) is degradation of the articular cartilage. Other important hallmarks include subclinical inflammation of the synovium and ectopic…
  • Abstract Number: 1044 • 2014 ACR/ARHP Annual Meeting

    Novel Compound Cytokine Release Inhibitory Drug 3 (CRID3) Inhibits the NLRP3 Inflammasome in Rheumatoid Arthritis

    Trudy McGarry1, Mary Connolly1, Rebecca C. Coll2, Avril A. B. Robertson3, Matthew A. Cooper3, Luke A. O'Neill2, Douglas J. Veale1 and Ursula Fearon1, 1Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, 2Inflammation Research, School of Biochemistry and Immunology, Dublin, Ireland, 3The University of Queensland, Brisbane, Australia

    Background/Purpose: The NLRP3 inflammasome is a multi-protein complex activated in response to environmental pathogens. This results in caspase-1-dependant cleavage of pro-IL-1β and IL-18 to their…
  • Abstract Number: 2500 • 2013 ACR/ARHP Annual Meeting

    Mast Cells Are a Major Source Of IL-17 In Synovium and Extra-Articular Tissues In Spondyloarthritis Related Diseases

    T. Noordenbos1, I. Gofita1, M. Alsina2, E.W.M. Vogels3, A. A. te Velde3, J. D. Cañete4, Dominique L. Baeten5 and N. Yeremenko1, 1Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 2Department of Dermatology, Hospital Clinic de Barcelona, Barcelona, Spain, 3Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre/University of Amsterdam, the Netherlands, Amsterdam, Netherlands, 4Rheumatology, Hospital Clinic, Barcelona, Spain, 5Department of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: IL-17 plays a key role in the pathogenesis of spondyloarthritis (SpA) as demonstrated by a recent proof-of-concept trial with the anti-IL17A mAb secukinumab. The…
  • Abstract Number: 1778 • 2013 ACR/ARHP Annual Meeting

    Physical Interactions Between Histidyl-tRNA Synthetase and Endogenous/Exogenous Alarmins Enhance Immunogenicity In a Model Of Antigen-Induced Myositis

    Irina Fernandez1, Lisa Harlow2, William Ridgway3 and Dana P. Ascherman4, 1Rheumatology, University of Miami, Miami, FL, 2Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, 3Immunology, Allergy and Rheumatology, University of Cincinnati, Cincinnati, OH, 4Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL

    Objective:  To assess the biological interplay between histidyl-tRNA synthetase (HRS) and different endogenous/exogenous ligands capable of generating signals through MyD88-dependent receptor systems in idiopathic inflammatory…
  • Abstract Number: 1156 • 2013 ACR/ARHP Annual Meeting

    Suppression Of Immune Responses and Joint Inflammation By Myeloid-Derived Suppressor Cells In a T Cell-Dependent Mouse Model Of Rheumatoid Arthritis

    Katalin Mikecz1, Julia Kurko1, Timea Ocsko1, Andras Vida1, Beata Tryniszewska1, Tibor A. Rauch1, Joel A. Block2, Robert S. Katz3, Anjali Nair2, Carla R. Scanzello4 and Tibor T. Glant1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Section of Rheumatology, Rush University Medical Center, Chicago, IL, 3Rush Medical College, Chicago, IL, 4Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of innate immune cells with immunosuppressive properties. We previously identified MDSCs in the synovial fluid (SF)…
  • Abstract Number: 1168 • 2013 ACR/ARHP Annual Meeting

    Innate Immune Cell Production Of Interleukin-12 Drives CpG-Induced Macrophage Activation Syndrome

    Lehn K. Weaver1 and Edward M. Behrens2, 1Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 2Pediatrics/Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Hemophagocytic syndromes are caused by an uncontrolled systemic inflammatory response resulting in cytopenias, multisystem organ failure, and rapid death, often despite aggressive therapy. Macrophage…
  • Abstract Number: 1149 • 2013 ACR/ARHP Annual Meeting

    Phenotypic and Molecular Profile Of Innate Lymphoid Cells In Chronic Synovial Inflammation

    Hulda S. Hreggvidsdottir1,2, Maureen C. Turina1, Troy Noordenbos1,3, Marius Munneke4, Charlotte Peters2, Jochem Bernink2, Jenny Mjosberg5, Dominique L. Baeten6 and Hergen Spits2, 1Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 2Tytgat Institute for Liver and Intestinal Research, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4Department of Hematology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 6Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Innate lymphoid cells (ILCs) represent a novel family of effector and regulatory cells in innate immunity and tissue remodelling. The family comprises several phenotypically…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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