Abstracts tagged "gout"

Abstract Number: 1576 • ACR Convergence 2021
Development of a Plain Radiographic Scoring System for New Bone Formation in Gout
Chang-Nam Son¹, Ken Cai², John Ferrier³, Yun-Jung Tsai³, Thomas Bardin⁴, Anthony Doyle⁵ and Nicola Dalbeth⁵, ¹Keimyung University School of Medicine, Daegu, Republic of Korea, ²University of Auckland, Sydney, Australia, ³Department of Radiology, Auckland District Health Board, Auckland, New Zealand, ⁴Hôpital Lariboisiere, Paris, France, ⁵University of Auckland, Auckland, New Zealand
Background/Purpose: Features of new bone formation (NBF) such as sclerosis and spurs are common on plain radiography in tophaceous gout. While a plain radiographic damage…
Abstract Number: 0666 • ACR Convergence 2021
Process Mapping Gout Hospitalizations: A Deep Dive into an Avoidable Epidemic
Mark Russell¹, Benjamin Ellis², Benjamin Clarke¹, Deepak Nagra¹ and James Galloway³, ¹King's College London, London, United Kingdom, ²Imperial College Healthcare NHS Trust, London, United Kingdom, ³Kings College London, London, United Kingdom
Background/Purpose: Hospital admissions for gout flares have increased dramatically in recent years. Strategies to reduce hospitalizations and improve uptake of urate-lowering therapy (ULT) are needed.…
Abstract Number: 1000 • ACR Convergence 2021
Molecular Mechanism of Inhibition of CD38 in Attenuation of Monosodium Urate Crystal-induced Inflammatory Responses in Macrophages
Huaping Qin¹, Patricia Oliveira¹, Tiffany Yan¹, Robert Terkeltaub² and Ru Liu Bryan³, ¹University of California San Diego, La Jolla, CA, ²VA/UCSD, San Diego, CA, ³University of California San Diego and VASDHS, San Diego, CA
Background/Purpose: CD38 can function as a degrading enzyme of nicotinamide adenine dinucleotide (NAD), a critical metabolic intermediate serving as enzyme cofactor in redox reactions and…
Abstract Number: 1577 • ACR Convergence 2021
Interleukin-37: Associations of Plasma Levels and Genetic Variants in Gout
Adela Navratilova¹, Veronika Voclonová², Hana Hulejová², Lucie Andrés Cerezo¹, Markéta Pavlíková³, Viktor Bečvář², Jakub Zavada¹, Karel Pavelka⁴, Ladislav Senolt⁴ and Blanka Stiburkova⁵, ¹Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, ³Department of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology and Department of Pediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: IL-37 is an anti-inflammatory cytokine, member of IL-1 family, related to inflammatory and autoimmune diseases. Here we aimed to investigate the association of genetic…
Abstract Number: 0667 • ACR Convergence 2021
Active Screening for Gout Permits Identifying a Larger Cardiovascular Population at High Mortality Risk
Silvia Ruiz-Simón¹, Irene Calabuig², Miguel Gómez-Garberí³ and MARIANO ANDRES⁴, ¹Universidad Miguel Hernández, Alicante, Spain, ²Hospital General Universitario de Alicante, Alicante, Spain, ³Hospital Universitario San Juan de Alicante, San Juan de Alicante, Spain, ⁴Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain
Background/Purpose: We have recently noted by active screening that about a third of gout cases in the cardiovascular population is not registered in records (Calabuig,…
Abstract Number: 1078 • ACR Convergence 2021
Rural Veterans with Gout – “Rheum” for Improvement
Jennifer Barton¹, Elizabeth Hooker², Christopher Larsen², Rachel Matsumoto² and Allison O'Neill², ¹VA Portland Health Care System/OHSU, Portland, OR, ²Center to Improve Veteran Involvement in Care/VA Portland Health Care System, Portland, OR
Background/Purpose: Gout is a form of inflammatory arthritis that can be “cured” with appropriate urate-lowering therapy to achieve a goal uric acid of 6mg/dL or…
Abstract Number: 1579 • ACR Convergence 2021
Phenome-Wide Association of Gout Risk Loci
Oleg Stens¹, Vivian Trang², Steven Cao², Robert Terkeltaub¹ and Rany Salem², ¹University of California San Diego School of Medicine, La Jolla, CA, ²University of California San Diego School of Public Health, La Jolla, CA
Background/Purpose: Gout is a complex disease involving changes in urate biology and inflammatory responses, and is associated with comorbidities including metabolic syndrome and cardiorenal disease.…
Abstract Number: 0668 • ACR Convergence 2021
Patient Perspectives and Preferences Regarding Gout and Gout Management: Impact on Adherence
Min Kyung Chung¹, Sung Soo Kim², Yun-Hong Cheon³, Seung Jae Hong⁴, Hyo Jin Choi⁵, Mi Ryoung Seo⁵, Ji Won Hwang⁶, Joong Kyong Ahn⁷, Sang-Heon Lee⁸, Hong Ki Min⁸, Hoon-Suk Cha⁹, Shin-Seok Lee¹⁰, Jennifer Lee¹¹, Ki Won Moon¹², Chang-Keun Lee¹³, Hyun-Ok Kim¹⁴, Young Sun Seo¹⁵, Seung-Cheol Shim¹⁶, Seong Wook Kang¹⁶, Jinhyun Kim¹⁶, Sang Tae Choi¹⁷, Jung Soo Song¹⁷ and Jisoo Lee¹, ¹Ewha Womans University College of Medicine, Seoul, Republic of Korea, ²Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea, ³Gyeongsang National University Hospital, Jinju, Republic of Korea, ⁴Kyung Hee University Hospital, School of Medicine, Kyung Hee University, Seoul, Republic of Korea, ⁵Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea, ⁶Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea, ⁷Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, ⁸Konkuk University Medical Center, Seoul, Republic of Korea, ⁹Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, ¹⁰Chonnam National University Medical School & Hospital, Gwangju, Republic of Korea, ¹¹Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea, ¹²Kangwon National University School of Medicine, Chuncheon, Republic of Korea, ¹³Asan Medical Center, SEOUL, Republic of Korea, ¹⁴Gyeongsang National University College of Medicine, Changwon, Republic of Korea, ¹⁵Gyeongsang National University Hospital, Changwon, Republic of Korea, ¹⁶Chungnam National University, Chungnam National University Hospital, Daejeon, Republic of Korea, ¹⁷Chung-Ang University School of Medicine, Seoul, Republic of Korea
Background/Purpose: Patient-centered management is becoming increasingly important in gout, but there are limited studies exploring patients’ perspectives and preferences. We aimed to investigate patients’ perspectives…
Abstract Number: 1095 • ACR Convergence 2021
Improved Arthrocentesis and Fluid Yield of the Non-Effusive Knee Using Pneumatic Compression
Ahsan Iqbal¹, Sumir Brahmbhatt¹, Maheswari Muruganandam², David Cisneros³, Adnan Kiani², Fatemeh Farshami⁴, Jaren Trost⁵, N. Suzanne Emil², Sharon Nunez¹ and Wilmer Sibbitt², ¹UNM, Albuquerque, NM, ²University of New Mexico, Albuquerque, NM, ³University of New Mexico School of Medicine, Albuquerque, NM, ⁴University of New Mexico, Albuquerque, MD, ⁵Optum, Albuquerque, NM
Background/Purpose: Arthrocentesis is critical for diagnosis and therapy of joint disease; however, it is very difficult to obtain diagnostic fluid from an arthritic but clinically…
Abstract Number: 1580 • ACR Convergence 2021
Whole Blood Gene Expression and eQTL Analysis Implicate GGT7 and FADS2 in Gout Pathogenesis
Richard Reynolds¹, Riku Takei¹, Jeffrey Edberg¹, Nicholas Sumpter¹, Tony Merriman² and Megan Leask¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Dunedin, New Zealand
Background/Purpose: Gene expression studies of whole blood represent a powerful approach for understanding the pathogenesis of gout because differentially expressed transcripts may reflect the activation…
Abstract Number: 0669 • ACR Convergence 2021
Early-Onset Gout (EOG) Patients Are an Important and Recalcitrant Phenotype Warranting Further Investigation: A Systematic Review
Anthony Amatucci¹, Brian LaMoreaux² and David Bulbin³, ¹Horizon Therapeutics, West Orange, NJ, ²Horizon Therapeutics plc, Deerfield, IL, ³Geisinger Health System, Danville, PA
Background/Purpose: Data suggests that the number of patients with early-onset gout (EOG), defined as patients under the age of 40 years, is increasing1. There is…
Abstract Number: 1099 • ACR Convergence 2021
Characteristics and Outcomes of Myocardial Infarction in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus, Systemic Sclerosis, Gout and Osteoarthritis Patients Using the National Inpatient Sample Database from 2002-2018
Sonia Gupta¹, Vinay thallapally², Sarah Aurit², Rouhin sen³ and Joseph Nahas², ¹Creighton University School of Medicine, Omaha, NE, ²Creighton University, Omaha, NE, ³Colorado University Anschutz Medical Campus, Denver, CO
Background/Purpose: Patients with the autoimmune rheumatic disease have an increased risk of acute myocardial infarction (MI). Our study was designed to compare the prevalence, characteristics…
Abstract Number: 1581 • ACR Convergence 2021
Genetic Effects on the Transition from Hyperuricemia to Gout
Nicholas Sumpter¹, Riku Takei¹, Richard Reynolds¹ and Tony Merriman², ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Dunedin, New Zealand
Background/Purpose: There is clear evidence of genetic control of hyperuricemia resulting in increased gout risk, however genetic control of the transition from hyperuricemia to gout…
Abstract Number: 0671 • ACR Convergence 2021
Concomitant Immunomodulation and Pegloticase Therapy: Experiences with a Variety of Immunomodulatory Agents in Two Community Rheumatology Practices
Aaron Broadwell¹, John Albert², Brian LaMoreaux³ and Lissa Padnick-Silver³, ¹Rheumatology and Osteoporosis Specialists, Shreveport, LA, ²Rheumatic Disease Center, Milwaukee, WI, ³Horizon Therapeutics plc, Deerfield, IL
Background/Purpose: Patients with uncontrolled or refractory gout have heavy disease burden,1 but few treatment options. Pegloticase is effective for lowering serum urate (SU) in these…
Abstract Number: 1184 • ACR Convergence 2021
Voluntary Online Gout Module: Housestaff Utilization and Efficacy
Sarah Tarplin¹, Susan Kroop² and Catherine Deffendall², ¹Vanderbilt Universty Medical Center, nashville, TN, ²Vanderbilt University, Nashville, TN
Background/Purpose: All Internal Medicine (IM) physicians should be competent in gout diagnosis and management. The purpose of this study is to assess learner engagement with…

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