Abstracts tagged "Fibroblasts"

Abstract Number: 1435 • ACR Convergence 2021
Identification of Distinct Fibroblast Populations in Systemic Sclerosis 3D Skin Tissues with Single Cell Omics
Noelle Kosarek¹, Heetaek Yang², Fred W. Kolling³, Tamar Abel⁴, Mengqi Huang⁵, Avi Smith⁶, Jonathan Garlick⁶, Patricia A. Pioli² and Michael L. Whitfield⁷, ¹Dartmouth Geisel School of Medicine, Hartford, VT, ²Geisel School of Medicine, Hanover, NH, ³Centers for Quantitative Biology, Hanover, ⁴Geisel School of Medicine, West Lebanon, NH, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶Tufts University School of Dental Medicine, Boston, MA, ⁷Geisel School of Medicine, Lebanon, NH
Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by skin and internal organ fibrosis, vascular abnormalities, and autoantibody formation. Single cell genomics studies…
Abstract Number: 157 • 2020 Pediatric Rheumatology Symposium
Chondrocytes Influence Fibroblast-like Synoviocytes from Patients with Juvenile Idiopathic Arthritis, Through the Abrogation of BMP Signaling, to Delay Cell Differentiation and Maturation
Megan Simonds ¹, Amanda Schlefman ², Kathleen Sullivan ³, Carlos Rose ⁴ and AnneMarie Brescia⁵, ¹Nemours Biomedical Research, Wilmington, ²Johns Hopkins Rheumatology, ST PETERSBURG, Florida, ³The Children's Hospital of Philadelphia, Philadelphia, ⁴Thomas Jefferson University/duPont Hospital for Children, Wilmington, ⁵Nemours/ Alfred I duPont Hospital for Children, Wilmington
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) progression leads to growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a key role in JIA pathogenesis; however, the…
Abstract Number: 2010 • 2019 ACR/ARP Annual Meeting
Individual Functions of Histone-acetyltransferases CBP and p300 in Regulating Autophagy and Proteasomal Degradation in Synovial Fibroblasts
Monika Krošel¹, Marcel Gabathuler ², Matija Tomšič ¹, Oliver Distler ³, Caroline Ospelt ⁴ and Kerstin Klein ⁵, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, Ljubljana, Slovenia, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland, Schlieren, ³Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, ⁴University Hospital Zürich, Zürich, Switzerland, ⁵Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland., Zürich, Switzerland
Background/Purpose: Tight control of the two major catabolic pathways proteasomal degradation and autophagy is critical for the maintenance of cellular homeostasis and cell survival. Here…
Abstract Number: 2863 • 2019 ACR/ARP Annual Meeting
Increased Expression of Extracellular Matrix Proteins in Human Fibroblast Synoviocytes and Lung Epithelial Cells Following Malondialdehyde-Acetaldehyde Adduct (MAA)/Citrullinated Protein Stimulation
Matthew O'Dell¹, Logan Duryee ¹, Lynell Klassen ¹, James O'Dell ², Bryant England ³, Michael Duryee ¹, Geoffrey Thiele ² and Ted Mikuls ², ¹University of Nebraska Medical Center, Omaha, NE, ²VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, ³VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha
Background/Purpose: Recently we have shown that both malondialdehyde-acetaldehyde adducts (MAA) and citrullinated proteins (CIT) are co-localized in joint and lung tissues of patients with rheumatoid…
Abstract Number: 16 • 2019 ACR/ARP Annual Meeting
Monoclonal ACPA Promote Synovial Fibroblasts Migration Through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Meng Sun¹, Bence Rethi ¹, Akilan Krishnamurthy ², Vijay Joshua ³, Alexandra Circiumaru ¹, Aase Hensvold ¹, Marianne Engström ⁴, Sergiu-Bogdan Catrina ⁵, Johanna Steen ⁶, Vivianne Malmström ³, Caroline Grönwall ³, Lars Klareskog ⁷, Heidi Wähämaa ¹ and Anca Catrina ⁷, ¹Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, ²Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Solna, Stockholm, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, ⁴Karolinska Institutet and Karolinska University Hospital, Stockholm, ⁵Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, ⁶Stockholm University, Stockholm, ⁷Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Anti-citrullinated protein antibodies (ACPAs) play an important role in rheumatoid arthritis (RA) pathogenesis. ACPAs have different amino acid motif recognition patterns and show cross-reactivity…
Abstract Number: 44 • 2019 ACR/ARP Annual Meeting
Validation of New Genes Identified in a Molecular Bayesian Network of Rheumatoid Arthritis Synovitis
Teresina Laragione¹, Carolyn Harris ¹, Wenhui Wang ¹, Jun Zhu ¹ and Percio Gulko ¹, ¹Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: We have previously identified new key regulators of Rheumatoid arthritis (RA) synovial pathology using a systems biology approach that combined RA gene expression datasets,…
Abstract Number: 815 • 2019 ACR/ARP Annual Meeting
Expression Profiling of Genes in Rheumatoid Fibroblast‑like Synoviocytes Regulated by Fas Ligand Using cDNA Microarray Analysis
Koji Fukuda¹, Yasushi Miura ², Shinya Hayashi ¹, Toshihisa Maeda ³ and Ryosuke Kuroda ¹, ¹Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ²Division of Orthopedic Science, Department Of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, ³Matsubara Mayflower Hospital, Kobe, Japan
Background/Purpose: Fas ligand (FasL) is a member of tumor necrosis factor superfamily (TNFSF6) and reported to contribute to synovial hyperplasia of rheumatoid arthritis (RA). Apoptosis…
Abstract Number: 979 • 2019 ACR/ARP Annual Meeting
Platelet Derived Growth Factor Receptor Alpha (PDGFRα) Blockade Inhibits Arthritis in Mice
Bhanupriya Madarampalli¹, Paul Panipinto ¹, Erica Chow ¹, Kendahl Sugai ¹, Fanqi Shi ¹ and Erika Noss ¹, ¹University of Washington, Seattle, WA
Background/Purpose: The interplay between infiltrating immune cells and activated joint stromal cells drives inflammation, cartilage destruction, and bone erosion in rheumatoid arthritis (RA). Among joint…
Abstract Number: 1049 • 2019 ACR/ARP Annual Meeting
Induction of a Profibrotic Phenotype in Normal Dermal Fibroblasts by Expression of PIM1 Kinase and Demonstration of Antifibrotic Effects of Inhibition of PIM Kinases in Systemic Sclerosis Dermal Fibroblasts
Danielle Pomante ¹, Sergio Jimenez ² and Sonsoles Piera-Velazquez¹, ¹Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, Philadelphia, PA
Background/Purpose: There is an urgent unmet need for effective therapeutic approaches for Systemic Sclerosis (SSc), a systemic autoimmune disease characterized by progressive fibrosis of skin…
Abstract Number: 990 • 2018 ACR/ARHP Annual Meeting
Guanylate Binding Protein 5 (GBP5) Inhibits Rheumatoid Arthritis Synovial Fibroblast Mediated Inflammation and Tissue Destruction
Mahamudul Haque¹, Anil K. Singh¹ and Salahuddin Ahmed^1,2, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Division of Rheumatology, University of Washington, Division of Rheumatology, School of Medicine, Seattle, WA
Background/Purpose: Guanylate binding protein 5 (GBP5), an interferon gamma (IFN-γ) inducible protein, helps to defend against invading pathogens. However, its role and properties beyond anti-viral…
Abstract Number: 994 • 2018 ACR/ARHP Annual Meeting
Platelet Derived Growth Factor Receptors (PDGFRs) and Their Implication in Inflammatory Arthritis
Bhanupriya Madarampalli¹, Joon Kyung Kim², Paul Panipinto¹, Hannah Labinsky¹ and Vineet Mahajan¹, ¹Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Rheumatoid arthritis (RA) is inflammatory joint disease characterized by immune infiltration and synovial hyperplasia. Hyperplastic synovium contains increased numbers of activated synovial fibroblasts, which…
Abstract Number: 1029 • 2018 ACR/ARHP Annual Meeting
Fibroblast-like Synoviocytes As Immune Effectors in the Pathogenesis of Synovial Lesion in Antibiotic-Refractory Lyme Arthritis
Klemen Strle¹, Robert Lochhead², Ruslan Sadreyev³, Allen C. Steere⁴ and John Aversa⁵, ¹Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, BOSTON, MA, ²Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, BOSTON, MA, ³Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, ⁴Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Orthopaedics and Rehabilitation, Yale Medical Group , Yale University School of Medicine, New Haven, CT
Background/Purpose: Antibiotic-refractory Lyme arthritis (LA) is characterized by marked proliferative synovitis that persists for months-to-years after oral and IV antibiotic therapy for Borrelia burgdorferi. Although…
Abstract Number: 1051 • 2018 ACR/ARHP Annual Meeting
Hoxd Genes Regulate Arthritis-Relevant Pathways
Kerstin Klein¹, Mojca Frank Bertoncelj¹, Monika Krošel¹, Matija Tomšič², Christoph Kolling³, Oliver Distler⁴ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, ³Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ⁴Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Gene expression and functions of synovial fibroblasts (SF) differ profoundly between distinct joints. This might lead to site-specific activation of arthritis-relevant pathways with implications…
Abstract Number: 1059 • 2018 ACR/ARHP Annual Meeting
Differentially-Utilized Transcription Factors and Enhancers in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes
Jonathan Mills¹, Gary S. Firestein² and Brian Pedersen², ¹Rheumatology, University of California, San Diego, San Diego, CA, ²Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: RA fibroblast-like synoviocytes (FLS) display a unique aggressive phenotype with a distinct epigenetic profile marked by altered chromatin accessibility. We hypothesized that differentially utilized…
Abstract Number: 1063 • 2018 ACR/ARHP Annual Meeting
Role of Mitochondrial-Bound HK2 in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Patricia Oliveira¹, Marta Fernandez Bustmanate², Ricard Garcia Carbonell³, Elsa Sanchez-Lopez⁴, Teresina Laragione⁵, Percio S. Gulko⁶, Gary S. Firestein⁷, Anne N Murphy³, Shigeki Miyamoto⁸ and Monica Guma^7,9, ¹Medicine, UCSD, San Diego, CA, ²Medicine, UCSD, La Jolla, CA, ³Pharmacology, UCSD, San Diego, CA, ⁴Department of Pharmacology, School of Medicine. UCSD., La Jolla, CA, ⁵Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ⁶Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Medicine, University of California San Diego, La Jolla, CA, ⁸Pharmacology, UCSD, La Jolla, CA, ⁹Medicine, Autonomous University of Barcelona, Bellatera, Spain
Background/Purpose: Hexokinases (HKs) catalyze the first step in glucose metabolism. HK2 constitutes the principal inducible isoform with a restricted distribution in normal adult tissues. Fibroblast-like…

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