ACR Meeting Abstracts

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Abstracts tagged "Fibroblasts"

  • Abstract Number: 891 • 2012 ACR/ARHP Annual Meeting

    Fatty Acids Promote Secretion of Proinflammatory and Prodestructive Factors by Synovial Fibroblasts

    Klaus W. Frommer1, Andreas Schäffler2, Stefan Rehart3, Angela Lehr4, Ulf Müller-Ladner5 and Elena Neumann6, 1Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Department of Internal Medicine III, Endocrinology, Diabetes, Metabolism, Justus-Liebig-University of Giessen, Giessen, Germany, 3Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, 4Dept Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, 5Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Bad Nauheim, Germany, 6Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany

    Background/Purpose: Due to their role in inflammatory metabolic diseases, we hypothesized that free fatty acids (FFA) are also involved in primary inflammatory joint diseases including…
  • Abstract Number: 2293 • 2012 ACR/ARHP Annual Meeting

    Interleukin-17A Positive Cells Are Increased in Systemic Sclerosis Skin and Their Number Is Inversely Correlated to Skin Thickness

    Marie-Elise Truchetet1, Nicolò Costantino Brembilla1, Elisa Montanari1, Paola Lonati2, Pier Luigi Meroni3 and Carlo Chizzolini1, 1University hospital of Geneva, Geneva, Switzerland, 2Division of Rheumatology, Istituto G. Pini, University of Milan, Milan, Italy, 3Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy

    Background/Purpose: T cell producing IL-17A are increased in the peripheral blood of individuals affected by systemic sclerosis (SSc). We asked the question whether IL-17A-producing cells…
  • Abstract Number: 1193 • 2012 ACR/ARHP Annual Meeting

    Podoplanin Expression in Rheumatoid Stroma Correlates with Lymphoid Neogenesis and Is Downregulated by Anti-TNF-α Therapy

    Regina Faré1, Elena Izquierdo1, Manuel J. Del Rey1, Raquel Celis2, Alicia Usategui1, Juan D. Cañete3 and Jose L. Pablos1, 1Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, 3Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain

    Background/Purpose:  In rheumatoid arthritis (RA), synovial fibroblasts (SF) expand and undergo phenotypic changes that contribute to chronic inflammation and joint destruction. Podoplanin (Pdp) is a…
  • Abstract Number: 2289 • 2012 ACR/ARHP Annual Meeting

    Adiponectin Has Potent Anti-Fibrotic Effects Mediated Via AMP Kinase: Novel Target for Fibrosis Therap

    Feng Fang1, Lei Liu2, Yang Yang2, Jun Wei1, Swati Bhattacharyya3, Ross Summer4, Boping Ye2 and John Varga3, 1Rheumatology Division, Northwestern University, Chicago, IL, 2School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, 3Division of Rheumatology, Northwestern University, Chicago, IL, 4Pulmonary Center, Boston University, Boston, MA

    Background/Purpose: Fibrosis in scleroderma is associated with transforming growth factor-β (TGF-β) signaling activation, collagen deposition and myofibroblast accumulation. Peroxisome proliferator activated receptor gamma (PPAR-γ) inhibits…
  • Abstract Number: 1496 • 2012 ACR/ARHP Annual Meeting

    Downregulated Expression of Metallothionein Genes in Response to the Gadolinium Contrast Agent Omniscan in Normal Human Differentiated Macrophages and Dermal Fibroblasts

    Peter J. Wermuth1, Francesco Del Galdo2, Sankar Addya3, Paolo Fortina3 and Sergio A. Jimenez1, 1Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Metallothioneins bind heavy metals with high affinity and can serve as storage proteins for labile Zn2+ which in turn can regulate immune system activity…
  • Abstract Number: 2309 • 2012 ACR/ARHP Annual Meeting

    Increased Levels of Ser 181 Phosphorylated SOX9 in SSc Dermal Fibroblasts: A Novel Participant in the Pathogenesis of SSc Fibrotic Process

    Sonsoles Piera-Velazquez, Jolanta Fertala and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: SOX9, a high mobility group (HMG) transcription factor is a master regulator of chondrogenesis and is essential for the maintenance of the chondrocyte-specific phenotype…
  • Abstract Number: 1492 • 2012 ACR/ARHP Annual Meeting

    IL-13 Receptors and Signaling in the Dermal Fibroblasts From Patients with Systemic Sclerosis

    Yuko Ota1, Yasushi Kawaguchi1, Atsushi Kitani2, Kae Takagi1, Hisae Ichida1, Yasuhiro Katsumata1, Takahisa Gono1, Masanori Hanaoka1, Yuko Okamoto1 and Hisashi Yamanaka1, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Mucosal Immunity Section, NIAID/NIH, Bethesda, MD

    Background/Purpose: Interleukin (IL)-13 is a pleiotropic cytokine involved in T helper type 2 cell immune response and in the development of fibrotic conditions such as…
  • Abstract Number: 1505 • 2012 ACR/ARHP Annual Meeting

    Inactivation of Tankyrases Ameliorates Canonical Wnt Signaling and Prevents Experimental Fibrosis

    Alfiya Distler1, Lisa Deloch2, Jingang Huang2, Clara Dees2, Neng Yu Lin2, Christian Beyer3, Oliver Distler4, Georg A. Schett5 and Joerg HW Distler1, 1Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 3Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 5Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Systemic sclerosis (SSc) is characterized by aberrant activation of fibroblasts with increased release of extracellular matrix components. Canonical Wnt signaling has recently emerged as…
  • Abstract Number: 1500 • 2012 ACR/ARHP Annual Meeting

    Activation of Pregnane X Receptor Induces Regression of Experimental Dermal Fibrosis

    Christian Beyer1, Alla Skapenko2, Alfiya Distler3, Clara Dees4, Helena Reichert5, Louis E. Munoz3, Jan Leipe6, Hendrik Schulze-Koops7, Oliver Distler8, Georg Schett9 and Joerg HW Distler3, 1Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Division of Rheumatology and Clinical Immunology, Med. Poliklinik,, University of Munich, Munich, Germany, 3Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 5Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 6Med. Poliklinik, University of Munich, Division of Rheumatology and Clinical Immunology, Munich, Germany, 7University of Munich, Munich, Germany, 8Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 9Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Pregnane-X-receptor (PXR) belongs to a superfamily of nuclear receptors that function as ligand-activated transcriptional factors. Although endogenous ligands have not yet been identified, PXR…
  • Abstract Number: 1499 • 2012 ACR/ARHP Annual Meeting

    The Soluble Guanylate Cyclase Mediates Its Anti-Fibrotic Effects by Inhibiting TGF-β Signaling

    Christian Beyer1, Sonia C. Schindler2, Alfiya Distler3, Clara Dees4, Helena Reichert2, Hümeyra Akan2, Peter Sandner5, Oliver Distler6, Georg Schett7 and Joerg HW Distler3, 1Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 3Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 5Bayer Health Care, Global Drug Discovery – Common Mechanism Research, Bayer Health Care, Global Drug Discovery – Common Mechanism Research, Wuppertal, Germany, 6Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 7Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: We have recently demonstrated that stimulation of the soluble guanylate cyclase (sGC) has potent anti-fibrotic activity in different models of fibrosis. sGC stimulation increases…
  • Abstract Number: 1517 • 2012 ACR/ARHP Annual Meeting

    TLR9 Signaling in Fibroblasts Promotes Pro-Fibrotic Responses Via TGF-Beta

    Yang Yang1, Feng Fang2, Lei Liu1, Junjie Shangguan3, Boping Ye1 and John Varga3, 1School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, 2Rheumatology Division, Northwestern University, Chicago, IL, 3Division of Rheumatology, Northwestern University, Chicago, IL

    Background/Purpose: Systemic sclerosis (SSc) is associated with progressive fibrosis and transforming growth factor β (TGF-β) is implicated in its pathogenesis. Toll-like receptors (TLR) respond to…
  • Abstract Number: 1610 • 2012 ACR/ARHP Annual Meeting

    The DNA Methylation Signature in Fibroblast-Like Synoviocytes (FLS) Defines Critical Pathogenic Pathways in Rheumatoid Arthritis (RA)

    David L. Boyle1, Robert Shoemaker2, David W. Anderson3, Wei Wang4 and Gary S. Firestein5, 1Div of Rheum, UCSD School of Medicine, La Jolla, CA, 2NexDx, Inc., San Diego, CA, 3Research and Development, NexDx, Inc., San Diego, CA, 4Chemistry, UCSD, La Jolla, CA, 5Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: A DNA methylation signature has been characterized that distinguishes RA FLS from osteoarthritis (OA) and normal (NL) FLS. The presence of epigenetic changes in…
  • Abstract Number: 1659 • 2012 ACR/ARHP Annual Meeting

    Ptpome Profile of Rheumatoid Arthritis Fibroblast-Like Synoviocytes: A Novel Role for the Tyrosine Phosphatase SHP-2 As a Modulator of Invasion and Survival

    Stephanie Stanford1, Michael Maestre2, Beatrix Bartok3, David L. Boyle4, Heather Arnett5, Tomas Mustelin6, Gary S. Firestein7 and Nunzio Bottini2, 1Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 2La Jolla Institute for Allergy and Immunology, La Jolla, CA, 3Rheumatology, UCSD School of Medicine, La Jolla, CA, 4Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, 5Amgen, Inc., Seattle, WA, 6Sanford-Burnham Institute for Medical Research, La Jolla, CA, 7Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). These cells assume a…
  • Abstract Number: 1775 • 2012 ACR/ARHP Annual Meeting

    The Phosphoinositide 3-Kinase Pathway Regulates Fibroblast-Like Synoviocyte Invasion

    Beatrix Bartok1, Deepa Hammaker2 and Gary S. Firestein3, 1Rheumatology, UCSD, La Jolla, CA, 2MC 0656, Univ of California San Diego, La Jolla, CA, 3Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: Cartilage destruction mediated by invasive fibroblast-like synoviocytes (FLS) plays a central role in pathogenesis of RA. Increased cell migration and degradation of extracellular matrix…
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