ACR Meeting Abstracts

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Abstracts tagged "Fibroblasts"

  • Abstract Number: 1029 • 2018 ACR/ARHP Annual Meeting

    Fibroblast-like Synoviocytes As Immune Effectors in the Pathogenesis of Synovial Lesion in Antibiotic-Refractory Lyme Arthritis

    Klemen Strle1, Robert Lochhead2, Ruslan Sadreyev3, Allen C. Steere4 and John Aversa5, 1Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, BOSTON, MA, 2Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, BOSTON, MA, 3Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 4Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5Orthopaedics and Rehabilitation, Yale Medical Group , Yale University School of Medicine, New Haven, CT

    Background/Purpose: Antibiotic-refractory Lyme arthritis (LA) is characterized by marked proliferative synovitis that persists for months-to-years after oral and IV antibiotic therapy for Borrelia burgdorferi. Although…
  • Abstract Number: 1051 • 2018 ACR/ARHP Annual Meeting

    Hoxd Genes Regulate Arthritis-Relevant Pathways

    Kerstin Klein1, Mojca Frank Bertoncelj1, Monika Krošel1, Matija Tomšič2, Christoph Kolling3, Oliver Distler4 and Caroline Ospelt1, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2University Medical Centre Ljubljana, Department of Rheumatology, Ljubljana, Slovenia, 3Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, 4Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Gene expression and functions of synovial fibroblasts (SF) differ profoundly between distinct joints. This might lead to site-specific activation of arthritis-relevant pathways with implications…
  • Abstract Number: 1059 • 2018 ACR/ARHP Annual Meeting

    Differentially-Utilized Transcription Factors and Enhancers in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes

    Jonathan Mills1, Gary S. Firestein2 and Brian Pedersen2, 1Rheumatology, University of California, San Diego, San Diego, CA, 2Medicine, University of California San Diego, La Jolla, CA

    Background/Purpose: RA fibroblast-like synoviocytes (FLS) display a unique aggressive phenotype with a distinct epigenetic profile marked by altered chromatin accessibility. We hypothesized that differentially utilized…
  • Abstract Number: 1063 • 2018 ACR/ARHP Annual Meeting

    Role of Mitochondrial-Bound HK2 in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Patricia Oliveira1, Marta Fernandez Bustmanate2, Ricard Garcia Carbonell3, Elsa Sanchez-Lopez4, Teresina Laragione5, Percio S. Gulko6, Gary S. Firestein7, Anne N Murphy3, Shigeki Miyamoto8 and Monica Guma7,9, 1Medicine, UCSD, San Diego, CA, 2Medicine, UCSD, La Jolla, CA, 3Pharmacology, UCSD, San Diego, CA, 4Department of Pharmacology, School of Medicine. UCSD., La Jolla, CA, 5Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 6Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 7Medicine, University of California San Diego, La Jolla, CA, 8Pharmacology, UCSD, La Jolla, CA, 9Medicine, Autonomous University of Barcelona, Bellatera, Spain

    Background/Purpose: Hexokinases (HKs) catalyze the first step in glucose metabolism. HK2 constitutes the principal inducible isoform with a restricted distribution in normal adult tissues. Fibroblast-like…
  • Abstract Number: 1065 • 2018 ACR/ARHP Annual Meeting

    Artesunate Can Synergize with Methotrexate on Inhibiting Migration and Invasion of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis

    Jian-Da Ma1, Jun Jing1, Jun-Wei Wang1, Tao Yan2, Yun-Shan Mou2, Ying-Qian Mo1 and Lie Dai1, 1Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, 2Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

    Background/Purpose: Fibroblast-like synoviocytes (FLS) play important roles on joint destruction in rheumatoid arthritis (RA). Recent reports showed that antimalaria drug artesunate presents anti-cancer potential by…
  • Abstract Number: 1068 • 2018 ACR/ARHP Annual Meeting

    Characterization of the Role of Endocannabinoid System Using Jwh-133, a Selective Cannabinoid CB2 Receptor Agonist, in IL-1β-Induced Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts

    Sabrina Fechtner1, Anil K. Singh1 and Salahuddin Ahmed1,2, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Division of Rheumatology, University of Washington, Division of Rheumatology, School of Medicine, Seattle, WA

    Background/Purpose: The endocannabinoid system (ECS) is comprised of two evolutionary conserved cannabinoid receptors 1 and 2 (CB1 and CB2) which participate in pain management through…
  • Abstract Number: 50 • 2018 ACR/ARHP Annual Meeting

    Intra-Articularly Delivering Lentivirus-Based CRISPR Interference Targeting Long Non-Coding RNA H19 in Synovial Fibroblasts Ameliorates Experimental Arthritis

    Chrong-Reen Wang1, Shih-Yao Chen2, Yu-Ting Lo3, Yu-Chi Chou4, Ming-Fei Liu1, Chao-Liang Wu5 and Ai-Li Shiau3, 1Internal Medicine, National Cheng Kung University Hospital and Medical College, Tainan, Taiwan, 2Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, 3Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 4Core Facility for Manipulation of Gene Function, Academia Sinica, Taipei, Taiwan, 5Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan

    Background/Purpose: Aberrantly higher expression of long non-coding RNAs (lncRNAs) in synovial fibroblasts (SFs) plays pathogenic roles in rheumatoid joint. Studying the effects on knocking down…
  • Abstract Number: 1822 • 2018 ACR/ARHP Annual Meeting

    RNA-Sequencing of Mouse and Human Synovial Fibroblasts Reveals Fibroblast Subset-Specific Responses to Inflammation

    Anqi Gao1, Kevin Wei2, Ilya Korsunsky3 and Michael Brenner4, 1Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 4Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts secrete inflammatory cytokines, degrade cartilage and mediate bone destruction. We have previously identified three synovial fibroblasts subsets with…
  • Abstract Number: 81 • 2018 ACR/ARHP Annual Meeting

    Additive Effects of Functional Rheumatoid Arthritis (RA) LBH Risk Alleles on LBH Gene Transcription

    Gyrid Nygaard, Deepa Hammaker, David L. Boyle and Gary S. Firestein, Medicine, University of California San Diego, La Jolla, CA

    Background/Purpose: LBH (Limb-bud and heart development gene) is dysregulated in RA, with a SNP associated with increased RA risk located in an upstream enhancer. This…
  • Abstract Number: 1964 • 2018 ACR/ARHP Annual Meeting

    Epigenetic Changes of Energy Metabolism-Related Genes in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Brian Pedersen1, Roxana Coras1,2, Wei Wang3, Gary S. Firestein1 and Monica Guma1,2, 1Medicine, University of California San Diego, La Jolla, CA, 2Medicine, Autonomous University of Barcelona, Bellatera, Spain, 3Chemistry and Biochemistry, University of California San Diego, La Jolla, CA

    Background/Purpose: Epigenetic changes contribute to the pathogenesis of rheumatoid arthritis (RA) and a comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS) has recently been described.…
  • Abstract Number: 114 • 2018 ACR/ARHP Annual Meeting

    Antifibrotic Regulation By Response Gene to Complement 32 Protein

    Sergei Atamas, Violeta Rus, Virginia Lockatell, Horea Rus and Irina Luzina, University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Pulmonary fibrosis is a serious problem in patients with scleroderma lung disease (SLD). Better therapies for pulmonary fibrosis are urgently needed. Identification of new…
  • Abstract Number: 1981 • 2018 ACR/ARHP Annual Meeting

    A Molecular Bayesian Network for Rheumatoid Arthritis Reveals Multiple Candidate Key Regulators for Disease Severity

    Wenhui Wang1, Amit Lahiri2, Teresina Laragione2, Jun Zhu1 and Percio S. Gulko2,3, 1Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 2Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 3Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic autoimmune joint disease. RA is pathologically heterogeneous with multiple contributing factors. While there has been a…
  • Abstract Number: 115 • 2018 ACR/ARHP Annual Meeting

    CTLA4-Ig/CD86 Interaction on Cultered Human Fibrocytes and Fibroblasts from Systemic Sclerosis Patients

    Maurizio Cutolo1, Paola Montagna2, Stefano Soldano1, Amelia Chiara Trombetta3, Barbara Ruaro4, Paola Contini5, Sabrina Paolino6, Carmen Pizzorni4, Elisa Alessandri4, Massimo Patanè1, Alberto Sulli4, Stefano Scabini7, Emanuela Stratta7 and Renata Brizzolara1, 1Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Polyclinic San Martino Hospital, Genova, Italy, Genoa, Italy, 2Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genova, Italy, 3Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genoa, Italy, 4Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, 5Division of Clinical Immunology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino, Genova, Italy, Genova, Italy, 6Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genova, Italy, 7Oncologic Surgery, Department of Surgery, IRCCS Polyclinic San Martino, Genova, Italy, Genoa, Italy

    Background/Purpose: CTLA4-Ig interacts with the cell surface costimulatory molecule CD86 and can downregulate the target cell activation [1]. Circulating fibrocytes (CFs) express markers of both…
  • Abstract Number: 1409 • 2017 ACR/ARHP Annual Meeting

    Ursolic Acid Promotes Apoptosis of Rheumatoid Athritis Synovial Fibroblasts By Upregulating Noxa Expression and Recruiting E3 Ligase Mule to Degrade Mcl-1

    Eugene Kim1, Solomon Agere1, Sadik Khuder2 and Salahuddin Ahmed1, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Department of Medicine, University of Toledo, Toledo, OH

    Background/Purpose: In our previous study, we discovered that ursolic acid (UA), a pentacyclic triterpenoid with anti-inflammatory properties, induces apoptosis in synovial fibroblasts from rheumatoid arthritis…
  • Abstract Number: 1415 • 2017 ACR/ARHP Annual Meeting

    TNF-Induced IRF1 Is Critical for the Inflammatory Gene Expression in Fibroblast-like Synoviocytes

    Michael Bonelli1, Karolina von Dalwigk2, Birgit Niederreiter1, Thomas Pap3, Josef S. Smolen4, Hans Peter Kiener1 and Thomas Karonitsch1, 1Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, 4Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are increasingly recognised as major pathogenic cells in synovial inflammation of patients with Rheumatoid Arthritis (RA). In response to pro-inflammatory stimuli,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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