Abstracts tagged "Epigenetics"

Abstract Number: 1889 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Arthritis (RA)-Associated Risk Allele LBH Alters the Function of a Differentially Methylated LBH Enhancer
Deepa Hammaker¹, Gary S. Firestein², Wei Wang³, John W. Whitaker⁴ and Anna-Karin Ekwall⁵, ¹Medicine, University of California San Diego, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, ³Chemistry, UCSD, La Jolla, CA, ⁴860 island ave, UCSD, San Diego, CA, ⁵Medicine, UC San Diego, La Jolla, CA
Background/Purpose Recent data suggest that epigenetics, including DNA methylation, contributes to imprinting RA fibroblast-like synoviocytes (FLS) and alters their behavior. To understand how RA-associated risk…
Abstract Number: 1887 • 2014 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Analysis of Twin Pairs Discordant for Systemic Sclerosis Reveals Distinct Signatures in Blood and Dermal Fibroblasts
Paula S. Ramos¹, Rick Jordan², James Lyons-Weiler², Thomas A. Medsger Jr.³ and Carol A. Feghali-Bostwick⁴, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, ³Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose Systemic sclerosis (SSc) is a chronic, multisystem, autoimmune inflammatory disease with genetic and non-genetic contributions to risk. The etiology of SSc, including the reasons…
Abstract Number: 1728 • 2014 ACR/ARHP Annual Meeting
Bromodomain Inhibitor JQ1 Modulates Collagen Processing and Ameliorates Bleomycin Induced Dermal Fibrosis in Mice
Sarah Trinder¹, Mary Tarriela², Adrian Gilbane¹, Robert Good³, Xu Shi-Wen⁴, David Abraham⁵ and Alan M. Holmes⁶, ¹Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, ³Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, ⁵Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁶Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is a complex pro-inflammatory scarring disease, characterised by elevated deposition of extracellular matrix (ECM) proteins, in particular collagen type I. The…
Abstract Number: 1132 • 2014 ACR/ARHP Annual Meeting
A Novel Epigenetic Mark, Histone H1 Fucosylation, Orchestrates Macrophage Differentiation and Plasticity By Remodeling the Enhancer Landscape in Rheumatoid Arthritis
Jun Li¹, Keith Giles², Parastoo Azadi³, Mayumi Ishihara³, PingAr Yang¹, Qi Wu¹, Bao Luo¹, David M. Spalding⁴, James A Mobley⁵, S. Louis Bridges Jr.^6,7, Hui-Chen Hsu¹ and John D. Mountz^1,8, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Stem cell Institute, Birmingham, AL, ³University of Georgia, Complex Carbohydrate Research Center, Athens, GA, ⁴University of Alabama at Birmingham, Division of Clinical Immunology & Rheumatology, Birmingham, AL, ⁵University of Alabama at Birmingham, Comprehensive Cancer Center Mass Spectrometry/Proteomics Facility, Birmingham, AL, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸Birmingham VA Medical Center, Birmingham, AL
Background/Purpose There is an imbalance of inflammatory M1 vs. anti-inflammatory M2 macrophages (MΦs) in rheumatoid arthritis (RA). The epigenetic codes underlying this M1 dominating pathogenesis…
Abstract Number: 1128 • 2014 ACR/ARHP Annual Meeting
Regulation of PIWIL4 By Histone Modifications in Rheumatoid Arthritis
Lenka Pleštilová¹, Niharika Gaur¹, Mária Filková², Borbala Aradi-Vegh¹, Ladislav Senolt³, Adrian Ciurea¹, Renate E. Gay⁴, Jiri Vencovsky³, Michel Neidhart⁵, Steffen Gay⁵ and Astrid Juengel¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ³Institute of Rheumatology and Clinic of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose Analog to miRNAs that bind to argonaute proteins to suppress gene expression, a new group of non-coding RNAs piwi-interacting RNAs (piRNAs, 26-31 nt) build…
Abstract Number: 1124 • 2014 ACR/ARHP Annual Meeting
Genome-Wide Profiling of DNA from Cartilage Reveals Regions Differently Methylated in Osteoarthritis Patients
Guangju Zhai¹, Ming Liu², Yuhua Zhang¹, Patricia E. Harper¹, Erfan Aref-Eshghi², Glynn Martin³, Andrew Furey³, Roger Green¹, Guang Sun⁴ and Proton Rahman⁵, ¹Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²Discipline of Genetics, Memorial University, St. John's, NF, Canada, ³Department of Surgery, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁵Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Osteoarthritis (OA) represents the most common form of arthritis and has substantial clinical and economic impact. Evidence supports that DNA methylation plays a significant…
Abstract Number: 1033 • 2014 ACR/ARHP Annual Meeting
Stat3 Promotes IL-10 Expression in SLE T Cells through Trans-activation and Chromatin Remodeling
Christian Hedrich¹, Thomas Rauen², Sokratis Apostolidis³, Alexandros P. Grammatikos⁴, Noe Rodriguez Rodriguez⁴, Christina Ioannidis³, Vasileios C. Kyttaris⁴, José C. Crispin⁴ and George C. Tsokos⁵, ¹Children's Hospital, Dresden, Germany, ²Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ³Medicine, Rheumatology, BIDMC, Boston, MA, ⁴Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-10 is an immune-regulatory cytokine that is expressed by a wide range of cells and tissues. It plays a central role in the regulation…
Abstract Number: 2736 • 2013 ACR/ARHP Annual Meeting
High Density Microarray Analysis Identifies Novel Differentially Expressed Long Noncoding RNAs In Rheumatoid Arthritis Synovial Fibroblasts
Mojca Frank Bertoncelj¹, Michelle Trenkmann¹, Christoph Kolling², Beat A. Michel³, Renate E. Gay⁴ and Steffen Gay¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Schultess Clinic, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland
Background/Purpose: Long noncoding RNAs (lncRNAs) have emerged as key regulators of gene expression. Recently, several new susceptibility loci were identified for rheumatoid arthritis (RA), mapping…
Abstract Number: 1380 • 2013 ACR/ARHP Annual Meeting
Histone Modifications In The Interluekin-6 Gene Promoter Region Of Rheumatoid Arthritis Synovial Fibroblasts
Takuma Tsuzuki Wada^1,2, Yasuto Araki^1,2, Kazuhiro Yokota¹, Fumihiko Miyoshi¹, Kojiro Sato¹ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: , Rheumatoid arthritis (RA) is a disease of unknown origin, which develops continuous inflammation and progressive joint destruction resulting from an autoimmune response mainly…
Abstract Number: 2724 • 2013 ACR/ARHP Annual Meeting
cAMP Responsive Element Modulator (CREM)α Governs CD8 Expression and Contributes to the Generation of CD3⁺CD4^–CD8^– T Cells in Lupus
Christian M. Hedrich¹, José C. Crispín¹, Thomas Rauen¹, Christina Ioannidis¹, Tomohiro Koga², Noe Rodriguez Rodriguez², Sokratis A. Apostolidis³, Vasileios C. Kyttaris² and George C. Tsokos¹, ¹Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: CD3+CD4-CD8- "double negative" T cells are expanded in the peripheral blood of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative T…
Abstract Number: 775 • 2013 ACR/ARHP Annual Meeting
Cytokine-Mediated Repression Of The Lncrna Hotair Enhances Intracellular Signaling and The Expression Of Adhesion Molecules In Synovial Fibroblasts
Michelle Trenkmann¹, Mojca Frank Bertoncelj¹, Matthias Brock², Christoph Kolling³, Renate E. Gay⁴, Beat A. Michel⁵, Diego Kyburz¹, Lars C. Huber² and Steffen Gay¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland, ³Schultess Clinic, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Rheumatoid arthritis (RA) synovial fibroblasts (SF) are characterized by a stably activated phenotype which is, at least in part, because of the epigenetic inheritance…
Abstract Number: 2731 • 2013 ACR/ARHP Annual Meeting
An Acetyl-Histone Mimetic Blocks Proinflammatory Activation Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
P. A. Kabala¹, A.M. Grabiec¹, C. Angiolilli¹, Nicholas Smithers², Jason Witherington³, Paul Peter Tak⁴, Rabinder Prinjha³ and Kris A. Reedquist⁵, ¹Department of Experimental Immunology, Department of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Immuno Inflammation, GlaxoSmithKline, Stevenage, United Kingdom, ³GlaxoSmithKline, Stevenage, United Kingdom, ⁴Academic Medical Center / University of Amsterdam, Department of Clinical Immunology and Rheumatology & GlaxoSmithKline, Amsterdam, Netherlands, ⁵Department of Experimental Immunology and Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Genetic backgrounds and environmental factors do not completely explain the etiology of disease and predisposition to rheumatoid arthritis (RA), and increasing attention has turned…
Abstract Number: 776 • 2013 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Alpha Modifies Chromatin Landscape and Amplifies Inflammatory Responses To Subsequent Stimuli In Synovial Fibroblasts
Angela Lee¹, Lionel B. Ivashkiv² and George D. Kalliolias¹, ¹Medicine, Hospital for Special Surgery, New York, NY, ²Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Fibroblast-like synoviocytes (FLS) cross-talk with macrophages (Mf) during the course of rheumatoid arthritis (RA). Our group has shown that TNFa, primarily Mf-derived within synovium,…
Abstract Number: 2734 • 2013 ACR/ARHP Annual Meeting
Epigenetic Control Of a Gene Regulatory Network Associated With Experimental Autoimmune Arthritis and Rheumatoid Arthritis
Andras Vida¹, Janos Gal², Gyorgyi Soos², Attila Balog³, Laszlo G. Puskas⁴, Katalin Mikecz¹, Tibor T. Glant¹ and Tibor A. Rauch¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Bacs-Kiskun County Hospital, Kecskemet, Hungary, ³Rheumatology, Albert Szent-Gyorgyi University, Szeged, Hungary, ⁴Laboratory of Functional Genomics, Biological Research Center, Szeged, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder that mainly affects the synovial joints, leading to destruction of articular cartilage and bone. There is…
Abstract Number: 2735 • 2013 ACR/ARHP Annual Meeting
Integrative Analysis Of Multiple Omics Technologies Reveals a Novel Therapeutic Target For Rheumatoid Arthritis (RA)
David L. Boyle¹, John Whitaker², Beatrix Bartok³, Wei Wang⁴ and Gary S. Firestein⁵, ¹Div of Rheum, UCSD School of Medicine, La Jolla, CA, ²Chemistry, UCSD School of Medicine, La Jolla, CA, ³Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁴Chemistry, UCSD, La Jolla, CA, ⁵Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Identifying novel therapeutic targets for immune-mediated disease has become increasingly challenging. We used an unbiased method to integrate multiple “omics” methodologies and evaluate…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].