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Abstracts tagged "Epigenetics"

  • Abstract Number: 2738 • 2019 ACR/ARP Annual Meeting

    Differential Methylation of Peripheral Blood Adaptive Immune Cells in Individuals at High Risk for RA and with Early RA Compared with Controls Identifies Pathways Important in Transition to Arthritis

    Rizi Ai1, David Boyle 2, Deepa Hammaker 3, Kevin Deane 4, V. Michael Holers 5, Andre Matti 6, William Robinson 7, Jane Buckner 8, Navin Rao 9, Frédéric Baribaud 10, George Vratsanos 11, Sunil Nagpal 9, Wei Wang 2 and Gary Firestein 3, 1University of California San Diego, San Diego, 2University of California, San Diego, San Diego, CA, 3University of California, San Diego, San Diego, 4University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 5University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, 6UCSD, La Jolla, CA, 7Stanford University, Stanford, CA, 8Benaroya Research Institute, Seattle, WA, 9Janssen R&D, Spring House, PA, 10Janssen Research & Development, LLC, Spring House, PA, 11JNJ, Raritan, NJ

    Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing RA because of serum anti-citrullinated protein antibody…
  • Abstract Number: 2740 • 2019 ACR/ARP Annual Meeting

    Takayasu Arteritis Associated Risk Locus in IL6 Represses the Anti-inflammatory Gene GPNMB Through Chromatin Looping and Recruiting MEF2-HDAC Complex

    Xiufang Kong 1 and Amr Sawalha2, 1University of Michigan & Fudan University, Ann Arbor, MI, 2University of Pittsburgh & University of Michigan, Pittsburgh, PA

    Background/Purpose: Previous work has revealed a genetic association between Takayasu arteritis and a non-coding genetic variant in an enhancer region within IL6 (rs2069837 A/G). The…
  • Abstract Number: 2743 • 2019 ACR/ARP Annual Meeting

    Characterizing the Epigenomic Landscape of Psoriasis Patients Destined to Develop Psoriatic Arthritis

    Remy Pollock1, Rohan Machhar 1, Vinod Chandran 2 and Dafna Gladman 3, 1Krembil Research Institute, University Health Network, Toronto, Canada, 2University Health Network, University of Toronto, Toronto, Canada, 3Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada

    Background/Purpose: Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA), an inflammatory musculoskeletal disease, usually after psoriasis onset. A large proportion of individuals with PsA…
  • Abstract Number: 816 • 2019 ACR/ARP Annual Meeting

    The Long Non-coding RNA HOTAIR Regulates BMP2 and Wnt Pathways in Synovial Fibroblasts

    Muriel Elhai1, Raphael Micheroli 1, Mojca Frank-Bertoncelj 2, Kerstin Klein 1, Oliver Distler 3 and Caroline Ospelt 2, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland., Zürich, Switzerland, 2University Hospital Zürich, Zürich, Switzerland, 3Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Mechanisms involved in joint patterning of rheumatic diseases remain unknown. The long non-coding RNA HOTAIR is exclusively expressed in synovial fibroblasts (SF) from lower…
  • Abstract Number: 1013 • 2019 ACR/ARP Annual Meeting

    Effects of Anti-TNF on MiR Expression in Monocytes and CD4+ T-Lymphocytes in Spondyloarthritis

    Olivier Fogel1, Maud Fagny 2, Elodie Roche 3, Nelly Sigrist 3, Jean-François Deleuze 4, Maxime Dougados 5, Corinne Miceli-Richard 1 and Jorg Tost 3, 1Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, 2CEA-CNRGH-Institut François Jacob- Laboratoire Epigenetique et Envrironnement, Evry, Ile-de-France, France, 3CEA-CNRGH-Institut François Jacob- Laboratoire Epigenetique et Envrironnement, Evry, France, 4CEA-CNRGH-Institut François Jacob, Evry, France, 5Cochin Hospital, Paris, France

    Background/Purpose: TNFα inhibitors are an effective treatment for many inflammatory diseases. However, their mechanism of action is more complicated than just blocking the targeted cytokine.…
  • Abstract Number: 1058 • 2019 ACR/ARP Annual Meeting

    Inhibition of Histone Readers Bromodomain and Extraterminal Domain Proteins Alleviates Scleroderma Fibrosis

    Sirapa Vichaikul 1, Phillip Campbell 2, M. Asif Amin 3, Jeffrey H. Ruth 3, Dallas Rohraff 1, David Fox 4, Dinesh Khanna 5, Amr Sawalha 6 and Pei-Suen Tsou3, 1University of Michigan, Ann Arbor, 2Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 3University of Michigan, Ann Arbor, MI, 4Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI, 5Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, 6University of Pittsburgh & University of Michigan, Pittsburgh, PA

    Background/Purpose: Epigenetic regulation, including histone acetylation, plays an important role in scleroderma (SSc) fibrosis. The binding of the bromodomain and extra-terminal domain proteins (BRDs) to…
  • Abstract Number: 1937 • 2019 ACR/ARP Annual Meeting

    Mononuclear Leukocyte DNA Methylome Imprinting of Networked Signaling and Immunity Regulatory Pathways in Gout

    Zengmiao Wang 1, Ying Zhao 1, Amanda Phipps-Green 2, Ru Liu-Bryan 3, Arnold Ceponis 1, David Boyle 4, Jun Wang 1, Tony Merriman 5, Wei Wang 4 and Robert Terkeltaub6, 1UCSD, La Jolla, CA, 2University of Otago, Otago, Otago, New Zealand, 3San Diego VA/UCSD, La Jolla, CA, 4University of California, San Diego, San Diego, CA, 5University of Otago, Birmingham, AL, 6San Diego VA/UCSD, San Diego, CA

    Background/Purpose: Gout encompasses acute arthritis flares mediated by innate autoinflammatory responses to urate crystals, chronic granulomatous tophi, and synovitis promoting bone erosion and soft tissue…
  • Abstract Number: 1996 • 2019 ACR/ARP Annual Meeting

    Bromodomain Inhibitor, I-BET762 Inhibits Production of Pro-inflammatory in Rheumatoid Arthritis Fibroblast-like Synoviocytes and Differentiation of Osteoclast

    Ra Ham Kim1, Hyun Jung Yoo 2, Shin Eui Kang 3, Ji soo Park 4, Seon Uk Kim 5, Eun Young Lee 6, Jin Kyun Park 6 and Yeong-Wook Song 7, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Repulbic of Korea, Seoul, Republic of Korea, 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Seoul, Republic of Korea, 5Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea, 6Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea, 7Seoul National University Hospital, Seoul, Republic of Korea

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by joint inflammation and bone destruction. The fibroblast-like synoviocyte(FLS) contributes to the pathogenesis of RA…
  • Abstract Number: 2001 • 2019 ACR/ARP Annual Meeting

    Survivin Controls the Transcriptional Activity by Changing the Pattern of Histone H3 Marks on Chromatin

    Karin Andersson 1, Malin Erlandsson 1, Anastasius Damdimopoulos 2, Robin Bremer 1, Maja Jensen 3, Maria-José Garcia-Bonete 3, Gergely Katona 3 and Maria Bokarewa1, 1Department of Rheumatology and Inflammation Research, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden, 2Department of Biosciences and Nutrition, Karolinska Institute, Solna, Sweden, Stockholm, Sweden, 3Department of Chemistry and Molecular Biology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden

    Background/Purpose: The oncoprotein survivin coded by the BIRC5 gene was described as an important marker in rheumatoid arthritis (RA). Survivin participates in cell division being…
  • Abstract Number: 2008 • 2019 ACR/ARP Annual Meeting

    Histone Lysine Methyltransferase MLL1 Regulates the Expression of Cytokines and Chemokines in Rheumatoid Arthritis Synovial Fibroblasts

    Yasuto Araki1, Keita Okamoto 1, Yoshimi Aizaki 1, Hiromi Oda 2 and Toshihide Mimura 1, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Department of Orthopedic Surgery, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily affects the joints. The inflammatory process causes the activation of synovial fibroblasts (SFs) and…
  • Abstract Number: 921 • 2018 ACR/ARHP Annual Meeting

    Multi-Omics Analysis Identifies a Gene Signature Associated with the Clinical Response to Anti-TNF Therapy in Rheumatoid Arthritis

    Adrià Aterido1, Jesús Tornero2, Francisco J Blanco3, Benjamin Fernandez Gutierrez4, Antonio Gonzalez5, Juan D. Cañete6, Joan Maymó7, Mercedes Alperi-López8, Alejandro Olivé-Marqués9, Hector Corominas10, Víctor Martínez-Taboada11, Isidoro Gonzalez-Alvaro12, Antonio Fernandez-Nebro13, Alba Erra14, Simón Sánchez-Fernández15, María López-Lasanta1, Mireia López-Corbeto1, Raül Tortosa1, Laia Codó16, Sara Marsal1 and Antonio Julià1, 1Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 2Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, 3Rheumatology Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 4Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain, 5Laboratorio Investigación 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 6Rheumatology Service, Hospital Clínic of Barcelona, Barcelona, Spain, 7Rheumatology Department, Hospital del Mar, Barcelona, Spain, 8Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, 9Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 10Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, 11Rheumatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 12Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 13UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain, 14Rheumatology Service, Hospital San Rafael, Barcelona, Spain, 15Rheumatology Department, Hospital General La Mancha Centro, Ciudad Real, Spain, 16Life Sciences Department, Barcelona Supercomputing Centre, Barcelona, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is the most common inflammatory arthritis affecting up to 1% of the population. Tumor Necrosis Factor (TNF) inhibitors have significantly improved…
  • Abstract Number: 1902 • 2018 ACR/ARHP Annual Meeting

    Pathogenic and Therapeutic Modulation of Activating Epigenetic Memory at a Novel Enhancer for TGFβ2 in Systemic Sclerosis

    Joseph Shin1, Zsuzsanna McMahan2, Julie J. Paik2, Ami A. Shah3, Fredrick M. Wigley3 and Harry C. Dietz1,4, 1Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 2Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 4Howard Hughes Medical Institue, Bethesda, MD

    Background/Purpose: Systemic Sclerosis (SSc) is an etiologically mysterious disease, in which adults acquire an inflammatory prodrome with progressive fibrosis of the skin and viscera. In…
  • Abstract Number: 1959 • 2018 ACR/ARHP Annual Meeting

    Stability of DNA Methylation Signature in Primary RA Synovial Fibroblasts Compared with Cultured Fibroblast-like Synoviocytes

    Rizi Ai1, Deepa Hammaker2, Wei Wang3 and Gary S. Firestein4, 1University of California San Diego, La Jolla, CA, 2Medicine, UC San Diego, La Jolla, CA, 3Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 4Medicine, University of California San Diego, La Jolla, CA

    Background/Purpose: Rheumatoid arthritis (RA) is an aggressive immune-mediated joint disease with synovial inflammation and joint destruction. Fibroblast-like synoviocytes (FLS) play a key role in mediating…
  • Abstract Number: 1964 • 2018 ACR/ARHP Annual Meeting

    Epigenetic Changes of Energy Metabolism-Related Genes in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Brian Pedersen1, Roxana Coras1,2, Wei Wang3, Gary S. Firestein1 and Monica Guma1,2, 1Medicine, University of California San Diego, La Jolla, CA, 2Medicine, Autonomous University of Barcelona, Bellatera, Spain, 3Chemistry and Biochemistry, University of California San Diego, La Jolla, CA

    Background/Purpose: Epigenetic changes contribute to the pathogenesis of rheumatoid arthritis (RA) and a comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS) has recently been described.…
  • Abstract Number: 2011 • 2018 ACR/ARHP Annual Meeting

    Juvenile Arthritis-Associated Single Nucleotide Polymorphisms Identified on Whole Genome Sequencing Show Enrichment within H3K9me3-Marked Regions

    Shannon O'Leary1, Evan Tarbell2, Kaiyu Jiang3, Tao Liu1,4 and James Jarvis5,6, 1Genetics, Genomics, & Bioinformatics Program, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY, 2Biochemistry, University at Buffalo, Buffalo, NY, 3Pediatrics, University at Buffalo, Buffalo, NY, 4Biochemistry, University at Buffalo Jacobs School of Medicine, Buffalo, NY, 5University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Genetics, Genomics, & Bioinformatics Program, Buffalo, NY, 6Pediatrics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY

    Background/Purpose: We have found extensive alterations in chromatin accessibility when the CD4+ T cells of children with active polyarticular juvenile idiopathic arthritis (JIA) are compared…
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