Abstracts tagged "Epigenetics"

Abstract Number: 2297 • 2012 ACR/ARHP Annual Meeting
Decrease Activity of DNA Demethylase in SSc Fibroblast and Microvascular Endothelial Cells: A Possible Mechanism for Persistence of SSc Phenotype
Bashar Kahaleh¹ and Yongqing Wang², ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: DNA methylation is one of the best-characterized epigenetic modifications that have been implicated in numerous biologic and pathologic processes. It is initiated by DNA…
Abstract Number: 2270 • 2012 ACR/ARHP Annual Meeting
The DNA Methylome of Systemic Lupus Erythematosus (SLE) From Whole Peripheral Blood Mononuclear Cells (PBMCs)
Robert Shoemaker¹, Lou H. Bookbinder², David L. Boyle³, Gary S. Firestein⁴, Jonathan E. Lim⁵ and David W. Anderson⁶, ¹Bioinformatics, NexDx, Inc., San Diego, CA, ²Molecular Biology, NexDx, Inc., San Diego, ³Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁴Div of Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁵Research and Development, NexDx, Inc., San Diego, ⁶Research and Development, NexDx, Inc., San Diego, CA
Background/Purpose: SLE is a disease where epigenetic mechanisms play a role. Methylation of DNA at CpG loci is known to influence the suppression or activation…
Abstract Number: 1610 • 2012 ACR/ARHP Annual Meeting
The DNA Methylation Signature in Fibroblast-Like Synoviocytes (FLS) Defines Critical Pathogenic Pathways in Rheumatoid Arthritis (RA)
David L. Boyle¹, Robert Shoemaker², David W. Anderson³, Wei Wang⁴ and Gary S. Firestein⁵, ¹Div of Rheum, UCSD School of Medicine, La Jolla, CA, ²NexDx, Inc., San Diego, CA, ³Research and Development, NexDx, Inc., San Diego, CA, ⁴Chemistry, UCSD, La Jolla, CA, ⁵Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: A DNA methylation signature has been characterized that distinguishes RA FLS from osteoarthritis (OA) and normal (NL) FLS. The presence of epigenetic changes in…
Abstract Number: 985 • 2012 ACR/ARHP Annual Meeting
Inverse Relation Between the tumor Necrosis Factor Promoter Methylation and Trascript Leveles in Leukocytes From Patients with Rheumatoid Arthritis
James R. Maxwell¹, Lyndsey H. Taylor², Richardo A. Pachecho², Neil Lawrence², Gordon W. Duff³, M. Dawn. Teare² and Anthony G. Wilson⁴, ¹University of Sheffield, Sheffield, United Kingdom, ²University of Sheffield, United Kingdom, ³Royal Hallamshire Hospital, Sheffield, United Kingdom, ⁴Infection and Immunity, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: The importance of the epigenetic signature in RA is unclear but levels of methylation of CpG motifs in the TNF promoter are known to…

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