Abstracts tagged "Environmental factors"

Abstract Number: 0024 • ACR Convergence 2022
Exposure to Pollutants with Endocrine Disrupting Properties Is Associated with Early Cartilage Defects and Chondrocyte Inflammatory and Oxidative Activation
Sabryne Berkani¹, Inés Kouki², Sylvie Babajko³, Audrey Pigenet⁴, padmaja Natarajan⁵, Philip Ordoukhanian⁶, Xavier Houard⁴, Martin Lotz⁷, Barbara Demeneix⁸, Jean-Baptiste Fini⁸, Francis Berenbaum⁹, Jérémie SELLAM¹⁰ and Alice Courties¹¹, ¹Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Department of Rheumatology, Assistance Publique , Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France, Paris, ²Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Department of Rheumatology, Assistance Publique , Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ³Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France, Paris, ⁴Sorbonne Université, INSERM UMR 938, Centre de Recherche Saint-Antoine, Hôpital Saint-Antoine, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France, Paris, ⁵Center for Computational Biology & Bioinformatics and Genomics Core, Scripps Research, La Jolla, California, USA, La Jolla, ⁶Center for Computational Biology & Bioinformatics and Genomics Core, Scripps Research, La Jolla, CA, ⁷Scripps Research, La Jolla, ⁸UMR 7221, Phyma, CNRS-Muséum National d'Histoire Naturelle, Sorbonne Université, 75005 Paris, France., Paris, ⁹Sorbonne University - Saint-Antoine hospital, Paris, France, ¹⁰Sorbonne Universite, AP-HP, Saint-Antoine hospital, Paris, France, ¹¹Service de Rhumatologie, AP-HP Hopital Saint-Antoine, Sorbonne Universite, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France
Background/Purpose: Humans are exposed to pollutants with endocrine disruptors (ED) properties from their in utero life. Among them, a mix of 15 pollutants (perfluorinated compounds,…
Abstract Number: 0091 • ACR Convergence 2022
Association of Area-Level Heat and Social Vulnerability with Recurrent Hospitalizations Among Individuals with Rheumatic Conditions
Leah Santacroce, Paul Dellaripa, Karen Costenbader, Jamie collins and Candace Feldman, Brigham and Women's Hospital, Boston, MA
Background/Purpose: The neighborhood where a person lives influences health behaviors, access, and outcomes, and contributes to disparities. The relationship between susceptibility to the effects of…
Abstract Number: 0196 • ACR Convergence 2022
The Impact of Barometric Pressure Waves on Connective Tissue Disorders
Fehmida Zahabi¹ and Kevin Kerr², ¹Texas Rheumatology Care, Plano, TX, ²Chimera Innovations LLC, Allen, TX
Background/Purpose: Pain is a disabling, depressing state which reduces an individual's productivity. Weather changes have been vaguely attributed to cause pain. Previous studies have had…
Abstract Number: 0739 • ACR Convergence 2021
Contextual Factors Should Complete the Assessment of Functioning in Patients with Axial Spondyloarthritis (axSpA)
Uta Kiltz¹, Eerik Ahomaa², Björn Buehring¹, Xenofon Baraliakos¹, David Kiefer¹, Jaclyn-Dalisay Leicht¹ and Jürgen Braun¹, ¹Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, ²St. Franziskus-Hospital, Department of Orthopedic Surgery, Cologne, Germany
Background/Purpose: Functioning of axSpA patients (pat.) is influenced by many factors, but how contextual factors influence functioning isn’t well studied. According to the International Classification…
Abstract Number: 0988 • ACR Convergence 2021
Risk Prediction Models for Incident Systemic Lupus Erythematosus Using Lifestyle/Environmental Risk Factors and a Genetic Risk Score
Jing Cui¹, Susan Malspeis¹, May Choi², Bing Lu³, Jeffrey Sparks⁴, Kazuki Yoshida⁴ and Karen Costenbader⁵, ¹Brigham Women's Hospital, Boston, MA, ²Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, ³Brigham and Women's Hospital and Harvard Medical School, Newton, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Brigham and Women's Hospital, Belmont, MA
Background/Purpose: The identification of lifestyle/environmental and genetic factors, influencing SLE risk introduces the potential to develop risk prediction models. We examined SLE risk prediction incorporating…
Abstract Number: 1021 • ACR Convergence 2021
Organic Dust Exposure Induces Post-translational Protein Modifications and a HLA-DR4-dependent Pro-inflammatory Lung Phenotype in a Murine Model of Interstitial Lung Disease
Jill Poole¹, Ted Mikuls¹, Amy Nelson¹, Rohit Gaurav¹, Michael Duryee¹, Geoffrey Thiele¹, Bryant England¹ and Dana Ascherman², ¹University of Nebraska Medical Center, Omaha, NE, ²University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Environmental and occupational exposures have been epidemiologically linked to the development of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Previous investigation and modeling have also…
Abstract Number: 1023 • ACR Convergence 2021
Racial and Ethnic Distribution of Rheumatic Diseases in Health Systems of the National Patient-Centered Clinical Research Network
William Nowell¹, Edward L. Barnes², Nupur Parikh¹, Shilpa Venkatachalam¹, Michael Kappelman², Jeffrey Curtis³, Peter Merkel⁴, Dianne Shaw⁵, Kalen Young⁵ and Michael George⁴, ¹Global Healthy Living Foundation, Upper Nyack, NY, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Vasculitis Foundation, Kansas City, MO
Background/Purpose: Ensuring adequate representation of racial/ethnic minorities in research necessitates understanding the prevalence of rheumatic and musculoskeletal diseases in these populations. We sought to evaluate…
Abstract Number: 1047 • ACR Convergence 2021
Exposure to Industrial Pollutants and Mortality Due to Inmune-mediated Inflammatory Systemic Diseases (IMD) in Spain
ana Perez¹, Arturo Rodriguez Pérez², Pablo Fernandez-Navarro³, Fernando Albarran⁴, Cristina Bohorquez⁴, Atusa Movasat⁴, Lucia Ruiz⁴, Paula Pretel⁴, elena Rabadan⁴, Valentina Emperiale⁴, Adrian abbasi⁵, julio suarez⁵, Lorena Montano⁴, emilio rico⁵, alfredo prieto², melchor Alvarez de Mon⁵ and beatriz perez³, ¹Hospital Universitario Príncipe de Asturias. Rheumatology. Medicine Faculty. Alcala University Department., Madrid, Spain, ²Faculty of Medicine. Alcala University, Alcala de Henares, Spain, ³Department of Epidemiology of Chronic Diseases.National Center of Epidemiology/CIBERESP. Instituto de Salud Carlos III, Madrid, Spain, ⁴Hospital Universitario Príncipe de Asturias, Rheumatology Department, Alcala de Henares, ⁵Hospital Universitario Príncipe de Asturias, Madrid, Spain
Background/Purpose: The etiology of many IMD is largely unknown; however, available data suggest that environmental contaminants could play a role in their origin. Industrial facilities…
Abstract Number: 1772 • ACR Convergence 2021
Autologous EBV-specific Cytotoxic T Cells in Systemic Lupus Erythematosus: An Innovative Phase I/IIa Clinical Trial
Antoine Enfrein¹, Beatrice Clemenceau², Soraya Saiagh³, Céline Bressollette⁴, Zahir Amoura⁵, Henri Vie² and Mohamed Hamidou¹, ¹Médecine interne, CHU de Nantes, Nantes, France, ²Inserm U1232, Université de Nantes, Nantes, France, ³Unité de Thérapie Cellulaire et Génique, CHU de Nantes, Nantes, France, ⁴Laboratoire de Virologie, CHU de Nantes, Nantes, France, ⁵Médecine interne, Hôpital Pitié Salpêtrière, AP-HP, Paris, France
Background/Purpose: Epstein-Barr Virus (EBV) has been suggested as a potential environmental factor in systemic lupus erythematosus (SLE) onset and disease activity. Here, we report the…
Abstract Number: 1377 • ACR Convergence 2020
Raynaud’s Phenomenon and Systemic Sclerosis in Post-9/11 Deployed Veterans Receiving Care Veterans Health Administration Care
Tracy Frech¹, Maureen Murtaugh¹, Megan Amuan² and Mary Jo Pugh¹, ¹University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, ²Veterans Affair Medical Center, Salt Lake City, UT
Background/Purpose: The purpose of this project was to describe Raynaud's phenomenon (RP), very early diagnosis of systemic sclerosis (VEDOSS), and systemic sclerosis (SSc) in Veterans…
Abstract Number: 1426 • ACR Convergence 2020
Prevalence of ANCA-associated Vasculitis and Spatial Association with Quarries in a French Northeast Region: A Capture-recapture and Geospatial Analysis
Stéphane Giorgiutti¹, Yannick Dieudonné¹, Olivier Hinschberger², Benoit Nespola³, Julien Campagne⁴, Hanta Nirina Rakotoarivelo⁵, Thierry Hannedouche⁶, Bruno Moulin⁶, Gilles Blaison⁵, Jean-Christophe Weber⁷, Marie-Caroline Dalmas⁸, Frederic De Blay⁹, Dan Lipsker¹⁰, Francois Chantrel¹¹, Jacques-Eric Gottenberg¹², Yves Dimitrov¹³, Olivier Imhoff¹⁴, Pierre-Edouard Gavand¹⁵, Emmanuel Andres¹⁶, Christian Debry¹⁷, Yves Hansmann¹⁸, Alexandre Klein¹⁹, Caroline Lohmann²⁰, François Mathiaux²¹, Aurélien Guffroy¹, Vincent Poindron¹, Thierry Martin¹, Anne-Sophie Korganow¹ and Laurent Arnaud²², ¹Department of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ²Department of Internal Medicine, Hôpital Emile Muller, Mulhouse, Mulhouse, France, ³Department of Immunobiology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ⁴Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, ⁵Department of Internal Medicine, Hôpitaux Civils de Colmar, Colmar, France, ⁶Department of Nephrology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ⁷Department of Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ⁸Department of Internal Medicine Endocrinology and Nutrition, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ⁹Pneumology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ¹⁰Department of Dermatology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ¹¹Department of Nephrology, Hôpital Emile Muller, Mulhouse, Strasbourg, France, ¹²Strasbourg University Hospital, Strasbourg, France, ¹³Department of Nephrology, Centre hospitalier de Haguenau, Haguenau, France, ¹⁴Department of Nephrology, Clinique Saint-Anne, Strasbourg, Strasbourg, France, ¹⁵Department of Internal Medicine, Clinique Rhena, Strasbourg, Strasbourg, France, ¹⁶Department of Internal Medicine, Diabete and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ¹⁷Department of Otorhinolaryngology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ¹⁸Department of Infectious Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ¹⁹Department of Nephrology, Hôpitaux Civils de Colmar, Colmar, France, ²⁰Department of Microbiology, Hôpital Emile Muller, Mulhouse, Mulhouse, France, ²¹Department of Biology, Hôpitaux Civils de Colmar, Strasbourg, France, ²²Department of Rheumatology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Background/Purpose: Studies addressing the epidemiology of ANCA-associated vasculitides (AAV) in different countries reported various prevalence rates and suggested that incidence may have increased over the…
Abstract Number: 1447 • ACR Convergence 2020
Vitamin D Deficiency Enhances Antiphospholipid Antibody-Mediated Thrombosis in a Passive Immunization Mouse Model
Rohan Willis¹, Karen Roye-Green², Zurina Romay-Penabad¹, Elizabeth Papalardo¹, Alvaro Schleh³, Vijaya Murthy⁴, Monica Smikle² and Emilio Gonzalez¹, ¹University of Texas Medical Branch, Galveston, TX, ²University of the West Indies, Kingston, Jamaica, ³Antiphospholipid Standardization Laboratory, GALVESTON, TX, ⁴University of Texas Medical Branch, League City, TX
Background/Purpose: Abnormal vitamin D levels occur frequently in antiphospholipid (APS) patients and are correlated with thrombosis. It remains unclear however if vitamin D deficiency observed…
Abstract Number: 1794 • ACR Convergence 2020
Systemic Lupus Erythematosus and Geomagnetic Disturbances: A Time Series Analysis
George Stojan¹, Flavia Giammarino² and Michelle Petri³, ¹Johns Hopkins University, BALTIMORE, MD, ²Deutsche Bank, London, United Kingdom, ³Johns Hopkins University School of Medicine, Baltimore
Background/Purpose: To examine the influence of solar cycle and geomagnetic effects on SLE disease activity.Methods: The data used for the analysis consisted of 327 observations…
Abstract Number: 1800 • ACR Convergence 2020
Association of Air Pollution with Systemic Lupus Erythematosus Disease Activity in the Central Valley of California
Mosaab Mohameden¹, Ali H.Ali², Zi Ying Li², Yabsira Abejie³, Ratnali Jain² and Candice Reyes Yuvienco⁴, ¹University of Cincinnati College of Medicine, Cincinnati, OH, ²University of California San Francisco Fresno, Fresno, CA, ³Floyd B. Buchanan High School, Fresno, CA, ⁴University of California San Francisco Fresno, Clovis, CA
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disease that affects at least 300,000 people in the United States creating a substantial socioeconomic…
Abstract Number: 1813 • ACR Convergence 2020
A Comprehensive Method to Study Environmental Chemicals in Serum in Patients with SLE
Cristina Lanata¹, Kim Taylor², James Hurst-Hopf¹, Laura Trupin¹, Patricia Katz³, Jinoos Yazdany¹, Maria Dall'Era⁴, Dimitri Abrahamsson¹, Lindsey Criswell⁵ and Roy Gerona¹, ¹UCSF, San Francisco, CA, ²University of California, San Francisco, San Francisco, CA, ³University of California, San Francisco, Novato, CA, ⁴Division of Rheumatology, University of California, San Francisco, CA, ⁵Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA
Background/Purpose: Environmental exposures may play a substantial role in the pathogenesis of Systemic Lupus Erythematosus (SLE), however it has been challenging to measure and capture…

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