Abstracts tagged "endothelial cells"

Abstract Number: 755 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Pattern in Systemic Sclerosis Microvascular Endothelial Cells: Identification of Epigenetically Affected Key Genes and Pathways
Shadia Nada¹, Ibtissam Gad², Ali Alqahtani³, Ahmad Assaly², Sadik Khuder⁴, Yongqing Wang⁵, Bashar Kahaleh¹ and Nezam Altorok¹, ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²University of Toledo, Toledo, OH, ³Internal Medicine, University of Toledo, Toledo, OH, ⁴Department of Medicine, University of Toledo, Toledo, OH, ⁵Medicine, University of Toledo, Toledo, OH
Background/Purpose: The etiology of systemic sclerosis (SSc) is not clear, but there is evidence suggesting a critical role for epigenetic alterations in disease pathogenesis and…
Abstract Number: 939 • 2017 ACR/ARHP Annual Meeting
Stimulator of Interferon Genes (STING)-Induced Endothelial-Mesenchymal Transition (EndMT) Contributes to Interstitial Lung Disease in Sting-Associated Vasculopathy with Onset in Infancy (SAVI) Patients
Louise Malle¹, Dan Yang², Adriana Almeida de Jesus¹, Guibin Chen², Bernadette Marrero¹, Gina A. Montealegre Sanchez¹, Yin Liu³, Gregor Dueckers⁴, Suzanne Ramsey⁵, Joseph Fontana⁶, Rachel VanTries¹, Yan Huang¹, Laisa Santiago⁷, Benito Gonzalez⁸, Paul Brogan⁹, Juergen Brunner¹⁰, Ebun Omoyinmi¹¹, Athimalaipet V. Ramanan¹², Amy Paller¹³, Olcay Y. Jones¹⁴, Seza Ozen¹⁵, Stephen R. Brooks¹⁶, Manfred Boehm¹⁷ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, ²Center for Molecular Medicine, NHLBI/NIH, Bethesda, MD, ³Scientific Review Branch, NIAMS/NIH, Bethesda, MD, ⁴Helios Kliniken - Kinderklinik, HELIOS Klinikum Krefeld, Krefeld, Germany, ⁵Pediatric Rheumatology, IWK Health Centre, Dalhousie University, Halifax, NS, Canada, ⁶Cardiovascular and Pulmonary Branch, NHLBI/NIH, Bethesda, MD, ⁷Johns Hopkins All Children's Hospital Rheumatology, Saint Petersburg, FL, ⁸Luis Calvo Mackenna Hospital, Santiago, Chile, ⁹Infection Inflammation and Rheumatology, UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, ¹⁰Division of Pediatric Rheumatology, Medical University Innsbruck, Innsbruck, Austria, ¹¹University College London Institute of Child Health, London, United Kingdom, ¹²Bristol Royal Hospital for Children, Bristol, United Kingdom, ¹³Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IN, ¹⁴Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, ¹⁵Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ¹⁶Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, ¹⁷Center for Molecular Medicine, NHLBI/ NIH, Bethesda, MD
Background/Purpose: Pulmonary fibrosis, is a life-threatening complication of the monogenic autoinflammatory interferonopathy, STING-Associated Vasculopathy with onset in Infancy (SAVI) that is caused by gain-of-function mutations…
Abstract Number: 967 • 2017 ACR/ARHP Annual Meeting
NF-κb-Inducing Kinase Regulates LTβR-Driven NF-κb Signaling and Inflammatory Activation of Endothelium
Paulina Kucharzewska¹, Chrissta Maracle², Jan Piet van Hamburg², Kim Jeucken², Henric Olsson¹ and Sander W. Tas³, ¹Bioscience, AstraZeneca, Göteborg, Sweden, ²2Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Sites of chronic inflammation, such as rheumatoid arthritis synovial tissue, are characterized by neovascularization and often contain tertiary lymphoid structures with characteristic features of…
Abstract Number: 1061 • 2017 ACR/ARHP Annual Meeting
Cardiac Endothelial Cell Transcriptome Analyses Support a Pathological Role of Metabolic and Inflammasome Genes in Anti-SSA/Ro-Associated Congenital Heart Block
Sara Rasmussen¹, Robert M. Clancy² and Jill P. Buyon², ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²NYU School of Medicine, New York, NY
Background/Purpose: The role of Type I IFN in anti-SSA/Ro-associated Congenital Heart Block (CHB) may include an adverse consequence to the cardiac vasculature. One scenario consistent…
Abstract Number: 1923 • 2017 ACR/ARHP Annual Meeting
Single Cell RNA Sequencing Reveals a Signature of Endothelial Injury in Scleroderma Skin
Sokratis Apostolidis¹, Giuseppina Stifano², Tracy Tabib³, Lisa Rice², Christina Morse³, Bashar Kahaleh⁴ and Robert A. Lafyatis³, ¹Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Boston University School of Medicine, Boston, MA, ³Medicine, Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Medicine/Rheumatology, University of Toledo, Toledo, OH
Background/Purpose: Vascular injury is a hallmark event in the pathogenesis of Systemic Sclerosis (SSc). Endothelial dysfunction happens early in the course of the disease and…
Abstract Number: 2143 • 2017 ACR/ARHP Annual Meeting
Circulating Endothelial Cells and Endothelial Activation Markers As Disease Activity Measures in Idiopathic Inflammatory Myopathies
Takayuki Kishi¹, Jonathan Chipman¹, Maryalice Stetler-Stevenson², Khanh Nghiem³, Melvina Evereklian¹, Margaret E. Rick³, Frederick W Miller¹ and Lisa G Rider¹, ¹Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ²Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, ³Coagulation Laboratory, Clinical Center, National Institutes of Health, Bethesda, MD
Background/Purpose: The idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases with chronic muscle inflammation and microvasculopathy of muscle and skin capillaries. Circulating endothelial cells (CECs),…
Abstract Number: 2338 • 2017 ACR/ARHP Annual Meeting
Plasma Exosomes from Children with Juvenile Dermatomyositis Are Taken up By Human Aortic Endothelial Cells and Are Associated with Altered Gene Expression in Those Cells
Kaiyu Jiang¹, Zihua Hu², Rie Karasawa³, Yanmin Chen¹ and James Jarvis⁴, ¹Pediatrics, University at Buffalo, Buffalo, NY, ²Center for Computational Research, University at Buffalo, Buffalo, NY, ³Institute of Medical Science, St. Marianna University School of Medicine, Japan, Kawasaki, Japan, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and…
Abstract Number: 2813 • 2017 ACR/ARHP Annual Meeting
Interferon-Induced APOL1 over-Expression Causes Autophagic Dysfunction and Mitochondrial Stress in Risk Variant-Carrying Endothelial Cells
Ashira Blazer¹, Sara Rasmussen², Androo Markham³, Shilpi Mehta-Lee⁴, Jill P. Buyon⁴ and Robert M. Clancy², ¹Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ³Medicine, NYU School of Medicine, New York, NY, ⁴NYU School of Medicine, New York, NY
Background/Purpose: In SLE Apolipoprotein L1 (APOL1) risk variants (RV) associate with cardiovascular and end stage renal disease. APOL1 induction initially promotes cellular maintenance through autophagy;…
Abstract Number: 2700 • 2016 ACR/ARHP Annual Meeting
The Lymphatic System: A Gatekeeper for Migration of Pathogenic T-Cells Towards Synovial Joints and Entheses in Psoriasis
Radjesh Bisoendial^1,2, Errol Prens³, Annemarie Mus², Patrick Asmawidjaja², Nadine Davelaar², Arien Hofman⁴, Jean-Bart Jaquet⁴, Mieke Hazes², Marc Kok¹, Wolfgang Weninger⁵ and Erik Lubberts², ¹Clinical Immunology and Rheumatology, Maasstad hospital, Rotterdam, Netherlands, ²Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ³Dermatology, Erasmus University medical Center, Rotterdam, Netherlands, ⁴Plastic surgery, Maasstad hospital, Rotterdam, Netherlands, ⁵Immune imaging, The Centenary Institute, Sydney, Australia
Background/Purpose: Psoriasis (PsO) is a common inflammatory skin disease that is characterized by acanthosis, impaired immune cell migration, and remodeling of the vascular and lymphatic…
Abstract Number: 2836 • 2016 ACR/ARHP Annual Meeting
Microparticles of Endothelial Origin in Women with Systemic LUPUS Erythematosus UNDER Treatment
WALTER CICARINI¹, KARINE SILVESTRE FERREIRA¹, Renato Vargas Consoli², Claudia Lopes Santoro Neiva³, PAULO MADUREIRA PADUA⁴, ANA FLAVIA PADUA DIAS⁵, fernanda freire Campos Sr.⁶, LUAN CARLOS ALVES¹, Cristina Mello Gomide Loures Sr.⁶, Marcos Ferreira Silva Sr.⁶, TANIA MARA PINTO DABES GUIMARAES¹, Vicente Peixoto Toledo Sr.⁶ and MARIA DAS GRAÇAS CARVALHO¹, ¹Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Belo Horizonte/MG, Brazil, ²Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil, Belo Horizonte, Brazil, ³Rheumatology Unit, Santa Casa Hospital-Belo Horizonte- Bras, Belo Horizonte, Brazil, ⁴Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil., Belo Horizonte/MG, Brazil, ⁵Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil, Belo Horizonte/MG, Brazil, ⁶Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Belo Horizonte, Brazil
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an inflammatory and multisystem disease. Microparticles (MPs) are cell membrane-shedded fragments released during apoptosis and cell activation. Several diseases are…
Abstract Number: 2876 • 2016 ACR/ARHP Annual Meeting
SLE Serum Impairs NO Production in Huvecs through Induction of eNOS Uncoupling
Jim Oates^1,2, Diane L. Kamen³ and Joy N Jones Buie⁴, ¹Medical Service, Ralph H. Johnson VAMC, Charleston, SC, ²Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ⁴Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) induces endothelial cell dysfunction (ECD) that can manifest as glomerulonephritis or atherosclerosis. Lupus-prone mice lacking endothelial nitric oxide synthase (eNOS,…
Abstract Number: 477 • 2016 ACR/ARHP Annual Meeting
Conventional Non-Steroidal Anti-Inflammatory Drugs, but Not COX2 Selective Inhibitors, Are Beneficial on Vascular Function in Arthritis: A Study in Adjuvant Induced Arthritis
Frank Verhoeven¹, Clément Prati², Katy Maguin-Gaté¹, Perle Totoson¹, Daniel Wendling³ and Céline Demougeot¹, ¹EA 4267 FDE, FHU INCREASE, Université de Bourgogne Franche-Comté, Besançon, France, ²FDE EA4267, FHU INCREASE, Bourgogne Franche-Comté University, Besançon, France, ³Service de Rhumatologie, CHU Jean Minjoz, Besancon, France
Background/Purpose: (RA) is associated with an increase in cardiovascular (CV) risk explained in part by an accelerated atherosclerosis as a consequence of endothelial dysfunction. Non-steroidal…
Abstract Number: 1127 • 2016 ACR/ARHP Annual Meeting
Extracellular Macrophage Migration Inhibitory Factor Is Essential for Hypoxia-Induced Angiogenesis in a Hypoxia Inducible Factor Independent Manner
Mathias Mursell^1,2, Martin Hahne^1,2,3, Peggy Kunath^1,2, Cindy Strehl^1,2, Paula Hoff^1,2, Frank Buttgereit² and Timo Gaber^1,2, ¹German Rheumatism Research Center (DRFZ), Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ³Miltenyi Biotec GmbH, Bergisch Gladbach, Germany
Background/Purpose: Angiogenesis is a hallmark of the pathogenesis of rheumatoid arthritis (RA) but also of other inflammatory processes, tissue regeneration and progressing tumors. In RA,…
Abstract Number: 2066 • 2016 ACR/ARHP Annual Meeting
Anti-Ds-DNA Antibodies Regulate Atherothrombosis in Systemic Lupus Erythematosus through the Induction of Netosis, the Prothrombotic and Proinflammatory Activities of Monocytes and the Endothelial Activation
Carlos Perez-Sanchez¹, Maria Ángeles Aguirre Zamorano¹, María Galindo², Patricia Ruiz-Limon³, Ivan Arias de la Rosa³, Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Pedro Segui¹, Eduardo Collantes-Estévez¹, Maria Jose Cuadrado⁴ and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: The role of anti-dsDNA in the pathogenesis of the systemic lupus erythematosus (SLE) has been clearly established. However, the influence of these autoantibodies in…
Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting
Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells
Rebecca Hasseli¹, Klaus W. Frommer², Markus Prof. Dr. Schönburg³, Stefan Prof. Dr. Rehart⁴, Ulf Müller-Ladner^5,6 and Elena Neumann², ¹Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ³Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, ⁴Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, ⁵Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁶Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…

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