Abstracts tagged "Early Rheumatoid Arthritis"

Abstract Number: 471 • 2019 ACR/ARP Annual Meeting
When Will I Get past This Exhaustion? Predictors of Improved Fatigue in the First Year of RA
Susan J. Bartlett¹, Orit Schieir ², Marie-France Valois ³, Carol Hitchon ⁴, Louis Bessette ⁵, Glen Hazlewood ⁶, Carter Thorne ⁷, Janet Pope ⁸, Gilles Boire ⁹, Diane Tin ¹⁰, Edward Keystone ¹¹, Vivian Bykerk ¹² and Canadian Early Arthritis Cohort (CATCH) Investigators ¹³, ¹McGill University, Montreal, QC, Canada, ²University of Toronto, Montreal, Canada, ³McGill University, Montreal, Canada, ⁴University of Manitoba, Winnipeg, Canada, ⁵Laval University, Quebec City, QC, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Southlake Regional Health Centre, Newmarket, ON, Canada, ⁸Western University, London, ON, Canada, ⁹Sherbrooke University, Sherbrooke, QC, Canada, ¹⁰Southlake Regional Health Centre, Newmarket, Canada, ¹¹Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ¹²Hospital for Special Surgery, New York City, NY, ¹³Canadian Early Arthritis Cohort (CATCH) Study, Toronto, Canada
Background/Purpose: Although overwhelming fatigue is common at the onset of RA, some patients continue to experience debilitating high levels of fatigue that impact mood, interfere with work…
Abstract Number: 1885 • 2019 ACR/ARP Annual Meeting
A Search to the Target Tissue in Which RA-specific Inflammation Starts: A Detailed MRI Study to Improve Identification of RA-specific Features in the Phase of Clinically Suspect Arthralgia
Xanthe ME Matthijssen¹, Fenne Wouters ², Debbie Boeters ², Aleid Boer ², Yousra Dakkak ², Ellis Niemantsverdriet ² and Annette van der Helm-van Mil ³, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³LUMC, Leiden, Zuid-Holland, Netherlands
Background/Purpose: Based on a unique cohort of clinically suspect arthralgia (CSA) patients, we analysed which combinations of MRI-features at onset were predictive for Rheumatoid Arthritis…
Abstract Number: 2871 • 2019 ACR/ARP Annual Meeting
Advances in Treatment of Rheumatoid Arthritis: ACPA-positive Patients Benefited More Than ACPA-negative Patients; 25 Year Results of a Longitudinal Cohort Study
Xanthe ME Matthijssen¹, Ellis Niemantsverdriet ², Thomas Huizinga ² and Annette van der Helm-van Mil ³, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³LUMC, Leiden, Zuid-Holland, Netherlands
Background/Purpose: The last 25 years, treatment of rheumatoid arthritis (RA) has changed considerably. Although clinically relevant joint damage has become infrequent, it is less established…
Abstract Number: 479 • 2019 ACR/ARP Annual Meeting
Impact of Achieving Early-sustained Remission on Preventing Long-term Functional Loss in Patients with Early Rheumatoid Arthritis
Evelyn Chow¹, Isaac T. Cheng ¹, Lai-Shan Tam ¹ and CRYSTAL Study Team Hong Kong ², ¹The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²The Chinese University of Hong Kong, Hong Kong
Background/Purpose: Preventing functional loss is crucial to early RA (ERA) patients in order to maintain usual activities of daily living. However, whether achieving early and…
Abstract Number: 1997 • 2019 ACR/ARP Annual Meeting
Histologic and Clinical Correlates of Ultrasound Measures of Joint Inflammation: Analysis of RA Tissue Obtained by Ultrasound Guided Biopsy in Phase 2 of the Accelerating Medicines Partnership RA Network
Diane Horowitz¹, Andrew Filer ², Jennifer Albrecht ³, Arthur Mandelin ⁴, Darren Tabechian ⁵, Edward DiCarlo ⁶, Brendan Boyce ³, Ellen Gravallese ⁷, Peter Gregersen ⁸, Dagmar Scheel-Toellner ⁹, Kevin Wei ¹⁰, Katherine Liao ¹¹, Larry Moreland ¹², V. Michael Holers ¹³, Michael Brenner ¹⁴, Jennifer Anolik ³ and Vivian Bykerk ¹⁵, ¹Northwell Health, Great Neck, NY, ²Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom, ³University of Rochester Medical Center, Rochester, NY, ⁴Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL, ⁵University of Rochester, Rochester, NY, ⁶Hospital for Special Surgery, New York, ⁷University of Massachusetts Medical School, Worcester, MA, ⁸Feinstein Institutes for Medical Research, Manhasset, NY, ⁹University of Birmingham, Birmingham, United Kingdom, ¹⁰Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Brigham and Women's Hospital, Boston, ¹²University of Pittsburgh, PITTSBURGH, PA, ¹³University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, ¹⁴Brigham and Women’s Hospital:, Boston, ¹⁵Hospital for Special Surgery, New York City, NY
Background/Purpose: The AMP-RA network applies cutting edge molecular single cell technologies to study synovial tissue obtained from rheumatoid arthritis (RA) patients using US guided synovial…
Abstract Number: 480 • 2019 ACR/ARP Annual Meeting
Not Achieving Clinical Remission Predicts a Poor Health-Related Quality of Life in Rheumatoid Arthritis Patients: Results of a Latin American Real World Database
Rocío-V. Gamboa-Cárdenas¹, Manuel Ugarte-Gil ², Cristina Reátegui-S ³, Victor Pimentel-Quiroz ⁴, Mariela Medina ¹, Zoila Rodríguez-Bellido ¹, Samira Garcia-H ⁵, Paola Zeña-Huancas ¹, Luciana Gil ¹, Erika Noriega ¹, Francisco Zevallos-M ¹, José Alfaro-Lozano ¹, Risto Perich-Campos ¹, César-A Pastor-A ⁶ and Graciela Alarcón ⁷, ¹Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Lima, Peru, ²Universidad Científica del Sur, Lima, Lima, Peru, ³Hospital Nacional Guillermo Almenara Irigoyen, Lima, Lima, Peru, ⁴Hospital Nacional Guillermo Almenara Irigoyen - EsSalud, Lima, Lima, Peru, ⁵Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Lima, Peru, ⁶Universidad Nacional Mayor de San Marcos, Lima, Lima, Peru, ⁷University of Alabama at Birmingham, Birmingham
Background/Purpose: Uncontrolled Rheumatoid Arthritis (RA) leads to disability, damage, and poor health-related quality of life (HRQoL). Current treatment recommendations emphasize the importance of achieving remission…
Abstract Number: 2019 • 2019 ACR/ARP Annual Meeting
Tenosynovitis at the Metatarsophalangeal Joints, a Novel Feature of RA: Results from an Anatomical and Large Magnetic Resonance Imaging Study of Tendon Sheaths of the Forefoot
Yousra Dakkak¹, Friso Jansen ¹, Marco DeRuiter ¹, Monique Reijnierse ¹ and Annette van der Helm-van Mil ², ¹Leiden University Medical Center, Leiden, Netherlands, ²LUMC, Leiden, Zuid-Holland, Netherlands
Background/Purpose: Recent magnetic resonance imaging (MRI)-studies revealed that tenosynovitis in the hands is associated with rheumatoid arthritis (RA). Although the forefoot is a preferential location…
Abstract Number: 481 • 2019 ACR/ARP Annual Meeting
Production of IL17A in Synovial Tissue Correlates with MRI RAMRIS Scores in ACPA Positive Early Rheumatoid Arthritis
Thomas Kirchgesner¹, Christine Galant ², Bernard Lauwerys ³, Bruno Vande Berg ¹, Tatiana Sokolova ⁴, Laurent Meric de Bellefon ⁵, Adrien Nzeusseu ⁵ and Patrick Durez ⁶, ¹Musculoskeletal Imaging Unit, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Bruxelles, Belgium, ²Histopathology, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Bruxelles, Belgium, ³Rheumatology, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Brussels, Belgium, ⁴Rheumatology, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Bruxelles, Belgium, ⁵Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique, Bruxelles, Belgium, ⁶Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, UCL Saint-Luc, Brussels, Belgium
Background/Purpose: We previously studied evolution of MRI RAMRIS scores in a group of 28 early rheumatoid (RA) patients treated with first-line infliximab (IFX) versus placebo.…
Abstract Number: 2208 • 2019 ACR/ARP Annual Meeting
Mediators of Bone Metabolism (DKK1, OPG, Sclerostin and RANKL) in a Cohort of Patients with Elderly-onset Arthritis
Anahy Brandy-Garcia¹, Melania Martínez-Morillo ¹, Roxana Coras ², Lourdes Mateo-Soria ³, Susana Holgado ¹, Maria Aparicio-Espinar ¹, Águeda Prior-Español ¹, Jordi Camins-Fabregas ⁴, Ivette Casafont-Solé ¹, Annika Nack ¹, Alejandro Olivé-Marqués ⁵, Monica Guma ⁶ and Laia Gifre ¹, ¹Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ². Department of Medicine, School of Medicine. University of California, San Diego, ³Rheumatology Service, Germans Trias i Pujol University Hospital, Spain, ⁴Rheumatology Service, Germans Trias i Pujol University Hospital, Badalona, Spain, ⁵Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain, ⁶Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States
Background/Purpose: Patients with elderly-onset arthritis have greater comorbidity than young patients, with a higher incidence of osteoporosis (OP), probably mediated by increased bone resorption. However,…
Abstract Number: 482 • 2019 ACR/ARP Annual Meeting
Antibody Repertoire Sequencing, Antigen Array Analysis, and Cytokine Profiling of Blood from Individuals at High-risk for RA Reveals Candidate Immunoglobulin V Genes, ACPA, and Cytokines That May Promote the Transition to Arthritis
Radhika Iyer¹, Amin Zia ¹, Michelle Bloom ¹, Sunil Nagpal ², Navin Rao ², Frédéric Baribaud ³, George Vratsanos ⁴, Wei Wang ⁵, Gary Firestein ⁶, David Boyle ⁵, Jane Buckner ⁷, V. Michael Holers ⁸, Kevin Deane ⁹ and William Robinson ¹⁰, ¹Stanford University, Stanford, ²Janssen R&D, Spring House, PA, ³Janssen Research & Development, LLC, Spring House, PA, ⁴JNJ, Raritan, NJ, ⁵University of California, San Diego, San Diego, CA, ⁶University of California, San Diego, San Diego, ⁷Benaroya Research Institute, Seattle, WA, ⁸University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, ⁹University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, ¹⁰Stanford University, Stanford, CA
Background/Purpose: The “Targeting Immune Responses for Prevention of RA” (TIP-RA) collaboration studies individuals at high risk for developing rheumatoid arthritis (RA) because of serum anti-citrullinated…
Abstract Number: 2269 • 2019 ACR/ARP Annual Meeting
Major Stressors in the Year Prior to Diagnosis Affects RA Characteristics at Presentation and 1 Year
Nicole Andersen¹, Orit Schieir ², Marie-France Valois ³, Gilles Boire ⁴, Janet Pope ⁵, Glen Hazlewood ⁶, Louis Bessette ⁷, Carol Hitchon ⁸, Diane Tin ⁹, Carter Thorne ¹⁰, Edward Keystone ¹¹, Vivian Bykerk ¹², Susan J. Bartlett ¹ and Canadian Early Arthritis Cohort (CATCH) Investigators ¹³, ¹McGill University, Montreal, QC, Canada, ²University of Toronto, Montreal, Canada, ³McGill University, Montreal, Canada, ⁴Sherbrooke University, Sherbrooke, QC, Canada, ⁵Western University, London, ON, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Laval University, Quebec City, QC, Canada, ⁸University of Manitoba, Winnipeg, Canada, ⁹Southlake Regional Health Centre, Newmarket, Canada, ¹⁰Southlake Regional Health Centre, Newmarket, ON, Canada, ¹¹Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ¹²Hospital for Special Surgery, New York City, NY, ¹³Canadian Early Arthritis Cohort (CATCH) Study, Toronto, Canada
Background/Purpose: Although many RA patients attribute their disease onset to recent life events, results from retrospective studies remain unclear. We compared characteristics of newly diagnosed…
Abstract Number: 563 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety of Abatacept in Combination with MTX in Early, MTX-Naïve, Anti-Citrullinated Protein Antibody–Positive Patients with RA: Primary and 1-Year Results from a Phase IIIb Study
Paul Emery¹, Yoshiya Tanaka², Vivian P. Bykerk³, Tom W.J. Huizinga⁴, Gustavo Citera⁵, Marleen Nys⁶, Sean E. Connolly⁷, Alyssa Johnsen⁷ and Roy Fleischmann⁸, ¹University of Leeds and Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ²University of Occupational and Environmental Health, Kitakyushu, Japan, ³Hospital for Special Surgery, New York, NY, ⁴Leiden University Medical Center, Leiden, Netherlands, ⁵Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁶Bristol-Myers Squibb, Braine L’Alleud, Belgium, ⁷Bristol-Myers Squibb, Princeton, NJ, ⁸Metroplex Clinical Research Center, Dallas, TX
Background/Purpose: In patients (pts) with early (disease duration ≤24 months [mths]), MTX-naïve RA and poor prognostic factors including anti-citrullinated protein antibody (ACPA) positivity (+), abatacept…
Abstract Number: 2845 • 2018 ACR/ARHP Annual Meeting
A Close Relationship between a Novel Visceral Adiposity Index and Bone Microstructure in Female Early Rheumatoid Arthritis Patients: A 1-Year Follow-up Study By HR-pQCT
Jiang Yue^1,2, Priscilla Wong¹, James F Griffith³, Jiankun XU⁴, Fan XIAO⁵, Dongze Wu^1,2, Edmund Li¹, Lydia Ho Pui Tam⁶, Martin Li⁷, Tena K. Li¹, Tracy Y. Zhu⁸, Vivian W. Hung⁸, Ling Qin⁹ and Lai-Shan Tam¹⁰, ¹Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, Hong Kong, China, ²Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ³Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, ⁴Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵Department of Imaging and Interventional Radiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁶Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁷Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁸Bone Quality and Health Centre of the Department of Orthopedics & Traumatology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, ⁹Bone Quality and Health Centre of the Department of Orthopaedics and Traumatology, The Prince of Wales Hospital, The Chinese University of Hong Kong, hongkong, Hong Kong, ¹⁰Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, Hong Kong, Hong Kong
Background/Purpose: Background: Obesity has been traditionally considered to protect the skeleton against osteoporosis and fracture. Recently, body fat, specifically visceral adipose tissue (VAT), has been…
Abstract Number: 576 • 2018 ACR/ARHP Annual Meeting
An Analysis of Early Introduction of Adalimumab and Subsequent Bio-Free Condition in the Patients with Rheumatoid Arthritis
Satoshi Ito¹, Yoichi Kurossawa^1,2, Eriko Hasegawa^1,2, Daisuke Kobayashi^1,2, Shinji Taniguhi¹, Asami Abe¹, Hiroshi Otani¹, Kiyoshi Nakazono¹, Akira Murasawa¹, Ichiei Narita² and Hajime Ishikawa¹, ¹Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan, ²Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Background/Purpose: HOPEFUL-1 trial showed efficacy of combination therapy with adalimumab (ADA) plus methotrexate (MTX) in MTX naïve patients with active early rheumatoid arthritis (eRA). In…
Abstract Number: 2873 • 2018 ACR/ARHP Annual Meeting
Remaining Pain and Widespread, Non-Inflammatory Pain Distribution during the First 12 Months after RA Diagnosis
Yvonne C. Lee¹, Orit Schieir², Marie-France Valois³, Susan J. Bartlett⁴, Gilles Boire⁵, Boulos Haraoui⁶, Carol A Hitchon⁷, Edward C. Keystone⁸, Diane Tin⁹, Carter Thorne¹⁰, Janet E. Pope¹¹ and Vivian P. Bykerk¹², ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²McGill University, Montreal, ON, Canada, ³McGill University, Montreal, QC, Canada, ⁴Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁶Institut de Recherche en Rhumatologie de Montréal (IRRM), Montreal, QC, Canada, ⁷University of Manitoba, Winnipeg, MB, Canada, ⁸Mount Sinai Hospital, Toronto, ON, Canada, ⁹The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹⁰University of Toronto, Newmarket, ON, Canada, ¹¹Department of Medicine, University of Western Ontario, London, ON, Canada, ¹²Hospital for Special Surgery, New York, NY
Background/Purpose: The incidence of fibromyalgia is highest in the first 12 months after RA diagnosis,1 indicating that this period may represent a critical window during…

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