ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 486

Evolution of Seropositive Arthralgia over Time: Predictors of Evolution to Rheumatoid Arthritis

Candice Low1, Richard Conway 2, Francis Young 1, Eamonn Molloy 3, Anne Barbara Mongey 3, Gerry Wilson 3, Ursula Fearon 4 and Douglas Veale 5, 1Saint Vincent's University Hospital, Dublin, Ireland, 2Blackrock Clinic, Dublin, Ireland, 3St Vincent's University Hospital, Dublin, Ireland, 4Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD, Dublin, Ireland, 5EULAR Centre For Arthritis And Rheumatic Diseases and The Conway Institute, Dublin, Ireland

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: Early Rheumatoid Arthritis

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Sunday, November 10, 2019

Session Title: RA – Diagnosis, Manifestations, & Outcomes Poster I: Risk Factors, Predictors, & Prognosis

Session Type: Poster Session (Sunday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Seropositive arthralgia is defined as joint pain in patients positive for rheumatoid factor (RF) or anti-citrullinated protein antibodies (ACPA). In some individuals it is a precursor to rheumatoid arthritis (RA). The factors which determine progression and outcomes in seropositive arthralgia patients remain to be fully defined. Our aim was to evaluate outcomes and prognostic factors, including arthroscopic findings, in a cohort of patients with seropositive arthralgia.

Methods: We performed a prospective study of consecutive patients with seropositive arthralgia. All patients were seropositive for RF and/or ACPA. Demographic and clinical characteristics were collected on all patients. Synovial biopsy was performed by needle arthroscopy in all patients, and macroscopic and histologic features recorded. The degree of synovitis and vascularity were recorded on a 0–100-mm visual analog scale. Diagnosis at last follow-up was recorded in all patients. Mann-Whitney U test was used to compare groups. GraphPad Prism Version 8 and IBM SPSS Statistics Version 24 were used for data analysis.

Results: 37 patients were recruited. Mean (SD) age was 50 (13) years. 26 (70%) were female. 31 (84%) were positive for RF and 32 (86%) for ACPA with 26 (70%) dual positive. Mean (SD) follow-up was 38 (13) months. Baseline characteristics are shown in Table 1. Final diagnosis was RA in 26 (70%), psoriatic arthritis in 2 (5%), connective tissue disease in 1 (3%), calcium pyrophosphate arthritis in 1 (3%), and remained seropositive arthralgia in 7 (19%). Baseline CRP was significantly higher in patients who developed RA than those who remained seropositive arthralgia, median (SD) 3.50 (2.00, 8.25) vs 1.00 (1.00, 2.00) mg/dL (p=0.0096), Figure 1. Baseline macroscopic synovitis and vascularity at arthroscopy were both significantly higher in those who developed RA than in those who remained as seropositive arthralgia, median (IQR) 60 (30, 80) vs 40 (20, 40) mm (p=0.021), and median (IQR) 50 (30, 73) vs 40 (20, 40) mm (p=0.021), Figure 1. Baseline DAS28-CRP, tender joint count, swollen joint count, and patient global assessment were not different between the groups. Baseline synovial cell immunophenotyping did not predict final diagnosis.

Conclusion: Elevated baseline CRP and arthroscopically determined macroscopic synovial inflammation and vascularity predict the development of RA in patients with seropositive arthralgia.

Table 1: Baseline characteristics of 37 patients with seropositive arthralgia

Figure 1: Comparison of CRP, macroscopic synovitis, and synovial vascularity in patients with seropositive arthralgia who did or did not progress to RA -RA: progressed to rheumatoid arthritis; SA: remained seropositive arthralgia-


Disclosure: C. Low, None; R. Conway, None; F. Young, None; E. Molloy, None; A. Mongey, None; G. Wilson, None; U. Fearon, None; D. Veale, Health Beacon, 1.

To cite this abstract in AMA style:

Low C, Conway R, Young F, Molloy E, Mongey A, Wilson G, Fearon U, Veale D. Evolution of Seropositive Arthralgia over Time: Predictors of Evolution to Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/evolution-of-seropositive-arthralgia-over-time-predictors-of-evolution-to-rheumatoid-arthritis/. Accessed January 16, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2019 ACR/ARP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/evolution-of-seropositive-arthralgia-over-time-predictors-of-evolution-to-rheumatoid-arthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.