Abstracts tagged "cutaneous lupus"

Abstract Number: 0970 • ACR Convergence 2021
Hippo Signaling Is a Novel Regulator of Apoptosis and Photosensitivity in Lupus Keratinocytes
Grace Hile¹, Patrick Coit², Bin Xu¹, Shannon Estadt¹, Jacob Martens³, Rachael Wasikowski¹, Lam Tsoi¹, Ramiro Iglesias-Bartolome⁴, Celine Berthier¹, Allison Billi⁵, Johann Gudjonsson⁵, Amr Sawalha² and J. Michelle Kahlenberg¹, ¹University of Michigan, Ann Arbor, MI, ²University of Pittsburgh, Pittsburgh, PA, ³Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, MI, ⁴NIH, National Cancer Institute, Bethesda, MD, ⁵Department of Dermatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Skin inflammation and photosensitivity are common manifestations of cutaneous (CLE) and systemic lupus erythematosus (SLE), yet the mechanisms underlying heightened cell death and epidermal…
Abstract Number: 1020 • ACR Convergence 2020
Relationship Between Skin-related Quality of Life, Psychosocial Stress, and Race in Cutaneous Lupus Erythematosus
Cristina Drenkard¹, Laura Aspey¹, Gaobin Bao¹, Caroline Gordon², Kristina Theis³, Charles Helmick³ and S. Sam Lim¹, ¹Emory University, Atlanta, GA, ²University of Birmingham, Birmingham, England, United Kingdom, ³Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Chronic stress may trigger or exacerbate physiologic pathways that worsen individual health and wellbeing. Stress is associated with the development and progression of skin…
Abstract Number: 088 • 2020 Pediatric Rheumatology Symposium
Sun Protection Use in Patients Followed in a Pediatric Rheumatology Clinic in an Urban Setting
Tamara Tanner¹, Gabriel Tarshish ², Dawn Wahezi ³ and Tamar Rubinstein ⁴, ¹Montefiore Medical Center, Bronx, ²Children's Hospital at Montefiore, New York, ³Children's Hospital at Montefiore, Bronx, ⁴Albert Einstein College of Medicine, White Plains
Background/Purpose: Exposure to sunlight has been implicated as a major contributing factor in the pathogenesis of systemic lupus erythematosus (SLE) and juvenile dermatomyositis (JDM). Despite…
Abstract Number: 65 • 2019 ACR/ARP Annual Meeting
CD6 Modulation Ameliorates Skin and Kidney Disease in a Spontaneous Murine Model of SLE
Samantha Chalmers¹, Sayra Garcia ¹, Rajalakshmy Ayilam Ramachandran ², Chandra Mohan ², Jeanette Ampudia ³, Cherie Ng ³, Stephen Connelly ³ and Chaim Putterman ⁴, ¹Albert Einstein College of Medicine, Bronx, NY, ²University of Houston, Houston, ³Equillium, Inc, San Diego, CA, ⁴Albert Einstein College of Medicine, New York, NY
Background/Purpose: T cells are an important contributor the pathogenesis of SLE and its various end organ manifestations. Thus, they present themselves as potential therapeutic targets;…
Abstract Number: 702 • 2019 ACR/ARP Annual Meeting
Seasonality of Cutaneous and Systemic Flares in Adults and Children in the Einstein Lupus Cohort
Tamara Tanner¹, Dawn Wahezi ², Ilir Agalliu ³, Chaim Putterman ⁴, Anna Broder ⁵, Nicole Jordan ⁴, Dalynah Maldonado Andujar ⁴ and Tamar Rubinstein ⁶, ¹Children's Hospital at Montefiore, Bronx, NY, ²Children’s Hospital at Montefiore, New York, ³Albert Einstein College of medicine, Bronx, ⁴Montefiore Medical Center, Bronx, ⁵Rheumatology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, ⁶Children's Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Ultra violet light (UV) exposure has been implicated as a major contributor to pathogenesis and flares in lupus. While some studies have looked at…
Abstract Number: 861 • 2019 ACR/ARP Annual Meeting
Cutaneous Lupus Erythematosus Disease Area & Severity Index (CLASI) Demonstrates Thresholds for Detection of Treatment Response in a Phase-2, Placebo-Controlled Trial of Ustekinumab in SLE
Victoria Werth¹, Bevra Hahn ², George Tsokos ³, Shawn Rose ⁴, Kaiyin Fei ⁴, Yun Gregan ⁴, Robert Gordon ⁴, Kim Hung Lo ⁴ and Ronald van Vollenhoven ⁵, ¹Hospital of the Univ of PA and Veteran’s Administration Med Center, Philadelphia, PA, ²University of California, Los Angeles, CA, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Janssen Research & Development, LLC, Spring House, PA, ⁵Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands
Background/Purpose: Ustekinumab (UST), an anti-IL-12/23 p40 monoclonal antibody, showed significantly greater improvement at week (wk) 24 compared with placebo (PBO) in Systemic Lupus Erythematosus Disease…
Abstract Number: 1111 • 2019 ACR/ARP Annual Meeting
Lupus Teledematology: A Pilot Project to Evaluate the Plausibility of a Rapid Access Dermatology Service for Lupus Patients
Richard Antbring¹, Malvina Cunningham ², Richard Bull ², Angela Pakozdi ¹, Ravindra Rajakariar ¹, Myles Lewis ¹, Andrea Cove-Smith ¹ and Debasish Pyne ³, ¹Barts Health Lupus Centre, London, United Kingdom, ²Barts Health NHS Trust, London, United Kingdom, ³Barts Lupus Centre, London, United Kingdom
Background/Purpose: Clinicians have been increasingly using social media sites professionally. Platforms such as WhatsApp ® could be a potentially effective tool in teledermatology for rapid diagnosis and/or…
Abstract Number: 2030 • 2019 ACR/ARP Annual Meeting
Staphylococcus Aureus Colonization Is Increased on Lupus Skin Lesions and Is Promoted by Interferon-Mediated Barrier Disruption
Sirisha Sirobhushanam¹, Navya Parsa ², Tamra Reed ¹, Celine Berthier ¹, Mrinal Sarkar ¹, Grace Hile ¹, Lam Tsoi ¹, Alexander Horswill ³, Johann Gudjonsson ¹ and J Michelle Kahlenberg ¹, ¹University of Michigan, Ann Arbor, MI, ²University of Toledo, Toledo, OH, ³University of Colorado, Denver, CO
Background/Purpose: Background/Purpose: Cutaneous inflammation is recurrent in systemic lupus erythematosus (SLE) and is often triggered by exposure to ultraviolet B (UVB) light. Type I interferons…
Abstract Number: 2031 • 2019 ACR/ARP Annual Meeting
Interferon Alpha Promotes Caspase-Dependent Apoptosis Independently of Reactive Oxygen Species in Ultraviolet B-Exposed Keratinocytes
Shannon Estadt¹ and J. Michelle Kahlenberg ¹, ¹University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by increased sensitivity to ultraviolet radiation (UVR). UVR can trigger cutaneous and systemic disease fares,…
Abstract Number: 2037 • 2019 ACR/ARP Annual Meeting
Understanding Langerhans Cell ADAM17 Levels in Systemic Lupus Erythematosus: Potential Contributor to Photosensitivity
Theresa Lu ¹, Noa Schwartz ², Thomas Li ², William Shipman ³, Dragos Dasoveanu ³, Yong Liu ⁴, Niroshana Anandasabapathy ⁴, Henry Lee ⁴, Ali Jabbari ⁵, James Krueger ⁵, Bebak Mehrara ⁶, Keila Veiga², Kira Minkis ⁴ and David Oliver ², ¹Hospital for Special Surgery, Weill Cornell Medicine (Microbiology and Immunology), New York, ²Hospital for Special Surgery, New York, ³Hospital for Special Surgery; Weill Cornell Medicine, New York, ⁴Weill Cornell Medicine (Dermatology), New York, ⁵Rockefeller University, New York, ⁶Memorial Sloan Kettering Cancer Center, New York
Background/Purpose: Photosensitivity resulting in inflammatory skin lesions is a hallmark of cutaneous lupus. Lesions can be disfiguring and have a negative impact on patients’ quality…
Abstract Number: 2897 • 2019 ACR/ARP Annual Meeting
Increased CD69+ Tissue-resident Memory T (TRM) Cells and STAT3 Expression in Cutaneous Lupus Erythematosus Patients Recalcitrant to Antimalarials
Majid Zeidi ¹, Kristen Chen ¹, Krisha Desai ¹, Hee Joo Kim ², Srita Chakka ³, Rachel Lim ⁴ and Victoria Werth¹, ¹Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA and Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, ²Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA andDepartment of Dermatology, University of Pennsylvania, Philadelphia, PA, USA and Department of Dermatology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea, Republic of (South), Philadelphia, ³Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, ⁴Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA, Philadelphia
Background/Purpose: Cutaneous lupus erythematosus (CLE) is an autoimmune disease with various subsets and clinical manifestations. T lymphocytes are the predominant cell type found in lesional…
Abstract Number: 725 • 2018 ACR/ARHP Annual Meeting
Preliminary Population-Based Incidence and Prevalence Estimates of Primary Discoid Lupus and Cutaneous Lupus Erythematosus from the Manhattan Lupus Surveillance Program
Peter M. Izmirly¹, Jill P. Buyon², H. Michael Belmont³, Sara Sahl⁴, Isabella Wan⁵, Jane E. Salmon⁶, Anca Askanase⁷, Joan Bathon⁸, Laura Geraldino-Pardilla⁷, Yousaf Ali⁹, Ellen M. Ginzler¹⁰, Chaim Putterman¹¹, Caroline Gordon¹², Charles G. Helmick¹³ and Hilary Parton¹⁴, ¹NYU Langone Health, New York, NY, ²Medicine, New York University School of Medicine, New York, NY, ³Medicine, NYU Langone Health, New York, NY, ⁴Pediatrics, Harbor-University of California at Los Angeles Medical Center, Torrance, CA, ⁵Medicine/Rheumatology, New York University School of Medicine, New York, NY, ⁶Medicine/Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁸Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁹Rheumatology, Mount Sinai Medical Center, New York, NY, ¹⁰Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY, ¹¹Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ¹²Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ¹³Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ¹⁴Bureau of Epidemiology Services, New York City Department of Health and Mental Hygiene, Long Island City, NY
Background/Purpose: The extant epidemiologic data of primary discoid lupus erythematosus (DLE) and primary cutaneous lupus erythematosus (CLE) remains limited with few published estimates for the…
Abstract Number: 2100 • 2018 ACR/ARHP Annual Meeting
Topical Endocannabinoid Administration Protects MRL-Lpr/Lpr Mice from Cutaneous Lupus Erythematosus
Samantha Chalmers¹, Sayra Garcia¹, Andrew Draganski¹, Jessica Doerner², Adam Friedman³, Joel Friedman¹ and Chaim Putterman⁴, ¹Albert Einstein College of Medicine, Bronx, NY, ²University of Pennsylvania, Philadelphia, PA, ³Dermatology, GW School of Medicine and Health Sciences, Washington, DC, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: Cutaneous lupus erythematosus (CLE) affects ~75% of SLE patients and has a profound impact on quality of life. While the morbidity from CLE is…
Abstract Number: 752 • 2016 ACR/ARHP Annual Meeting
Anti-Ro Positivity Is a Predictor of Responsiveness to Topical Steroids or Hydroxychloroquine in Patients with Discoid but Not Subacute Cutaneous Lupus
Rajaie Namas¹, Corey Powell² and J. Michelle Kahlenberg³, ¹Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI, ²Consulting for Statistics, Computing and Analytics Research, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Cutaneous lupus erythematosus (CLE) lesions are difficult to treat and medications are often chosen based only on provider experience. Thus, we chose to assess…
Abstract Number: 1397 • 2016 ACR/ARHP Annual Meeting
Correlation and Responsiveness of Cutaneous Lupus Disease Area and Severity Index (CLASI) and Skindex-29 with Cutaneous Childhood Lupus Erythematosus (cSLE)
Ashwaq Aleed, CCHMC, cincinnati, OH; Pediatric, Qassim University, Qassim, Saudi Arabia
Correlation and Responsiveness of Cutaneous Lupus Disease Area and Severity Index (CLASI) and Skindex-29 with Cutaneous Childhood Lupus Erythematosus (cSLE) *Ashwaq AlEÕed, **Nora Al Mutairi ,…

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