ACR Meeting Abstracts

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Abstracts tagged "cutaneous lupus"

  • Abstract Number: 799 • 2015 ACR/ARHP Annual Meeting

    Transcriptional Profiling of Cutaneous Lupus Reveals Pronounced Changes in Keratinocyte and Myeloid Lineage Expressed Genes and Demonstrates Uniquely Regulated Interferon Pathways Between Rash Subtypes

    Celine C. Berthier1, Jasmine Stannard2, Emily Myers3, William Swindell4, Lori Lowe4, Tamra J. Reed5, Johann Gudjonsson4 and J. Michelle Kahlenberg6, 1Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, 2Int. Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, 3Internal Medicine, Rheumatology, Georgetown University, Washington, DC, 4Dermatology, University of Michigan, Ann Arbor, MI, 5Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, 6Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Cutaneous lupus rashes can be substantial, disfiguring, and often refractory to usual lupus therapies.  Phenotypic presentation and risk of systemic lupus manifestations differs by…
  • Abstract Number: 861 • 2014 ACR/ARHP Annual Meeting

    Ultraviolet B Generates Type 1 Interferon and Induces Autoantibody-Mediated Disease in a Mouse Model of Cutaneous Lupus

    Clayton Sontheimer1 and Keith B. Elkon2, 1Pediatric Rheumatology, University of Washington, Seattle, WA, 2Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose Photosensitivity is a common symptom in patients with systemic lupus erythematosus (SLE) and lupus skin lesions often contain plasmacytoid dendritic cells (pDC). The mechanisms…
  • Abstract Number: 641 • 2014 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminase Inhibition Mitigates NET Formation and Protects Against Kidney, Skin, and Vascular Disease in Lupus-Prone MRL/Lpr Mice

    Jason S. Knight1, Venkataraman Subramanian2, Alexander A. O'Dell1, Srilakshmi Yalavarthi1, Wenpu Zhao3, Carolyne K. Smith3, Jeffrey B. Hodgin4, Paul Thompson2 and Mariana J. Kaplan3, 1Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2The Scripps Research Institute, Jupiter, FL, 3Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4Department of Pathology, University of Michigan, Ann Arbor, MI

    Background/Purpose:  An imbalance between neutrophil extracellular trap (NET) production and NET degradation has been observed in systemic lupus erythematosus (SLE), potentially contributing to autoantigen externalization,…
  • Abstract Number: 1860 • 2013 ACR/ARHP Annual Meeting

    Novel Proinflammatory Microvesicles That Carry LL-37 In Patients With Cutaneous Lupus

    Ming-Lin Liu1,2,3, Muhammad Bashir1,4, Meena Sharma1,4, Honghui Xu1,4, Kevin Williams3, Cynthia O. Anyanwu4,5, Joyce Okawa1,6 and Victoria P. Werth1,4, 1Department of Dermatology, University of Pennsylvania, Philadelphia, PA, 2Department of Dermatology,, Philadelphia V.A. Hospital, Philadelphia, PA, 3Department of Medicine, Temple University School of Medicine, Philadelphia, PA, 4Department of Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA, 5Department of Dermatology, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, 6Department of Dermatology, Veteran Affairs Medical Center, Philadelphia, PA

    Background/Purpose: Cutaneous lupus erythematosus (CLE) refers to variants of lupus erythematosus (LE) with exclusively or predominantly skin manifestations. CLE is associated with accumulation of autoantibodies…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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