Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Mucocutaneous lupus is a common manifestation in both adult and children with lupus (60-85%). The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) allows for measuring active inflammation(CLASI-A;range 0-70)and chronic damage (CLASI_D; range 0-59)has been developed and validated for use in adults. The Skindex is a skin-specific Quality of Life (QoL; range 0–100; 100=worst QoL). Neither the CLASI nor the Skindex-29 has been validated for use in cSLE. The objective of this study was to assess the validity of the CLASI and Skindex29 in cSLE.
Methods : In this ongoing study, 33 cSLE patients were enrolled to date. Besides the CLASI, physicians-rated cSLE activity (SLEDAI) and completed the SLICC/ACR damage index (SDI). The Skindex was modified to a 28-item scale given difference between the adult and children life styles. PatientsÕ QoL was rated using the PedsQL Generic Core (GC) scale and the Rheumatology Module (RM) and the Skindex29.
Results: Patients (age: 3-18years; 87% females) had moderately active cSLE (mean± SD; SLEDAI 9.6 ± 7.4), 44.4% had a SDI score>0; and PedsQL-GC/RM scores 75±17.06/74.2±14.8, respectively. The mucocutaneous (MC)scores were 2.6 ± 1.5 for SLEDAI-MC and 0.36 ±0.55 for SDI-MC. As shown in Table 1/Figure1,cSLE activity (SLEDAI, SLEDAI-MC), damage (SDI, SDI-MC) and QoL(PedsQL-GC/MC)were moderately associated with CLASI-A, CLASI-D and Skindex scores, respectively.
Conclusion: We found the CLASI and the modified Skindex feasible and to show construct validity when used in cSLE. Additional research is needed to confirm the responsiveness to change of these two indices when use in cSLE.
|Figure 1: The relation between different scores.|
|Table 1: Show the Correlation Coefficients between the scores.|
To cite this abstract in AMA style:Aleed A. Correlation and Responsiveness of Cutaneous Lupus Disease Area and Severity Index (CLASI) and Skindex-29 with Cutaneous Childhood Lupus Erythematosus (cSLE) [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/correlation-and-responsiveness-of-cutaneous-lupus-disease-area-and-severity-index-clasi-and-skindex-29-with-cutaneous-childhood-lupus-erythematosus-csle/. Accessed October 20, 2020.
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