ACR Meeting Abstracts

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Abstracts tagged "complement"

  • Abstract Number: 2401 • ACR Convergence 2024

    A Novel Modeling Approach to Elucidate the Role of Autoantibodies in Complement Activation in SLE

    David Pisetsky1, Yuankang Zhao2, Matthew Engelhard3, Amanda Eudy4, Philip Tedeschi5, Alex Verdone5, Megan Clowse6, Lisa Criscione-Schreiber2, Jayanth Doss3, Mithu Maheswaranathan2, Rebecca Sadun3, Kai Sun3 and Jennifer Rogers2, 1Duke University Medical Center, Durham, NC, 2Duke University, Durham, 3Duke University, Durham, NC, 4Duke University, Raleigh, NC, 5Immunovant, Inc, New York, NY, 6Duke University, Chapel Hill, NC

    Background/Purpose: In SLE, ANAs can promote pathogenesis by forming immune complexes (ICs) that activate complement.  While antibodies to DNA (anti-DNA) are known to be associated…
  • Abstract Number: 0298 • ACR Convergence 2024

    RAY121, a Novel Recycling Monoclonal Antibody Against Complement C1s: Safety, Pharmacokinetic and Pharmacodynamic Data from a Phase 1a First in Human Clinical Trial in Healthy Adults

    Miwa Haranaka1, Akinori Yamada2, Saki Takahashi2, Keisuke Gotanda2, Sonoko Nakano-Kanatani2, Nana Uemura2, Kensuke Ohnishi2, Masanobu Nishidate2, Ichio Ohnami2 and Megumi Kai3, 1Souseikai Hakata Clinic, Fukuoka, Japan, 2Chugai Pharmaceutical Co., Ltd., Tokyo, Japan, 3Oita University, Oita, Japan

    Background/Purpose: Complement C1s is one of the major components of the classical complement pathway (CP), and the abnormal activation of CP is implicated in several…
  • Abstract Number: 2478 • ACR Convergence 2024

    Avacopan versus a Prednisone Taper in Patients with ANCA-Associated Vasculitis Without Kidney Involvement in a Phase 3 Trial

    Christian Pagnoux1, Antoine Neel2, Sarah Bray3, Rachel E. Gurlin4, Darcy Trimpe5, David Jayne6 and Peter Merkel7, and ADVOCATE Study Group, 1Mount Sinai Hospital, Toronto, ON, Canada, 2Department of Internal Medicine, CHU Nantes, Nantes, France, 3Amgen Ltd, Cambridge, United Kingdom, 4Amgen Inc., Mountain View, CA, 5Amgen Inc., Thousand Oaks, CA, 6University of Cambridge, Cambridge, United Kingdom, 7University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are subtypes of ANCA-associated vasculitis that frequently involve the kidneys. However, a subset of patients with…
  • Abstract Number: 0461 • ACR Convergence 2024

    Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid Arthritis

    ivan Ferraz-Amaro1, Maria Garcia-Gonzalez2, Fuensanta Gomez-Bernal3, Juan Carlos Quevedo-Abeledo4 and Miguel Angel Gonzalez-Gay5, 1Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 2Hospital Universitario de Canarias, SC Tenerife, Canarias, Spain, 3Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 4Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de GC, Canarias, Spain, 5University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain

    Background/Purpose: The complement (C) system has been implicated in the etiopathogenesis of rheumatoid arthritis (RA). We aimed to examine the correlation between an in-depth evaluation…
  • Abstract Number: 2480 • ACR Convergence 2024

    Avacopan versus a Prednisone Taper in Patients with ANCA-Associated Vasculitis and Ear, Nose, or Throat Involvement in a Phase 3 Trial

    Robert Spiera1, Robert Lebovics2, Sarah Bray3, Rachel E. Gurlin4, David Jayne5 and Peter Merkel6, and ADVOCATE Study Group, 1Scleroderma, Vasculitis, and Myositis Center, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, 2Hackensack Meridian University Health System, Hackensack, NJ, 3Amgen Ltd, Cambridge, United Kingdom, 4Amgen Inc., Mountain View, CA, 5University of Cambridge, Cambridge, United Kingdom, 6University of Pennsylvania, Philadelphia, PA

    Background/Purpose: In the phase 3 ADVOCATE trial, 45.2% and 42.1% of patients in the avacopan and prednisone taper groups, respectively, had active ear, nose, or…
  • Abstract Number: 0471 • ACR Convergence 2024

    Understanding the Role of the Complement System in Insulin Resistance and Metabolic Syndrome in Patients with Rheumatoid Arthritis

    Jose Viotti-Serra1, Maria Garcia-Gonzalez2, Fuensanta Gomez-Bernal1, Juan Carlos Quevedo-Abeledo3, Miguel Angel Gonzalez-Gay4 and ivan Ferraz-Amaro5, 1Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 2Hospital Universitario de Canarias, SC Tenerife, Canarias, Spain, 3Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de GC, Canarias, Spain, 4University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain, 5Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain

    Background/Purpose: The complement (C) system has been associated with the etiopathogenesis of rheumatoid arthritis (RA). Insulin resistance (IR) and metabolic syndrome are prevalent among RA…
  • Abstract Number: 2483 • ACR Convergence 2024

    Efficacy and Safety of Avacopan over 12 Months in Japanese Patients with MPA/GPA: A Single-center Study

    Yusuke Ushio1, Hiromi Shimada2, taichi miyagi3, Koichi Sugihara4, Mao Mizusaki5, Rina Mino5, Hayamasa yamaguchi5, Naoto Manabe5, Shusaku Nakashima2 and Hiroaki Dobashi2, 1Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Miki, Kita District, Kagawa, Japan, 2Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan, 3Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, kidagun, Japan, 4Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Kagawa Prefecture, Japan, 5Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Japan

    Background/Purpose: Avacopan, an oral C5a receptor inhibitor, was demonstrated to be an alternative to glucocorticoids (GC) in the treatment of microscopic polyangiitis (MPA)/granulomatosis with polyangiitis…
  • Abstract Number: 0497 • ACR Convergence 2024

    Relationship Between the Complement System and Subclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis

    Adrián Quevedo-Rodríguez1, Marta Hernández-Díaz2, Dara Rodríguez-González22, Fuensanta Gomez-Bernal3, Juan Carlos Quevedo-Abeledo4, Agustín F González-Rivero2, Elena González López5, gonzalo Ocejo-Viñals5, Miguel Angel Gonzalez-Gay6 and ivan Ferraz-Amaro7, 1Hospital de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Spain, 2Hospital Universitario de Canarias, SANTA CRUZ DE TENERIFE, Spain, 3Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 4Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de GC, Canarias, Spain, 5Department of Immunology, Marqués de Valdecilla University Hospital (HUMV), Santander, Spain, 6University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain, 7Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain

    Background/Purpose: Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) events and CV mortality. Carotid subclinical atherosclerosis is independently associated with incident…
  • Abstract Number: 2488 • ACR Convergence 2024

    Patient Characteristics and Treatment Patterns Before and After Initiation of Avacopan in the United States: An Early View Based on a Claims Database Analysis

    Sushmitha Inguva1, Pallavi Rane1, Darcy Trimpe1, Sam Oh1, Jasjit Multani2, Hsiu-Ching Chang2, Marie Yasuda2, Chi-Chang Chen2, Duvuru Geetha3, Peter Merkel4 and Zachary Wallace5, 1Amgen Inc., Thousand Oaks, CA, 2IQVIA, Wayne, PA, 3Johns Hopkins University, Baltimore, MD, 4University of Pennsylvania, Philadelphia, PA, 5Massachusetts General Hospital, Newton, MA

    Background/Purpose: The United States (US) Food and Drug Administration approved avacopan to treat adults with severe active granulomatosis with polyangiitis or microscopic polyangiitis in October…
  • Abstract Number: 0556 • ACR Convergence 2023

    Classical Complement Activation in Lupus Nephritis Correlates with Disease Biomarkers: Results from Two Observational Studies

    Edmund Chang1, Julian Low1, Noosha Yousefpour1, Min Bao1, Jeannette Osterloh1, Qing Chang1, Dean Artis1, Henk-Andre Kroon1, Yaisa Andrews-Zwilling1, Maria Dall'Era2, Ted Yednock1 and Ann Mongan1, 1Annexon Biosciences, Brisbane, CA, 2University of California San Francisco, San Francisco, CA

    Background/Purpose: Lupus nephritis (LN) is an autoantibody-mediated disease that can activate C1q and the classical complement pathway. Pathogenic anti-C1q antibodies (PACAs) are often present, amplifying…
  • Abstract Number: 0924 • ACR Convergence 2023

    Distinct Cell-Bound Complement Activation Products Associate with Disease Activity and Immune Transcriptional Signatures in SLE

    Gabriel Arguelles, Lynne Mitchell, Dennis Hourcade, John Atkinson, Elisha Roberson and Alfred Kim, Washington University School of Medicine, St. Louis, MO

    Background/Purpose: Complement plays a central role in SLE, generating an array of bioactive soluble and cell-bound complement activation products (CB-CAPs) during disease activity. Data are…
  • Abstract Number: 0562 • ACR Convergence 2023

    HDL-Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus

    Ivan Ferraz Amaro1, Maria García-González1, Fuensanta Gómez-Bernal1, Juan Carlos Quevedo-Abeledo2, Yolanda Fernández-Cladera1, Agustín F González-Rivero1 and Miguel A Gonzalez-Gay3, 1Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 2Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain, 3IDIVAL and School of Medicine, UC, Santander; Department of Rheumatology, IIS-Fundación Jiménez Díaz, Madrid, Santander, Spain

    Background/Purpose: Cholesterol efflux capacity (CEC), the ability of high-density lipoprotein (HDL) cholesterol to accept cholesterol from macrophages, has been linked to cardiovascular events. Systemic lupus…
  • Abstract Number: 1591 • ACR Convergence 2023

    Complement Factor D/Adipsin Knockout Mice Demonstrate Disparate Pain and Structural Damage Phenotypes in Obesity-induced Post Traumatic Osteoarthritis

    Kelsey Collins1, Kristin Lenz2, Arin Oestreich2, Luke Springer2, Antonina Akk2, Huimin Yan2, Xiaobo Wu2, John Atkinson3, Christine Pham4 and Farshid Guilak4, 1University of California San Francisco, San Francisco, CA, 2Washington University in St. Louis, St. Louis, MO, 3Washington University School of Medicine, St. Louis, MO, 4Washington University, St. Louis, MO

    Background/Purpose: Osteoarthritis (OA) is the leading cause of musculoskeletal pain, which is a primary driver of care-seeking behavior. There is lack of mechanistic information detailing…
  • Abstract Number: 0565 • ACR Convergence 2023

    Insulin Resistance and the Complement System Are Linked in Patients with Systemic Lupus Erythematosus

    José María Viotti-Serra1, Maria García-González1, Fuensanta Gómez-Bernal1, Juan Carlos Quevedo-Abeledo2, Yolanda Fernández-Cladera1, Agustín F González-Rivero1, Miguel A Gonzalez-Gay3 and Ivan Ferraz Amaro1, 1Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 2Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain, 3IDIVAL and School of Medicine, UC, Santander; Department of Rheumatology, IIS-Fundación Jiménez Díaz, Madrid, Santander, Spain

    Background/Purpose: Systemic lupus erythematosus (SLE) patients more commonly have insulin resistance (IR) than control subjects. Recent studies have revealed that the complement (C) system is…
  • Abstract Number: 1605 • ACR Convergence 2023

    Complement Activation as a Marker of Thrombosis Risk in Antiphospholipid Antibody Positive Patients: Prospective Results from AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (“Registry”)

    Cecile Yelnik1, Shruti Chaturvedi2, Julien Labreuche1, Xiang-Zuo Pan3, H Michael Belmont4, Kello Nina5, Paul R. Fortin6, D. Ware Branch7, Yu Zuo8, Rohan Willis9, Robert Brodsky10, Jane Salmon11, Maria Laura Bertolaccini12, Hannah Cohen13, Michelle Petri14, Doruk Erkan11 and On Behalf Of APS ACTION15, 1University of Lille, Lille, France, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3John Hopkins University, Baltimore, MD, 4NYU School of Medicine, New York, NY, 5Northwell Health, Brooklyn, NY, 6Centre ARThrite - CHU de Québec - Université Laval, Quebec City, QC, Canada, 7University of Utah, Salt Lake City, UT, 8University of Michigan, Ann Arbor, MI, 9University of Texas Medical Branch, Galveston, TX, 10Johns Hopkins University, Baltimore, MD, 11Hospital for Special Surgery, New York, NY, 12King's College London, London, United Kingdom, 13University College London Hospitals NHS Foundation Trust, London, United Kingdom, 14Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 15on behalf of APS ACTION, New York, NY

    Background/Purpose: Recent studies implicate complement activation in the pathophysiology of antiphospholipid syndrome (APS), especially in patients with severe manifestations, such as catastrophic APS (CAPS). This…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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