Abstracts tagged "complement"

Abstract Number: 642 • 2019 ACR/ARP Annual Meeting
Complement Deposition C4d on Platelets Is Associated with Vascular Events in Systemic Lupus Erythematosus
Elisabet Svenungsson ¹, Johanna Gustavsson ², Giorgia Grosso ², Iva Gunnarsson ², Bo Nilsson ³, Anders Larsson ³, Anders Bengtsson ⁴ and Christian Lood⁵, ¹Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ²Karolinska Institutet, Stockholm, Sweden, ³Uppsala University, Uppsala, Sweden, ⁴Lund University, Lund, Sweden, ⁵University of Washington, Seattle
Background/Purpose: Complement components, including C4d, can be detected on the surface of activated platelets and they have been associated with vascular disease in systemic lupus…
Abstract Number: 669 • 2019 ACR/ARP Annual Meeting
Complement Activation in Probable Systemic Lupus Erythematosus (pSLE) May Predict Progression to SLE Defined by Fulfillment of ACR Classification Criteria
Rosalind Ramsey-Goldman¹, Roberta Alexander ², Sonali Narain ³, Cristina Arriens ⁴, Elena Massarotti ⁵, Daniel Wallace ⁶, Amit Saxena ⁷, Christopher Collins ⁸, Chaim Putterman ⁹, Kenneth Kalunian ¹⁰, Tyler O'Malley ¹¹, Armida Sace ², Rowena LaFon ², Jo-Anne Ligayon ², Claudia Ibarra ², John Conklin ², Thierry Dervieux ² and Arthur Weinstein ¹², ¹Northwestern University, Chicago, IL, ²Exagen, Vista, CA, ³Northwell Health, Great Neck, Long Island, NY, ⁴Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Brigham and Women's Hospital/Harvard Medical School, Boston, MA, ⁶Cedars Sinai Medical Center/UCLA, Los Angeles, CA, ⁷New York University School of Medicine, New York, NY, ⁸MedStar Washington Hospital Center, Department of Rheumatology, Washington, DC, ⁹Albert Einstein College of Medicine, New York, NY, ¹⁰Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, CA, ¹¹Exagen, Oceanside, CA, ¹²Georgetown University & Exagen, Inc, Claremont, CA
Background/Purpose: We reported (Ramsey-Goldman et al., Arthritis Rheumatol 2018: 70 [suppl 10]) that cell-bound complement activation products (CB-CAPs) and a multi-analyte assay panel with algorithm…
Abstract Number: 686 • 2019 ACR/ARP Annual Meeting
Association Between the Soluble Terminal Complement Complex C5b-9 (sC5b-9) and Signs of Active Kidney Disease in a Swiss SLE Cohort
Kristin Schmiedeberg ¹, Ruediger B. Mueller ², Thomas Neumann ¹, Ian Pirker ¹, Philipp Rein ³, Camillo Ribi ⁴, Andrea Rubbert-Roth ⁵, Michael Kirschfink ⁶, Reinhard Voll ⁷ and Johannes von Kempis¹, ¹Division of Rheumatology and Immunolog, Kantonsspital St. Gallen, St. Gallen, Sankt Gallen, Switzerland, ²Clinic of Rheumatology, Medical University Hospital Aarau, Aarau, Aargau, Switzerland, ³Division of Rheumatology and Immunolog, Kantonsspital St. Gallen, St.Gallen, Sankt Gallen, Switzerland, ⁴Service of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Vaud, Switzerland, ⁵Division of Rheumatology, Kantonsspital St. Gallen, St. Gallen, Sankt Gallen, Switzerland, ⁶Institute of Immunology, University of Heidelberg, Heidelberg, Germany, ⁷Division of Rheumatology and Clinical Immunology, Medical Centre - University of Freiburg, Freiburg, Germany
Background/Purpose: There is a lack of reliable biomarkers for disease activity in SLE. While C3a, an anaphylatoxin generated during of complement activation, could be predictive…
Abstract Number: 1266 • 2019 ACR/ARP Annual Meeting
AGBL3 as a Novel Gene Associated with Hereditary Hypocomplementemic Urticarial Vasculitis and Favorable Response to Rituximab
Ahmet Gul¹, Nesllihan Abaci ² and Sema Sirma-Ekmekci ², ¹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, Istanbul, Turkey, ²Department of Genetics, Istanbul University Institute for Experimental Medical Research, Istanbul, Turkey, Istanbul, Turkey
Background/Purpose: Urticarial skin lesions are well-known features of autoinflammatory disorders associated with NLRP3 and NLRP12 variants. However hereditary forms of hypocomplementemic urticarial vasculitis (HUV) with…
Abstract Number: 1825 • 2019 ACR/ARP Annual Meeting
Comparison of the Thrombosis Risk Score with Triple Positivity in SLE Thrombosis
Michelle Petri¹, Jessica Li ¹, John Conklin ², Tyler O'Malley ³, Jo-Anne Ligayon ², Leilani Wolover ² and Thierry Dervieux ², ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Exagen, Vista, CA, ³Exagen, Oceanside, CA
Background/Purpose: We previously developed a Thrombosis Risk Score, a sum of three factors: lupus anticoagulant (by RVVT confirm); low C3; and C4d bound to platelets.…
Abstract Number: 2887 • 2019 ACR/ARP Annual Meeting
Cell-bound Complement Activation Products in Combination with Low Complement C3 or C4 Have Superior Diagnostic Performance in Systemic Lupus Erythematosus
Sonali Narain¹, Daniel Wallace ², Chaim Putterman ³, Cristina Arriens ⁴, Anca Askanase ⁵, Kenneth Kalunian ⁶, Christopher Collins ⁷, Amit Saxena ⁸, Elena Massarotti ⁹, Roberta Alexander ¹⁰, Claudia Ibarra ¹⁰, Tyler O'Malley ¹¹, John Conklin ¹⁰, Rosalind Ramsey-Goldman ¹², Joseph Ahearn ¹³, Susan Manzi ¹³, Arthur Weinstein ¹⁰ and Thierry Dervieux ¹⁰, ¹Northwell Health, Great Neck, Long Island, NY, ²Cedars Sinai Medical Center/UCLA, Los Angeles, CA, ³Albert Einstein College of Medicine, New York, NY, ⁴Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Columbia University, New York, ⁶Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, CA, ⁷MedStar Washington Hospital Center, Department of Rheumatology, Washington, DC, ⁸New York University School of Medicine, New York, NY, ⁹Brigham and Women's Hospital/Harvard Medical School, Boston, MA, ¹⁰Exagen, Vista, CA, ¹¹Exagen, Oceanside, CA, ¹²Northwestern University, Chicago, IL, ¹³Allegheny Health Network, Pittsburgh
Background/Purpose: Cell-bound complement activation products (CB-CAPs) are stable forms of classical complement activation ex-vivo, with high sensitivity and specificity for systemic lupus erythematosus (SLE). We…
Abstract Number: 931 • 2018 ACR/ARHP Annual Meeting
Patients with Seropositive Rheumatoid Arthritis Who Do Not Mount a CRP Response When They Have Synovitis Are Immunologically Distinct and Are Poorly Served By Current Management Strategies
Thomas McDonnell¹, Claire Bradford², Divya Raj³, Coziana Ciurtin⁴, Elizabeth Jury² and Jessica Manson⁵, ¹Rayne Institute, University College London, London, United Kingdom, ²Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom, ³Rheumatology, University College London Hospitals NHS Trust, London, United Kingdom, ⁴University College London, London, United Kingdom, ⁵University College London Hospitals NHS Trust, London, United Kingdom
Background/Purpose: An atypical subgroup of patients with seropositive rheumatoid arthritis (RA) has been identified with confirmed synovitis but normal levels of the acute phase protein…
Abstract Number: 1017 • 2018 ACR/ARHP Annual Meeting
Autoantigen Pentraxin-3 Is an Inflammatory Cytokine Storms Suppressor By Switching Monocytes Pyroptosis to Apoptosis in a Complement-Dependent Manner in Rheumatoid Arthritis
Xuan Zhang¹ and Xunyao Wu², ¹Rheumatology, Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College Hospital, beijing, China
Background/Purpose: A delayed diagnoses and therapy of ACPA (Anti cyclic citrullinated peptide antibody)-negative RA patients might be associated with effective serum biomarkers in clinic. Methods:…
Abstract Number: 1098 • 2018 ACR/ARHP Annual Meeting
Comparative Analysis of the Total Proteome of the Skin Lesions from Cutaneous Lupus Erythematosus (CLE) and Dermatomyositis (DM)
Timothy B. Niewold¹, Alexander Meves², Julia S. Lehman³, Karin Popovic-Silwerfeldt⁴, Cristine Charlesworth⁵, Marie Wahren-Herlenius⁶, Elisabet Svenungsson⁷ and Vilija Oke⁸, ¹Colton Center for Autoimmunity, New York University, New York, NY, ²Cancer Cenetr, Dermatology, Mayo Clinic, Rochester, MN, ³Pathology and Dermatology, Mayo Clinic College of Medicine and Science, Rochester, MN, MN, ⁴Department of Clinical Sciences, Dermatology Clinic, Danderyds Hospital,, Stockholm, Sweden, ⁵Mayo Clinic, Rochester, MN, ⁶Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁷Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ⁸Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Cutaneous lupus erythematosus (CLE) and dermatomyositis (DM) are autoimmune diseases. The histopathological pattern of skin involvement can be similar, i.e. interface dermatitis, but the…
Abstract Number: 1708 • 2018 ACR/ARHP Annual Meeting
Serum Complement Regulatory Proteins and Disease Activity of Systemic Lupus Erythematosus
Min-Hua Tseng¹ and Jing-Long Huang², ¹Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ²Medicine, Chang-Gung University, Taoyuan city, Taiwan
Background/Purpose: Although aberrant complement activation is involved in the pathogenesis of systemic lupus erythematosus (SLE), the role of complement regulatory proteins in disease activity of…
Abstract Number: 2030 • 2018 ACR/ARHP Annual Meeting
Patients with Childhood-Onset SLE (cSLE) and Hypertension Have Consistently Higher Serum Concentrations of C3 and C4 Than Those without Hypertension
Evan Mulvihill¹, Stacy P. Ardoin², Susan D Thompson³, Bi Zhou⁴, Gakit Yu⁵, Nora G. Singer⁶, Deborah M. Levy⁷, Hermine I. Brunner⁸, Yee Ling Wu⁹, Haikady Nagaraja¹⁰, Laura E. Schanberg¹¹ and Chack-Yung Yu², ¹Pediatrics and Rheumatology, Nationwide Children's Hospital, Columbus, OH, ²Division of Rheumatology, Nationwide Children’s Hospital, Columbus, OH, ³Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁵Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ⁶Departments of Medicine and Pediatrics, Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH, Cleveland, OH, ⁷Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, ⁸Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁹Department of Microbiology and Immunology, Loyola University Chicago, Chicago, IL, ¹⁰College of Public Health, The Ohio State University, Columbus, OH, ¹¹Duke University Medical Center, Durham, NC
Background/Purpose: Chronic systemic inflammation, mediated in part by complement, and inadequate vascular repair mechanisms affect patients with cSLE from a young age and are associated…
Abstract Number: 670 • 2017 ACR/ARHP Annual Meeting
Membrane Attack Complex (MAC) Deposition in Lupus Nephritis Is Associated with Hypertension and Poor Clinical Response to Treatment
Shudan Wang¹, Ming Wu², Luis Chiriboga³, Briana Zeck⁴ and H. Michael Belmont⁵, ¹Department of Medicine, Division of Rheumatology, New York University School Medicine, New York City, NY, ²New York University School of Medicine, New York, NY, ³Pathology, New York University School Medicine, New York, NY, ⁴Pathology, New York University School Medicine, New York City, NY, ⁵Medicine, New York University School of Medicine, New York, NY
Background/Purpose: LN is characterized by deposition of immune complexes in the kidney. Activation of the classical complement pathway by dsDNA is believed to play a…
Abstract Number: 1077 • 2017 ACR/ARHP Annual Meeting
The Lectin Pathway of the Complement System Is Activated in Patients with Systemic Lupus Erythematosus
Anne Troldborg^1,2, Steffen Thiel³, Marten Trendelenburg⁴, Justa Friebus-Kardash⁵, Josephine Nehring⁵, Rudi Steffensen⁶, Søren Werner Karlskov Hansen⁷, Magdalena Janina Laska¹, Bent Deleuran⁸, Jens Christian Jensenius¹, Anne Voss⁹ and Kristian Stengaard-Pedersen¹⁰, ¹Biomedicine, Aarhus University, Aarhus, Denmark, ²clinical medicine, Aarhus University, Aarhus, Denmark, ³Institute of Biomedicine, Aarhus University, Aarhus, DK, Aarhus, Denmark, ⁴Department of Biomedicine, Division of Internal Medicine, Basel, Switzerland, ⁵University Hospital Basel, Division of Internal Medicine, Basel, Switzerland, ⁶Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, ⁷Department of Cancer and Inflammation Research, University of Souther Denmark, Odense, Denmark, ⁸Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁹Rheumatology, Odense University Hospital, Odense, Denmark, ¹⁰Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: The pathogenesis of Systemic Lupus Erythematosus (SLE) involves complement activation. It is well established that activation of complement through the classical pathway (CP) and…
Abstract Number: 1671 • 2017 ACR/ARHP Annual Meeting
Complement C4 Gene Copy Number Variations Bestow Large Ranges of Serum C4 Protein Levels in Chinese Patients with Systemic Lupus Erythematosus (SLE) and Contribute to Organ and Cardiovascular Damages over Time
Chi Chiu Mok¹, Emily King², Bi Zhou³, Gakit Yu⁴, Yee Ling Wu⁵ and CHACK-YUNG Yu⁶, ¹Rheumatology, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Pediatrics, Nationwide Children's Hospital, Columbus, OH, ³Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁴Center for Molecular and Human Genetics, Nationwide Children's Hospital, Columbus, OH, ⁵Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, ⁶Pediatrics, Ohio State Univ, Columbus, OH
Background/Purpose: Human SLE is characterized by fluctuating serum levels of complement proteins. There are frequent copy number variations (CNVs) of complement C4A and C4B genes…
Abstract Number: 1842 • 2017 ACR/ARHP Annual Meeting
Subsetting Systemic Lupus Erythematosus By Interferon Gene Signatures and Serologies (anti-dsDNA and Low Complement) Uncovers Significant Clinical Diversity
Michelle Petri¹, Steven Watts², Richard Higgs², MaryAnn Morgan-Cox² and Matthew D Linnik³, ¹Medicine (Rheumatology), Division of Rheumatology, Johns Hopkins University School of Medicine, MD, USA, Baltimore, MD, ²Eli Lilly and Company, Indianapolis, IN, ³Immunology, Lilly Biotechnology Center, San Diego, CA
Background/Purpose: Personalized therapy in systemic lupus erythematosus (SLE) will require identifying SLE subsets that will benefit from different targeted therapies. Belimumab, for example, has…