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Abstracts tagged "complement"

  • Abstract Number: 0085 • ACR Convergence 2020

    Classifications of Inflammatory Myopathies: Differentially Expressed Membrane-Bound Complement Regulators Allow Specific Patterns of Membrane Attack Complex Deposition

    Fadi Charouf1, Netanel Karbian1, Itamar Altman1, Yakov Fellig1 and Dror Mevorach1, 1Hadassah-University Hospital, Jerusalem, Yerushalayim, Israel

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of heterogeneous disorders that typically present with proximal muscle weakness. According to the classification criteria, IMs are…
  • Abstract Number: 0262 • ACR Convergence 2020

    SLE Pregnancies: C4 as Predictor of Flares and Adverse Pregnancy Outcomes

    Francesca Crisafulli1, Laura Andreoli1, Matteo Filippini1, Micaela Fredi1, Maria Chiara Gerardi1, Roberto Gorla2, Maria Grazia Lazzaroni1, Daniele Lini1, Cecilia Nalli2, Marco Taglietti1, Andrea Lojacono3, Sonia Zatti3, Cristina Zanardini3, Franco Franceschini1 and Angela Tincani1, 1Rheumatology and Clinical Immunology Unit, Spedali Civili and University of Brescia, Brescia, Lombardia, Italy, 2Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, Lombardia, Italy, 3Obstetrics and Gynecology Unit, Spedali Civili and University of Brescia, Brescia, Lombardia, Italy

    Background/Purpose: SLE pregnancies have an increased risk of Adverse Pregnancy Outcomes (APO). In clinical practice, low C3 and C4 levels are associated with active disease…
  • Abstract Number: 0528 • ACR Convergence 2020

    The Complex Relationship Between C4b Binding Protein, Warfarin and Antiphospholipid Antibodies

    Giorgia Grosso1, Kerstin Sandholm2, Aleksandra Antovic1, Iva Gunnarsson1, Agneta Zickert1, Anna Vikerfors3, Lennart Truedsson4, Maria Bruzelius1, Bo Nilsson5, Kristina Nilsson Ekdahl5 and Elisabet Svenungsson1, 1Karolinska University Hospital, Stockholm, Sweden, 2Linnaeus Center for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden, 3Swedish Medical Products Agency, Uppsala, Sweden, 4Lunds University, Lund, Sweden, 5Uppsala University, Uppsala, Sweden

    Background/Purpose: C4b Binding Protein (C4BP) is the main inhibitor of the classical complement pathway. Both β2glycoprotein-I (β2GPI), the main antigen in the antiphospholipid syndrome (APS),…
  • Abstract Number: 0938 • ACR Convergence 2020

    Low Preconceptional Complement Level Is Related with an Adverse Obstetric Outcome in a Multicentric Cohort of Pregnancy in Patients with APS and aPL Positivity

    Cecilia Nalli1, Daniele Lini2, Laura Andreoli2, Francesca Crisafulli2, Micaela Fredi2, Maria Grazia Lazzaroni2, Victoria Bitsadze3, Antonia Calligaro4, Valentina Canti5, Roberto Caporali6, Francesco Carubbi7, Cecilia Chighizola8, Paola Conigliaro9, Caterina De Carolis10, Teresa Del Ross4, Maria Favaro4, Maria Gerosa11, Annamaria Iuliano12, Jamilya Khizroeva3, Alexander Makatsariya3, Pierlugi Meroni13, Marta Mosca14, Melissa Padovan15, Roberto Perricone9, Patrizia Rovere-Querini16, Gian Domenico Sebastiani12, Chiara Tani14, Marta Tonello4, Dina Zucchi14, Franco Franceschini17 and Angela Tincani2, 1Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, Lombardia, Italy, 2Rheumatology and Clinical Immunology Unit, Spedali Civili and University of Brescia, Brescia, Lombardia, Italy, 3Department of Obstetrics and Gynecology of I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia, 4Rheumatology Unit, Department of Medicine, University Hospital of Padua, Padua, Italy, 5Immunology, Rheumatology, Allergology and Rare Disease-IRCCS San Raffaele Hospital, Laboratory of Autoimmunity and vascular inflammation San Raffaele, Milan, Italy, 6Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, 7Department of Biotechnological and Applied Clinical Science, Rheumatology Unit, School of Medicine, University of L'Aquila, L'Aquila, Italy, 8Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Experimental Laboratory of Immunorheumatological Researches, Istituto Auxologico Italiano, Milan, Italy, 9Rheumatology, Allergology and Clinical Immunology, Department of "Medicina dei Sistemi", University of Rome Tor Vergata, Rome, Italy, 10Polymedical Center for Prevention of Recurrent Spontaneous Abortion, Rome, Italy, 11Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan, Italy, 12Rheumatology Unit, Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy, 13Division of Rheumatology, ASST.G Pini, Department of Clinical Sciences and Community Health, University of Milan and Istituto Auxologico Italiano, Milan, Italy, 14Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 15UO e Sezione di Reumatologia, Dipartimento di Scienze Mediche, Universita' degli Studi di Ferrara, Ferrara, Italy, 16Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita-Salute San Raffaele - IRCCS Ospedale San Raffaele, Milan, Italy, 17Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy

    Background/Purpose: The role of complement in the aPL related pathology has been widely studied in animal models. aPL can induce fetal loss in experimental animals but…
  • Abstract Number: 1510 • ACR Convergence 2020

    Platelet-bound C4d Is Associated with Platelet Activation and Arterial Thrombotic Events

    Yevgeniya Gartshteyn1, Adam Mor2, Daichi Shimbo2, Leila Khalili3, Teja Kapoor4, Laura Geraldino-Pardilla5, Roberta Vezza Alexander6, Thierry Dervieux7 and Anca Askanase2, 1Columbia University College of Physicians and Surgeons, Glen Rock, NJ, 2Columbia University College of Physicians and Surgeons, New York, NY, 3Columbia University Medical Center, New Haven, CT, 4Columbia University College of Physicians and Surgeons, Leonia, NJ, 5Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, 6Exagen Inc, Vista, CA, 7Prometheus Biosciences Inc, Irvine, CA

    Background/Purpose: Platelets have a well-defined role in arterial thrombosis, and platelet-bound complement activation products (PC4d) correlate with vascular thromboses in patients with Systemic Lupus Erythematosus…
  • Abstract Number: 1636 • ACR Convergence 2020

    8 Years Follow-Up of a Novel Autoinflammatory Disease: CD59 Malfunction Causes Hemolytic Anemia, Recurrent Guillain-Barre Syndrome, and Strokes in Pediatric Populations and Respond Well to Eculizumab and Pozelimab

    Dror Mevorach1 and Netanel Karbian1, 1Hadassah-University Hospital, Jerusalem, Yerushalayim, Israel

    Background/Purpose: In 2013 we have described the first patients with a novel autoinflammatory disease manifested in 4 children with recurrent Guillain-Barre syndrome and hemolytic anemia…
  • Abstract Number: 1670 • ACR Convergence 2020

    Low Copy Number of Long C4 Genes Is a Genetic Risk Factor for Childhood Onset SLE (cSLE) but Is Associated with Higher Age of Disease Onset

    Fatima Barbar-Smiley1, Danlei Zhou2, Joanne Drew2, Bi Zhou2, Cagri Yildirim-Toruner2, Vidya Sivaraman3, Wael Jarjour4, Stacy Ardoin2 and Chack-Yung Yu5, 1Nationwide Children's Hospital/The Ohio State University, Columbus, OH, 2Nationwide Children's Hospital, Columbus, OH, 3Nationwide Children's Hospital, Bexley, OH, 4The Ohio State University, Columbus, OH, 5Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH

    Background/Purpose: Hypocomplementemia is a marked feature of systemic lupus erythematosus (SLE), which may be a result of consumption initiated by immune complexes between self-nuclear antigens…
  • Abstract Number: 1791 • ACR Convergence 2020

    Renal Tubular Complement C9 Deposition Is Associated with Renal Tubular Damage and Fibrosis in Lupus Nephritis

    Shudan Wang1, Ming Wu2, Luis Chiriboga2, Beatrice Goilav3, Shuwei Wang4, Chaim Putterman5, Daniel Schwartz6, James Pullman6, Anna Broder7 and H. Michael Belmont8, 1Montefiore Medical Center / Albert Einstein College of Medicine, Bronx, NY, 2NYU Langone Health, New York, 3The Children’s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, 4Morristown Medical Center, Morristown, NJ, 5Albert Einstein College of Medicine, Bronx, NY, 6Montefiore Medical Center, Bronx, NY, 7Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 8New York University, New York, NY

    Background/Purpose: Tubulointerstitial damage in lupus nephritis (LN) is a strong predictor of progression to chronic kidney disease (CKD) and end stage renal disease (ESRD). While…
  • Abstract Number: 1792 • ACR Convergence 2020

    Platelet-bound C4d Is Associated with an Increased Risk of Arterial and Venous Thromboses in SLE

    Yevgeniya Gartshteyn1, Roberta Vezza Alexander2, John Conklin3, Thierry Dervieux4 and Anca Askanase5, 1Columbia University College of Physicians and Surgeons, Glen Rock, NJ, 2Exagen Inc, Vista, CA, 3Exagen Inc., Vista, CA, 4Prometheus Biosciences Inc, San Diego, CA, 5Columbia University College of Physicians and Surgeons, New York, NY

    Background/Purpose: Platelet-bound complement activation products (PC4d), defined as PC4d20 net mean fluorescent intensity [MFI], or a thrombotic risk score that includes PC4d, C3 and anti-phosphatidylserine/prothrombin…
  • Abstract Number: 1797 • ACR Convergence 2020

    A Multianalyte Assay Panel (MAP) with Algorithm Containing Cell-Bound Complement Activation Products (CB-CAPs) Is Superior to Anti-dsDNA and Low Serum Complement Levels in Predicting Transition of Probable Lupus to ACR Classified Lupus Within 2 Years

    Rosalind Ramsey-Goldman1, Roberta Vezza Alexander2, Cristina Arriens3, Sonali Narain4, Elena Massarotti5, Daniel J Wallace6, Amit Saxena7, Christopher Collins8, Chaim Putterman9, Kenneth Kalunian10, Armida Sace2, Rowena LaFon2, JoAnne Ligayon2, John Conklin11 and Arthur Weinstein12, 1Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Exagen Inc, Vista, CA, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Northwell Health, Great Neck, NY, 5Brigham and Women's Hospital, Boston, MA, 6Cedars-Sinai Medical Center, Beverly Hills, CA, 7NYU School of Medicine, New York, 8MedStar Washington Hospital Center, Washington, DC, 9Albert Einstein College of Medicine, Bronx, NY, 10University of California San Diego, La Jolla, CA, 11Exagen Inc., Vista, CA, 12Loma Linda University and Exagen, Inc, Claremont, CA

    Background/Purpose: We reported previously (Ramsey-Goldman et al., Arthritis Rheumatol 2020) that score > 0.8 of a multianalyte assay panel (MAP) with algorithm predicts fulfillment of…
  • Abstract Number: 1801 • ACR Convergence 2020

    An Engineered Extracellular Matrix‐rich Decellularized Substrate Based Podocytes Culture System to Study Intracellular Complement Production and Activation

    Abhigyan Satyam1, Maria Tsokos2 and George Tsokos2, 1Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School, boston, 2Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA

    Background/Purpose: Current technologies do not support long-term cell viability, differentiation and maintenance of podocytes. We developed a biophysical approach, termed macromolecular crowding (MMC), to create…
  • Abstract Number: 1802 • ACR Convergence 2020

    Vitamin D Level: Predictor of SLE Disease Activity in AA Cohort with CLE?

    Ileannette Robledo-Vega1, John Scheinuk2, Emmanuel Pardo2, Ansley Pratt2, Soham Mahato3, Andrew G. Chapple2 and Myriam Guevara4, 1Louisiana State University Health Sciences Center, New Orlenas, LA, 2Louisiana State University, New Orleans, LA, 3LSUHSC School of Public Health, New Orleans, LA, 4Lousiana State University Health Sciences Center, New Orleans, LA

    Background/Purpose: There are few predominant African American (AA) epidemiological studies in Cutaneous Lupus Erythematosus (CLE). The Gilliam classification divides CLE into lupus specific, acute cutaneous…
  • Abstract Number: 1808 • ACR Convergence 2020

    Erythrocyte Complement Receptor 1 (ECR1) and Erythrocyte Bound C4d (EC4d) Associate with Adverse Pregnancy Outcomes and Preeclampsia in Pregnant Women with Systemic Lupus Erythematosus (SLE)

    Jill Buyon1, John Conklin2, Michael Golpanian1, JoAnne Ligayon3, Thierry Dervieux4, Peter Izmirly1, H. Michael Belmont1, Jane Salmon5 and Roberta Vezza Alexander3, 1New York University, New York, NY, 2Exagen Inc., Vista, CA, 3Exagen Inc, Vista, CA, 4Exagen Inc, San Diego, CA, 5Hospital for Special Surgery, New York, NY

    Background/Purpose: Despite improvement in management and outcomes of pregnancies complicated by SLE, the risk of adverse events and preeclampsia (PE) continues to exceed that of…
  • Abstract Number: 1810 • ACR Convergence 2020

    Complement Activation in Systemic Lupus Erythematosus Patients with Low Disease Activity Is Not Inhibited by Hydroxychloroquine

    Anne Margrethe Troldborg1, Annette Hansen2, Kristian Stengaard-Pedersen2 and Steffen Thiel2, 1Aarhus University Hospital, Arhus, Denmark, 2Aarhus University, Aarhus, Denmark

    Background/Purpose: Mortality in patients with systemic lupus erythematosus (SLE) is significantly higher than in the general population. Treatment of SLE patients has improved, however, a…
  • Abstract Number: 1814 • ACR Convergence 2020

    The Association of Urinary Membrane Attack Complex (C5b-9) with Proteinuria and Glomerular Activity in Lupus Nephritis

    Shudan Wang1, Erica Moore2, Brianna Lally3, Beatrice Goilav4, Chaim Putterman3 and Anna Broder5, 1Montefiore Medical Center / Albert Einstein College of Medicine, Bronx, NY, 2Albert Einstein College of Medicine, Bronx, 3Albert Einstein College of Medicine, Bronx, NY, 4The Children’s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, 5Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY

    Background/Purpose: Complement activation is known to play a major role in lupus nephritis (LN). Urinary membrane attack complex (C5b-9) has been shown to correlate with…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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