ACR Meeting Abstracts

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Abstracts tagged "Collagen"

  • Abstract Number: 2035 • 2018 ACR/ARHP Annual Meeting

    Effect of Baricitinib on Joint-Related Biomarkers in Patients with Moderate-to-Severe Rheumatoid Arthritis

    Christian S. Thudium1, Anne C. Bay-Jensen1, Suntara Cahya2, Ernst R. Dow2, Morten A. Karsdal1, Alisa E. Koch2, Wenling Zhang2 and Robert J. Benschop2, 1Nordic Bioscience, Herlev, Denmark, 2Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Baricitinib (bari) is an oral selective inhibitor of Janus kinase (JAK) 1 and JAK2. In the phase 3 study RA-BUILD (NCT01721057), once-daily bari yielded…
  • Abstract Number: 44 • 2018 ACR/ARHP Annual Meeting

    Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target in Patients with Rheumatoid Arthritis

    Lisa Goschl1, Victoria Saferding2, Johan Bäcklund3, Clemens Scheinecker4, Josef S. Smolen5, Günter Steiner6, Wilfried Ellmeier1 and Michael Bonelli7, 1Medical University of Vienna,Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, 2Medical University of Vienna, Austria, Vienna, Austria, 3Karolinska Institute,Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, 4Medical University of Vienna, Divison of Rheumatology, Vienna, Austria, 5Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 6Division of Rheumatology, Department of Internal Medicine III, Medical University Vienna, Austria, Vienna, Austria, 7Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Despite enormous efforts to develop new therapeutic strategies for treatment of rheumatoid arthritis (RA), the large number of non responding patients to currently available…
  • Abstract Number: 46 • 2018 ACR/ARHP Annual Meeting

    Organic Dust Inhalants Shift Immune Responses and Extracellular Matrix Balance between Synovium and Lung in the Collagen-Induced Arthritis Mouse Model

    Michael J. Duryee1, Jill Poole2, Amy Nelson3, Katherine Janike2, Lynell W. Klassen4, James R. O'Dell4, Bryant R. England5, Ted R. Mikuls6 and Geoffrey M. Thiele7, 1Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2Medicine, University of Nebraska Medical Center, Omaha, NE, 3Department of Medicine, University of Nebrasa Medical Center, Omaha, NE, 4Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 5Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, 6Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 7University of Nebraska Medical Center, Omaha, NE

    Background/Purpose:   Emerging evidence suggests that the lungs may be an initiating site of autoimmunity leading to RA with organic inhalant exposures such as those…
  • Abstract Number: 58 • 2018 ACR/ARHP Annual Meeting

    Inhibition of Lipid Phosphatase SHIP1 Expands Myeloid-Derived Suppressor Cells and Attenuates Rheumatoid Arthritis in Mice

    Eui Young So1, Changqi Sun2, Patrycja M Dubielecka1, Anthony M. Reginato3 and Olin D. Liang1, 1Division of Hematology/Oncology, Rhode Island Hospital, Providence, RI, 2Division of Rheumatology, Rhode Island Hosital/The Warren Alpert School of Medicine of Brown University, Providence, RI, 3Division of Rheumatology, Rhode Island Hospital, Providence, RI

    Background/Purpose: The SH2-containing inositol-5’-phosphatase-1 (SHIP1) controls PI3K initiated signaling by limiting membrane recruitment and activation of AKT. SHIP1 knockout in mice leads to an increase…
  • Abstract Number: 465 • 2017 ACR/ARHP Annual Meeting

    Basement Membrane Remodeling in Rheumatoid Arthritis Associates with Disease Activity, Response to IL-6 Inhibitor Treatment and Radiographic Progression: Analysis of Two Phase III Clinical Trials

    Natasja Stæhr Gudman1, Pernille Juhl1, Christian S. Thudium2, Peter Junker3, Anne Sofie Siebuhr4, Inger Byrjalsen1, Morten Karsdal5 and Anne C. Bay-Jensen4, 1Nordic Bioscience, Herlev, Denmark, 2Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 3Department of Rheumatology C, Odense University Hospital, Odense, Denmark, 4Rheumatology, Nordic Bioscience, Herlev, Denmark, 5Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is associated with neovascularization of the synovial membrane and increased risk of cardiovascular co-morbidity. The extra cellular matrix below the endothelial…
  • Abstract Number: 489 • 2017 ACR/ARHP Annual Meeting

    Endotypic Clustering of Rheumatoid Arthritis Patients through the Use of Tissue Specific Serum Biomarkers Identifies Structural Progressors

    Joseph Patrick Michele Blair1, Cecilie Liv Bager1, Line Mærsk Staunstrup1, Henning Bay Nielsen1, Morten Karsdal2 and Anne-C. Bay-Jensen3, 1ProScion, Herlev, Denmark, 2Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, 3Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Treatment of RA patients is guided by measures of disease activity such as DAS28, best practice recommendation, and less often by a treat-to-target approach.…
  • Abstract Number: 762 • 2017 ACR/ARHP Annual Meeting

    M10, a Caspase Cleavage Product of the Hepatocyte Growth Factor Receptor, Downregulates Bone Morphogenetic Protein-9-Induced Smad1/5/8 Phosphorylation and Collagen Production in Human Lung Fibroblasts

    Atsushi Noguchi, Ilia Atanelishvili, Tanjina Akter, Richard M. Silver and Galina S. Bogatkevich, Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: We recently identified M10, a caspase cleavage product of the hepatocyte growth factor receptor, as an anti-fibrotic peptide that interacts with Smad2 and inhibits…
  • Abstract Number: 1226 • 2017 ACR/ARHP Annual Meeting

    Association of Dorsal Flat Vertebra/Platyspondylia As a Form of Vertebral Dysplasia within Type II Collage Disorders

    Pilar Ahijado-Guzman1, Raul Veiga2, Miguel Cantalejo1, Justo Ruiz3 and Antonio Zapatero3, 1Rheumatology Unit. Fuenlabrada’s Hospital, Madrid, Madrid, Spain, 2Rheumatology Unit. Fuenlabrada’s Hospital, Madrid, Fuenlabrada, Spain, 3Department of Internal Medicine. Fuenlabrada’s Hospital, Madrid, Madrid, Spain

    Background/Purpose: Defects in the type II collagen gene are described. These predispose humans to various phenotypic combinations in families with skeletal dysplasia, and/or disease by…
  • Abstract Number: 1725 • 2017 ACR/ARHP Annual Meeting

    Insulin-like Growth Factor Binding Protein-4 Exerts Anti-Fibrotic Effects and Its Levels Are Reduced in SSc-Associated Lung Fibrosis

    Yunyun Su1, Stanley Hoffman2 and Carol A. Feghali-Bostwick3, 1Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, charleston, SC, 2Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 3Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC

    Background/Purpose: The Insulin-like growth factor (IGF) system plays an important role in cellular growth, proliferation, differentiation, apoptosis and transformation; IGF binding proteins (IGFBP) exert cell…
  • Abstract Number: 1930 • 2017 ACR/ARHP Annual Meeting

    Interleukin 1β Decreases Capacity for Repair Human Cartilage Lesions By Mesenchymal Stromal Cells on Collagen/Proteoglycan Scaffolds

    Clara Sanjurjo-Rodríguez1, ROCÍO CASTRO-VIÑUELAS2, Tamara Hermida-Gómez3, ISAAC FUENTES BOQUETE4, Francisco Javier De Toro Santos5, Francisco J Blanco6 and SILVIA MARIA DÍAZ-PRADO4, 1of Biomedical Sciences, Medicine and Physiotherapy., Cell Therapy and Regenerative Medicine Group. Universidade da Coruña. INIBIC. CIBER-BBN., A CORUÑA, Spain, 2Biomedical Sciences. Medicine and Physiotherapy, Cell Therapy and Regenerative Medicine Group. Universidade da Coruña. INIBIC., A CORUÑA, Spain, 3Rheumatology, INIBIC. Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. CIBER-BBN., A Coruña, Spain, 4Biomedical Sciences, Medicine and Physiotherapy, Cell Therapy and Regenerative Medicine Group. Universidade da Coruña. INIBIC. CIBER-BBN., A CORUÑA, Spain, 5Reumatology, Cell Therapy and Regenerative Medicine Group. Universidade da Coruña. INIBIC. CIBER-BBN. Complejo Hospitalario Universitario A Coruña (SERGAS)., La Coruña, Spain, 6Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain

    Background/Purpose: There is controversy about the effect of catabolic cytokines in regenerative medicine. The purpose of this study was to evaluate the effect of interleukin…
  • Abstract Number: 2688 • 2017 ACR/ARHP Annual Meeting

    Collagen Metabolite Biomarker Levels Are Associated with the Amount of Fibrosis in Internal Organs in Systemic Sclerosis Patients

    Anne Sofie Siebuhr1, Satoshi Kubo2, Pernille Juhl3, K Nakano4, S Nakayamada5, Morten Karsdal6, Anne-C. Bay-Jensen7 and Yoshiya Tanaka8, 1the first department of internal medicine, University of occupational and environmental health, Fukuoka, Japan, 2The first department of internal medicine, University of Occupational en environmental Health, Fukuoka, Japan, 3Nordic Bioscience, Herlev, Denmark, 4the first department of internal medicin, University of occupational and environmental health, fukuoka, Japan, 5The first department of internal medicine, University of Occupational and environmental Health, fukuoka, Japan, 6Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, 7Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark, 8The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

    Background/Purpose: Biomarkers that can monitor the fibrotic burden will aid in trial enrichment and personalized health care in SSc. SSc is associated with internal organ…
  • Abstract Number: 1103 • 2016 ACR/ARHP Annual Meeting

    Gingival Tissue-Derived MSC Cells (GMSC) Suppress Osteoclastogenesis and Bone Erosion in Collagen-Induced Arthritis Thought CD73 Signal Pathway

    Yongjiang Zheng1,2, Julie Wang3, Nancy J. Olsen4, Limin Rong1 and Song Guo Zheng4,5, 1Center for Clinic Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, 2Medicine, Penn State University Hershey Medical Center, Hershey, PA, 3Medicine, Penn State Hershey Medical Center, Hershey, PA, 4Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA, 5Medicine/Rheumatology, Penn State University Milton S. Hershey Medical Center, Hershey, PA

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic inflammatory synovitis leading to joint destruction and systemic bone loss. Osteoclasts are responsible for bone destruction in…
  • Abstract Number: 1455 • 2016 ACR/ARHP Annual Meeting

    Collagen-Induced Arthritis and Uveitis in Mice Lacking TNF Receptors

    Chiharu Iwahashi1, Minoru Fujimoto2, Tomoharu Ohkawara3, Hayato Urushima1, Satoshi Serada1 and Tetsuji Naka4, 1Laboratory for Immune Signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan, 2Laboratry of immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan, 3Laboratory for immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan, 4Laboratory for immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan

    Background/Purpose: Tumor necrosis factor (TNF) is a critical effector of the autoimmune inflammation in rheumatoid arthritis (RA) and uveitis. TNF inhibitors are preferably used in…
  • Abstract Number: 1652 • 2016 ACR/ARHP Annual Meeting

    Basement Membrane Remodeling Is Significantly Increased with Rheumatoid Arthritis and Suppressed By IL6 Inhibition: Analysis of Two Phase III Clinical Trial

    Natasja Stæhr Gudman1, Pernille Juhl2, Christian S. Thudium3, Anne Sofie Siebuhr4, Inger Byrjalsen5, Morten Asser Karsdal4 and Anne C. Bay-Jensen4, 1Nordic Bioscience A/S, Herlev, Denmark, 2Biomarkers & Research, Nordic Bioscience, Herlev, Denmark, 3Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 4Rheumatology, Nordic Bioscience, Herlev, Denmark, 5Nordic Bioscience, Clinical Development, Herlev, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is associated with neovascularization of the synovial membrane and increased risk of cardiovascular disease, consequent to vascular and endothelial dysfunction, which…
  • Abstract Number: 1857 • 2016 ACR/ARHP Annual Meeting

    A Novel Highly Selective 5-Hydroxytryptamine 2B (5-HT2B) Receptor Antagonist Ameliorating Fibrosis in Preclinical Models of Systemic Sclerosis

    Christina Wenglén1, Lars Pettersson2, Helena Arozenius2 and Gunilla Ekström1, 1R&D, AnaMar AB, Lund, Sweden, 2AnaMar AB, Lund, Sweden

    Background/Purpose:   Methods:   Results:   Conclusion: The results demonstrate that the 5-HT2B receptor antagonist AM1125 prevents pro-fibrotic events in human dermal fibroblasts and attenuates…
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