ACR Meeting Abstracts

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Abstracts tagged "Collagen"

  • Abstract Number: 2070 • 2016 ACR/ARHP Annual Meeting

    Long Noncoding RNA H19X Is a Master Regulator of Extracellular Matrix Production in Systemic Sclerosis and Other Fibrotic Disease

    Elena Pachera1, Shervin Assassi2, Gloria Salazar2, Mojca Frank Bertoncelj1, Rucsandra Dobrota1, Matthias Brock3, Fina Kurreeman4, Jeska K. de Vries-Bouwstra4, Tobias Messemaker4, Carol Feghali-Bostwick5, Jeorg HW Distler6, Gabriela Kania1 and Oliver Distler1, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Department of Internal Medicine - Rheumatology, University of Texas-McGovern Medical School, Houston, TX, 3Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 6Internal Medicine 3, University of Erlangen, Erlangen, Germany

    Background/Purpose:  Long noncoding RNAs (lncRNAs) are an emerging class of large noncoding transcripts involved in the regulation of gene expression in health and disease. We…
  • Abstract Number: 1147 • 2015 ACR/ARHP Annual Meeting

    TGFß1 Blocks Chondrocyte Hypertrophy and Increases Cell Viability in Cultured Cartilage Explants but Does Not Protect Against Proteoglycan Loss

    Arjan van Caam, Wojciech Madej, Henk van Beuningen, Esmeralda Blaney Davidson and Peter van der Kraan, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: In osteoarthritis, cartilage degradation is partly due to chondrocytes gaining a hypertrophy-like phenotype. TGFβ1 is considered to be a protective factor for articular cartilage by blocking…
  • Abstract Number: 2570 • 2015 ACR/ARHP Annual Meeting

    Comparative Analysis of Collagen-Antibody Induced Arthritis and the  Arthritis Inhibitory Potential of Specific ACPA in Two Mouse Subspecies Genetically Separated about One Million Years Ago

    Christina Grimm1, Bianka Marklein1, Zoltan Konthur2, Gerd Burmester1 and Karl Skriner1, 1Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is believed to be induced by environmental, genetic and immunological factors. Monoclonal Anti-citrullinated protein/peptide autoantibodies (ACPA) target different citrullinated proteins years…
  • Abstract Number: 1742 • 2015 ACR/ARHP Annual Meeting

    Fingerprint Biomarkers of Type I and III Collagen in Axial Spondyloarthropathy (axSpA) and Psoriatic Arthritis (PsA). Association with Disease Activity and Diagnostic Capacity

    Natasja Stæhr Gudman1, Anne Friesgaard Christensen2, Grith Lykke Sørensen3, Anne C. Bay-Jensen4, Anne Sofie Siebuhr5, Morten Asser Karsdal6, Heidi Lausten Munk7, Leif Ejstrup8, Anne Gitte Loft9 and Peter Junker10, 1Nordic Bioscience A/S, Herlev, Denmark, 2Rheumatology, Odense University Hospital, Odense, Denmark, 3Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark, 4Biomarkers and Research, Rheumatology, Nordic Bioscience, Herlev, Denmark, 5Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 6Research & Development, Nordic Bioscience, Herlev, Denmark, 7Department of Rheumatology, Odense University Hospital, Odense, Denmark, 8Odense University Hosp, SDR Blvd, Odense, Denmark, 9Department of Rheumatology, Vejle Hospital, Vejle, Denmark, 10University of Southern Denmark, Odense, Denmark

    Background/Purpose: AxSpA and PsA are core members of the spondyloarthritis complex. One cardinal characteristic shared by these two conditions is increased remodeling of bone and…
  • Abstract Number: 1671 • 2015 ACR/ARHP Annual Meeting

    Discovery of PRN1008, a Novel, Reversible Covalent BTK Inhibitor in Clinical Development for Rheumatoid Arthritis

    Ronald J. Hill1, Patrick Smith2, Janakan Krishnarajah3, J. Michael Bradshaw1, Mohammad Masjedizadeh1, Angelina Bisconte1, Dane Karr1, Timothy D. Owens1, Ken Brameld1, Jens Oliver Funk1, David M. Goldstein1, Philip A. Nunn1 and Steven G. Gourlay1, 1Principia Biopharma, South San Francisco, CA, 2d3 Medicine, Parsippany, NJ, 3Linear Research Pty Ltd, Perth, Australia

    Background/Purpose: There is strong pre-clinical validation for Bruton’s Tyrosine Kinase (BTK) as a therapeutic target for autoimmune diseases based on multiple animal models. Principia discovered…
  • Abstract Number: 1306 • 2015 ACR/ARHP Annual Meeting

    MRI Erosions in Undifferentiated Arthritis. Different Associations with the Collagen IIA N-Terminal Propeptide (PIIANP) and Galectin-3 in Pre-RA and Other Arthritides

    Saida Farah Issa1, Anne Duer2, Mikkel Østergaard3, Hanne Lindegaard1, Kim Hørslev-Petersen4, Merete Lund Hetland5, Jakob M. Møller6, Anne Friesgaard Christensen7 and Peter Junker1, 1Department of Rheumatology, Odense University Hospital, Odense, Denmark, 2Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark, 3Center for Rheumatology and Spine Diseases, Glostrup Hospital, Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, University of Copenhagen, Denmark, Glostrup, Denmark, 4Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, 5DANBIO, Center for Rheumatology and Spine Diseases, Glostrup Univ Hospital, Glostrup, Denmark, 6Department of Radiology, Copenhagen University Hospital Herlev, Herlev, Denmark, 7Department of Rheumatology, Vejle Hospital, Vejle, Denmark

    Background/Purpose: Galectin-3 has been implicated as a mediator of inflammation and erosive progression in animal arthritis and rheumatoid arthritis(RA). The type IIA procollagen peptide(PIIANP) is…
  • Abstract Number: 1729 • 2014 ACR/ARHP Annual Meeting

    Adenosine A2A Receptor (A2AR) Promotes Collagen Type 3 Expression Via β-Catenin Activation

    Miguel Perez-Aso1 and Bruce N. Cronstein2, 1545 1st Ave., New York University, New York City, NY, 2NYU School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose A2AR stimulation promotes collagen 1 and 3 (Col1 and Col3) synthesis, principal mediators of fibrosis and scarring. We have recently demonstrated that the A2AR…
  • Abstract Number: 1722 • 2014 ACR/ARHP Annual Meeting

    TLR4 and TLR7 Are Required for Gadolinium Based Contrast Agent Induction of Dermal and Pulmonary Fibrosis in an Adenine-Induced Model of Chronic Renal Failure

    Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA

    Background/Purpose : Nephrogenic Systemic Fibrosis (NSF) is a generalized progressive fibrotic disorder that occurs in some patients with renal insufficiency exposed to various gadolinium based…
  • Abstract Number: 1137 • 2014 ACR/ARHP Annual Meeting

    Multiway Transcriptomic Analysis of Monocyte-Derived Dendritic Cells Discriminates Effects of Disease and of HLA-B27 in Spondyloarthritis

    Emmanuel Chaplais1, Alice Talpin2, Félicie Costantino1, Clémence Desjardin1, Nelly Bonilla2, Ariane Leboime3, Roula Said Nahal4, Franck Letourneur2, Jacques Sébastien2, Gilles Chiocchia5, Maxime Breban1 and Henri-Jean Garchon1, 1INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, 2INSERM U1016, Cochin Institute, Paris, France, 3Rheumatology Division, Ambroise-Paré Hospital AP-HP, Boulogne-Billancourt, France, 4Service de Rhumatologie, Hopital Ambroise Pare, Boulogne-Billancourt, France, 5Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France

    Background/Purpose Spondyloarthritis (SpA) etiology is largely multifactorial with a genetic component dominated by the long-known strong association with the HLA-B27 allele. This allele, however, is…
  • Abstract Number: 1026 • 2014 ACR/ARHP Annual Meeting

    Monosodium Urate Monohydrate Crystals Induces the Expression of Ihh and MMP-13 in ATDC5 Cells: Implications in Osteoarthritis (OA) Development.

    Melissa Ramirez1, Josh Potvin1, Diana Ramirez2 and Anthony M. Reginato3, 1Division of Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI, 2Department of Orthopaedic Surgery, The Warren Alpert School of Medicine at Brown University, Providence, RI, 3Rheumatology, The Warren Alpert School of Medicine at Brown University, Providence, RI

    Background/Purpose: Cartilage damage is often observed in affected joints with advance gout1. Musculoskeletal ultrasound studies have highlighted the close relationship between monosodium urate (MSU) crystals…
  • Abstract Number: 964 • 2014 ACR/ARHP Annual Meeting

    Skin Collagen Synthesis Rates Distinguish Between Early and Late Diffuse Scleroderma Patients

    Claire Emson1, Martin Decaris1, Michelle Gatmaitan1, Flora Luo1, Dan Holochwost1, Simplicia FloraCruz1, Thomas Angel1, Kelvin Li1, Marc Hellerstein1, Fredrick M. Wigley2, Scott Turner1,3 and Francesco Boin2, 1KineMed Inc., Emeryville, CA, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 35980 Horton Street, Suite 470, KineMed Inc., Emeryville, CA

    Background/Purpose The synthesis and degradation of extracellular matrix (ECM), particularly collagen, is one of the central mechanisms perturbed in scleroderma (SSc). Understanding the kinetics of…
  • Abstract Number: 629 • 2014 ACR/ARHP Annual Meeting

    Biomarkers of Chondrocyte Activity Are Increased in Psoriasis Arthritis and Spondyloarthritis

    Natasja Stæhr Gudman1, Heidi Lausten Munk2, Anne Friesgaard Christensen3, Leif Ejstrup4, Grith Lykke Sørensen5, Anne Gitte Loft3, Morten A. Karsdal6, Anne C. Bay-Jensen7, Yi He8, Anne Sofie Siebuhr9 and Peter Junker2, 1Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 2Department of Rheumatology, Odense University Hospital, Odense, Denmark, 3Department of Rheumatology, Vejle Hospital, Vejle, Denmark, 4Department of Rheumatology, Esbjerg Hospital, Esbjerg, Denmark, 5Cardiovascular and Renal Research, Institute of Molecular Medicin, University of Southern Denmark, Odense, Denmark, 6Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 7Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 8Nordic Bioscience, Herlev, Denmark, 9Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark

    Background/Purpose: Psoriasis arthritis (PsA) and spondyloarthritis (SpA) are both inflammatory joint diseases in which the pathogenesis is not fully understood. However, both pathologies are associated…
  • Abstract Number: 879 • 2013 ACR/ARHP Annual Meeting

    Serological Biomarkers Of Specific Mode Of Action For Early Identification Of Rheumatoid Arthritis Patients Who Respond To Anti-IL6 Or Anti-TNF Treatment

    Anne C. Bay-Jensen1, Natasja Stæhr Gudman2, Anne Sofie Siebuhr1, Claus Christiansen3 and Morten Asser Karsdal2, 1Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 3Nordic Bioscience, Herlev, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized debilitating joint destruction, if not treated aggressively in the patient in most need of treatment. …
  • Abstract Number: 652 • 2013 ACR/ARHP Annual Meeting

    Pirfenidone and BIBF1120 Suppress Collagen Synthesis In Skin Fibroblast From Patients With Systemic Sclerosis

    Yuko Ota1, Yasushi Kawaguchi1, Kae Takagi1, Hisae Ichida1, Yasuhiro Katsumata1, Takahisa Gono1, Yuko Okamoto1, Tomoaki Higuchi2, Hidenaga Kawasumi1 and Hisashi Yamanaka1, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Institute Of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: Pirfenidone (5-methyle-1-phenyl-2- [1H]-pyridone) and BIBF1120 (Nintedanib) are currently evaluated in clinical trials as a potential idiopathic pulmonary fibrosis (IPF). Pirfenidone was approved as the…
  • Abstract Number: 657 • 2013 ACR/ARHP Annual Meeting

    Lipoic Acid Plays a Crucial Role In Scleroderma Dermal Fibroblasts

    Pei-Suen Tsou1, Beatrix Balogh2, Adam J. Pinney2, George Zakhem2, Ann Kendzicky2, Elena Schiopu3, Dinesh Khanna4, David A. Fox5 and Alisa E. Koch5,6, 1Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2University of Michigan Medical School, Ann Arbor, MI, 3Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 4Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 5Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 6VA Medical Service, Ann Arbor, MI

    Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by vasculopathy and fibrosis of the skin and organs. Increase in oxidative stress and platelet-derived…
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