Abstract Number: 1742 • 2015 ACR/ARHP Annual Meeting
Fingerprint Biomarkers of Type I and III Collagen in Axial Spondyloarthropathy (axSpA) and Psoriatic Arthritis (PsA). Association with Disease Activity and Diagnostic Capacity
Background/Purpose: AxSpA and PsA are core members of the spondyloarthritis complex. One cardinal characteristic shared by these two conditions is increased remodeling of bone and…Abstract Number: 1671 • 2015 ACR/ARHP Annual Meeting
Discovery of PRN1008, a Novel, Reversible Covalent BTK Inhibitor in Clinical Development for Rheumatoid Arthritis
Background/Purpose: There is strong pre-clinical validation for Bruton’s Tyrosine Kinase (BTK) as a therapeutic target for autoimmune diseases based on multiple animal models. Principia discovered…Abstract Number: 1306 • 2015 ACR/ARHP Annual Meeting
MRI Erosions in Undifferentiated Arthritis. Different Associations with the Collagen IIA N-Terminal Propeptide (PIIANP) and Galectin-3 in Pre-RA and Other Arthritides
Background/Purpose: Galectin-3 has been implicated as a mediator of inflammation and erosive progression in animal arthritis and rheumatoid arthritis(RA). The type IIA procollagen peptide(PIIANP) is…Abstract Number: 1729 • 2014 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A2AR) Promotes Collagen Type 3 Expression Via β-Catenin Activation
Background/Purpose A2AR stimulation promotes collagen 1 and 3 (Col1 and Col3) synthesis, principal mediators of fibrosis and scarring. We have recently demonstrated that the A2AR…Abstract Number: 1722 • 2014 ACR/ARHP Annual Meeting
TLR4 and TLR7 Are Required for Gadolinium Based Contrast Agent Induction of Dermal and Pulmonary Fibrosis in an Adenine-Induced Model of Chronic Renal Failure
Background/Purpose : Nephrogenic Systemic Fibrosis (NSF) is a generalized progressive fibrotic disorder that occurs in some patients with renal insufficiency exposed to various gadolinium based…Abstract Number: 1137 • 2014 ACR/ARHP Annual Meeting
Multiway Transcriptomic Analysis of Monocyte-Derived Dendritic Cells Discriminates Effects of Disease and of HLA-B27 in Spondyloarthritis
Background/Purpose Spondyloarthritis (SpA) etiology is largely multifactorial with a genetic component dominated by the long-known strong association with the HLA-B27 allele. This allele, however, is…Abstract Number: 1026 • 2014 ACR/ARHP Annual Meeting
Monosodium Urate Monohydrate Crystals Induces the Expression of Ihh and MMP-13 in ATDC5 Cells: Implications in Osteoarthritis (OA) Development.
Background/Purpose: Cartilage damage is often observed in affected joints with advance gout1. Musculoskeletal ultrasound studies have highlighted the close relationship between monosodium urate (MSU) crystals…Abstract Number: 964 • 2014 ACR/ARHP Annual Meeting
Skin Collagen Synthesis Rates Distinguish Between Early and Late Diffuse Scleroderma Patients
Background/Purpose The synthesis and degradation of extracellular matrix (ECM), particularly collagen, is one of the central mechanisms perturbed in scleroderma (SSc). Understanding the kinetics of…Abstract Number: 629 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Chondrocyte Activity Are Increased in Psoriasis Arthritis and Spondyloarthritis
Background/Purpose: Psoriasis arthritis (PsA) and spondyloarthritis (SpA) are both inflammatory joint diseases in which the pathogenesis is not fully understood. However, both pathologies are associated…Abstract Number: 879 • 2013 ACR/ARHP Annual Meeting
Serological Biomarkers Of Specific Mode Of Action For Early Identification Of Rheumatoid Arthritis Patients Who Respond To Anti-IL6 Or Anti-TNF Treatment
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized debilitating joint destruction, if not treated aggressively in the patient in most need of treatment. …Abstract Number: 652 • 2013 ACR/ARHP Annual Meeting
Pirfenidone and BIBF1120 Suppress Collagen Synthesis In Skin Fibroblast From Patients With Systemic Sclerosis
Background/Purpose: Pirfenidone (5-methyle-1-phenyl-2- [1H]-pyridone) and BIBF1120 (Nintedanib) are currently evaluated in clinical trials as a potential idiopathic pulmonary fibrosis (IPF). Pirfenidone was approved as the…Abstract Number: 657 • 2013 ACR/ARHP Annual Meeting
Lipoic Acid Plays a Crucial Role In Scleroderma Dermal Fibroblasts
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by vasculopathy and fibrosis of the skin and organs. Increase in oxidative stress and platelet-derived…Abstract Number: 248 • 2013 ACR/ARHP Annual Meeting
Hand Osteoarthritis Is Associated With Increased Type II Collagen Degradation In Women: The Ofely Study
Background/Purpose: Hand osteoarthritis (OA) is one of the most common sites of OA and predominantly affects women. Patients with knee, hip or spine OA exhibit…Abstract Number: 61 • 2013 ACR/ARHP Annual Meeting
Epigenome-Wide DNA Methylation Study Reveals Hypermethylated Collagen Genes and Suggests a Role for TGFβ in Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic disability in the U.S., affecting 40% of individuals over the age of 70 and costing $128…Abstract Number: 77 • 2013 ACR/ARHP Annual Meeting
Human Mesenchymal Stem Cells Cultured On Collagen Scaffolds For Cartilage Tissue Engineering
Background/Purpose: Osteoarthritis is a degenerative disease without a treatment. Tissue Engineering could provide an alternative tool for cartilage repair. The aim of this study was…
ACR Meeting Abstracts