Abstracts tagged "Collagen"

Abstract Number: 0029 • ACR Convergence 2022
Characterizing the Anti-fibrotic Effect of Tofacitinib in TGF-β Stimulated Fibroblast-like Synoviocytes from Patients with OA
Sofie Falkenløve Madsen¹, Sarah Madsen², Elle Hollaar³, Thorbjørn Gantzel⁴, Anne-Christine Bay-Jensen³ and Christian Thudium³, ¹University of Copenhagen / Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, University of Copenhagen, Herlev, Denmark, ³Nordic Bioscience, Herlev, Denmark, ⁴Gentofte Hospital, Gentofte, Denmark
Background/Purpose: Many osteoarthritis (OA) patients develop fibrosis of the synovial membrane leading to joint swelling, stiffness, and pain. Synovial fibroblasts activated in the synovial membrane…
Abstract Number: 0620 • ACR Convergence 2022
Neovascularization Is Altered by Rheumatoid Arthritis Synovial Fibroblasts and Canstatin in Vitro and in Vivo
Corinna Heck¹, Daria Kürsammer¹, Klaus Frommer², Mona Arnold³, Stefan Rehart⁴, Ulf Müller-Ladner⁵ and Elena Neumann³, ¹Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Bad Nauheim, Germany, ²Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Bad Nauheim, Germany, ³JLU Gießen, Campus Kerckhoff, Bad Nauheim, Germany, ⁴Agaplesion Markus Hospital, Dpt of Orthopaedics and Trauma Surgery, Frankfurt, Germany, ⁵JLU Campus KK, Bad Nauheim, Germany
Background/Purpose: In the pathogenesis of rheumatoid arthritis (RA), neovascularization is increased in the activated and inflamed synovium. RA synovial fibroblasts (RASF) are key players in…
Abstract Number: 1215 • ACR Convergence 2022
Identifying a Pain Signature in Classical Ehlers-Danlos Syndrome: Preliminary Results from Questionnaires and Experimental Pain Testing
Marlies Colman, Inge De Wandele, Lies Rombaut, Delfien Syx, Fransiska Malfait and Jessica Van Oosterwijck, Ghent University, Ghent, Belgium
Background/Purpose: Chronic pain is one of the most common complaints of individuals with Ehlers-Danlos syndrome (EDS) and the effects of the existing therapeutical modalities are…
Abstract Number: 1610 • ACR Convergence 2022
Are Serological Protease-mediated Peptides of Tissue Remodeling and Inflammation the New Disease Activity Biomarkers in Psoriatic Arthritis Patients?
Solveig S. Groen¹, Signe Holm Nielsen², Anne-Christine Bay-Jensen², Mozhgan Rasti³, Darshini Ganatra³, Katerina Oikonomopoulou³ and Vinod Chandran⁴, ¹Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Schroeder Arthritis Institute, Krembil Research Institute, Toronto, ON, Canada, ⁴Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto/ Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Inflammatory and degenerative processes in the joint tissues are hallmarks of patients with psoriatic arthritis (PsA). Here, proteases play a major role in remodeling…
Abstract Number: 0539 • ACR Convergence 2021
Vgll3-transgenic Autoimmune Mice Display Features of Cutaneous Fibrosis
Mehrnaz Gharaee-Kermani¹, Allison Billi², Marisa Hildebrandt², Jacob Martens³, Rachael Wasikowski², Joanne (Michelle) Kahlenberg¹ and Johann Gudjonsson², ¹Internal Medicine - Division of Rheumatology and Department of Dermatology, University of Michigan, Ann Arbor, MI, ²Department of Dermatology, University of Michigan, Ann Arbor, MI, ³Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, MI
Background/Purpose: Fibrosis is characterized by collagen deposition, fibro/myofibroblast accumulation, and extracellular matrix remodeling and can lead to disfiguring skin changes. In cutaneous lupus, scar formation…
Abstract Number: 1128 • ACR Convergence 2021
Inter-relationships Between Multiple Joint Osteoarthritis and Collagen Biomarkers in Men: The Johnston County Osteoarthritis Project
Amanda Nelson¹, Liubov Arbeeva¹, Duncan Lascelles², Jordan Renner¹, Yvonne Golightly¹, Morten Karsdal³, Anne-Christine Bay-Jensen³ and Richard Loeser⁴, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²North Carolina State University, Raleigh, NC, ³Nordic Bioscience, Herlev, Denmark, ⁴University of North Carolina, Chapel Hill, NC
Background/Purpose: To determine inter-relationships between blood-based collagen formation and degradation biomarkers and multiple joint osteoarthritis (MJOA) phenotypes in a community-based cohort.Methods: Data were from Johnston…
Abstract Number: 1475 • ACR Convergence 2021
Long Term Compressive Loading Modulates the Extracellular Matrix Response to Growth Factors in Bovine Cartilage Explants
Frederik Gillesberg¹, Amalie Engstrøm¹, Morten Karsdal², Anne-Christine Bay-Jensen³ and Christian S Thudium³, ¹University of Copenhagen, Herlev, Denmark, ²Nordic Bioscience, Herlev, ³Nordic Bioscience, Herlev, Denmark
Background/Purpose: Mechanical loading of cartilage is an essential part of the function and maintenance of the joint. Despite the apparent importance of continuous mechanical loading,…
Abstract Number: 0355 • ACR Convergence 2020
Collagen Turnover Markers Are Associated with Active Psoriatic Arthritis and Decrease with Guselkumab Treatment in a Phase-3 Clinical Trial
Georg Schett¹, Matthew J. Loza², Arumugam Palanichamy², Oliver FitzGerald³, Christopher Ritchlin⁴, Frédéric Baribaud⁵ and Kristen Sweet⁵, ¹Friedrich-Alexander-Universität Erlangen- Nuremberg, Erlangen, Germany, ²Janssen Research & Development, LLC, Spring House, ³Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland, ⁴Department of Medicine, University of Rochester Medical Center, Rochester, NY, ⁵Janssen Research & Development, LLC, Spring House, PA
Background/Purpose: Guselkumab (GUS), an interleukin-23p19-subunit monoclonal antibody, demonstrated efficacy compared to placebo (PBO) in reducing skin and musculoskeletal signs and symptoms in patients with active…
Abstract Number: 0424 • ACR Convergence 2020
Anti-Collagen II Antibodies in Patients with Relapsing Polychondritis
Kristina Wells¹, Marcela Ferrada², Emily Rose², Keith Sikora³, Wendy Goodspeed², Kaitlin Quinn⁴ and Peter C. Grayson⁵, ¹Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, ²Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³National Institutes of Health Clinical Center, Bethesda, MD, ⁴Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Washington, DC, ⁵Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD
Background/Purpose: Relapsing polychondritis (RP) is a highly heterogenous systemic inflammatory disorder that affects many organ systems, in particular, cartilaginous structures. Clinical presentations in RP are…
Abstract Number: 1106 • ACR Convergence 2020
MMP Mediated Type I Collagen Degradation Is Associated with Erosive Hand Osteoarthritis in a Hospital-based Observational Cohort – the NOR-HAND Study
Christian Thudium¹, Neha Sharma², Marthe Gløersen³, Peder Frederiksen², Anne C. Bay-Jensen¹ and Ida Haugen³, ¹Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Herlev, ³Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Hand osteoarthritis (OA) is a common degenerative joint disease affecting mainly the interphalangeal and first carpometacarpal joints. The disease manifests as inflammation and deterioration…
Abstract Number: 1108 • ACR Convergence 2020
Cartilage Biomarkers s-Coll2-1 and s-Coll2-1NO2 Are Associated with Knee Osteoarthritis MRI Features and Predict Disease Worsening
Yves Henrotin¹, Anne-Christine Hick², Berenice Costes³, Alain Labasse³, Thierry Conrozier⁴, Michel Malaise⁵, Yves Maugars⁶, Franz Pelousse⁷, Jean-Marc Lemaire⁸, Cedric Tits⁹, Thibault Helleputte⁹ and Damien Loeuille¹⁰, ¹University of Liège, Liège, Belgium, ²Artialis SA, Liège, Belgium, ³Artialis SA, Liege, Belgium, ⁴5. Department of Rheumatology, Hôpital Nord Franche-Comté, Belfort, France, ⁵University of Liège, Liege, Belgium, ⁶Service de rhumatologie, Hôtel-Dieu, CHU de Nantes, Nantes, France, ⁷SODIRAY, Solution Diagnostique Radiologique, Liège, Belgium, ⁸SODIRAY, Solution Diagnostique Radiologique, Liege, Belgium, ⁹Data-Driven Precision Medicine, DNAlytics, Louvain-la-Neuve, Belgium, ¹⁰CHU NANCY Rheumatology, NANCY
Background/Purpose: To identify if biochemical markers s-Coll2-1, a peptide of type collagen and its nitrated from, s-Coll2-1NO2 are associated to knee osteoarthritis (OA), focusing on…
Abstract Number: 1256 • ACR Convergence 2020
Mast Cells Contribute to the Development of Sialadenitis Associated with Sjögren’s Syndrome via Inducing Tissue Fibrosis by TGFβ Production
Shinjiro Kaieda¹, Kyoko Fujimoto¹ and Hiroaki Ida¹, ¹Kurume University School of Medicine, Kurume, Japan
Background/Purpose: Mast cells have been implicated in many immune-inflammatory disorders. They mediate a variety of inflammatory and fibrotic conditions, but their role in sialadenitis in…
Abstract Number: 1913 • ACR Convergence 2020
Investigation of the Cellular Mechanism for Estradiol-Induced Dermal Fibrosis
DeAnna Baker Frost¹, Alisa Savchenko², Adeyemi Ogunleye³, Milton Armstrong² and Carol Feghali-Bostwick⁴, ¹The Medical University of South Carolina, Charleston, ²Medical University of South Carolina, Charleston, SC, ³University of North Carolina Chapel Hill, Chapel Hill, NC, ⁴The Medical University of South Carolina, Charleston, SC
Background/Purpose: Estradiol (E2), one of the three forms of estrogen, is pro-fibrotic in the skin because it positively influences ECM production in the dermis. In…
Abstract Number: 1040 • 2019 ACR/ARP Annual Meeting
Proposition of a Novel Animal Model of Systemic Sclerosis Induced by Type V Collagen in C57BL/6 Mice Reproducing Fibrosis, Vasculopathy and Autoimmunity
Walcy Teodoro¹, Ana Paula Velosa ², Zelita Aparecida Queiroz ¹, Lais Araujo ³, Sergio Catanozi ¹, Antonio dos Santos Filho ⁴, Cleonice Bueno ⁴, Margarete Vendramini ⁴, Sandra Moraes Fernezlian ¹, Esmeralda Eher ⁴, Jurandir Tomaz de Miranda ¹, Fernanda Lopes ⁴, Sandra G. Pasoto ⁵, Percival Degrava Sampaio-Barros ⁶ and Vera Luiza Capelozzi ¹, ¹Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ²Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, São Paulo, Sao Paulo, Brazil, ³Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, São Paulo, Sao Paulo, Brazil, ⁴Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ⁵Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Brazil, ⁶Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Brazil, Sao Paulo, Brazil
Background/Purpose: A better knowledge of the mechanisms and biomarkers of skin and lung damage in systemic sclerosis (SSc) related fibrosis remain a challenge. Our aim was…
Abstract Number: 1045 • 2018 ACR/ARHP Annual Meeting
The Coll2-1 Peptide of Collagen Type II: A New Actor of Synovitis in Osteoarthritis
Cécile Lambert¹, Didier Borderie², Jean-Emile Dubuc³, François Rannou² and Yves Henrotin^4,5, ¹Bone and Cartilage Research Unit, University of Liege, Liege, Belgium, ²Inserm umr 1124, Laboratory of pharmacology, toxicology and cell signaling, University Paris Descartes, Paris, France, ³Orthopaedic Department, University Clinics St Luc, Brussels, Belgium, ⁴Physical Therapy and Rehabilitation, Princess Paola Hospital, Marche-en-Famenne, Belgium, ⁵Bone and Cartilage Research Unit, University of Liege, Liège, Belgium
Background/Purpose: We evaluated the inflammatory effect of Coll2-1 peptide in osteoarthritic synoviocytes and rats by comparing peptide-induced inflammatory reaction with the one induced by bovine…

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