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Abstracts tagged "citrullination"

  • Abstract Number: 1769 • 2015 ACR/ARHP Annual Meeting

    Role of Topical Administration of Peptidylarginine Deiminase  Inhibitors in Murine Lupus

    Erica Moore1, Huw Lewis2, Carolyne K. Smith1, Venkataraman Subramaniam3, Victoria Hoffmann4, Paul Thompson5 and Mariana J. Kaplan1, 1Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Immuno Inflammation, GSK, Stevenage, United Kingdom, 3University of Massachusetts, Boston, MA, 4ORS, National Institutes of Health, Bethesda, MD, 5University of Massachusetts, Worcester, MA

    Background/Purpose: Peptidylarginine deiminases (PADs), specifically PAD4,  have recently been implicated in the pathogenesis of systemic lupus erythematosus (SLE) through their role in citrullinating histones in…
  • Abstract Number: 1617 • 2015 ACR/ARHP Annual Meeting

    Evidence for Citrullinated Inhibitor of DNA Binding 1 (Id1) As a Novel Autoantigen Candidate in Rheumatoid Arthritis

    Ray A. Ohara1, Gautam Edhayan1, W. Alexander Stinson2, Phillip L. Campbell1, Henriette A. Remmer3, M. Asif Amin1, David A. Fox1 and Jeffrey H. Ruth1, 1Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 3Biomedical Research Core Facilities, Proteomics & Peptide Synthesis Core, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Inhibitor of DNA-binding 1 (Id1) is a nuclear transcription factor actively transcribed in endothelial progenitor cells and in cells that exhibit hyperproliferative responses such…
  • Abstract Number: 1510 • 2015 ACR/ARHP Annual Meeting

    The Association Between HDL Cholesterol Efflux Capacity, Citrullinated ApoA1 and Anti-Citrullinated ApoA1 Antibodies in Rheumatoid Arthritis

    Katherine Liao1, Jing Cui1, Christopher Rhodes2, Lauren J. Lahey2, Martin Playford3, I-Hsin Kuo1, Michelle Frits1, Christine Iannaccone1, Jonathan S. Coblyn4, Michael Weinblatt1, Nancy Shadick5, Nehal N. Mehta3 and Jeremy Sokolove2, 1Division of Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Boston, MA, 2Medicine, VA Palo Alto HealthCare System and Stanford University, Palo Alto, CA, 3NHLBI, National Institutes of Health, Bethesda, MD, 4Brigham & Women's Hospital, Boston, MA, 5Division of Rheumatology, Immunology & Allergy, Brigham & Women's Hospital, Boston, MA

    Background/Purpose: High density lipoprotein (HDL) cholesterol efflux capacity measures how well HDL particles remove cholesterol from lipid-laden macrophages, such as those found in atherosclerotic plaques. …
  • Abstract Number: 1371 • 2015 ACR/ARHP Annual Meeting

    Complement-Mediated Neutrophil Lysis-a Mechanism Promoting Hypercitrullination in Rheumatoid Arthritis?  

    Tal Gazitt1, Christian Lood2, Jeffrey Ledbetter3 and Keith B. Elkon3, 1Rheumatology, University of Washington, Seattle, WA, 2University of Washington, Lund, Sweden, 3Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Protein citrullination, the post-translational conversion of arginine to citrulline, mediated by peptidylarginine deiminase (PAD) enzymes, is considered a likely mechanism for the stimulation of…
  • Abstract Number: 1038 • 2015 ACR/ARHP Annual Meeting

    Tumor Necrosis Factor Alpha and Peptidylarginine Deiminase 4 in Lung and Joint Inflammation

    Mandar Bawadekar1, Annette Gendron-Fitzpatrick2, Thomas F. Warner3, Lennart K.A. Lundblad4, Paul Thompson5 and Miriam A. Shelef1,6, 1Medicine, University of Wisconsin, Madison, WI, 2Comparative Pathology Laboratory of the Research Animal Resources Center and Pathobiological Sciences, University of Wisconsin, Madison, WI, 3Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, 4Medicine, The University of Vermont, Burlington, VT, 5University of Massachusetts, Worcester, MA, 6Medicine, William S. Middleton Memorial Veterans Hospital, Madison, WI

    Background/Purpose: The relationship between lung and joint inflammation in rheumatoid arthritis is poorly understood. About 10% of people with rheumatoid arthritis develop interstitial lung disease…
  • Abstract Number: 1034 • 2015 ACR/ARHP Annual Meeting

    Immunomodulation By a Second-Generation Peptidyl Arginine Deiminase Inhibitor Abrogates Collagen-Induced Arthritis in a Therapeutic Protocol

    Anne-Marie Quirke1, Joanna Kawalkowska2, Fatemeh Ghari3, Venkataraman Subramaniam4, Paul Thompson5, Richard O. Williams1, Nick La Thangue3 and Patrick J. Venables1, 1Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 2Kennedy Institute for Rheumatology, University of Oxford, Oxford, United Kingdom, 3Department of Oncology, University of Oxford, Oxford, United Kingdom, 4Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, 5University of Massachusetts, Worcester, MA

    Background/Purpose: Citrullination is a post translational modification of arginine catalysed by peptidyl arginine deiminases (PADs) and may be important in generating pathogenic autoantibodies to citrullinated…
  • Abstract Number: 444 • 2014 ACR/ARHP Annual Meeting

    Evidence for Citrullination of the Nuclear Transciption Factor Inhibitor of DNA Binding 1 (Id1) in Rheumatoid Arthritis

    Ray A. Ohara1, Gautam Edhayan1, Christine M. Ha1, M. Asif Amin1, Ali S. Arbab2, Phillip L. Campbell3, David A. Fox1 and Jeffrey H. Ruth1, 1Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Georgia Regents University, Augusta, GA, 3Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Citrullination is a post-translational modification mediated by peptidyl arginine deiminase (PAD) enzyme in which arginine is converted to citrulline. Inhibitor of DNA binding 1…
  • Abstract Number: 452 • 2014 ACR/ARHP Annual Meeting

    The Use of Multiplex Bead Array to Follow the Effect of Rituximab on IgG and IgA Serum Autoantibody Responses to Citrullinated Epitopes in Patients with Rheumatoid Arthritis

    Geraldine Cambridge1, Lauren J. Lahey2, Maria J. Leandro1, William H. Robinson2 and Jeremy Sokolove2, 1Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 2VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA

    Background/Purpose The majority of patients with established Rheumatoid arthritis (RA) have autoantibodies against the Fc of IgG (Rheumatoid factors-RhF) and to citrullinated protein antigens (ACPAs).…
  • Abstract Number: 433 • 2014 ACR/ARHP Annual Meeting

    Bronchiectasis: A Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis

    Anne-Marie Quirke1, Elizabeth Perry2, Alison Cartwright1, Clive Kelly3, Anthony De Sozya4,5, Paul Eggleton6, David Hutchinson2 and Patrick Venables7, 1Kennedy Institute, Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Rheumatology, Royal Cornwall Hospital, Truro, United Kingdom, 3Rheumatology, Queen Elizabeth Hospital, Gateshead, United Kingdom, 4Institute for Cellular Medicine, Newcastle University, Newcastle, United Kingdom, 5Sir William Leech Centre, The Freeman Hospital, Newcastle, United Kingdom, 6Medical School, University of Exeter, Exeter, United Kingdom, 7Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom

    Background/Purpose Anti-citrullinated peptide antibodies (ACPA) are associated with smoking in patients with rheumatoid arthritis (RA). Bronchiectasis (BR), which tends to occur in non-smokers, has been…
  • Abstract Number: 361 • 2014 ACR/ARHP Annual Meeting

    Citrullinated 14-3-3η Antibodies Are Specific for Early and Established RA and Are Complementary to ACPA

    Anthony Marotta1, Dirkjan van Schaardenburg2, Gilles Boire3, Désirée van der Heijde4, Robert Landewé5, Maarten Boers6, C.F. Allaart7, Mairead Murphy8, Samina Turk9, Vivian P. Bykerk10, Edward Keystone11, Katherine A. Siminovitch11 and Walter P. Maksymowych12, 11423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada, 2Dr Jan van Breemenstraat 2, Reade, Amsterdam, Netherlands, 3Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, 4Leiden University Medical Center, Leiden, Netherlands, 5Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 6Deapartment of Epidemiology and Biostatistics, Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands, 7Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 8Augurex Life Sciences Corp., North Vancouver, BC, Canada, 9Reade, Amsterdam, Netherlands, 10Divison of Rheumatology, Hospital for Special Surgery, New York, NY, 11Mount Sinai Hospital, Toronto, ON, Canada, 12Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose Citrullination is a post-translational modification whereby arginine (Arg) is deiminated by PAD enzymes to form citrulline (Cit). In RA, current ACPA assays measure the…
  • Abstract Number: 359 • 2014 ACR/ARHP Annual Meeting

    14-3-3η Cit:Arg Antibody Ratios:  Are We Overlooking the Prognostic Utility of Citrullinated Antibodies By Only Looking at Titers?

    Anthony Marotta1, Samina Turk2, Mairead Murphy3, Walter P. Maksymowych4 and Dirkjan van Schaardenburg5, 11423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada, 2Reade, Amsterdam, Netherlands, 3Augurex Life Sciences Corp., North Vancouver, BC, Canada, 4Department of Medicine, University of Alberta, Edmonton, AB, Canada, 5Dr Jan van Breemenstraat 2, Reade, Amsterdam, Netherlands

    Background/Purpose Citrullination is a post-translational modification whereby arginine (Arg) is deiminated by PAD enzymes to form citrulline (Cit). In RA, there are auto-antibodies (AAb) to…
  • Abstract Number: 2426 • 2013 ACR/ARHP Annual Meeting

    Signaling Abnormalities In Neutrophil Granulocytes Of Rheumatoid Arthritis Patients Are Associated With Increased Extracellular Trap Formation and Provide a Basis For The Induction Of Anti-Citrullinated Peptide Antibodies

    Chanchal Sur Chowdhury1, Stavros Giaglis2,3, Ulrich A. Walker4, Andreas Buser5, Paul Hasler2 and Sinuhe Hahn6, 1Dept. of Biomedicine, Laboratory of Prenatal Diagnostics, University Hospital Basel, Basel, Switzerland, 2Dept. of Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, 3Dept. of Biomedicine, Laboratory of Prenatal Madicine, University Hospital Basel, Basel, Switzerland, 4Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, 5Division of Hematology; Swiss Red Cross Blood Transfusion Centre, University Hospital Basel, Basel, Switzerland, 6Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland

    Background/Purpose: Rheumatoid arthritis (RA) is often associated with anti-citrullinated peptide antibodies (ACPAs) in the serum. While ACPAs have been associated with increased inflammation, joint destruction…
  • Abstract Number: 1399 • 2013 ACR/ARHP Annual Meeting

    Citrullinated Proteoglycan (Aggrecan) Present In Human Cartilage Is Recognized By Serum Antibodies From Rheumatoid Arthritis Patients

    Timea Ocsko1, Beata Tryniszewska1, Andras Vida1, Janos Gal2, Gyorgyi Soos2, Zoltan Szekanecz3, Tibor A. Rauch1, Joshua Jacobs1, Tibor T. Glant1 and Katalin Mikecz1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Rheumatology, Bacs-Kiskun County Hospital, Kecskemet, Hungary, 3Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary

    Background/Purpose: Citrullination is a post-translational protein modification, where arginine (Arg) is converted to citrulline (Cit) by peptidyl arginine deiminases (PADI). The presence of anti-citrullinated protein…
  • Abstract Number: 813 • 2013 ACR/ARHP Annual Meeting

    Citrulline Specific CD4+ T Cells Exhibit a Th1 Memory Phenotype In Rheumatoid Arthritis Subjects and Their Ex Vivo Frequency Is Influenced By Both Disease Duration and Biologic Therapy

    Eddie James1, Mary Rieck2, Jennifer Pieper3, John Gebe4, Betty Yue4, Megan Tatum5, Charlotta Sandin6, Lars Klareskog7, Vivianne Malmström8 and Jane Buckner9, 1Benaroya Research Institute, Seattle, WA, 2Translational Research Program, Benaroya Research Institute, Seattle, WA, 3Department of Medicine, Karolinska Institutet, Rheumatology Unit, Stockholm, Sweden, 4Diabetes Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, 5Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, 6Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 7Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 8Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 9Translational Research Program, Benaroya Research Institute, Seattle, WA 98101, USA,, Seattle, WA

    Background/Purpose: Rheumatoid arthritis is thought to be a T cell mediated disease, based on its strong association with HLA class II alleles, clinical responsiveness to…
  • Abstract Number: 774 • 2013 ACR/ARHP Annual Meeting

    Citrullination Of ENA-78/CXCL5 Changes Its Receptor Affinity From CXCR2 To CXCR1 and Induces Monocyte Migration

    Ken Yoshida1, Alisa E. Koch1,2, Ray A. Ohara3, Phillip L. Campbell1, M. Asif Amin1, David A. Fox1 and Jeffrey H. Ruth4, 1Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 2VA Medical Service, Ann Arbor, MI, 3University of Michigan Medical School, Ann Arbor, MI, 4Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: We previously showed that citrullinated epithelial-derived neutrophil-activating peptide 78/CXCL5 (citENA-78/CXCL5) was significantly higher in rheumatoid arthritis (RA) synovial fluids (SFs) compared to osteoarthritis (OA)…
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