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Abstracts tagged "citrullination"

  • Abstract Number: 1070 • 2018 ACR/ARHP Annual Meeting

    Seroreactivity Against Recombinant Citrullinated Myosin Is Associated with Measures of Diastolic Dysfunction in Patients with Rheumatoid Arthritis

    Christian Geier1, Justyna Fert-Bober2, Jon T. Giles1, Cesare Russo1, Sabahat Bokhari3, Aylin Tugcu1, Jenny Van Eyk2 and Joan Bathon1, 1Columbia University, New York, NY, 2Cedars-Sinai Medical Center, Los Angeles, CA, 3Cardiology, Columbia University, New York, NY

    Background/Purpose: Diastolic dysfunction and heart failure with preserved EF are more prevalent in RA. We have previously shown increased staining for citrullinated substrates in necropsied…
  • Abstract Number: 2049 • 2018 ACR/ARHP Annual Meeting

    Expression and Function of a Novel Citrullinated Form of Interleukin 6 in Rheumatoid Arthritis

    Chenyang Lu, Ray A. Ohara, Phillip L. Campbell, Yuxuan Du, W. Alexander Stinson, Jonatan Hervoso, Ellen Cealey, David Fox and M. Asif Amin, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, MI

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by synovial hyperplasia, progressive joint destruction and the presence of anti-citrullinated peptide antibodies (ACPAs) in…
  • Abstract Number: 485 • 2017 ACR/ARHP Annual Meeting

    Different Citrullination Profiles in Spontaneous Versus Leukemia-Associated Rheumatoid Arthritis

    Tal Gazitt1, Son Hong Nguyen2, Ari Salinger2, Christian Lood3, Xizhang Sun1, Lena M. Tanaka1, David Feith4, Jeffrey Ledbetter5, Gordon Starkebaum6, Thomas Loughran Jr.7, Paul R. Thompson2 and Keith B. Elkon8, 1Division of Rheumatology, University of Washington, Seattle, WA, 2Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 3Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, 4Hematology and Oncology, University of Virginia, Charlottesville, VA, 5University of Washington, Seattle, WA, 6Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 7Hematology Oncology, University of Virginia, Charlottesville, VA, 8Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA

    Background/Purpose: Protein citrullination, the post-translational conversion of arginine to citrulline, mediated by peptidylarginine deiminase (PAD) enzymes, is considered a likely mechanism for the stimulation of…
  • Abstract Number: 837 • 2017 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis and Risk for Chronic Obstructive Pulmonary Disease or Asthma Among Women during 38 Years of Prospective Follow-up

    Jeffrey A. Sparks1, Tzu-Chieh Lin2, Carlos Camargo3, Medha Barbhaiya4, Sara K. Tedeschi5, Karen H. Costenbader2, Benjamin Raby6, Hyon K. Choi7 and Elizabeth Karlson4, 1Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 4Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Division of Rheumatology, Immunology and Allergy,, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 6Pulmonary Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 7Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose : Rheumatoid arthritis (RA) has been associated with increased risk for chronic obstructive pulmonary disease (COPD) and asthma, but these findings may have been…
  • Abstract Number: 470 • 2016 ACR/ARHP Annual Meeting

    Crucial Involvement of Citrullinated Proteins and ACPA in the Development of Peptide-Glucose-6-Phosphate Isomerase Induced Arthritis

    Hoshimi Kawaguchi1, Isao Matsumoto1, Hiroshi Ebe1, Naoto Umeda1, Yuya Kondo1, Hiroto Tsuboi2 and Takayuki Sumida1, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Division of Clinical Immunology, Doctoral Programs in Clinical Science, Graduated School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: Various citrullinated proteins and anti-citrullinated protein antibodies (ACPA) are increased in patients with rheumatoid arthritis (RA). ACPA have high specificity for RA, and are…
  • Abstract Number: 581 • 2016 ACR/ARHP Annual Meeting

    Cell-Mediated Neutrophil Lysis-a Mechanism Promoting Hypercitrullination in Rheumatoid Arthritis?

    Tal Gazitt1, Christian Lood1, Xizhang Sun2, David Feith3, Jeffrey Ledbetter2, Gordon Starkebaum1, Thomas Loughran Jr.4 and Keith B. Elkon1, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2University of Washington, Seattle, WA, 3Hematology and Oncology, University of Virginia, Charlottesville, VA, 4Hematology Oncology, University of Virginia, Charlottesville, VA

    BACKGROUND/PURPOSE:Protein citrullination, the post-translational conversion of arginine to citrulline, mediated by peptidylarginine deiminase (PAD) enzymes, is considered a likely mechanism for the stimulation of anti-citrullinated…
  • Abstract Number: 913 • 2016 ACR/ARHP Annual Meeting

    Aggregatibacter Actinomycetemcomitans-Induced Hypercitrullination Links Periodontal Infection to Autoimmunity in Rheumatoid Arthritis

    Maximilian F. Konig1,2, Loreto Abusleme3, Jesper Reinholdt4, Robert J. Palmer3, Kevon Sampson1, Ricardo P. Teles5, Peter A. Nigrovic6, Antony Rosen1, Jeremy Sokolove7, Jon T. Giles8, Niki M. Moutsopoulos3 and Felipe Andrade1, 1Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 4Department of Biomedicine, Aarhus University, Aarhus, Denmark, 5Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 6Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 7Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 8Columbia University, College of Physicians and Surgeons, Division of Rheumatology, New York, NY

    Background/Purpose: A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as sites…
  • Abstract Number: 1461 • 2016 ACR/ARHP Annual Meeting

    Modification of Proteins with Malondialdehyde-Acetaldehyde and Citrulline Elicit Antibody Responses in DBA/1J Mice

    Peter M. Maloley1, Michael J. Duryee2, Carlos D. Hunter2, James R. O'Dell3, Daniel R. Anderson1, Ted R Mikuls4, Geoffrey M. Thiele1 and Lynell W. Klassen3, 1University of Nebraska Medical Center, Omaha, NE, 2Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 4Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Previous studies have shown that proteins modified with malondialdehyde-acetaldehyde (MAA) and/or citrulline (CIT) co-localize in rheumatoid arthritis (RA) synovial tissues, are pro-inflammatory, and promote…
  • Abstract Number: 3020 • 2016 ACR/ARHP Annual Meeting

    Citrullination of Inhibitor of DNA Binding-1 at Specific Locations Leads to Autoantigenicity in Rheumatoid Arthritis

    Ray A. Ohara1, Henriette A. Remmer2, Phillip L. Campbell3, David A. Fox3 and Jeffrey H. Ruth3, 1Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, 3Internal Medicine, Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose:  Inhibitor of DNA binding-1 (Id1) is a nuclear transcription factor that regulates cell growth and differentiation via selective binding and sequestering of other transcription…
  • Abstract Number: 3148 • 2016 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminase 2 Is Required for Tumor Necrosis Factor Alpha Induced Citrullination and Arthritis, but Not Neutrophil Extracellular Trap Formation

    Mandar Bawadekar1, Daeun Shim1, Ryan Rebernick1, Chloe Peyton1, Chad J. Johnson2, Thomas F. Warner3, Dres Damgaard4, Claus Henrik Nielsen5, Anthony P. Nicholas6, Ger JM Pruijn7, Jeniel E. Nett8 and Miriam A. Shelef1,9, 1Department of Medicine, Division of Rheumatology, University of Wisconsin-Madison, Madison, WI, 2Department of Medicine, University of Wisconsin-Madison, Madison, WI, 3Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 4Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, 5Danish Rheumatologic Biobank and DANBIO registry, Rigshospitalet, Glostrup, Gentofte and Herlev University Hospital, Copenhagen, Denmark, 6Neurology, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL, 7Biomolecular Chemistry, Institute for Molecules and Materials and Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands, 8Medicine and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, 9William S. Middleton Memorial Veterans Hospital, Madison, WI

    Background/Purpose: The presence of anti-citrullinated protein antibodies in rheumatoid arthritis points to a potential role for citrullination in disease pathogenesis. Peptidylarginine deiminases (PADs) catalyze the…
  • Abstract Number: 905 • 2015 ACR/ARHP Annual Meeting

    Citrullinated Epithelial-Derived Neutrophil-Activating Peptide 78 (ENA-78/CXCL5) Induces Monocyte Migration Via JNK and NFκB Signaling Pathways

    Ray A. Ohara1, Nicholas Lepore2, W. Alexander Stinson3, Gautam Edhayan3, Phillip L. Campbell1, Sarah Arwani1, Rachel Morgan1, Jeffrey H. Ruth1, Alisa E. Koch1,4, David A. Fox1 and M. Asif Amin1, 1Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 3Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 4Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by monocyte (MN) infiltration into the synovium. Citrullination is a post-translational modification of arginine to…
  • Abstract Number: 530 • 2015 ACR/ARHP Annual Meeting

    Immunomodulation of Naïve RA Patients PBMCs with a Multi-Epitope Peptide Derived from Citrullinated Autoantigens

    Smadar Gertel1, Yehuda Shoenfeld2 and Howard Amital3, 1Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 2Head Dept of Medicine B, Sheba Medical Center, Ramat-Gan, Israel, 3Sheba Medical Center, Tel-Hashomer, Israel

    Background/Purpose: Citrullinated peptides are major targets of disease-specific autoantibodies in rheumatoid arthritis (RA). We generated a multi-epitope citrullinated peptide (Cit-ME), derived from major prevalent citrullinated…
  • Abstract Number: 528 • 2015 ACR/ARHP Annual Meeting

    RA33 Challenges the Paradigm of Autoantigen Selection in Rheumatoid Arthritis

    Maximilian F. Konig1, Jon Giles2, Peter A. Nigrovic3 and Felipe Andrade1, 1Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 2Rheumatology, Columbia University Medical Center, NY, NY, 3Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Antibodies against citrullinated proteins (ACPAs) are the autoimmune hallmark of rheumatoid arthritis (RA), and can precede the onset of symptomatic disease by years. By…
  • Abstract Number: 521 • 2015 ACR/ARHP Annual Meeting

    Targeted Quantitative Analysis to Identify Citrullinated Peptides in the Synovial Fluid of Patients with Rheumatoid Arthritis

    Min Jueng Kang1, Ji Soo Kim2, Eugene C. Yi1 and Eun Young Lee2, 1Molecular Medicine and Biopharmaceutical Sciences, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Background/Purpose: The protein/peptide citrullination is a post-translational modification and the citrullinated peptide epitopes are recognized by anti-citrullinated protein/peptide antibody (ACPA), which is a major diagnostic…
  • Abstract Number: 1946 • 2015 ACR/ARHP Annual Meeting

    A Novel HLA-DRB1*10:01 Restricted T Cell Epitope from Citrullinated Type II Collagen Relevant for Rheumatoid Arthritis

    Karine Chemin1, Sabrina Pollastro2, Eddie James3, Changrong Ge4, Inka Albrecht5, Jessica Herrath6, Christina Gerstner7, Thais Rizzi2, Karolina Tandre8, Lars Rönnblom8, Anca I Catrina9, Rikard Holmdahl10, L. Klareskog11, Niek De Vries12 and Vivianne Malmström11, 1Medicine, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 2Department of Clinical Immunology and Rheumatology, Amsterdam, Netherlands, 3Benaroya Research Institute at Virginia Mason, Seattle, WA, 4Department of Medical Biochemistry and Biophysics, Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden, 5Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 6Department of Medicine,, Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 7Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden, 8Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 9Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 10Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 11Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 12Dept. of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and immunology Center, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Antibodies against citrullinated collagen type II (Cit-CII) are common in sera and synovial fluids of Rheumatoid Arthritis (RA) patients, whereas the known CII T-cell…
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