Abstract Number: 157 • 2020 Pediatric Rheumatology Symposium
Chondrocytes Influence Fibroblast-like Synoviocytes from Patients with Juvenile Idiopathic Arthritis, Through the Abrogation of BMP Signaling, to Delay Cell Differentiation and Maturation
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) progression leads to growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a key role in JIA pathogenesis; however, the…Abstract Number: 1990 • 2019 ACR/ARP Annual Meeting
Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor
Background/Purpose: Semaphorins (Sema) are a family of proteins associated with neuronal development and guidance. Sema4D/CD100 was first identified as a regulator of immune response in…Abstract Number: 19 • 2019 ACR/ARP Annual Meeting
Inhibition of IkB Kinase-IKK Complex of Canonical NF-κB Pathway in Antiphospholipid Antibody-Mediated Endothelial Cell Activation
Background/Purpose: Antiphospholipid antibodies (aPL) activate several target cell types leading to inflammatory damage and thrombosis in the antiphospholipid syndrome (APS). NF-κB activation is essential for…Abstract Number: 90 • 2019 ACR/ARP Annual Meeting
SLAMF6 Clustering Is Required to Augment Autoimmune T Cell Activation
Background/Purpose: The signaling lymphocytic activation molecule (SLAM) family is encompassed by nine distinct receptors that are hematopoietic restricted. Among these, SLAMF6 is highly expressed in…Abstract Number: 1989 • 2019 ACR/ARP Annual Meeting
Netrin-1 and Its Receptor Unc5B Mediates Tenofovir Induced Bone Loss and Dipyridamole, an Agent That Blocks Adenosine Transporter, Is Able to Modulate the Signal
Background/Purpose: Osteopenia and fragility fractures have been associated with HIV infection. Tenofovir, a common antiviral in HIV treatment, also leads to increases in bone catabolism…Abstract Number: 847 • 2018 ACR/ARHP Annual Meeting
Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Chondrocyte Phenotype through Activation of Calcium/Calmodulin Kinase 2
Background/Purpose: Basic calcium phosphate crystals (BCP) are frequently found in osteoarthritic joints. Whether BCP crystal deposition is a cause or consequence of osteoarthritis (OA) pathology…Abstract Number: 1058 • 2018 ACR/ARHP Annual Meeting
Doxycycline Directly Scavenges Reactive Oxygen Species and Inhibits the Formation of Malondialdehyde-Acetaldehyde-Protein Adducts – a Novel Mechanism of Action for an Old Drug
Background/Purpose: Oxidative stress plays a role in the progression of inflammatory diseases such as Rheumatoid Arthritis (RA) due to the imbalance between levels of reactive…Abstract Number: 1999 • 2018 ACR/ARHP Annual Meeting
Aberrant Expression of the GluN2B N-Methyl D-Aspartate Receptor Subunit in Osteoarthritic Chondrocytes Causes Disease-Associated Changes in Chondrocyte Phenotype through Altered Expression of Core Components of the Chondrocyte Circadian Clock
Background/Purpose: Circadian clocks are key regulators of cell behaviour. Disruption to cell clocks is implicated in a range of diseases. Expression of two core clock…Abstract Number: 2000 • 2018 ACR/ARHP Annual Meeting
Interleukin-1β, Oxidative Stress and Basic Calcium Phosphate Crystals Induce Osteoarthritis-like Changes in Chondrocyte Phenotype By Altering the Expression of PERIOD2, a Core Component of the Chondrocyte Circadian Clock
Background/Purpose: Almost all cells contain a circadian clock. Cell clocks are key regulators of cell activity and cell differentiation. In osteoarthritis (OA), chondrocytes inappropriately undergo…Abstract Number: 2948 • 2018 ACR/ARHP Annual Meeting
Deconstructing the in Situ Myeloid Cell Microenvironment in Human Lupus Nephritis Tissue
Background/Purpose: The cell-types and pathways driving lupus nephritis (LN) are incompletely understood. The Accelerating Medicine Partnership lupus network Pathway Exploration and Analysis in RenaL disease…Abstract Number: 83 • 2017 ACR/ARHP Annual Meeting
Whole Blood Stimulations Identify Elevated T Cell Cytokines and Altered Granulocyte/Dendritic Cell Signaling in SLE Patients with Variable Disease Activity
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by loss of immune tolerance to self-antigens and periods of waxing and waning disease. The clinical aspects of…Abstract Number: 299 • 2017 ACR/ARHP Annual Meeting
Bik Plays an Important Role of Cell Proliferation Caused By Nitric Oxide in Rheumatoid Arthritis Synovium
Background/Purpose: Nitric oxide (NO), a proinflammatory mediator responsible for various physiological processes, plays a central role in the pathogenesis of rheumatoid arthritis (RA). As a…Abstract Number: 1073 • 2017 ACR/ARHP Annual Meeting
Aberrant Cell Signaling in Peripheral Blood Mononuclear Cells upon Interferon Alpha Stimulation in Patients with Primary Sjögren’s Syndrome Associates with Type I Interferon Signature
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a complex heterogeneous systemic autoimmune disease. Biomarkers for patient stratification are scarce. Several single nucleotide polymorphisms within type I…Abstract Number: 2089 • 2017 ACR/ARHP Annual Meeting
Arhalofenate Acid Inhibits Urate Crystal-Induced Inflammatory Responses through Activation of AMP-Activated Protein Kinase (AMPK) Signaling
Background/Purpose: Arhalofenate is an investigational drug with dual uricosuric and anti-inflammatory properties. Arhalofenate reduced the risk of acute flare while lowering serum urate levels in…Abstract Number: 2436 • 2017 ACR/ARHP Annual Meeting
MiR-146a Upregulates the TLR4/NF-κb Signaling Pathway to Promote Cytokine Expression and Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Background/Purpose: To investigate the role of miR-146a in the activation of toll-like receptor-4 (TLR4)/ nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway, and…
ACR Meeting Abstracts