Abstracts tagged "cartilage"

Abstract Number: 1971 • ACR Convergence 2020
Gut Microbiome Transplantation from MRL/MpJ Mice Prevents Post-Traumatic Osteoarthritis in C57BL6/J Mice
Matlock Jeffries¹, Jake Martin¹, Vladislav Izda¹, Cassandra Garman¹, Cassandra Velasco¹ and Christopher Dunn², ¹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²University of Oklahoma HSC, Edmond, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
Abstract Number: 0426 • ACR Convergence 2020
T-Cell Receptor (TCR) Sequencing Reveals Decreased Diversity and Clonotypic Expansion of T-cells in Relapsing Polychondritis (RP)
Emily Rominger¹, Sufia Bakshi², Emily Rose³, Marcela Ferrada³, Peter C. Grayson⁴, Robert Colbert⁵ and Keith Sikora⁶, ¹Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, ²National Institutes of Health, Bethesda, MD, ³Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD, ⁵Pediatric Clinical Trials Unit and Office of Clinical Director, NIAMS, NIH, Bethesda, MD, ⁶National Institutes of Health Clinical Center, Bethesda, MD
Background/Purpose: Relapsing polychondritis (RP) is a rare, systemic inflammatory disease characterized by recurrent inflammation of cartilaginous structures, including the nose/ears, joints, and trachea. The etiology of…
Abstract Number: PP03 • ACR Convergence 2020
Connecting with Rheumatology Professionals and Thought Leaders Inspired the Creation of a New Program Focused on Relapsing Polychondritis (“RP”), a Rare Rheumatic Disease: Participating at ACR Annual Meetings Has Provided Exceptional Opportunities to Learn and Build Relationships
Nancy Linn¹, Catherine Bammert², David Bammert³ and Michael Linn⁴, ¹Relapsing Polychondritis Foundation, Palos Verdes Estates, CA, ²MD Anderson, Houston, TX, ³Relapsing Polychondritis Foundation, Houston, TX, ⁴Relapsing Polychondritis Foundation, New York, NY
Background/Purpose: In 2011, I was diagnosed with relapsing polychondritis ("RP"), a debilitating and sometimes fatal rheumatic disease that is characterized by inflammation of cartilage and…
Abstract Number: 0427 • ACR Convergence 2020
Validation of Physician Global Assessment as an Outcome Measure in Relapsing Polychondritis
Emily Rose¹, Marcela Ferrada¹, Kaitlin Quinn², Wendy Goodspeed¹, Laurent Arnaud³ and Peter C. Grayson⁴, ¹Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, BETHESDA, MD, ²Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Washington, DC, ³Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, Alsace, France, ⁴Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD
Background/Purpose: Relapsing polychondritis (RP) is a rare systemic inflammatory disorder of cartilage that lacks validated disease activity measures. Physician global assessment (PhGA) is a measure…
Abstract Number: PP04 • ACR Convergence 2020
My Multidisciplinary Healthcare Team and Patient Advocacy Groups Saved My Life
Tedi LaMere¹, Michael Linn² and David Bammert³, ¹Relapsing Polychondritis Foundation, Kalispell, MT, ²Relapsing Polychondritis Foundation, New York, NY, ³Relapsing Polychondritis Foundation, Houston, TX
Background/Purpose: I enjoyed being physically active my entire life – climbing mountains, hunting, and hiking. This drastically changed around 2012, when I noticed that I was…
Abstract Number: 0509 • ACR Convergence 2020
Classification of Patients with Relapsing Polychondritis Based on Somatic Mutations in UBA1
Marcela Ferrada¹, Keith Sikora², Sinisa Savic³, Yiming Luo⁴, Kristina Wells⁵, Emily Rose¹, Kaitlin Quinn⁶, Wendy Goodspeed¹, Anne Jones⁷, Mimi Le⁸, Amanda Ombrello⁹, Zuoming Deng¹⁰, Massimo Gadina¹¹, Wanxia Tsai¹², Ivona Aksentijevich⁷, Daniel Kastner¹³, David Beck¹⁴ and Peter C. Grayson¹⁵, ¹Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institutes of Health Clinical Center, Bethesda, MD, ³University of Leeds, England, United Kingdom, ⁴Rheumatology Fellowship and Training Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, ⁵Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, ⁶Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Washington, DC, ⁷National Human Genome Research Institute, Bethesda, MD, ⁸Oregon Health & Science University, Portland, ⁹National Institutes of Health, Bethesda, ¹⁰National Institute of Arthritis Musculoskeletal and Skin diseases, Bethesda, ¹¹National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, ¹²National Institute of Arthritis Musculoskeletal and Skin diseases, Bethesda, MD, ¹³National Human Genome Research Institute (NHGRI), NIH, Bethesda, MD, ¹⁴National Human Genome Research Institute, Bethesda, ¹⁵Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD
Background/Purpose: Relapsing polychondritis (RP) is a rare, heterogenous, systemic inflammatory disease with a predilection for cartilaginous structures. Recently we discovered myeloid-restricted somatic mutations in UBA1 in…
Abstract Number: PP05 • ACR Convergence 2020
Coping Through Advocacy – My Story Living with Relapsing Polychondritis
Allegonda Imeson¹, ¹The Canadian Society for Relapsing Polychondritis, Stony Plain, AB, Canada
Background/Purpose: Becoming a mother was the most pivotal moment of my life. From early on, I instilled the importance of a physical, healthy lifestyle for my two…
Abstract Number: 0557 • ACR Convergence 2020
The Joint Association of Steps/day and Typical Sedentary Bout Length with Worsening Knee Cartilage Damage over Two Years: The MOST Study
Dana Voinier¹, Tuhina Neogi², Joshua Stefanik³, Ali Guermazi², Frank Roemer⁴, Hiral Master⁵, Louise Thoma⁶, Meredith Christiansen⁷, Jason Jakiela¹, Michael Nevitt⁸, Cora Lewis⁹, James Torner¹⁰ and Daniel White¹, ¹University of Delaware, Newark, DE, ²Boston University School of Medicine, Boston, MA, ³Northeastern University, Boston, MA, ⁴Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, ⁵Vanderbilt University Medical Center, Nashville, TN, ⁶University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷University of Delaware, New York, NY, ⁸University of California San Fransisco, Orinda, CA, ⁹University of Alabama Birmingham, Birmingham, AL, ¹⁰University of Iowa, Iowa City, IA
Background/Purpose: Knee cartilage requires loading, e.g., walking, to remain healthy. When cartilage is deprived of loading, i.e., during bouts of sedentary time, it becomes vulnerable…
Abstract Number: PP06 • ACR Convergence 2020
Only in My Dreams Can I Do the Things I Used to Do: Where There Is Research, There Is Hope
Dan Smith¹, Robert Smith¹ and Jillian Covault¹, ¹Canton, MI
Background/Purpose: In Mach 2020, I was diagnosed with relapsing polychondritis ("RP"), a multisystem, rheumatologic disease characterized by inflammation of cartilaginous structures including the ear, nose,…
Abstract Number: 0693 • ACR Convergence 2020
Effect of Physical Activity on Cartilage Degradation and Inflammation in Individuals with Lumbar Spinal Stenosis
Gustavo Almeida¹, Samannaaz Khoja², Lauren Terhorst³, Gwendolyn Sowa⁴, Sara Piva² and Michael Schneider², ¹Department of Physical Therapy, UT HEALTH SAN ANTONIO, San Antonio, TX, ²Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ³Department of Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Guidelines recommend 150 minutes a week in moderate-intensity physical activity (MPA) to improve health in individuals with chronic disease such as those with lumbar…
Abstract Number: PP10 • ACR Convergence 2020
Patients with Relapsing Polychondritis (“RP”) and an Advocate Manufactured Custom Cloth Masks to Combat COVID-19: This Mask Project Provided a Sense of Purpose, Created Unity, Increased Awareness of RP, Facilitated Research, and Generated Hope
Isabel Bautista¹ and Michael Linn², ¹Relapsing Polychondritis Foundation, Wilmington, CA, ²Relapsing Polychondritis Foundation, New York, NY

Background/Purpose: In 2013, I was diagnosed with Relapsing Polychondritis ("RP"), a systemic inflammatory disease of unknown etiology that can be fatal. The disease affects multiple…
Abstract Number: 0696 • ACR Convergence 2020
Femoral Cartilage Ultrasound Echo-Intensity Associates with Arthroscopic Cartilage Damage in People Following Anterior Cruciate Ligament Reconstruction
Matthew Harkey¹, Erin Little², Mikaela Thompson³, Ming Zhang⁴, Jeffrey Driban⁴ and Matthew Salzler³, ¹University of Massachusetts, Worcester, MA, ²Tufts Medical Center, Cambridge, MA, ³Tufts Medical Center, Boston, ⁴Tufts Medical Center, Boston, MA
Background/Purpose: Over one-third of people will develop knee osteoarthritis within 10 years of an anterior cruciate ligament (ACL) injury. Ultrasound may be used to monitor…
Abstract Number: 0700 • ACR Convergence 2020
Lipoxin A4 Induces Lipid Class Switching and Inflammation Resolution at the Genomic Level in Human Osteoarthritis
Mandar Dave¹, Abul Islam², Akshat Parekh³, Jay Patel⁴, Arushi Chawla⁵ and Ashok Amin⁶, ¹Department of Rheumatology and Pathology, New York University Hospital for Joint Diseases, New York, ²Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh, ³Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, ⁴Northeast Ohio Medical University, Rootstown, OH, ⁵Gujarat Forensic Science University, Gujarat, India, ⁶Department of Rheumatology and Pathology, New York University Hospital for Joint Diseases, New York, NY
Background/Purpose: Human OA-affected cartilage does not show the cardinal signs of inflammation (redness and swelling with heat and pain—rubor et tumor cum calore et dolor) because…
Abstract Number: 0704 • ACR Convergence 2020
The Murine Ear Wound Cartilage Superhealer Trait, Mediated by the Gut Microbiome, Is Transgenerationally Heritable Following Cecal Transplantation
Christopher Dunn¹, Cassandra Garman², Cassandra Velasco², Vladislav Izda², Jake Martin² and Matlock Jeffries², ¹University of Oklahoma Health Sciences Center, Oklahoma City, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
Abstract Number: 0706 • ACR Convergence 2020
Adenosine A2A Receptor Activation Reduces Markers of Chondrocyte Senescence and Cartilage Inflammation Associated with Osteoarthritis
Benjamin Friedman¹ and Bruce Cronstein², ¹NYU Rheumatology, New York, NY, ²NYU Grossman School of Medicine, New York, NY
Background/Purpose: Osteoarthritis is an aging-associated disorder linked to dysfunctional metabolism, chronic inflammation, oxidative stress, and cellular senescence. Cellular senescence is associated with stable cell cycle…

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