ACR Meeting Abstracts

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Abstracts tagged "cartilage"

  • Abstract Number: PP10 • ACR Convergence 2020

    Patients with Relapsing Polychondritis (“RP”) and an Advocate Manufactured Custom Cloth Masks to Combat COVID-19: This Mask Project Provided a Sense of Purpose, Created Unity, Increased Awareness of RP, Facilitated Research, and Generated Hope

    Isabel Bautista1 and Michael Linn2, 1Relapsing Polychondritis Foundation, Wilmington, CA, 2Relapsing Polychondritis Foundation, New York, NY

    Background/Purpose: In 2013, I was diagnosed with Relapsing Polychondritis ("RP"), a systemic inflammatory disease of unknown etiology that can be fatal. The disease affects multiple…
  • Abstract Number: 0696 • ACR Convergence 2020

    Femoral Cartilage Ultrasound Echo-Intensity Associates with Arthroscopic Cartilage Damage in People Following Anterior Cruciate Ligament Reconstruction

    Matthew Harkey1, Erin Little2, Mikaela Thompson3, Ming Zhang4, Jeffrey Driban4 and Matthew Salzler3, 1University of Massachusetts, Worcester, MA, 2Tufts Medical Center, Cambridge, MA, 3Tufts Medical Center, Boston, 4Tufts Medical Center, Boston, MA

    Background/Purpose: Over one-third of people will develop knee osteoarthritis within 10 years of an anterior cruciate ligament (ACL) injury. Ultrasound may be used to monitor…
  • Abstract Number: 0700 • ACR Convergence 2020

    Lipoxin A4 Induces Lipid Class Switching and Inflammation Resolution at the Genomic Level in Human Osteoarthritis

    Mandar Dave1, Abul Islam2, Akshat Parekh3, Jay Patel4, Arushi Chawla5 and Ashok Amin6, 1Department of Rheumatology and Pathology, New York University Hospital for Joint Diseases, New York, 2Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh, 3Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 4Northeast Ohio Medical University, Rootstown, OH, 5Gujarat Forensic Science University, Gujarat, India, 6Department of Rheumatology and Pathology, New York University Hospital for Joint Diseases, New York, NY

    Background/Purpose: Human OA-affected cartilage does not show the cardinal signs of inflammation (redness and swelling with heat and pain—rubor et tumor cum calore et dolor) because…
  • Abstract Number: 0704 • ACR Convergence 2020

    The Murine Ear Wound Cartilage Superhealer Trait, Mediated by the Gut Microbiome, Is Transgenerationally Heritable Following Cecal Transplantation

    Christopher Dunn1, Cassandra Garman2, Cassandra Velasco2, Vladislav Izda2, Jake Martin2 and Matlock Jeffries2, 1University of Oklahoma Health Sciences Center, Oklahoma City, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
  • Abstract Number: 0706 • ACR Convergence 2020

    Adenosine A2A Receptor Activation Reduces Markers of Chondrocyte Senescence and Cartilage Inflammation Associated with Osteoarthritis

    Benjamin Friedman1 and Bruce Cronstein2, 1NYU Rheumatology, New York, NY, 2NYU Grossman School of Medicine, New York, NY

    Background/Purpose: Osteoarthritis is an aging-associated disorder linked to dysfunctional metabolism, chronic inflammation, oxidative stress, and cellular senescence. Cellular senescence is associated with stable cell cycle…
  • Abstract Number: 1115 • ACR Convergence 2020

    The Relation of MRI-Based Cartilage Lesions to Knee Replacement and Knee Pain Severity in Osteoarthritis: The Multicenter Osteoarthritis Study

    Tuhina Neogi1, David Felson1, Kathy Bacon2, James Torner3, Cora Lewis4, Michael Nevitt5 and S. Reza Jafarzadeh1, 1Boston University School of Medicine, Boston, MA, 2Boston University School of Medicine, Boston, 3University of Iowa, Iowa City, IA, 4University of Alabama Birmingham, Birmingham, AL, 5University of California, San Francisco, San Francisco, CA

    Background/Purpose: Recently, the FDA has indicated that data supporting imaging biomarkers of relevance to clinically important outcomes, such as knee replacement (KR) may be considered…
  • Abstract Number: 1129 • ACR Convergence 2020

    Discordance in Patient and Physician Assessment of Disease Activity in Relapsing Polychondritis

    Emily Rose1, Marcela Ferrada1, Kaitlin Quinn2, Wendy Goodspeed1, Laurent Arnaud3 and Peter C. Grayson4, 1Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Washington, DC, 3Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, Alsace, France, 4Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD

    Background/Purpose: Relapsing polychondritis (RP) is a rare chronic disabling inflammatory condition primarily affecting cartilage tissue. Self-reported patient outcome measures, which have not been evaluated in…
  • Abstract Number: 1491 • ACR Convergence 2020

    Association of a Leaky Gut but Not Microbial Dysbiosis with Obesity-related OA: A Translational Study

    Richard Loeser1, Liubov Arbeeva1, Kathryn Kelley2, Anthony Fodor3, Shan Sun3, Veronica Ulici4, Lara Longobardi2, Yang Cui2, Susan Sumner2, Andrea Azcarate-Peril2, Balfour Sartor2, Ian Carrol2 and Amanda Nelson1, 1University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, 2University of North Carolina, Chapel Hill, NC, 3University of North Carolina-Charlotte, Charlotte, NC, 4Brown University, Providence, RI

    Background/Purpose: To test the hypothesis that an altered gut microbiota (dysbiosis) plays a causal role in the obese OA phenotype (obesity with both hand and…
  • Abstract Number: 1565 • ACR Convergence 2020

    Joint Cartilage Damage Evaluated by Ultrasound in Patients with Systemic Lupus Erythematosus

    Takehisa Ogura1, Ayako Hirata2, Yuki Inoue2, Takaharu Katagiri2, Yuto Takakura2 and Hideto Kameda3, 1Division of Rheumatology, Department of Internal Medicine, Toho University, Meguro-ku, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Toho University, Tokyo, Japan, 3Toho University, Tokyo, Japan

    Background/Purpose: Arthritis in systemic lupus erythematosus (SLE) is typically non-erosive, although some patients with SLE show erosive destruction or Jaccoud’s arthropathy. Previously we have confirmed…
  • Abstract Number: 0423 • ACR Convergence 2020

    Defining Ear Chondritis: Data from 685 Patients with Relapsing Polychondritis

    Marcela Ferrada1, Nathalie Costedoat-Chalumeau2, Guillaume Moulis3, Nancy Linn4, Emily Rose1 and Peter C. Grayson5, 1Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2APHP, Université de Paris, Paris, France, 3Toulouse University hospital, Toulouse, France, 4Relapsing Polychondritis Foundation, Palos Verdes Estates, CA, 5Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD

    Background/Purpose: Ear chondritis is often considered the pathognomonic feature of relapsing polychondritis (RP).  Although painful redness and swelling of the pinna and a resultant cauliflower…
  • Abstract Number: 1637 • ACR Convergence 2020

    Comparison of Nation-wide Epidemical Study on 2009 and That on 2019 Revealed That Improvement of Disease Severity and Mortality Rate May Come from Progress of Proficient Management in Patients with Relapsing Polychondritis in Japan

    Jun Shimizu1, Yoshihisa Yamano1, Kimito Kawahata2 and Noboru Suzuki1, 1St. Marianna University School of Medicine, Kawasaki, Japan, 2Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

    Background/Purpose: We conducted a retrospective survey study in 2009 and collected clinical data of 239 patients with relapsing polychondritis (RP). Using the survey data, we…
  • Abstract Number: 0424 • ACR Convergence 2020

    Anti-Collagen II Antibodies in Patients with Relapsing Polychondritis

    Kristina Wells1, Marcela Ferrada2, Emily Rose2, Keith Sikora3, Wendy Goodspeed2, Kaitlin Quinn4 and Peter C. Grayson5, 1Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, 2Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3National Institutes of Health Clinical Center, Bethesda, MD, 4Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Washington, DC, 5Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD

    Background/Purpose: Relapsing polychondritis (RP) is a highly heterogenous systemic inflammatory disorder that affects many organ systems, in particular, cartilaginous structures. Clinical presentations in RP are…
  • Abstract Number: 1759 • ACR Convergence 2020

    Rheumatoid Arthritis Affects the Ossicular Joints: A Human Otopathologic Study

    Melissa Castillo-Bustamante1, Marc Polanik1, Dhrumi Gandhi1, Elliott Kozin1 and Aaron Remenschneider1, 1Massachusetts Eye and Ear Infirmary/Harvard University, Boston, MA

    Background/Purpose: Inflammation of synovial joints in small and large extremities is commonly seen in Rheumatoid arthritis (RA). To date little is known about how this disease…
  • Abstract Number: 0425 • ACR Convergence 2020

    MAGIC Syndrome in a Cohort of Patients with Relapsing Polychondritis

    Yiming Luo1, Emily Rose2, Keith Sikora3, Kaitlin Quinn4, Kristina Wells5, Emily Rominger5, Wendy Goodspeed6, Peter C. Grayson7 and Marcela Ferrada6, 1Rheumatology Fellowship and Training Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, 2Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethsda, 3Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, 4Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, 5Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, 6Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 7Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD

    Background/Purpose: Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome is an extremely rare condition that encompasses symptoms of relapsing polychondritis (RP) and Behcet’s disease…
  • Abstract Number: 1971 • ACR Convergence 2020

    Gut Microbiome Transplantation from MRL/MpJ Mice Prevents Post-Traumatic Osteoarthritis in C57BL6/J Mice

    Matlock Jeffries1, Jake Martin1, Vladislav Izda1, Cassandra Garman1, Cassandra Velasco1 and Christopher Dunn2, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2University of Oklahoma HSC, Edmond, OK

    Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
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