Abstract Number: 1594 • ACR Convergence 2023
Oral Delivery of Δ9-Tetrahydrocannabinol Provides Symptom and Disease Modification in a Mouse Model of Knee Osteoarthritis
Background/Purpose: Osteoarthritis (OA) results in joint pain, cartilage degeneration, and synovitis. Recent studies suggest that some OA patients are self-medicating with cannabis. Δ9-tetrahydrocannabinol (THC) is…Abstract Number: 1874 • ACR Convergence 2023
Cartilage Thickness Measures Are More Responsive Than Cartilage Area Loss Measures: A Comparison of Quantitative and Semi-quantitative Cartilage Assessments from the Osteoarthritis Initiative
Background/Purpose: Cartilage loss in 1-2 year osteoarthritis clinical trials is often small, but a critical outcome measure. The aim of this study was to compare…Abstract Number: 1987 • ACR Convergence 2023
Clinical and Imaging Characteristics of Individuals Who Underwent Knee Replacement During Years 3 to 5 in the FORWARD Study: A Post Hoc Analysis
Background/Purpose: Sprifermin is an investigational intra-articular (IA) recombinant human truncated fibroblast growth factor-18 (rhFGF-18) therapy evaluated to date in three knee osteoarthritis (KOA) trials (NCT00911469…Abstract Number: 0319 • ACR Convergence 2023
Knee Flexion Contracture Was Associated with Articular Cartilage Loss in the Central Region but Cartilage Preservation in the Posterior Region of the Tibia: Data from the Osteoarthritis Initiative
Background/Purpose: A knee flexion contracture (FC), present in ~⅓ of patients with knee OA1, is the inability to fully extend the knee2, 3. Having a…Abstract Number: 0749 • ACR Convergence 2023
Impact of Sprifermin on Denuded Areas of Subchondral Bone (dABs): A Post Hoc Analysis of the FORWARD Study
Background/Purpose: Sprifermin, recombinant human fibroblast growth factor 18 (rhFGF-18), is being investigated as a potential disease-modifying osteoarthritis drug. The Phase 2 FORWARD study demonstrated that…Abstract Number: 0821 • ACR Convergence 2023
Effects of Sprifermin on a Novel Outcome of Osteoarthritis Symptom Progression: Post Hoc Analysis of the FORWARD Study
Background/Purpose: People with knee OA (KOA) desire therapies which delay or reverse disease progression supporting the need for disease-modifying OA drugs (DMOADs). Sprifermin, truncated recombinant…Abstract Number: 0822 • ACR Convergence 2023
From Biomarkers to Endotypes: Data-driven Identification of Knee Osteoarthritis Patients Subtypes
Background/Purpose: Osteoarthritis (OA) is a diverse and multifaceted condition. Despite its widespread incidence, the core mechanisms of the disease remain elusive, and therapeutic interventions are…Abstract Number: 0874 • ACR Convergence 2023
RNA-Binding Proteins That Are Highly Expressed and Enriched in Healthy Cartilage but Suppressed in Osteoarthritis
Background/Purpose: RNA-binding proteins (RBPs) have diverse and essential biological functions, but their role in cartilage health and disease is largely unknown. The objectives of this…Abstract Number: 0877 • ACR Convergence 2023
Loss of Transient Receptor Potential Channel 1 (TRPC1) Links Regulation of Intracellular Calcium to Cellular Senescence and Leads to Development of Osteoarthritis
Background/Purpose: Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane. It is crucial for the…Abstract Number: 0882 • ACR Convergence 2023
Activation of Ovarian Cancer G-Protein Coupled Receptor (OGR1) Attenuates Chondrocytes Inflammation via ERK1/2 Signaling Pathways in an in Vitro Model of Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is the most prevalent joint disease, accounting for 50% of the musculoskeletal burden. Inflammation plays a crucial role in the development of…Abstract Number: 0883 • ACR Convergence 2023
The Role of Plasmin and Fibrinolysis Pathways in Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is the major cause of joint failure. Increasing evidence suggests that activation of fibrinolysis is involved in the pathogenesis of OA. Here…Abstract Number: 0884 • ACR Convergence 2023
Identification of a Mast Cell-high Synovial Pathotype of Osteoarthritis
Background/Purpose: Mast cells in the osteoarthritis (OA) synovium correlate with disease severity. This study aimed to further elucidate the role of mast cells in OA…Abstract Number: 0885 • ACR Convergence 2023
Mice Fed a Well-formulated Ketogenic Diet After OA Induction Develop Worse OA Outcomes and Increased Pain Sensitivity
Background/Purpose: A ketogenic diet (KD) has beneficial effects in preclinical models of a variety of systemic autoimmune diseases. In this study, we set out to…Abstract Number: 1581 • ACR Convergence 2023
Microbiome Transplantation Prevents Osteoarthritis in Mice and Is Associated with Immunophenotype Changes
Background/Purpose: MRL/MpJ mice are protected from developing post-traumatic osteoarthritis (OA). We have previously shown transplantation prior to OA induction prevents OA development. We now extend…Abstract Number: 051 • 2023 Pediatric Rheumatology Symposium
Juvenile Relapsing Polychondritis: A Single Center Cohort
Background/Purpose: Relapsing polychondritis (RPC) is a rare multisystemic autoimmune disease associated with recurrent, progressive inflammation in cartilaginous structures. In children, the most common manifestations are…
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