ACR Meeting Abstracts

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Abstracts tagged "cartilage"

  • Abstract Number: 58 • 2013 ACR/ARHP Annual Meeting

    Saturated Fatty Acids Act Synergistically With Interleukin 1 Beta To Increase Inflammation, Endoplasmic Reticulum Stress and Cell Death In Human Articular Chondrocytes 

    Oscar Alvarez-Garcia1, Nicole H Rogers2, Roy G Smith3 and Martin K. Lotz1, 1Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 2California Institute for Biomedical Research (Calibr), La Jolla, CA, 3Department of Metabolism and Aging, Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL

    Background/Purpose: Obesity is a major risk factor for the development of osteoarthritis (OA). Altered biomechanics have been postulated as the main causative mechanism, but recent…
  • Abstract Number: 156 • 2013 ACR/ARHP Annual Meeting

    Cartilage Peptide Profiling: Identifying Novel OA Biomarkers For Early Disease Detection

    Valentina Calamia1, Lucía Lourido1, Diego López1, Jesus Mateos1, Patricia Fernández-Puente1, Carolina Fernández-Costa2, Beatriz Rocha2, Cristina Ruiz-Romero3 and Francisco J. Blanco1, 1Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, 2Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, 3Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain

    Background/Purpose: Cartilage secretome contains a complex matrix of proteolytically derived peptides that may provide useful information of the biological events occurring in the articular joint…
  • Abstract Number: 771 • 2013 ACR/ARHP Annual Meeting

    The S100A9 Inhibitor Paquinimod (ABR-215757) Reduces Synovial Activation, Osteophyte Formation and Cartilage Damage In Experimental Osteoarthritis

    Rik Schelbergen1, Arjen B. Blom1, Tomas Leanderson2, Helena Eriksson3, Wim B. van den Berg4 and Peter L.E.M. van Lent1, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Immunology Group, Lund University, Lund, Sweden, 3BioScience, Active Biotech AB, Lund, Sweden, 4Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Synovial activation is present in a large subset of osteoarthritis (OA) patients and it is thought to play an important role in the development…
  • Abstract Number: 44 • 2013 ACR/ARHP Annual Meeting

    Suppressor Of Cytokine Signaling 3 Negatively Modulates Leptin-Mediated Catabolic and Proinflammatory Effects In Cartilage – New Potential Mechanism To Target Obesity-Induced Osteoarthritis

    Anna Koskinen1, Katriina Vuolteenaho1, Riku Korhonen1, Teemu Moilanen1,2 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland

    Background/Purpose: Adipocytokine leptin has been suggested to link obesity and osteoarthritis (OA). Initially leptin was found to regulate energy metabolism through central nervous system. More…
  • Abstract Number: 69 • 2013 ACR/ARHP Annual Meeting

    Interconnected Cellular Projections and Gap Junctions Mediate Metabolic Coupling Between Chondrocytes Located In Different Layers Of The Tissue: Cell-To-Cell Communication In Normal and Osteoarthritic Cartilage

    Maria Dolores Mayan1,2,3, Paula Carpintero-Fernández1,2, Raquel Gago-Fuentes1,2, Patricia Fernández-Puente1, Purificacion Filgueira-Fernandez1, Noa Goyanes1, Virgin Valiunas4, Peter Brink4, Gary Goldberg5 and Francisco J. Blanco6,7, 1Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, Xubias de Arriba 84, 15006, A Coruña, Spain, 2These authors contribute equally to this work, A Coruña, Spain, 3Correspondence to: [email protected] and [email protected], A Coruña, Spain, 4Department of Physiology and Biophysics. State University of New York, Stony Brook, New York, SC, 5Department of Molecular Biology. Medical Center Drive, University of Medicine and Dentistry of New Jersey, Stratford, NJ, 6Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, 7Proteo-Red/ISCIII, Madrid, Spain

    Background/Purpose: We have recently found that articular chondrocytes from human adults contain long cytoplasmic arms that cross the extracellular matrix and physically connect two chondrocytes…
  • Abstract Number: 238 • 2013 ACR/ARHP Annual Meeting

    Structural Predictors Of Ten Year Knee Cartilage Volume Loss

    Dawn Aitken1, Hussain Ijaz Khan1, Changhai Ding2, Leigh Blizzard3, Jean-Pierre Pelletier4, Johanne Martel-Pelletier4, Flavia Cicuttini5 and Graeme Jones2, 1Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, 2Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, 3Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, 4Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 5Department of Epidemiology and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, Australia

    Background/Purpose: Cartilage volume loss is considered a key feature of knee osteoarthritis (OA) and increased loss over two years is associated with future knee replacement…
  • Abstract Number: 49 • 2013 ACR/ARHP Annual Meeting

    Chondrocyte-Specific Bone Morphogenetic Protein-2 Overexpression Results In Severe Aggravation Of Osteophyte Formation In Experimental Osteoarthritis Without Altering Cartilage Damage In Young Mice

    Esmeralda N. Blaney Davidson1, Elly L. Vitters2, Miranda B. Bennink3, Fons AJ Loo2, Wim B. van den Berg3 and Peter M. van der Kraan2, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: In murine osteoarthritis (OA) models chondrocytes surrounding lesions express elevated levels of Bone Morphogenetic Protein-2 (BMP2). This growth factor is well known for its…
  • Abstract Number: 2753 • 2013 ACR/ARHP Annual Meeting

    Relationship Of Pre-Radiographic MRI Lesions With Prevalent Frequent Knee Symptoms and Incident Persistent Knee Symptoms In Persons At Higher Risk For Knee Osteoarthritis

    Leena Sharma1, Joan S. Chmiel1, Orit Almagor1, Dorothy D. Dunlop2, Marc C. Hochberg3, Charles Eaton4, C. Kent Kwoh5, Rebecca D. Jackson6, Joan M. Bathon7, Ali Guermazi8, Frank Roemer9, Michel Crema8, W. Jerry Mysiw6 and Michael C. Nevitt10, 1Northwestern University, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine, University of Maryland School of Medicine, Baltimore, MD, 4Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, 5School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 6Ohio State University, Columbus, OH, 7Columbia University, New York, NY, 8Boston University, Boston, MA, 9Klinikum Augsburg, Augsburg, Germany, 10Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA

    Background/Purpose: The clinical significance of pre-radiographic MRI lesions in persons at risk for knee OA is unclear.  Understanding whether such lesions are inconsequential or early…
  • Abstract Number: 239 • 2013 ACR/ARHP Annual Meeting

    A Family History Of Knee Joint Replacement Increases The Progression Of Knee Joint Radiographic Osteoarthritis and Cartilage Volume Loss Over Ten Years

    Hussain Ijaz Khan1, Dawn Aitken1, Louisa Chou1, Andrew McBride1, Changhai Ding2, Jean Pierre Pelletier3,4, Johanne M. Pelletier5, Leigh Blizzard6, Flavia Cicuttini7 and Graeme Jones2, 1Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, 2Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, 3Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, 4Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 5Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, 6Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, 7Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia

    Background/Purpose: Osteoarthritis (OA) is a disease of multifactorial origin with a modest but significant heritable effect for disease severity in the knee joint. The aim…
  • Abstract Number: 50 • 2013 ACR/ARHP Annual Meeting

    Cartilage Matrix Remodeling and Activation Of Canonical Wnt- Signaling Precedes Calcification and OA-Like Changes In Mice

    Jessica Bertrand1, Tabea Kräft2, Yvonne Nitschke3, Thelonius Hawellek4, Jan Hubert4, Lars Godmann5 and Thomas Pap5, 1Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, 2Inst, University Hospital Münster, Muenster, Germany, 3University Hospital Münster, Muenster, Germany, 4University Hospital Hamburg, Hamburg, Germany, 5Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany

    Background/Purpose: Calcification of cartilage is a common finding during osteoarthritis (OA) and is directly linked to the severity of cartilage degradation. We have found in…
  • Abstract Number: 2729 • 2013 ACR/ARHP Annual Meeting

    Identification Of Osteoarthritis Patients With Chronic Inflammation Driven Disease Progression

    Anne Sofie Siebuhr1, Kristian Kjaer Petersen2, Lars Arendt-Nielsen3, Line Egsgaard2, Thomas Navndrup Eskehave4, Ole Simonsen5, Claus Christiansen4,6, Hans Christian Hoeck4, Morten Asser Karsdal7 and Anne C. Bay-Jensen8, 1Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, 3Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, 4Center for Clinical and Basic Research and C4Pain, Aalborg, Denmark, 5Frederikshavn Hospital, Frederikshavn, Denmark, 6Nordic Bioscience, Herlev, Denmark, 7Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 8Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark

    Background/Purpose: In osteoarthritis (OA) it is evident that a subset of patients experiences chronic tissue inflammation and may benefit from anti-inflammatory treatment. The systemic inflammation…
  • Abstract Number: 80 • 2013 ACR/ARHP Annual Meeting

    Tidemark Duplication In Osteoarthritis: Evidence Of Incremental Progression?

    Martine P. Roudier1, Paul A. Manner2 and Peter A. Simkin3, 1Pathology, University of Washington, Seattle, WA, 2Orthopaedics, University of Washington, Seattle, WA, 3Div of Rheumatology, University of Washington, Seattle, WA

    ·         Background/Purpose: Osteoarthritis (OA) is commonly envisioned as a gradual, relentlessly progressive process of "wear and tear" leading to eventual joint failure.  As we see…
  • Abstract Number: 51 • 2013 ACR/ARHP Annual Meeting

    Collagen-Based Microspheres Delivering TGF-β3 For Mesenchymal STEM CELL Differentiation: An Innovative Strategy For Cartilage Engineering

    Marc Mathieu1, E Belamie2, M-N Labour2, Sylvain Vigier2, Christian Jorgensen3 and Daniele Noel4, 1INSERM U844, Montpellier, France, 2ICGM UMR 5253, MONTPELLIER, France, 3Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, 4Inserm U844, UM1, Montpellier, France

    Background/Purpose: Because of a poor self-healing ability, joint cartilage undergoes progressive degradation in the course of aging or following traumatic injuries. One promising therapeutic approach…
  • Abstract Number: 2519 • 2012 ACR/ARHP Annual Meeting

    IL-1β and TNF-α Regulate the Global and Locus-Specific hydroxymethylation  of Genomic DNA by Modulating the Expression and Activity of Tet-1 in Human OA Chondrocytes

    Abdul Haseeb1 and Tariq M. Haqqi2, 1Medicine/Rheumatology, Case Western Reserve University, Cleveland, OH, 2Medicine/Rheumatology/Haman 586, Metro Health Medical Center, Cleveland, OH

    Background/Purpose: 5-hydroxymethylcytosine (5-hmC), which is formed by the oxidation of 5-methylcytosine (5-mC), is a recently discovered epigenetic mark and is highest in brain and in…
  • Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting

    Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis

    Brett A. Tonkin1, Evange Romas2, Natalie A. Sims1 and Nicole C. Walsh1, 1St Vincent's Institute of Medical Research, Melbourne, Australia, 2Dept. of Rheumatology, St Vincent's Hospital, Melbourne, Australia

    Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…
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