ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "cartilage"

  • Abstract Number: 2520 • 2012 ACR/ARHP Annual Meeting

    Suppressor of Cytokine Signaling 3 Is Reduced in Obese Patients with Osteoarthritis and Regulates Leptin Responses in Chondrocytes

    Anna Koskinen1, Katriina Vuolteenaho1, Riku Korhonen1, Teemu Moilanen2 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland

    Background/Purpose: Leptin is an adipokine whose concentrations in circulation are proportional to body fat stores and body mass index (BMI). Initially leptin was discovered to…
  • Abstract Number: 17 • 2012 ACR/ARHP Annual Meeting

    Synovial Overexpression of Wnt and Wnt-1-Induced Secreted Protein 1 Induces Cartilage Damage by Skewing of TGF-Beta Signaling and Reduction of the Anti-Hypertrophy Factor Sox9

    Martijn H. van den Bosch1, Arjen B. Blom1, Peter L. van Lent2, Henk M. van Beuningen1, Fons A. van de Loo3, Esmeralda N. Blaney Davidson1, Peter M. van der Kraan1 and Wim B. van den Berg4, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 4Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. We found highly increased expression of canonical Wnts 2b and 16…
  • Abstract Number: 2519 • 2012 ACR/ARHP Annual Meeting

    IL-1β and TNF-α Regulate the Global and Locus-Specific hydroxymethylation  of Genomic DNA by Modulating the Expression and Activity of Tet-1 in Human OA Chondrocytes

    Abdul Haseeb1 and Tariq M. Haqqi2, 1Medicine/Rheumatology, Case Western Reserve University, Cleveland, OH, 2Medicine/Rheumatology/Haman 586, Metro Health Medical Center, Cleveland, OH

    Background/Purpose: 5-hydroxymethylcytosine (5-hmC), which is formed by the oxidation of 5-methylcytosine (5-mC), is a recently discovered epigenetic mark and is highest in brain and in…
  • Abstract Number: 19 • 2012 ACR/ARHP Annual Meeting

    Stress-Induced Cartilage Degradation Does Not Depend On NLRP3-Inflammasome in Osteoarthritis

    Carole Bougault1, Marjolaine Gosset2, Xavier Houard3, Colette Salvat4, Lars Godmann5, Thomas Pap5, Claire Jacques1 and Francis Berenbaum6, 1Ur-4, Pierre et Marie Curie University Paris VI, Paris, France, 2EA 2496, Paris Descartes University, Montrouge, France, 3Sorbonne Universités, UPMC Univ Paris 06, UMRS 938 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France, 4UR4, University Pierre and Marie Curie, Paris, France, 5Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, 6Rheumatology, AP-HP, St Antoine Hospital, Paris, France

    Background/Purpose: The cartilage matrix breakdown in osteoarthritis (OA) is due to both abnormal mechanical stress and activation of catabolic processes involving metalloproteinases (MMPs). Currently, IL-1beta…
  • Abstract Number: 22 • 2012 ACR/ARHP Annual Meeting

    Protective Properties of Conditioned Media From Adipose Stem Cells On Osteoarthritic Chondrocytes

    Maria Isabel Guillén1, Julia Platas1, Vicente Mirabet2, Miguel Angel Castejón3, Francisco Gomar4 and Maria Jose Alcaraz1, 1Pharmacology, University of Valencia, Burjasot, Valencia, Spain, 2Generalitat Valenciana, Valencia, Spain, 3De la Ribera University Hospital, Alzira, Spain, 4Surgery, University of Valencia and University Hospital, Valencia, Spain

    Background/Purpose: Adipose-derived mesenchymal stem cells (ASC) exhibit a high potential for cell therapy and they might also act as a cellular source for supplying soluble…
  • Abstract Number: 25 • 2012 ACR/ARHP Annual Meeting

    Activation of the Canonical Wnt Signaling Pathway Is Tissue Dependent in Osteoarthritic Joints: Distinct Mechanisms of Regulation by Wnt Antagonists

    Thomas Funck-Brentano1, Wafa Bouaziz1, Hilene Lin1, Valerie Geoffroy1, Eric Hay1 and Martine Cohen-Solal2, 1INSERM U606 Paris 7 university, Paris, France, 2Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France

    Background/Purpose: Wnt signaling pathway is a major regulator of bone and cartilage remodeling. Modulation of this pathway has lead to controversial results on joint cartilage…
  • Abstract Number: 250 • 2012 ACR/ARHP Annual Meeting

    Incident and Worsening Cartilage Damage in the Lateral Compartment and Multiple Subregions Worsening in the Medial Compartment Increase the Risk for Knee Replacement – Data From the Osteoarthritis Initiative

    Frank Roemer1, C. Kent Kwoh2, Michael J. Hannon3, Robert M. Boudreau4, Felix Eckstein5, David J. Hunter6, Zhijie Wang3, Markus R. John7 and Ali Guermazi8, 1Klinikum Augsburg, Augsburg, Germany, 2School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 3Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 4Epidemiology, University of Pittsburgh, Pittsburgh, PA, 5Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, 6Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, 7Novartis Pharma AG, Basel, Switzerland, 8Boston University, Boston, MA

    Background/Purpose: Knee joint replacement (KR) is a cost-effective procedure with good long-term outcomes. However, at present there is no clear consensus on indications for KR.…
  • Abstract Number: 994 • 2012 ACR/ARHP Annual Meeting

    The Genome-Wide Expression of Human Osteoarthritic Cartilage Shows A Differential Pattern Between Two Subgroups of OA Patients

    Ignacio Rego-Perez1, Juan Fernandez-Tajes1, Angel Soto-Hermida2, Mercedes Fernandez Moreno1, Maria Eugenia Vazquez Mosquera3, Natividad Oreiro1, Carlos Fernandez-Lopez1, Estefania Cortes Pereira1, Sara Relaño-Fernandez1 and Francisco J. Blanco1, 1INIBIC-Hospital Universitario A Coruña. Genomic Group. Rheumatology Division., A Coruña, Spain, 2INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, 3Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain

     Background/Purpose: Many genes, many of them still unknown, are involved in the etiology and development of OA. Today, different tools are available to try to…
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