Abstract Number: 63 • 2013 ACR/ARHP Annual Meeting
Investigations On The Role Of Delta/Notch Like EGF-Related Receptor In The Pathogenesis Of Osteoarthritis
Background/Purpose: Delta/Notch like EGF-related receptor (DNER) is a single-pass transmembrane protein with characteristic EGF-like repeats in the extracellular domain, similar to those of the Notch…Abstract Number: 1132 • 2013 ACR/ARHP Annual Meeting
Sensitivity To Change Of Radiographic Fixed-Location and Magnetic Resonance Imaging-Based Cartilage Thickness Measures In The Lateral Compartment Of Knees With Radiographic Osteoarthritis – Data From The Osteoarthritis Initiative
Background/Purpose: Radiographic joint space width (JSW) is frequently employed to indirectly assess structural progression in the medial femorotibial compartment, but it is unclear whether assessment…Abstract Number: 64 • 2013 ACR/ARHP Annual Meeting
Fibulin-3 In Joint Aging and Osteoarthritis Pathogenesis
Background/Purpose: Osteoarthritis (OA) is the most common joint disease. Among the earliest lesions during OA development is disruption of the superficial zone (SZ) of articular…Abstract Number: 1127 • 2013 ACR/ARHP Annual Meeting
Semiquantitative MRI Features Of Knee Osteoarthritis Show Compartment-Specific Relationships With Quantitative Cartilage Thickness Loss: The Multicenter Osteoarthritis Study
Background/Purpose: Structural progression of knee OA has been associated with several radiographic and MRI-measured pathological features of OA, including malalignment, meniscal pathology and bone marrow…Abstract Number: 66 • 2013 ACR/ARHP Annual Meeting
Follistatin-Like Protein 1 Is An Important Regulator Of Chondrogenesis
Background/Purpose: Chondrocytes play a pivotal role in osteoarthritis (OA) because they are the only cells in the articular cartilage that are responsible for maintenance of…Abstract Number: 1129 • 2013 ACR/ARHP Annual Meeting
Development and Validation Of a Rapid Knee Cartilage Quantification Method
Background/Purpose: Cartilage morphometry on magnetic resonance images (MRIs) may become an acceptable outcome measure for clinical trials among patients with knee osteoarthritis (OA). However, obtaining…Abstract Number: 69 • 2013 ACR/ARHP Annual Meeting
Interconnected Cellular Projections and Gap Junctions Mediate Metabolic Coupling Between Chondrocytes Located In Different Layers Of The Tissue: Cell-To-Cell Communication In Normal and Osteoarthritic Cartilage
Background/Purpose: We have recently found that articular chondrocytes from human adults contain long cytoplasmic arms that cross the extracellular matrix and physically connect two chondrocytes…Abstract Number: 769 • 2013 ACR/ARHP Annual Meeting
Synovial Wnt and WISP1 Expression Induces Expression Of Cartilage-Degrading Metalloproteinases In The Synovium
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. Previously, we found strong upregulation of Wnts 2b and 16 and…Abstract Number: 75 • 2013 ACR/ARHP Annual Meeting
Decorin-Deficiency Alters Cartilage Stiffness and Attenuates The Development Of Osteoarthritis In Mice
Background/Purpose: In articular (AC) and growth plate (GP) cartilage, the small leucine-rich proteoglycan decorin is mainly present within the interterritorial regions (ITs) of the extracellular…Abstract Number: 770 • 2013 ACR/ARHP Annual Meeting
Suppressor Of Cytokine Signaling-3 Is a Critical Regulator Of gp130 Cytokine Signaling In Articular Chondrocytes
Background/Purpose: Cartilage damage is a key feature of inflammatory and degenerative arthritis and an important determinant of patient outcomes. Chondrocytes are the only cells in…Abstract Number: 77 • 2013 ACR/ARHP Annual Meeting
Human Mesenchymal Stem Cells Cultured On Collagen Scaffolds For Cartilage Tissue Engineering
Background/Purpose: Osteoarthritis is a degenerative disease without a treatment. Tissue Engineering could provide an alternative tool for cartilage repair. The aim of this study was…Abstract Number: 771 • 2013 ACR/ARHP Annual Meeting
The S100A9 Inhibitor Paquinimod (ABR-215757) Reduces Synovial Activation, Osteophyte Formation and Cartilage Damage In Experimental Osteoarthritis
Background/Purpose: Synovial activation is present in a large subset of osteoarthritis (OA) patients and it is thought to play an important role in the development…Abstract Number: 78 • 2013 ACR/ARHP Annual Meeting
Norepinephrine (NE) Inhibits Mesenchymal Stem Cell (MSCs) Chondrogenesis By Accelerating Hypertophy – Relevance For Cartilage Regeneration
Background/Purpose: The high potential of mesenchymal stem cells (MSCs) in cartilage regeneration is undoubtful. The presence of MSCs in healthy or arthritic cartilage has also…Abstract Number: 238 • 2013 ACR/ARHP Annual Meeting
Structural Predictors Of Ten Year Knee Cartilage Volume Loss
Background/Purpose: Cartilage volume loss is considered a key feature of knee osteoarthritis (OA) and increased loss over two years is associated with future knee replacement…Abstract Number: 59 • 2013 ACR/ARHP Annual Meeting
Downregulated Forkhead-Box Class O Transcription Factors Attenuate Oxidative Stress Resistance In Human Chondrocytes
Background/Purpose: Aging-associated changes in articular chondrocytes represent a major risk factor for osteoarthritis (OA). The major signaling pathway that regulates cellular aging is the Insulin/IGF-1/Pl3k/Akt/forkhead-box…
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