Abstract Number: 58 • 2013 ACR/ARHP Annual Meeting
Saturated Fatty Acids Act Synergistically With Interleukin 1 Beta To Increase Inflammation, Endoplasmic Reticulum Stress and Cell Death In Human Articular Chondrocytes
Background/Purpose: Obesity is a major risk factor for the development of osteoarthritis (OA). Altered biomechanics have been postulated as the main causative mechanism, but recent…Abstract Number: 156 • 2013 ACR/ARHP Annual Meeting
Cartilage Peptide Profiling: Identifying Novel OA Biomarkers For Early Disease Detection
Background/Purpose: Cartilage secretome contains a complex matrix of proteolytically derived peptides that may provide useful information of the biological events occurring in the articular joint…Abstract Number: 771 • 2013 ACR/ARHP Annual Meeting
The S100A9 Inhibitor Paquinimod (ABR-215757) Reduces Synovial Activation, Osteophyte Formation and Cartilage Damage In Experimental Osteoarthritis
Background/Purpose: Synovial activation is present in a large subset of osteoarthritis (OA) patients and it is thought to play an important role in the development…Abstract Number: 44 • 2013 ACR/ARHP Annual Meeting
Suppressor Of Cytokine Signaling 3 Negatively Modulates Leptin-Mediated Catabolic and Proinflammatory Effects In Cartilage – New Potential Mechanism To Target Obesity-Induced Osteoarthritis
Background/Purpose: Adipocytokine leptin has been suggested to link obesity and osteoarthritis (OA). Initially leptin was found to regulate energy metabolism through central nervous system. More…Abstract Number: 69 • 2013 ACR/ARHP Annual Meeting
Interconnected Cellular Projections and Gap Junctions Mediate Metabolic Coupling Between Chondrocytes Located In Different Layers Of The Tissue: Cell-To-Cell Communication In Normal and Osteoarthritic Cartilage
Background/Purpose: We have recently found that articular chondrocytes from human adults contain long cytoplasmic arms that cross the extracellular matrix and physically connect two chondrocytes…Abstract Number: 238 • 2013 ACR/ARHP Annual Meeting
Structural Predictors Of Ten Year Knee Cartilage Volume Loss
Background/Purpose: Cartilage volume loss is considered a key feature of knee osteoarthritis (OA) and increased loss over two years is associated with future knee replacement…Abstract Number: 49 • 2013 ACR/ARHP Annual Meeting
Chondrocyte-Specific Bone Morphogenetic Protein-2 Overexpression Results In Severe Aggravation Of Osteophyte Formation In Experimental Osteoarthritis Without Altering Cartilage Damage In Young Mice
Background/Purpose: In murine osteoarthritis (OA) models chondrocytes surrounding lesions express elevated levels of Bone Morphogenetic Protein-2 (BMP2). This growth factor is well known for its…Abstract Number: 2753 • 2013 ACR/ARHP Annual Meeting
Relationship Of Pre-Radiographic MRI Lesions With Prevalent Frequent Knee Symptoms and Incident Persistent Knee Symptoms In Persons At Higher Risk For Knee Osteoarthritis
Background/Purpose: The clinical significance of pre-radiographic MRI lesions in persons at risk for knee OA is unclear. Understanding whether such lesions are inconsequential or early…Abstract Number: 239 • 2013 ACR/ARHP Annual Meeting
A Family History Of Knee Joint Replacement Increases The Progression Of Knee Joint Radiographic Osteoarthritis and Cartilage Volume Loss Over Ten Years
Background/Purpose: Osteoarthritis (OA) is a disease of multifactorial origin with a modest but significant heritable effect for disease severity in the knee joint. The aim…Abstract Number: 50 • 2013 ACR/ARHP Annual Meeting
Cartilage Matrix Remodeling and Activation Of Canonical Wnt- Signaling Precedes Calcification and OA-Like Changes In Mice
Background/Purpose: Calcification of cartilage is a common finding during osteoarthritis (OA) and is directly linked to the severity of cartilage degradation. We have found in…Abstract Number: 2729 • 2013 ACR/ARHP Annual Meeting
Identification Of Osteoarthritis Patients With Chronic Inflammation Driven Disease Progression
Background/Purpose: In osteoarthritis (OA) it is evident that a subset of patients experiences chronic tissue inflammation and may benefit from anti-inflammatory treatment. The systemic inflammation…Abstract Number: 80 • 2013 ACR/ARHP Annual Meeting
Tidemark Duplication In Osteoarthritis: Evidence Of Incremental Progression?
· Background/Purpose: Osteoarthritis (OA) is commonly envisioned as a gradual, relentlessly progressive process of "wear and tear" leading to eventual joint failure. As we see…Abstract Number: 51 • 2013 ACR/ARHP Annual Meeting
Collagen-Based Microspheres Delivering TGF-β3 For Mesenchymal STEM CELL Differentiation: An Innovative Strategy For Cartilage Engineering
Background/Purpose: Because of a poor self-healing ability, joint cartilage undergoes progressive degradation in the course of aging or following traumatic injuries. One promising therapeutic approach…Abstract Number: 2519 • 2012 ACR/ARHP Annual Meeting
IL-1β and TNF-α Regulate the Global and Locus-Specific hydroxymethylation of Genomic DNA by Modulating the Expression and Activity of Tet-1 in Human OA Chondrocytes
Background/Purpose: 5-hydroxymethylcytosine (5-hmC), which is formed by the oxidation of 5-methylcytosine (5-mC), is a recently discovered epigenetic mark and is highest in brain and in…Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting
Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis
Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…