Abstracts tagged "cartilage"

Abstract Number: 239 • 2013 ACR/ARHP Annual Meeting
A Family History Of Knee Joint Replacement Increases The Progression Of Knee Joint Radiographic Osteoarthritis and Cartilage Volume Loss Over Ten Years
Hussain Ijaz Khan¹, Dawn Aitken¹, Louisa Chou¹, Andrew McBride¹, Changhai Ding², Jean Pierre Pelletier^3,4, Johanne M. Pelletier⁵, Leigh Blizzard⁶, Flavia Cicuttini⁷ and Graeme Jones², ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ⁴Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ⁵Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ⁶Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁷Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Osteoarthritis (OA) is a disease of multifactorial origin with a modest but significant heritable effect for disease severity in the knee joint. The aim…
Abstract Number: 50 • 2013 ACR/ARHP Annual Meeting
Cartilage Matrix Remodeling and Activation Of Canonical Wnt- Signaling Precedes Calcification and OA-Like Changes In Mice
Jessica Bertrand¹, Tabea Kräft², Yvonne Nitschke³, Thelonius Hawellek⁴, Jan Hubert⁴, Lars Godmann⁵ and Thomas Pap⁵, ¹Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ²Inst, University Hospital Münster, Muenster, Germany, ³University Hospital Münster, Muenster, Germany, ⁴University Hospital Hamburg, Hamburg, Germany, ⁵Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Calcification of cartilage is a common finding during osteoarthritis (OA) and is directly linked to the severity of cartilage degradation. We have found in…
Abstract Number: 2729 • 2013 ACR/ARHP Annual Meeting
Identification Of Osteoarthritis Patients With Chronic Inflammation Driven Disease Progression
Anne Sofie Siebuhr¹, Kristian Kjaer Petersen², Lars Arendt-Nielsen³, Line Egsgaard², Thomas Navndrup Eskehave⁴, Ole Simonsen⁵, Claus Christiansen^4,6, Hans Christian Hoeck⁴, Morten Asser Karsdal⁷ and Anne C. Bay-Jensen⁸, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, ³Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁴Center for Clinical and Basic Research and C4Pain, Aalborg, Denmark, ⁵Frederikshavn Hospital, Frederikshavn, Denmark, ⁶Nordic Bioscience, Herlev, Denmark, ⁷Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁸Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: In osteoarthritis (OA) it is evident that a subset of patients experiences chronic tissue inflammation and may benefit from anti-inflammatory treatment. The systemic inflammation…
Abstract Number: 80 • 2013 ACR/ARHP Annual Meeting
Tidemark Duplication In Osteoarthritis: Evidence Of Incremental Progression?
Martine P. Roudier¹, Paul A. Manner² and Peter A. Simkin³, ¹Pathology, University of Washington, Seattle, WA, ²Orthopaedics, University of Washington, Seattle, WA, ³Div of Rheumatology, University of Washington, Seattle, WA
· Background/Purpose: Osteoarthritis (OA) is commonly envisioned as a gradual, relentlessly progressive process of "wear and tear" leading to eventual joint failure. As we see…
Abstract Number: 51 • 2013 ACR/ARHP Annual Meeting
Collagen-Based Microspheres Delivering TGF-β3 For Mesenchymal STEM CELL Differentiation: An Innovative Strategy For Cartilage Engineering
Marc Mathieu¹, E Belamie², M-N Labour², Sylvain Vigier², Christian Jorgensen³ and Daniele Noel⁴, ¹INSERM U844, Montpellier, France, ²ICGM UMR 5253, MONTPELLIER, France, ³Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, ⁴Inserm U844, UM1, Montpellier, France
Background/Purpose: Because of a poor self-healing ability, joint cartilage undergoes progressive degradation in the course of aging or following traumatic injuries. One promising therapeutic approach…
Abstract Number: 2669 • 2013 ACR/ARHP Annual Meeting
Treatment Of Knee Osteoarthritis Patients With Strontium Ranelate Reduces The Loss Of Cartilage Volume and Bone Marrow Lesions As Assessed By Magnetic Resonance Imaging: Data From The Phase III Strontium Ranelate Efficacy In Knee Osteoarthrtis Trial
Johanne Martel-Pelletier¹, Camille Roubille¹, Jean-Pierre Raynauld¹, François Abram², Marc Dorais³, Philippe Delorme¹ and Jean-Pierre Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada
Background/Purpose: This study aimed to evaluate in a subpopulation of osteoarthritis (OA) patients from the SEKOIA Phase III trial the disease-modifying (DMOAD) effect of strontium…
Abstract Number: 84 • 2013 ACR/ARHP Annual Meeting
New Formulation With Potential To Prevent and Treat Osteoporosis and Osteoarthritis
A. Torrent¹, E. Montell², J. Vergés¹, P. Dalmau³, R. Ruhí³, M.C. Carceller⁴, A. Blanco⁴, M.C. Terencio⁴, M.L. Ferrándiz⁴ and M.J. Alcaraz⁵, ¹Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain, ²Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain, ³Technological Extraction Dept, BIOIBERICA S.A., Palafolls, Spain, ⁴Department of Pharmacology and IDM, University of Valencia, Burjassot, Spain, ⁵University of Valencia, Burjasot, Valencia, Spain
Background/Purpose: Osteoarthritis (OA) is a multidimensional disease that affects all anatomical joint structures, particularly cartilage, synovium and subchondral bone. In turn, osteoporosis (OP) is a…
Abstract Number: 2670 • 2013 ACR/ARHP Annual Meeting
Does Change In Femorotibial Cartilage Thickness Differ Between Acutely Anterior-Cruciate Ligament Injured Knees Treated With and Without Reconstructive Surgery
Wolfgang Wirth¹, Felix Eckstein¹, Martin Hudelmaier², Stefan Lohmander³ and Richard Frobell⁴, ¹Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ²Paracelsus Medical University, Salzburg, Austria, ³Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, ⁴Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose: An ACL tear is a serious knee injury, involving chronic alterations in joint biomechanics. The risk of developing knee OA after an ACL tear…
Abstract Number: 85 • 2013 ACR/ARHP Annual Meeting
Cartilaginous Uric Acid Deposition In Advanced Osteoarthritis: Innocent Bystander Or Promotor Of Cartilage Destruction?
Tim Bongartz¹, Andre M Oliveira², Rafael J Sierra³, Arlen D Hanssen³ and Michael J Taunton³, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Pathology, Mayo Clinic, Rochester, MN, ³Orthopedic Surgery, Mayo Clinic, Rochester, MN
Background/Purpose: Recent studies have suggested that synovial fluid uric acid could contribute to tissue inflammation, disease severity and progression of osteoarthritis (OA). Intraarticular uric acid…
Abstract Number: 1950 • 2013 ACR/ARHP Annual Meeting
Relationship Between Radiographic Joint Space Narrowing, Sonographic Cartilage Thickness and Anatomy In Rheumatoid Arthritis and Control Joints
Peter Mandl¹, Gabriela Supp², Gabor Baksa³, Daniel Aletaha⁴, Reka Kurucz⁵, Dora Niedermayer⁶, Helga Radner⁷, Paul Studenic⁸, Peter V. Balint⁹ and Josef S. Smolen¹⁰, ¹Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Semmelweis University, Budapest, Hungary, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Austria, ⁵National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ⁶PsAID taskforce, EULAR, Zurich, Switzerland, ⁷Department of Internal Medicine III; Division of Rheumatology, Medical University Vienna, Vienna, Austria, ⁸Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁹Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ¹⁰Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: To validate ultrasound (US) for measuring cartilage thickness, by evaluating cartilage thickness on cadaver specimens of metacarpophalangeal (MCP) joints by US and conventional measurement.…
Abstract Number: 60 • 2013 ACR/ARHP Annual Meeting
O-Linked N-Acetylglucosamine Modified Proteome Of Human Osteoarthritic Cartilage: Biological Significance
Jessica Andrés-Bergós^1,2, María Luisa Hernáez³, Miguel Otero², Ane Larranaga-Vera¹, Sandra Pérez-Baos¹, Mary B. Goldring², Gabriel Herrero-Beaumont¹ and Raquel Largo⁴, ¹Joint and Bone Research Unit. IIS-Fundación Jiménez Díaz. UAM, Madrid, Spain, ²Tissue Engineering Repair and Regeneration Program, Hospital for Special Surgery and Weill Cornell Medical College, New York, NY, ³Proteomics Unit, Universidad Complutense de Madrid-Parque Científico de Madrid, ProteoRed ISCIII, Madrid, Spain, ⁴Bone and Joint Research Unit, IIS-Fundación Jiménez Díaz, Madrid, Spain
Background/Purpose: O-linked N-acetylglucosamine (O-GlcNAc) post-translational modifications have been implicated in the control of different signaling cascades and in the development and progression of degenerative and…
Abstract Number: 1898 • 2013 ACR/ARHP Annual Meeting
Repression Of Wolf-Hischhorn Syndrome Candidate-1 (WHSC1) Contributes To The Osteoarthritis-Inducing Cartilage Loss Of Functions
Francisco Espinoza¹, Yves-Marie Pers², Paul Chuchana³, Jean Marc Brondello⁴ and Christian Jorgensen², ¹INSERM U844, MONTPELLIER, France, ²Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, ³INSERM U844, Montpellier, France, ⁴Inserm U844, UM1, Montpellier, France
Background/Purpose: Accumulation of senescent p16INK4A-positive cells within numerous tissues through out life span contributes to the onset of several age-related disease such as intervertebral disc…
Abstract Number: 61 • 2013 ACR/ARHP Annual Meeting
Epigenome-Wide DNA Methylation Study Reveals Hypermethylated Collagen Genes and Suggests a Role for TGFβ in Osteoarthritis
Matlock A. Jeffries^1,2, Amr H. Sawalha³ and Judith A. James⁴, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis & Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic disability in the U.S., affecting 40% of individuals over the age of 70 and costing $128…
Abstract Number: 1119 • 2012 ACR/ARHP Annual Meeting
Prediction of MRI-Detected Cartilage Loss Over 30 Months Using Simplified Radiographic and Clinical Stratification: The MOST Study
Frank Roemer¹, David T. Felson², Jingbo Niu³, Yuqing Zhang², Michael C. Nevitt⁴, Michel Crema⁵, Cora E. Lewis⁶, James Torner⁷ and Ali Guermazi⁵, ¹Klinikum Augsburg, Augsburg, Germany, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁵Boston University, Boston, MA, ⁶Preventive Medicine, University of Alabama, Birmingham, Birmingham, AL, ⁷Epidemiology, University of Iowa, Iowa City, Iowa City, IA
Background/Purpose: MRI-detected cartilage loss is the main structural outcome measure in large studies of knee OA. Definition of subjects at high risk for cartilage loss…
Abstract Number: 10 • 2012 ACR/ARHP Annual Meeting
Fibronectin Fragment Induces Procatabolic Effects Through TLR-2 Signaling Pathway in Human Articular Chondrocytes
Su Jin Park¹, Eun-Jeong Cheon² and Hyun Ah Kim³, ¹Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ²Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Hallym university, Kyunggi, South Korea
Background/Purpose: Fibronectin fragments (FN-fs) are increased in the synovial fluid of osteoarthritis patients and have a potent chondrolytic effect. However, little is known about the…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].