Abstracts tagged "cartilage"

Abstract Number: 1399 • 2013 ACR/ARHP Annual Meeting
Citrullinated Proteoglycan (Aggrecan) Present In Human Cartilage Is Recognized By Serum Antibodies From Rheumatoid Arthritis Patients
Timea Ocsko¹, Beata Tryniszewska¹, Andras Vida¹, Janos Gal², Gyorgyi Soos², Zoltan Szekanecz³, Tibor A. Rauch¹, Joshua Jacobs¹, Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, Bacs-Kiskun County Hospital, Kecskemet, Hungary, ³Rheumatology, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary
Background/Purpose: Citrullination is a post-translational protein modification, where arginine (Arg) is converted to citrulline (Cit) by peptidyl arginine deiminases (PADI). The presence of anti-citrullinated protein…
Abstract Number: 66 • 2013 ACR/ARHP Annual Meeting
Follistatin-Like Protein 1 Is An Important Regulator Of Chondrogenesis
Yury Chaly¹, Sonja Smith², Daniel Bushnell³, Brian Campfield⁴, Harry Blair⁵ and Raphael Hirsch⁶, ¹Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ²University of Iowa Carver College of Medicine, Iowa City, IA, ³Division of Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁴Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁵University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁶Department of Pediatrics,, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Chondrocytes play a pivotal role in osteoarthritis (OA) because they are the only cells in the articular cartilage that are responsible for maintenance of…
Abstract Number: 1132 • 2013 ACR/ARHP Annual Meeting
Sensitivity To Change Of Radiographic Fixed-Location and Magnetic Resonance Imaging-Based Cartilage Thickness Measures In The Lateral Compartment Of Knees With Radiographic Osteoarthritis – Data From The Osteoarthritis Initiative
Wolfgang Wirth¹, Jeffrey W. Duryea², Michael C. Nevitt³, Robert J. Buck⁴, David Hunter⁵ and Felix Eckstein¹, ¹Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ²Radiology, Brigham and Women's Hospital, Boston, MA, ³Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁴StatAnswers Consulting, Minneapolis, MN, ⁵Royal North Shore Hospital, St. Leonards, Australia
Background/Purpose: Radiographic joint space width (JSW) is frequently employed to indirectly assess structural progression in the medial femorotibial compartment, but it is unclear whether assessment…
Abstract Number: 75 • 2013 ACR/ARHP Annual Meeting
Decorin-Deficiency Alters Cartilage Stiffness and Attenuates The Development Of Osteoarthritis In Mice
Tobias Gronau¹, Uwe Hansen², Daniela Seidler², Renato Iozzo³, Attila Aszodi⁴, Carina Prein⁵, Hauke Clausen-Schaumann⁵, Karsten Krüger⁶, Frank Mooren⁶, Jessica Bertrand¹, Thomas Pap⁷, Peter Bruckner² and Rita Dreier², ¹Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ²Institute for Physiological Chemistry & Pathobiochemistry, University Hospital Münster, Münster, Germany, ³Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, ⁴Experimental Surgery and Regenerative Medicine, Ludwig-Maximilians-University Munich, Munich, Germany, ⁵Department of Applied Sciences and Mechatronics, Munich University of Applied Sciences, Munich, Germany, ⁶Institute of Sports Medicine, Justus-Liebig University Giessen, Giessen, Germany, ⁷Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: In articular (AC) and growth plate (GP) cartilage, the small leucine-rich proteoglycan decorin is mainly present within the interterritorial regions (ITs) of the extracellular…
Abstract Number: 1127 • 2013 ACR/ARHP Annual Meeting
Semiquantitative MRI Features Of Knee Osteoarthritis Show Compartment-Specific Relationships With Quantitative Cartilage Thickness Loss: The Multicenter Osteoarthritis Study
Ali Guermazi¹, Felix Eckstein², Daichi Hayashi³, Frank Roemer⁴, Wolfgang Wirth², Tianzhong Yang⁵, Jingbo Niu⁶, Leena Sharma⁷, Michael C. Nevitt⁸, Cora E. Lewis⁹, James Torner¹⁰ and David T. Felson¹¹, ¹Boston University, Boston, MA, ²Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ³Department of Radiology, Boston University School of Medicine, Boston, MA, ⁴Radiology, Boston University School of Medicine, Boston, MA, ⁵Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ⁶Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁷Northwestern University, Chicago, IL, ⁸Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁹Preventive Medicine, University of Alabama, Birmingham, Birmingham, AL, ¹⁰Epidemiology, University of Iowa, Iowa City, Iowa City, IA, ¹¹Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Structural progression of knee OA has been associated with several radiographic and MRI-measured pathological features of OA, including malalignment, meniscal pathology and bone marrow…
Abstract Number: 77 • 2013 ACR/ARHP Annual Meeting
Human Mesenchymal Stem Cells Cultured On Collagen Scaffolds For Cartilage Tissue Engineering
Clara Sanjurjo-Rodríguez¹, Adela Helvia Martínez-Sánchez², Tamara Hermida-Gómez¹, Isaac M. Fuentes-Boquete^1,2, Francisco J. De Toro^2,3, Julia Buján⁴, Silvia Díaz-Prado^2,3 and Francisco J. Blanco², ¹Grupo de Bioingeniería Tisular y Terapia Celular (CBTTC-CHUAC). CIBER-BBN/ISCIII. Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de Coruña (CHUAC). SERGAS. Universidade de A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, ³INIBIC-Universidade da Coruña, A Coruña, Spain, ⁴University of Alcalá de Henares, Department of Medical Specialties, Madrid, Spain
Background/Purpose: Osteoarthritis is a degenerative disease without a treatment. Tissue Engineering could provide an alternative tool for cartilage repair. The aim of this study was…
Abstract Number: 1129 • 2013 ACR/ARHP Annual Meeting
Development and Validation Of a Rapid Knee Cartilage Quantification Method
Ming Zhang¹, Jeffrey B. Driban², Lori Lyn Price³, Daniel Harper¹, Grace H. Lo⁴, Eric Miller⁵, Robert J. Ward⁶ and Timothy E. McAlindon⁷, ¹Rheumotology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁴VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ⁵Department of Electrical and Computer Engineering, Tufts University, Medford, MA, ⁶Radiology, Tufts Medical Center, Boston, MA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Cartilage morphometry on magnetic resonance images (MRIs) may become an acceptable outcome measure for clinical trials among patients with knee osteoarthritis (OA). However, obtaining…
Abstract Number: 78 • 2013 ACR/ARHP Annual Meeting
Norepinephrine (NE) Inhibits Mesenchymal Stem Cell (MSCs) Chondrogenesis By Accelerating Hypertophy – Relevance For Cartilage Regeneration
Zsuzsa Jenei-Lanzl¹, Peter Angele², Frieder Kees³, Georg Pongratz⁴ and Rainer H. Straub⁵, ¹Department of Internal Medicine, University Hospital Regensburg, 1Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Regensburg, Germany, ²Department of Trauma Surgery, University Hospital Regensburg, Germany, Regensburg, Germany, ³Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany, ⁴Internal Medicine, University Hospital Regensburg, Regensburg, Germany, ⁵Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: The high potential of mesenchymal stem cells (MSCs) in cartilage regeneration is undoubtful. The presence of MSCs in healthy or arthritic cartilage has also…
Abstract Number: 769 • 2013 ACR/ARHP Annual Meeting
Synovial Wnt and WISP1 Expression Induces Expression Of Cartilage-Degrading Metalloproteinases In The Synovium
Martijn H. van den Bosch¹, Arjen B. Blom¹, Sylvia W. Suen², Anke E. van Erp², Fons A. van de Loo³, Esmeralda N. Blaney Davidson¹, Peter M. van der Kraan³, Peter L. van Lent⁴ and Wim B. van den Berg⁵, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. Previously, we found strong upregulation of Wnts 2b and 16 and…
Abstract Number: 59 • 2013 ACR/ARHP Annual Meeting
Downregulated Forkhead-Box Class O Transcription Factors Attenuate Oxidative Stress Resistance In Human Chondrocytes
Yukio Akasaki and Martin K. Lotz, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA
Background/Purpose: Aging-associated changes in articular chondrocytes represent a major risk factor for osteoarthritis (OA). The major signaling pathway that regulates cellular aging is the Insulin/IGF-1/Pl3k/Akt/forkhead-box…
Abstract Number: 151 • 2013 ACR/ARHP Annual Meeting
The mtDNA Haplogroups Influence The Cartilage Integrity In Osteoarthritis. Data From The Osteoarthritis Initiative (OAI)
Ignacio Rego-Pérez¹, Angel Soto-Hermida², Mercedes Fernández-Moreno², Sonia Pértega-Díaz³, Juan Fernández-Tajes², María Eugenia Vázquez-Mosquera², Estefanía Cortés-Pereira², Sara Relaño-Fernández², Natividad Oreiro-Villar², Carlos Fernández-López² and Francisco J. Blanco^4,5,6, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁴Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain, ⁶CIBER-BBN-ISCIII, Madrid, Spain
Background/Purpose: Magnetic resonance imaging (MRI) is ideally suited for detect structural changes and degradation in cartilage against the limitations of radiographic common methods. Changes in…
Abstract Number: 770 • 2013 ACR/ARHP Annual Meeting
Suppressor Of Cytokine Signaling-3 Is a Critical Regulator Of gp130 Cytokine Signaling In Articular Chondrocytes
Xiao Liu^1,2, Kate E Lawlor^1,2, Ben A Croker¹ and Ian P Wicks^1,2,3, ¹Inflammation Division, Walter & Eliza Hall Institute of Medical Research, Parkville, Australia, ²Department of Medical Biology, University of Melbourne, Parkville, Australia, ³Department of Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia
Background/Purpose: Cartilage damage is a key feature of inflammatory and degenerative arthritis and an important determinant of patient outcomes. Chondrocytes are the only cells in…
Abstract Number: 58 • 2013 ACR/ARHP Annual Meeting
Saturated Fatty Acids Act Synergistically With Interleukin 1 Beta To Increase Inflammation, Endoplasmic Reticulum Stress and Cell Death In Human Articular Chondrocytes
Oscar Alvarez-Garcia¹, Nicole H Rogers², Roy G Smith³ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²California Institute for Biomedical Research (Calibr), La Jolla, CA, ³Department of Metabolism and Aging, Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL
Background/Purpose: Obesity is a major risk factor for the development of osteoarthritis (OA). Altered biomechanics have been postulated as the main causative mechanism, but recent…
Abstract Number: 250 • 2012 ACR/ARHP Annual Meeting
Incident and Worsening Cartilage Damage in the Lateral Compartment and Multiple Subregions Worsening in the Medial Compartment Increase the Risk for Knee Replacement – Data From the Osteoarthritis Initiative
Frank Roemer¹, C. Kent Kwoh², Michael J. Hannon³, Robert M. Boudreau⁴, Felix Eckstein⁵, David J. Hunter⁶, Zhijie Wang³, Markus R. John⁷ and Ali Guermazi⁸, ¹Klinikum Augsburg, Augsburg, Germany, ²School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁵Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ⁶Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁷Novartis Pharma AG, Basel, Switzerland, ⁸Boston University, Boston, MA
Background/Purpose: Knee joint replacement (KR) is a cost-effective procedure with good long-term outcomes. However, at present there is no clear consensus on indications for KR.…
Abstract Number: 111 • 2012 ACR/ARHP Annual Meeting
Ultrasound Measurement of Metacarpal Cartilage Thickness Correlates with Joint Space Narrowing in the Metacarphalangeal Joints of Patients with Rheumatoid Arthritis
Peter Mandl¹, Helga Radner², Gabriela Supp³, Peter V. Balint⁴, Daniel Aletaha³ and Josef S. Smolen⁵, ¹Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III; Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ⁵Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: To correlate cartilage thickness as measured by ultrasound (US) with joint space narrowing as measured by conventional radiography in the metacarpophalangeal (MCP) joints of…

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