Abstracts tagged "Bone"

Abstract Number: 156 • 2016 ACR/ARHP Annual Meeting
Detection of Finger Joint Osteophytes and Bone Erosions By Ultrasound; A Comparison to Computed Tomography and Histology
Martin Stradner¹, Stephanie Finzel², Rusmir Husic¹, Manuel Dreu³, Alexander Hofmeister⁴, christine Beham-Schmid⁵, Winfried Graninger¹ and Christian Dejaco¹, ¹Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ²Department of Rheumatology and Clinical Immunology, Medical Faculty, University Medical Center, University of Freiburg, Freiburg, Germany, ³Department of Anatomy, Medical University of Graz, Graz, Austria, ⁴Core Facility Alternative Biomodels & Preclinical Imaging, Medical University of Graz, Graz, Austria, ⁵5Institute of Pathology, Medical University of Graz, Graz, Austria
Background/Purpose: Ultrasound (US) is an emerging technique for the examination of osteoarthritis of the hands (HOA).Bone erosions and osteophytes are hallmarks of advanced HOA. We…
Abstract Number: 984 • 2015 ACR/ARHP Annual Meeting
Tofacitinib Inhibits Inflammation and New Bone Formation in Murine Spondyloarthritis but Does Not Adversely Inhibit Normal Human MSC Function
Rik Lories¹, Katelijne De Wilde², Kerri Heritage¹, Richard Cuthbert³, Elena Jones³, Karlijn Debusschere⁴, Dennis McGonagle³ and Dirk Elewaut⁵, ¹Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven and University Hospitals Leuven., Leuven, Belgium, ²Laboratory for Molecular Immunology and Inflammation; Department of Rheumatology,, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Laboratory for Molecular Immunology and Inflammation; Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ⁵Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium
Background/Purpose: Inflammation and new bone formation at entheseal sites are hallmarks of spondyloarthritis (SpA). As TNF inhibition has only limited impact on new bone formation,…
Abstract Number: 1035 • 2015 ACR/ARHP Annual Meeting
Synovium-Derived microRNAs Inhibit Bone Formation in Rheumatoid Arthritis
Ellen M. Gravallese¹, Yukiko Maeda², Nicholas H Farina³, Paul Fanning⁴ and Jane Lian³, ¹Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Department of Biochemistry, University of Vermont, Burlington, VT, ⁴Department of Orthopedics, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Articular bone erosion in rheumatoid arthritis (RA) is a consequence of synovial inflammation that leads to disability for patients. Cells within the synovium secrete…
Abstract Number: 1152 • 2015 ACR/ARHP Annual Meeting
Comprehensive Novel Proteomic Analysis of RA Synovial Fluid Highlights the Distinct Protein Profiles of Bone and Cartilage Metabolism
Yasushi Kondo¹, Katsuya Suzuki¹, Masaru Takeshita², Yoshiaki Kassai³, Keiko Koga³, Yuumi Gotou⁴, Takahiro Miyazaki³, Rimpei Morita⁵, Yasuo Niki⁶, Atsuko Murota¹, Ayumi Nishikawa¹, Hironari Hanaoka¹, Yuko Kaneko⁷, Hidekata Yasuoka⁷, Kunihiro Yamaoka¹, Akihiko Yoshimura⁵ and Tsutomu Takeuchi⁸, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan, ⁴Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Tokyo, Japan, ⁵Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan, ⁶Department of Orthopaedic Surgery, Keio University, Tokyo, Japan, ⁷Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ⁸Dept. of Internal Medicine, School of Medicine Keio University, Tokyo, Japan
Background/Purpose: Growing interest has arisen in the search for specific pathophysiology and biomarker for rheumatoid arthritis (RA) utilizing synovial fluid (SF) proteomic analysis. However the…
Abstract Number: 1307 • 2015 ACR/ARHP Annual Meeting
Does Computerized Segmentation of Early Erosions on Magnetic Resonance Imaging Predict Functional Ability in Rheumatoid Arthritis?
Matthew Jessome¹, Michael Tomizza¹, Karen A. Beattie², William G. Bensen², Raja Bobba², Alfred Cividino², Patrick D. Emond², Chris Gordon², Lawrence Hart², George Ioannidis², Maggie Larche², Arthur Lau³, Ruben Tavares², Stephen Tytus² and Jonathan D. Adachi², ¹McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³Division of Rheumatology, McMaster University, Hamilton, ON, Canada
Background/Purpose: Functional ability of rheumatoid arthritis (RA) patients is reduced by both acute (inflammatory) and chronic (joint damage) disease manifestations. However, the impact of early…
Abstract Number: 1315 • 2015 ACR/ARHP Annual Meeting
Detecting Subtle Changes in Bone Structure Following Three-Month Anti-TNF Theraphy Using High-Resolution Peripheral Quantitative Computed Tomography
Matthew Tanaka¹, Favian Su², Min Hee Lee^3,4, Andrew J. Burghardt⁵, Thomas M. Link⁴, Jonathan D. Graf⁶, John Imboden⁷ and Xiaojuan Li⁸, ¹University of California Berkeley, Berkeley, CA, ²Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ³Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea, ⁴Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁵Department of Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, ⁶Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁷Rheumatology, Rheumatology, University of California San Francisco, San Francisco, CA, ⁸Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA
Background/Purpose: Radiographs have been traditionally used to detect bone erosions and joint space narrowing (JSN) in rheumatoid arthritis (RA), but they are not sensitive to…
Abstract Number: 1744 • 2015 ACR/ARHP Annual Meeting
Free DKK-1 Serum Levels Are Unchanged in Spondyloarthritis Patients Treated By Etanercept
Corinne Miceli-Richard¹, Bernard Combe², Francis Berenbaum³, Thierry Schaeverbeke⁴, Maria Dilleen⁵, Nandan Koppiker⁶, Isabelle Logeart⁷, Arnaud Dubanchet⁷ and Maxime Dougados⁸, ¹Rhuematology, Cochin Hospital, Paris Descartes University, Paris, France, ²Rheumatology, Hopital Lapeyronie, Montpellier, France, ³Rheumatology and Paris VI University, Saint-Antoine Hospital, Paris, France, ⁴Rheumatology, CHU Bordeaux, Bordeaux, France, ⁵Pfizer GIPB, Sandwich, United Kingdom, ⁶Pfizer PGRD, Sandwich, United Kingdom, ⁷Pfizer, Paris, France, ⁸Paris-Descartes University, Paris, France
Background/Purpose: DKK-1 and SOST are two inhibitory proteins of the Wnt signaling pathway that lead to decreased bone formation by osteoblasts and osteocytes, respectively. Functional…
Abstract Number: 2047 • 2015 ACR/ARHP Annual Meeting
A Randomised Double-Blind Placebo-Controlled Trial of Vitamin D Supplementation in Juvenile-Onset Systemic Lupus Erythematosus: Effects on Microarchitecture Measured By HR-pQCT
Glauce Lima¹, Juliane Paupitz¹, Nadia E Aikawa², Jackeline Couto Alvarenga³, Eloisa Bonfá¹ and Rosa M R Pereira⁴, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Vitamin D has an important effect in bone quality and vitamin D deficiency in Juvenile-onset Systemic Lupus Erythematosus patients (JoSLE) may be associated with…
Abstract Number: 2087 • 2015 ACR/ARHP Annual Meeting
Defective Circadian Control in Mesenchymal Cells Reduces Adult Bone Mass
Julia F. Charles¹ and Joerg Ermann², ¹Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Genetic disruption of the circadian molecular clock in mice is a powerful tool to dissect the role of circadian rhythms in health and disease.…
Abstract Number: 2210 • 2015 ACR/ARHP Annual Meeting
Immunological Dysregulation and Inadequate Hypoxia Adaptation – HIF-Stabilization As Possible Prevention of Fracture Healing Disorders in RA or Immune-Suppressed Patients
Annemarie Lang^1,2,3, Sarah Fuegener², Paula Hoff^1,2, Katharina Schmidt-Bleek⁴, Timo Gaber^1,2 and Frank Buttgereit², ¹German Rheumatism Research Center (DRFZ), Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ³Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, ⁴Julius Wolff Institut, Charité University Medicine, Berlin, Germany
Background/Purpose: Patients suffering from rheumatoid arthritis (RA) are often affected by fracture-healing complications such as increased fracture healing time or non-unions. There is not much…
Abstract Number: 2211 • 2015 ACR/ARHP Annual Meeting
Extracellular Vesicles from Cow Milk Accelerate Osteoblast Differentiation into Osteocytes, However, Type I Collagen Synthesis Is Reduced and Bone Matrix Organization Is Impaired
Marina C. Oliveira¹, Onno J. Arntz¹, Esmeralda Blaney Davidson¹, Wim van den Berg¹, Adaliene V.M. Ferreira² and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Nutrition, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Background/Purpose: Milk consumption during childhood stimulates bone growth but the claimed beneficial effect of milk on bone at adulthood is a matter of debate. Recently…
Abstract Number: 2571 • 2015 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Prevents Loss of Bone Strength in a Mouse Model of Collagen-Induced Arthritis
Hiroto Yoshida, Yuanyuan Bi, Miho Suzuki, Keisuke Tanaka and Yoshihiro Matsumoto, Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a disease that typically induces secondary osteoporosis, which increases the risk of bone fractures and, consequently, mortality. Bone fracture is…
Abstract Number: 202 • 2015 ACR/ARHP Annual Meeting
Bone Accrual in the Dnase II-Deficient Model of Autoimmunity Requires Sting, As Well As Hematopoietic and Stromal Elements
Rebecca Baum¹, Shruti Sharma¹, Ann Marshak-Rothstein¹, Katherine A. Fitzgerald¹ and Ellen M. Gravallese², ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: We have previously identified a role for cytosolic DNA sensors in bone by analyzing mice that develop inflammatory polyarthritis and trabecular bone accrual in…
Abstract Number: 2700 • 2015 ACR/ARHP Annual Meeting
Trabecular Thinning in Metacarpophalangeal Joints of Anticitrullinated Peptide Antibody Positive Patients with Arthralgia
Kresten Krarup Keller¹, Jesper Skovhus Thomsen², Kristian Stengaard-Pedersen¹, Andreas Wiggers Nielsen¹, Berit Schiøtz-Christensen³, Lone Svendsen⁴, Merete Graakjær⁵, Peter Mosborg Pedersen⁶, Barbara Unger⁷, Bente Langdahl⁸ and Ellen-Margrethe Hauge¹, ¹Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ²Aarhus University, Aarhus, Denmark, ³Spine Centre of Southern Denmark, Middelfart, Denmark, ⁴Private Practice in Rheumatology, Skanderborg, Denmark, ⁵Clinic of Rheumatology Aarhus, Aarhus, Denmark, ⁶Randers Hospital, Randers, Denmark, ⁷Horsens Hospital, Horsens, Denmark, ⁸Endocrinology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Rheumatoid arthritis (RA) is characterized by synovitis leading to bone erosions and joint destruction, but little is known about bone structure in the joints…
Abstract Number: 355 • 2015 ACR/ARHP Annual Meeting
The Clinical and Genetic Spectrum of Low Alkaline Phosphatase in Adults
Leyre Riancho-Zarrabeitia¹, Maria T. García-Unzueta², Jair A. Tenorio³, Juan Gómez-Gerique⁴, Víctor L Ruiz Pérez³, Karen E. Heath³, Pablo Lapunzina³ and José A. Riancho⁵, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ²Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ³Institute of Medical and Molecular Genetics. Hospital U. La Paz. IdiPAZ. Autonomous University of Madrid. CIBERER., Madrid, Spain, ⁴Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁵Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. University of Cantabria, Santander, Spain
Background/Purpose: Different from infantile forms, adult forms of hypophosphatasia have less severe manifestations and may go unrecognized. Low serum levels of alkaline phosphatase (ALP), the…

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