Abstracts tagged "Bone"

Abstract Number: 1671 • 2016 ACR/ARHP Annual Meeting
Pirfenidone Might Inhibit New Bone Formation in Spondyloarthritis: Proof of Concept Study Using Cell Culture Models
Julie Laustsen¹, Søren Lomholt¹, Pernille Andersen², Jens Kelsen³ and Tue Wenzel Kragstrup^1,4, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark, ³Department of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark, ⁴Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized…
Abstract Number: 355 • 2015 ACR/ARHP Annual Meeting
The Clinical and Genetic Spectrum of Low Alkaline Phosphatase in Adults
Leyre Riancho-Zarrabeitia¹, Maria T. García-Unzueta², Jair A. Tenorio³, Juan Gómez-Gerique⁴, Víctor L Ruiz Pérez³, Karen E. Heath³, Pablo Lapunzina³ and José A. Riancho⁵, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ²Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ³Institute of Medical and Molecular Genetics. Hospital U. La Paz. IdiPAZ. Autonomous University of Madrid. CIBERER., Madrid, Spain, ⁴Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ⁵Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. University of Cantabria, Santander, Spain
Background/Purpose: Different from infantile forms, adult forms of hypophosphatasia have less severe manifestations and may go unrecognized. Low serum levels of alkaline phosphatase (ALP), the…
Abstract Number: 2716 • 2015 ACR/ARHP Annual Meeting
Dysregulated Osteoclastogenesis Is Related to Natural Killer T Cell Dysfunction in Rheumatoid Arthritis
Seung-Jung Kee¹, Hye Mi Jin², Jeong-Hwa Kang², Young-Nan Cho², Ki-Jeong Park², Hyun-Ju Jung² and Yong-Wook Park², ¹Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea
Background/Purpose: The aims of the present study were to investigate the role played by natural killer T (NKT) cells in osteoclastogenesis and their effects on…
Abstract Number: 358 • 2015 ACR/ARHP Annual Meeting
Bone Microstructure Assessed By Hrpqct in Subjects with Hyperuricemia without Arthritis
Roland Kocijan¹, Arastoo Nia¹, Christian Muschitz², David Simon³, Corinna Geiger¹, Judith Haschka⁴, Arnd Kleyer³, Sara Bayat⁵, Juergen Rech⁵, Annemarie Kocijan⁶, Larissa Dzirlo⁷, Monika Graninger⁷ and Heinrich Resch¹, ¹Medical Department II, Karl Landsteiner Society for Gastroenterology and Rheumatology, St. Vincent Hospital, Vienna, Austria, ²Medical Department II, St. Vincent Hospital, Vienna, Austria, ³Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Optimal Essen e.U., Vienna, Austria, ⁷Medical Department III, St. Vincent Hospital, Vienna, Austria
Background/Purpose: Gouty arthritis is a common inflammatory joint disorder and hyperuricemia (HU) is known to be the main risk factor. Beside clinical signs of inflammation…
Abstract Number: 3172 • 2015 ACR/ARHP Annual Meeting
Effect of Anti Citrullinated Protein Antibodies on Periarticular and Systemic Bone Mass in Early Arthritis Patients
Irene Llorente Cubas*¹, Leticia Merino-Meléndez², Ana M. Ortiz Garcia², Eugenio Escolano³, Teresa Velasco¹, Elena García², Esther Vicente-Rabaneda², Alberto Garcia-Vadillo⁴, Rosario Garcia-Vicuña⁴, Isidoro González-Alvaro*² and Santos Castañeda*², ¹Rheumatology, H.U La Princesa, Madrid, Spain, ²Rheumatology, H.U. La Princesa, Madrid, Spain, ³Radiology Department, H.U La Princesa, Madrid, Spain, ⁴Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain
Background/Purpose: Recently it has been described that anti citrullinated protein antibodies (ACPA) can induce differentatiomn and activation of osteoclasts even before arthritis onset (1,2). The…
Abstract Number: 362 • 2015 ACR/ARHP Annual Meeting
Reference Curves of Bone Parameters Obtained By High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) in Healthy Women from 20 to 85 Years Old
Jackeline Couto Alvarenga¹, Henrique Fuller², Sandra G. Pasoto², Stephanie Boutroy³ and Rosa M R Pereira⁴, ¹Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³INSERM U831 and Université de Lyon, Lyon, France, ⁴Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Bone is a dynamic tissue, and its formation and resorption are continuous processes that promote changes throughout the life of the organism, and changes…
Abstract Number: 3176 • 2015 ACR/ARHP Annual Meeting
New Prospects for Interpreting Bony Depressions in Juvenile Idiopathic Arthritis: A Novel MRI Computer-Assisted Technique for Detection of Erosive Progression
Pieter van Dijkhuizen^1,2, Carlotta Covizzi¹, Andrea Schiappacasse³, Michela Moraldo⁴, Matteo Santoro⁵, Francesca Magnaguagno⁶, Gianmichele Magnano⁷, Alberto Martini^1,4 and Clara Malattia^1,4, ¹Istituto G Gaslini, Pediatria II, Reumatologia, Genova, Italy, ²UMC Utrecht, Wilhelmina Children’s Hospital, Pediatric rheumatology, Utrecht, Netherlands, ³DIBRIS Università degli studi di Genova, Genova, Italy, ⁴DINOGMI Università degli studi di Genova, Genova, Italy, ⁵Camelot Biomedical Systems, Genova, Italy, ⁶Istituto G Gaslini, UO Radiologia Pediatrica, Genoa, Italy, ⁷Istituto G Gaslini, UO Radiologia Pediatrica, Genova, Italy
Background/Purpose: Structural damage is the main disease outcome to be avoided in JIA. The gold standard to assess joint damage in JIA is X-ray, which…
Abstract Number: 532 • 2015 ACR/ARHP Annual Meeting
Plasma Levels of Bone Morphogenetic Protein (BMP) Subgroups and Their Inhibitors (noggin, sclerostin) in Rheumatoid Arthritis Patients and Correlation with Disease Activity, Clinical and Radiographic Progression: Preliminary Results
Ozge Kockara¹, Sebnem Ataman², Merve Sibel Gungoren³, Filiz Akbiyik³ and Erdem Karabulut⁴, ¹Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, ²Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey, ³Medical Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁴Biostatistics, Hacettepe University Faculty of Medicine, Ankara, Turkey
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory disease that leads to bone erosion. Bone morphogenetic proteins (BMPs) have favourable effects in the recovery of bone…
Abstract Number: 984 • 2015 ACR/ARHP Annual Meeting
Tofacitinib Inhibits Inflammation and New Bone Formation in Murine Spondyloarthritis but Does Not Adversely Inhibit Normal Human MSC Function
Rik Lories¹, Katelijne De Wilde², Kerri Heritage¹, Richard Cuthbert³, Elena Jones³, Karlijn Debusschere⁴, Dennis McGonagle³ and Dirk Elewaut⁵, ¹Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven and University Hospitals Leuven., Leuven, Belgium, ²Laboratory for Molecular Immunology and Inflammation; Department of Rheumatology,, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Laboratory for Molecular Immunology and Inflammation; Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ⁵Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium
Background/Purpose: Inflammation and new bone formation at entheseal sites are hallmarks of spondyloarthritis (SpA). As TNF inhibition has only limited impact on new bone formation,…
Abstract Number: 1035 • 2015 ACR/ARHP Annual Meeting
Synovium-Derived microRNAs Inhibit Bone Formation in Rheumatoid Arthritis
Ellen M. Gravallese¹, Yukiko Maeda², Nicholas H Farina³, Paul Fanning⁴ and Jane Lian³, ¹Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Department of Biochemistry, University of Vermont, Burlington, VT, ⁴Department of Orthopedics, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Articular bone erosion in rheumatoid arthritis (RA) is a consequence of synovial inflammation that leads to disability for patients. Cells within the synovium secrete…
Abstract Number: 1152 • 2015 ACR/ARHP Annual Meeting
Comprehensive Novel Proteomic Analysis of RA Synovial Fluid Highlights the Distinct Protein Profiles of Bone and Cartilage Metabolism
Yasushi Kondo¹, Katsuya Suzuki¹, Masaru Takeshita², Yoshiaki Kassai³, Keiko Koga³, Yuumi Gotou⁴, Takahiro Miyazaki³, Rimpei Morita⁵, Yasuo Niki⁶, Atsuko Murota¹, Ayumi Nishikawa¹, Hironari Hanaoka¹, Yuko Kaneko⁷, Hidekata Yasuoka⁷, Kunihiro Yamaoka¹, Akihiko Yoshimura⁵ and Tsutomu Takeuchi⁸, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan, ⁴Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Tokyo, Japan, ⁵Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan, ⁶Department of Orthopaedic Surgery, Keio University, Tokyo, Japan, ⁷Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ⁸Dept. of Internal Medicine, School of Medicine Keio University, Tokyo, Japan
Background/Purpose: Growing interest has arisen in the search for specific pathophysiology and biomarker for rheumatoid arthritis (RA) utilizing synovial fluid (SF) proteomic analysis. However the…
Abstract Number: 1307 • 2015 ACR/ARHP Annual Meeting
Does Computerized Segmentation of Early Erosions on Magnetic Resonance Imaging Predict Functional Ability in Rheumatoid Arthritis?
Matthew Jessome¹, Michael Tomizza¹, Karen A. Beattie², William G. Bensen², Raja Bobba², Alfred Cividino², Patrick D. Emond², Chris Gordon², Lawrence Hart², George Ioannidis², Maggie Larche², Arthur Lau³, Ruben Tavares², Stephen Tytus² and Jonathan D. Adachi², ¹McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³Division of Rheumatology, McMaster University, Hamilton, ON, Canada
Background/Purpose: Functional ability of rheumatoid arthritis (RA) patients is reduced by both acute (inflammatory) and chronic (joint damage) disease manifestations. However, the impact of early…
Abstract Number: 1315 • 2015 ACR/ARHP Annual Meeting
Detecting Subtle Changes in Bone Structure Following Three-Month Anti-TNF Theraphy Using High-Resolution Peripheral Quantitative Computed Tomography
Matthew Tanaka¹, Favian Su², Min Hee Lee^3,4, Andrew J. Burghardt⁵, Thomas M. Link⁴, Jonathan D. Graf⁶, John Imboden⁷ and Xiaojuan Li⁸, ¹University of California Berkeley, Berkeley, CA, ²Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ³Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea, ⁴Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁵Department of Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, ⁶Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁷Rheumatology, Rheumatology, University of California San Francisco, San Francisco, CA, ⁸Radiology & Biomedical Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA
Background/Purpose: Radiographs have been traditionally used to detect bone erosions and joint space narrowing (JSN) in rheumatoid arthritis (RA), but they are not sensitive to…
Abstract Number: 1744 • 2015 ACR/ARHP Annual Meeting
Free DKK-1 Serum Levels Are Unchanged in Spondyloarthritis Patients Treated By Etanercept
Corinne Miceli-Richard¹, Bernard Combe², Francis Berenbaum³, Thierry Schaeverbeke⁴, Maria Dilleen⁵, Nandan Koppiker⁶, Isabelle Logeart⁷, Arnaud Dubanchet⁷ and Maxime Dougados⁸, ¹Rhuematology, Cochin Hospital, Paris Descartes University, Paris, France, ²Rheumatology, Hopital Lapeyronie, Montpellier, France, ³Rheumatology and Paris VI University, Saint-Antoine Hospital, Paris, France, ⁴Rheumatology, CHU Bordeaux, Bordeaux, France, ⁵Pfizer GIPB, Sandwich, United Kingdom, ⁶Pfizer PGRD, Sandwich, United Kingdom, ⁷Pfizer, Paris, France, ⁸Paris-Descartes University, Paris, France
Background/Purpose: DKK-1 and SOST are two inhibitory proteins of the Wnt signaling pathway that lead to decreased bone formation by osteoblasts and osteocytes, respectively. Functional…
Abstract Number: 2047 • 2015 ACR/ARHP Annual Meeting
A Randomised Double-Blind Placebo-Controlled Trial of Vitamin D Supplementation in Juvenile-Onset Systemic Lupus Erythematosus: Effects on Microarchitecture Measured By HR-pQCT
Glauce Lima¹, Juliane Paupitz¹, Nadia E Aikawa², Jackeline Couto Alvarenga³, Eloisa Bonfá¹ and Rosa M R Pereira⁴, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Vitamin D has an important effect in bone quality and vitamin D deficiency in Juvenile-onset Systemic Lupus Erythematosus patients (JoSLE) may be associated with…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].