Date: Sunday, November 8, 2015
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: Bone is a dynamic tissue, and its formation and resorption are continuous processes that promote changes throughout the life of the organism, and changes in bone microstructure contribute to fracture risk. High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) can assess microstructural and biomechanical properties of human distal end. Faced with so multitude of applications and perspectives of HR-pQCT, it is necessary to establish normal standard curves. The aim of this cross-sectional study is to establish normal values related to age, weight and height using HR-pQCT regarding volumetric bone mineral density (vBMD), microstructure, cortical porosity and estimated bone strength at the distal radius and tibia from a women population aged 20 to 85 years.
Methods: References curves were calculated in 450 healthy women (> 50 women per decade). The HR-pQCT acquisitions (XtremeCT, Scanco Medical) were performed using the standard scanning protocol. Statistical analysis including linear regression models were developed to predict the values of the twenty normal curves measured according to age, weight and height. The outcome variables used in our analyses included the following: Volumetric bone density parameters (mg HA/ccm): trabecular bone density (Tb.vBMD), cortical bone density (Ct.vBMD); Bone structure parameters: number of trabeculae (Tb.N, 1/mm), trabecular thickness (Tb.Th, mm), trabecular separation (Tb.Sp, mm), cortical thickness (Ct.Th, mm); Cortical porosity parameters: cortical porosity (Ct.Po, 1), mean cortical pore diameter (Ct.Po.Dm, mm); Finite element analysis (FEA): stiffness (S, kN/mm), estimated failure load (F.Load, N).
Results: Evaluation of the distal radius by HR-pQCT: All parameters showed linear curves with age, except for Ct.Po, S and F.Load. Positive correlations were observed between stiffnewomenss and Tb.vBMD (r: 0.644, p < 0.001), Ct.vBMD (r: 0.521, p < 0.001), Tb.N (r: 0.245, p < 0.001), Tb.Th (r: 0.616, p < 0.001), Ct.Th (r: 0.619, p < 0.001), Ct.Po.Dm (r: 0.140, p < 0.001) and F.Load (r: 0.995, p < 0.001). In contrast, weak negative correlations were detected between S and Tb.Sp (r: -0.312, p < 0.001) and Ct.Po (r: -0.162, p= 0.015). Evaluation of the tibia by HR-pQCT: All obtained curves were linear, except for Ct.vBMD, Ct.Th and Ct.Po. The cortical density and thickness showed a plateau until about 50 years of age, following by a decreasing curve. Positive correlations were observed between stiffness and Tb.vBMD (r: 0.571, p < 0.001), Ct.vBMD (r: 0.316, p < 0.001), Tb.N (r: 0.298, p < 0.001), Tb.Th (0.355, p < 0.001), Ct.Th (r: 0.392, p < 0.001) and F.Load (r: 0.955, p < 0.001). Moreover, negative correlations were found between S and Tb.Sp (r: -0.354, p < 0.001) and Ct.Po (r: -0.273, p < 0.001).
Conclusion: This study established a set of reference data for HR-pQCT parameters in a heathy women population, which will be useful for interpreting clinical data from patients in clinical practice and in future studies.
To cite this abstract in AMA style:Alvarenga JC, Fuller H, Pasoto SG, Boutroy S, Pereira RMR. Reference Curves of Bone Parameters Obtained By High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) in Healthy Women from 20 to 85 Years Old [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/reference-curves-of-bone-parameters-obtained-by-high-resolution-peripheral-quantitative-computed-tomography-hr-pqct-in-healthy-women-from-20-to-85-years-old/. Accessed September 25, 2021.
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