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Abstracts tagged "Bone"

  • Abstract Number: 061 • 2020 Pediatric Rheumatology Symposium

    Perspectives of Radiologist Physicians in the Imaging of Chronic Nonbacterial Osteomyelitis

    Farzana Nuruzzaman1, Mingqian Huang 2, Christian Hedrich 3, Hermann Girschick 4, Julie Cherian 1, Karen Onel 5, T. Shawn Sato 6, Polly Ferguson 7 and Yongdong Zhao 8, 1Stony Brook Children's Hospital, Stony Brook, 2Mount Sinai Hospital, New York, New York, 3University of Liverpool, Liverpool, United Kingdom, 4Wuerzburg, Germany, 5Hospital for Special Surgery, New York, 6University of Iowa, Iowa City, 7University of Iowa Carver College of Medicine, Iowa City, 8University of Washington, Seattle

    Background/Purpose: Radiological imaging is integral to the diagnosis of chronic nonbacterial osteomyelitis (CNO) and has been included as a central component in suggested diagnostic criteria…
  • Abstract Number: 3 • 2019 ACR/ARP Annual Meeting

    Pannexin-1 KO Mice Are Unresponsive to Tenofovir Induced Bone Loss

    Ane Larrañaga-Vera1, Francisco Conesa-Buendia 2, Bruce Cronstein 3 and Aranzazu Mediero 2, 1NYU Langone Health, New York, NY, 2IIS-FUNDACION JIMENEZ DIAZ, Madrid, Spain, 3NYU Langone, New York

    Background/Purpose: Tenofovir is an anti-retroviral agent commonly used to treat human immunodeficiency virus (HIV)-infected patients as part of the drug regimen known as highly active…
  • Abstract Number: 1435 • 2019 ACR/ARP Annual Meeting

    Acute Effects of IL-6 Blockade, TNFα Inhibitor or Glucocorticoids on Bone Turnover Markers and Wnt Inhibitors in Early Rheumatoid Arthritis

    Angelo Fassio1, GIovanni Adami 1, Ombretta Viapiana 1, Luca Idolazzi 1, Giovanni Orsolini 1, Alessandro Giollo 1, Davide Gatti 2 and Maurizio Rossini 1, 1University of Verona, Verona, Italy, 2Univerisity of Verona, Verona, Italy

    Background/Purpose: Wnt signaling is an important regulator of bone remodeling and it is involved in the pathogenesis of focal and systemic bone loss in Rheumatoid…
  • Abstract Number: 1983 • 2019 ACR/ARP Annual Meeting

    Preclinical Evaluation of Targeting TGF-beta Signaling and Senescence in ex Vivo Models of Human Knee and Spine Osteoarthritis

    Jeroen Geurts1, Cordula Netzer 2, Stefan Schären 2 and Thomas Hugle 3, 1University Hospital Lausanne (CHUV), Lausanne, Switzerland, 2University Hospital Basel, Basel, Switzerland, 3University Hospital Lausanne, Lausanne, Switzerland

    Background/Purpose: The absence of effective disease-modifying drugs remains an important unmet need in the treatment of osteoarthritis. In recent years, novel pharmacological treatments including targeting…
  • Abstract Number: 2196 • 2019 ACR/ARP Annual Meeting

    Machine Learning Defines the Relationship Between Structural Knee Osteoarthritis and Patient-Important Outcomes: An 8-year Study of 47,858 Knee MRIs from the Osteoarthritis Initiative (OAI)

    Michael Bowes1, Katherine Kacena 2, Oras Alabas 3, Alan Brett 1, Bright Dube 4, Neil Bodick 5 and Philip G Conaghan 6, 1Imorphics, Manchester, England, United Kingdom, 2BioBridges, Wellesley Hills, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 4University of Leeds, LEEDS, England, United Kingdom, 5Flexion Therapeutics, Burlington, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom

    Background/Purpose: Osteoarthritis (OA) is a slowly progressing disease which may be asymptomatic for many years. Therapy development has been hampered by poor understanding of both…
  • Abstract Number: 1044 • 2018 ACR/ARHP Annual Meeting

    Alendronate-CGS21680 Conjugates Prevent Bone Erosion in a Murine Osteolysis Model

    Ane Larrañaga Vera1, Kiran Toti2, Eugene Warnick2, Harsha Rao2, Zhan-Guo Gao2, Alexandra Gadiano2, Aranzazu Mediero3, Kenneth A. Jacobson2 and Bruce N. Cronstein4, 1Medicine, New York University School of Medicine, New York, NY, 2Molecular Recognition Section, NIDDK-NIH, Bethesda, MD, 3Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain, 4Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY

    Background/Purpose: The most common cause of total joint replacement revision surgeries is loosening of the implant due to loss of bone around the prosthesis. Wear…
  • Abstract Number: 2810 • 2018 ACR/ARHP Annual Meeting

    Fracture and Bone Mineral Density Response By Baseline Risk in Patients Treated with Abaloparatide Followed By Alendronate

    Benjamin Leder1, Carol Zapalowski2, Ming-Yi Hu3 and Gary Hattersley2, 1Endocrine, Harvard Medical School, Boston, MA, 2Radius Health, Inc., Waltham, MA, 3Biometrics, Radius Health, Inc., Waltham, MA

    Background/Purpose: Abaloparatide (ABL) is an anabolic PTHrP analog approved to treat postmenopausal women with osteoporosis at high risk of fracture. In the ACTIVE Phase 3…
  • Abstract Number: 1067 • 2018 ACR/ARHP Annual Meeting

    Simulating the Pathogenesis of Arthritis in Vitro By Developing a Human-Based Multicomponent 3D Joint Model

    Alexandra Damerau1,2, Annemarie Lang1,2, Moritz Pfeiffenberger1,2, Timo Gaber1,3 and Frank Buttgereit1,2, 1Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, 3Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Berlin, Germany

    Background/Purpose: Although arthritis is a matter of research since more than 140 years, there is currently no valid 3D model available, which is able to…
  • Abstract Number: 2811 • 2018 ACR/ARHP Annual Meeting

    Abaloparatide Effect on Bone Mineral Density and Fracture Incidence in Postmenopausal Women with Osteoporosis Aged 80 Years or Older

    Susan L. Greenspan1, Lorraine A Fitzpatrick2, Bruce Mitlak2, Yamei Wang2, Nicholas C. Harvey3, Chad Deal4, Felicia Cosman5 and Michael McClung6, 1Medicine, University of Pittsburgh, Pittsburgh, PA, 2Radius Health, Inc., Waltham, MA, 3MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, 4Cleveland Clinic, Shaker Heights, OH, 5Columbia University College of Physicians and Surgeons, New York, NY, 6Oregon Osteoporosis Center, Portland, OR

    Background/Purpose: The risk of fracture increases with increasing age. Thus, it is important to understand efficacy and safety of osteoporosis treatments in elderly patients. In…
  • Abstract Number: 1197 • 2018 ACR/ARHP Annual Meeting

    The Characteristics of the Distribution of Normal Feeding Vessels between Young and Elderly Adults in Wrist Joints of Healthy Volunteers Depicted By Ultrasound (MSKUS)

    Kenta Misaki1, Kei Ikeda2, Kenshi Inoue3, Moemi Miyazaki3, Naofumi Dobashi3 and Yasuhiko Imaizumi4, 1Rheumatology, Kita-Harima Medical Center, Ono, Japan, 2Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, 3Kita-Harima Medical Center, Ono, Japan, 4kita-Harima Medical Center, Ono, Japan

    Background/Purpose: Synovial vascularity as measured by power Doppler (PD) of MSKUS is correlated to rheumatoid arthritis disease activity, and PD signal reveals the prevalence of…
  • Abstract Number: 2812 • 2018 ACR/ARHP Annual Meeting

    Evaluation of Cortical Microarchitecture, Bone Stiffness and Bone Remodeling in Patients with Atypical Femoral Fracture

    Mariana O Perez1, Diogo S Domiciano1, Luciene M Reis2, Vanda Jorgetti2 and Rosa M R Pereira1, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, 2Nephrology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

    Background/Purpose: Atypical femoral fractures (AFF) are low energy femoral fractures and subtrochanteric/diaphyseal localization that have been related to long-term bisphosphonate therapy. Patients with AFF exhibit…
  • Abstract Number: 1481 • 2018 ACR/ARHP Annual Meeting

    Are ACPA Associated with More Bone Loss over Time in Patients with RA?

    Emma de Moel1, Josephine Amkreutz1, Lotte Heimans2, Cornelia F. Allaart3, Tom W.J. Huizinga4 and Diane van der Woude4, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Internal Medicine, Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, LUMC, Leiden, Netherlands, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are one of the most important serological markers for rheumatoid arthritis (RA) and have been suggested to play a pathophysiologic…
  • Abstract Number: 1830 • 2018 ACR/ARHP Annual Meeting

    Role of BMP2 in Entheseal Bone Formation in Inflammatory Arthritis

    Yukiko Maeda1, Jozsef Karman2 and Ellen M. Gravallese3, 1Medicine, University of Massachusetts Medical School, Worcester, MA, 2Abbvie Bioresearch Center, Worcester, MA, 3Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Spondyloarthritis (SpA) is common, with a prevalence of ~1% in the United States. Patients with SpA suffer from pain and disability due to inflammation…
  • Abstract Number: 1987 • 2018 ACR/ARHP Annual Meeting

    Elucidation of the Function of Dendritic Cell-Specific Transmembrane Protein (DCSTAMP) in Osteoclast Differentiation

    Ananta Paine1, Maria de la Luz Garcia-Hernandez2, Dongge Li3, Minsoo Kim4 and Christopher T. Ritchlin2, 1Department of Medicine, Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 2Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 3Allergy, Immunology and Rheumatology, Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 4Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA, Rochester, NY

    Background/Purpose: Osteoclasts (OC) are bone-resorbing, multinuclear cells that originate from myeloid progenitor cells through repetitive cycles of cell-cell fusion. Dendritic cell-specific transmembrane protein (DCSTAMP) is…
  • Abstract Number: 1989 • 2018 ACR/ARHP Annual Meeting

    A Regulatory Role of ANTXR1 in RANKL-Induced Osteoclast Differentiation and Function

    Myeung Su Lee1, Changhoon Lee2, Chong Hyuk Chung3, Wan-Hee Yoo4, Jin Jung Choi5, Jong Min Baek6 and Ju-Young Kim7, 1Department of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, Wonkwnag University Hospital, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, IKSAN, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of chonbuk national university-Biomedical Research Institute of chonbuk national university hospital, Jeonju, Korea, Republic of (South), 5Rheumatology, CHA University Medical Center at Bundang, Sungnam, Korea, Republic of (South), 6Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Korea, Republic of (South), 7Imaging Science-based Lung and Bone Diseases Research Center, School of Medicine, Wonkwang University, IKSAN, Korea, Republic of (South)

    Background/Purpose: Anthrax toxin receptor 1 (ANTXR1) has been known to have relationship with extracellular transmembrane protein deeply associated with the process of bone formation and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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