ACR Meeting Abstracts

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Abstracts tagged "Bone"

  • Abstract Number: 1067 • 2018 ACR/ARHP Annual Meeting

    Simulating the Pathogenesis of Arthritis in Vitro By Developing a Human-Based Multicomponent 3D Joint Model

    Alexandra Damerau1,2, Annemarie Lang1,2, Moritz Pfeiffenberger1,2, Timo Gaber1,3 and Frank Buttgereit1,2, 1Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, 3Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Berlin, Germany

    Background/Purpose: Although arthritis is a matter of research since more than 140 years, there is currently no valid 3D model available, which is able to…
  • Abstract Number: 2811 • 2018 ACR/ARHP Annual Meeting

    Abaloparatide Effect on Bone Mineral Density and Fracture Incidence in Postmenopausal Women with Osteoporosis Aged 80 Years or Older

    Susan L. Greenspan1, Lorraine A Fitzpatrick2, Bruce Mitlak2, Yamei Wang2, Nicholas C. Harvey3, Chad Deal4, Felicia Cosman5 and Michael McClung6, 1Medicine, University of Pittsburgh, Pittsburgh, PA, 2Radius Health, Inc., Waltham, MA, 3MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, 4Cleveland Clinic, Shaker Heights, OH, 5Columbia University College of Physicians and Surgeons, New York, NY, 6Oregon Osteoporosis Center, Portland, OR

    Background/Purpose: The risk of fracture increases with increasing age. Thus, it is important to understand efficacy and safety of osteoporosis treatments in elderly patients. In…
  • Abstract Number: 1197 • 2018 ACR/ARHP Annual Meeting

    The Characteristics of the Distribution of Normal Feeding Vessels between Young and Elderly Adults in Wrist Joints of Healthy Volunteers Depicted By Ultrasound (MSKUS)

    Kenta Misaki1, Kei Ikeda2, Kenshi Inoue3, Moemi Miyazaki3, Naofumi Dobashi3 and Yasuhiko Imaizumi4, 1Rheumatology, Kita-Harima Medical Center, Ono, Japan, 2Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, 3Kita-Harima Medical Center, Ono, Japan, 4kita-Harima Medical Center, Ono, Japan

    Background/Purpose: Synovial vascularity as measured by power Doppler (PD) of MSKUS is correlated to rheumatoid arthritis disease activity, and PD signal reveals the prevalence of…
  • Abstract Number: 2812 • 2018 ACR/ARHP Annual Meeting

    Evaluation of Cortical Microarchitecture, Bone Stiffness and Bone Remodeling in Patients with Atypical Femoral Fracture

    Mariana O Perez1, Diogo S Domiciano1, Luciene M Reis2, Vanda Jorgetti2 and Rosa M R Pereira1, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, 2Nephrology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

    Background/Purpose: Atypical femoral fractures (AFF) are low energy femoral fractures and subtrochanteric/diaphyseal localization that have been related to long-term bisphosphonate therapy. Patients with AFF exhibit…
  • Abstract Number: 1481 • 2018 ACR/ARHP Annual Meeting

    Are ACPA Associated with More Bone Loss over Time in Patients with RA?

    Emma de Moel1, Josephine Amkreutz1, Lotte Heimans2, Cornelia F. Allaart3, Tom W.J. Huizinga4 and Diane van der Woude4, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Internal Medicine, Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, LUMC, Leiden, Netherlands, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are one of the most important serological markers for rheumatoid arthritis (RA) and have been suggested to play a pathophysiologic…
  • Abstract Number: 1830 • 2018 ACR/ARHP Annual Meeting

    Role of BMP2 in Entheseal Bone Formation in Inflammatory Arthritis

    Yukiko Maeda1, Jozsef Karman2 and Ellen M. Gravallese3, 1Medicine, University of Massachusetts Medical School, Worcester, MA, 2Abbvie Bioresearch Center, Worcester, MA, 3Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Spondyloarthritis (SpA) is common, with a prevalence of ~1% in the United States. Patients with SpA suffer from pain and disability due to inflammation…
  • Abstract Number: 1987 • 2018 ACR/ARHP Annual Meeting

    Elucidation of the Function of Dendritic Cell-Specific Transmembrane Protein (DCSTAMP) in Osteoclast Differentiation

    Ananta Paine1, Maria de la Luz Garcia-Hernandez2, Dongge Li3, Minsoo Kim4 and Christopher T. Ritchlin2, 1Department of Medicine, Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 2Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 3Allergy, Immunology and Rheumatology, Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 4Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA, Rochester, NY

    Background/Purpose: Osteoclasts (OC) are bone-resorbing, multinuclear cells that originate from myeloid progenitor cells through repetitive cycles of cell-cell fusion. Dendritic cell-specific transmembrane protein (DCSTAMP) is…
  • Abstract Number: 1989 • 2018 ACR/ARHP Annual Meeting

    A Regulatory Role of ANTXR1 in RANKL-Induced Osteoclast Differentiation and Function

    Myeung Su Lee1, Changhoon Lee2, Chong Hyuk Chung3, Wan-Hee Yoo4, Jin Jung Choi5, Jong Min Baek6 and Ju-Young Kim7, 1Department of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), 3Division of Rheumatology, Department of Internal Medicine, Wonkwnag University Hospital, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, IKSAN, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of chonbuk national university-Biomedical Research Institute of chonbuk national university hospital, Jeonju, Korea, Republic of (South), 5Rheumatology, CHA University Medical Center at Bundang, Sungnam, Korea, Republic of (South), 6Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Korea, Republic of (South), 7Imaging Science-based Lung and Bone Diseases Research Center, School of Medicine, Wonkwang University, IKSAN, Korea, Republic of (South)

    Background/Purpose: Anthrax toxin receptor 1 (ANTXR1) has been known to have relationship with extracellular transmembrane protein deeply associated with the process of bone formation and…
  • Abstract Number: 2065 • 2018 ACR/ARHP Annual Meeting

    Blockade of the JAK/STAT Pathway Inhibits Inflammation and Bone Formation in Two Murine Models of Spondyloarthritis

    Yukiko Maeda1, Zheni Stavre1, Tingting Huang2, Catherine Manning2, Bryant Shaughn3, Michael Macoritto3, Deborah Hyland3, Wendy Waegell3 and Ellen M. Gravallese4, 1Medicine, University of Massachusetts Medical School, Worcester, MA, 2Medicine, University of Massachusetts Medical School, worcester, MA, 3Abbvie Bioresearch Center, worcester, MA, 4Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Spondyloarthritis (SpA) results in significant pain and loss of function due to inflammation and resulting enthesial/periosteal bone formation. Inhibition of the Janus kinase (JAK)/STAT…
  • Abstract Number: 2206 • 2018 ACR/ARHP Annual Meeting

    Joint Repair While Initiating Biologic Therapy in Rheumatoid Arthritis

    Scott Brunet1,2,3, Sarah Manske1,2,3, Klaus Engelke4,5, Steven K. Boyd1,2,3 and Cheryl Barnabe2,6, 1Biomedical Engineering, University of Calgary, Calgary, AB, Canada, 2McCaig Institute for Bone and Joint Health, Calgary, AB, Canada, 3Department of Radiology, University of Calgary, Calgary, AB, Canada, 4Institute of Medical Physics, University of Erlangen, University of Erlangen-Nuremberg, Erlangen, Germany, 5Department of Medicine, Erlangen University Hospital, Erlangen, Germany, 6Division of Rheumatology, University of Calgary, Calgary, AB, Canada

    Background/Purpose: Functional decline and reduced quality of life for patients with rheumatoid arthritis (RA) results from chronic changes to joints in patients, including bone erosions…
  • Abstract Number: 2207 • 2018 ACR/ARHP Annual Meeting

    Detecting Hand Joint Ankylosis in Radiographic Images Using Deep Learning: A Step in Development of Automatic Radiographic Scoring System for Bone Destruction

    Keisuke Izumi1,2, Masahiro Hashimoto3, Kanata Suzuki4, Toshio Endoh4, Kentaro Doi5, Yuki Iwai5, Masahiro Jinzaki3, Shigeru Ko6 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, 3Department of Radiology, Keio University School of Medicine, Tokyo, Japan, 4Machine Learning Technology Project, Artificial Intelligence Laboratory, FUJITSU LABORATORIES LTD., Kawasaki, Japan, 5SOLUTIONS DEVELOPMENT DEPT.I, MEDICAL SOLUTIONS DIV.V, Healthcare Solutions Unit. II, FUJITSU LTD., Tokyo, Japan, 6Department of Systems Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose:  Artificial intelligence (AI) techniques including deep learning have been rapidly evolving and shown good performance in many fields over recent years. However, there are…
  • Abstract Number: 40 • 2018 ACR/ARHP Annual Meeting

    IFN Regulatory Factor 3 but Not IFN Regulatory Factor 7 Contributes to Bone Erosion in Collagen Induced Arthritis

    Susan Sweeney1, David L. Boyle2, Yuya Fujita3, Anthony Bui4, Gary S. Firestein2 and Maripat Corr5, 1Lilly Research Laboratories, Eli Lily, San Diego, CA, 2Medicine, University of California San Diego, La Jolla, CA, 3Medicine, University of California San Diego, La jolla, CA, 4Medicine, University of California San Diego, San Diego, CA, 5University of California San Diego, La Jolla, CA

    Background/Purpose: Type I interferons and their mRNA signatures have become prominent in biomarkers of autoimmune and autoinflammatory disease activity. Two master regulators of type I…
  • Abstract Number: 2210 • 2018 ACR/ARHP Annual Meeting

    Effects of Anti-Citrullinated Peptide Antibody (ACPA) on Bone Microstructure in Rheumatoid Arthritis: A HR-pQCT Study

    Ikuko Tanaka1, Takashi Kato2, Motokazu Kai3, Kunikazu Ogawa3, Hiroaki Mizuno1, Mari Ushikubo4, Keisuke Izumi5, Hisaji Oshima6 and Shigenori Tamaki1, 1Nagoya Rheumatology Clinic, Nagoya, Japan, 2Department of Radiology, National Center for Geratrics and Gerontology, Obu, Japan, 3Mie Rheumatology Clinic, Suzuka, Japan, 4National Tokyo Medical Center, Tokyo, Japan, 5Department of connective Tissue Disease, National Tokyo Medical Center, Tokyo, Japan, 6Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan

    Background/Purpose: Rheumatoid arthritis (RA) induces systemic osteoporosis as well as osteoporotic change in the bones having arthritis by RA. Recently immune complex and anti-citrullinated peptide…
  • Abstract Number: 41 • 2018 ACR/ARHP Annual Meeting

    TAS5315, a Novel Bruton’s Tyrosine Kinase Inhibitor, Improves Bone Strength in Mouse Model for Rheumatoid Arthritis

    Ryuusuke Kaneko, Fumihito Hosoi, Satoru Iguchi, Hiroaki Hayashi, Yohei Yoshiga, Yoshinori Nakachi, Daichi Akasaka, Kenji Tanaka, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan

    Background/Purpose: The erosions of bone and cartilage are a cardinal feature of rheumatoid arthritis (RA) and associated with disease severity and poor functional outcome. Although…
  • Abstract Number: 2302 • 2018 ACR/ARHP Annual Meeting

    Forearm Bone Mineral Density and Fracture Incidence in Postmenopausal Women with Osteoporosis

    Nelson B. Watts1, Robin K. Dore2, Sanford Baim3, Gary Hattersley4, Greg Williams5, Yamei Wang4, Tamara D. Rozental6 and Meryl S. LeBoff7, 1Mercy Health Osteoporosis and Bone Health Services, Cincinnati, OH, 2Univ of California, Los Angeles, CA, 3Rush Medical College, Chicago, IL, 4Radius Health, Inc., Waltham, MA, 5Clinical Development, Radius Health, Inc., Waltham, MA, 6Beth Israel Deaconess Medical Center, Boston, MA, 7Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Wrist fractures are the most common fracture of the upper extremity and increase subsequent fracture risk in women with postmenopausal osteoporosis. Most wrist fractures…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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