Abstracts tagged "Bone"

Abstract Number: 061 • 2020 Pediatric Rheumatology Symposium
Perspectives of Radiologist Physicians in the Imaging of Chronic Nonbacterial Osteomyelitis
Farzana Nuruzzaman¹, Mingqian Huang ², Christian Hedrich ³, Hermann Girschick ⁴, Julie Cherian ¹, Karen Onel ⁵, T. Shawn Sato ⁶, Polly Ferguson ⁷ and Yongdong Zhao ⁸, ¹Stony Brook Children's Hospital, Stony Brook, ²Mount Sinai Hospital, New York, New York, ³University of Liverpool, Liverpool, United Kingdom, ⁴Wuerzburg, Germany, ⁵Hospital for Special Surgery, New York, ⁶University of Iowa, Iowa City, ⁷University of Iowa Carver College of Medicine, Iowa City, ⁸University of Washington, Seattle
Background/Purpose: Radiological imaging is integral to the diagnosis of chronic nonbacterial osteomyelitis (CNO) and has been included as a central component in suggested diagnostic criteria…
Abstract Number: 3 • 2019 ACR/ARP Annual Meeting
Pannexin-1 KO Mice Are Unresponsive to Tenofovir Induced Bone Loss
Ane Larrañaga-Vera¹, Francisco Conesa-Buendia ², Bruce Cronstein ³ and Aranzazu Mediero ², ¹NYU Langone Health, New York, NY, ²IIS-FUNDACION JIMENEZ DIAZ, Madrid, Spain, ³NYU Langone, New York
Background/Purpose: Tenofovir is an anti-retroviral agent commonly used to treat human immunodeficiency virus (HIV)-infected patients as part of the drug regimen known as highly active…
Abstract Number: 1435 • 2019 ACR/ARP Annual Meeting
Acute Effects of IL-6 Blockade, TNFα Inhibitor or Glucocorticoids on Bone Turnover Markers and Wnt Inhibitors in Early Rheumatoid Arthritis
Angelo Fassio¹, GIovanni Adami ¹, Ombretta Viapiana ¹, Luca Idolazzi ¹, Giovanni Orsolini ¹, Alessandro Giollo ¹, Davide Gatti ² and Maurizio Rossini ¹, ¹University of Verona, Verona, Italy, ²Univerisity of Verona, Verona, Italy
Background/Purpose: Wnt signaling is an important regulator of bone remodeling and it is involved in the pathogenesis of focal and systemic bone loss in Rheumatoid…
Abstract Number: 1983 • 2019 ACR/ARP Annual Meeting
Preclinical Evaluation of Targeting TGF-beta Signaling and Senescence in ex Vivo Models of Human Knee and Spine Osteoarthritis
Jeroen Geurts¹, Cordula Netzer ², Stefan Schären ² and Thomas Hugle ³, ¹University Hospital Lausanne (CHUV), Lausanne, Switzerland, ²University Hospital Basel, Basel, Switzerland, ³University Hospital Lausanne, Lausanne, Switzerland
Background/Purpose: The absence of effective disease-modifying drugs remains an important unmet need in the treatment of osteoarthritis. In recent years, novel pharmacological treatments including targeting…
Abstract Number: 2196 • 2019 ACR/ARP Annual Meeting
Machine Learning Defines the Relationship Between Structural Knee Osteoarthritis and Patient-Important Outcomes: An 8-year Study of 47,858 Knee MRIs from the Osteoarthritis Initiative (OAI)
Michael Bowes¹, Katherine Kacena ², Oras Alabas ³, Alan Brett ¹, Bright Dube ⁴, Neil Bodick ⁵ and Philip G Conaghan ⁶, ¹Imorphics, Manchester, England, United Kingdom, ²BioBridges, Wellesley Hills, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ⁴University of Leeds, LEEDS, England, United Kingdom, ⁵Flexion Therapeutics, Burlington, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: Osteoarthritis (OA) is a slowly progressing disease which may be asymptomatic for many years. Therapy development has been hampered by poor understanding of both…
Abstract Number: 1044 • 2018 ACR/ARHP Annual Meeting
Alendronate-CGS21680 Conjugates Prevent Bone Erosion in a Murine Osteolysis Model
Ane Larrañaga Vera¹, Kiran Toti², Eugene Warnick², Harsha Rao², Zhan-Guo Gao², Alexandra Gadiano², Aranzazu Mediero³, Kenneth A. Jacobson² and Bruce N. Cronstein⁴, ¹Medicine, New York University School of Medicine, New York, NY, ²Molecular Recognition Section, NIDDK-NIH, Bethesda, MD, ³Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain, ⁴Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: The most common cause of total joint replacement revision surgeries is loosening of the implant due to loss of bone around the prosthesis. Wear…
Abstract Number: 2810 • 2018 ACR/ARHP Annual Meeting
Fracture and Bone Mineral Density Response By Baseline Risk in Patients Treated with Abaloparatide Followed By Alendronate
Benjamin Leder¹, Carol Zapalowski², Ming-Yi Hu³ and Gary Hattersley², ¹Endocrine, Harvard Medical School, Boston, MA, ²Radius Health, Inc., Waltham, MA, ³Biometrics, Radius Health, Inc., Waltham, MA
Background/Purpose: Abaloparatide (ABL) is an anabolic PTHrP analog approved to treat postmenopausal women with osteoporosis at high risk of fracture. In the ACTIVE Phase 3…
Abstract Number: 1067 • 2018 ACR/ARHP Annual Meeting
Simulating the Pathogenesis of Arthritis in Vitro By Developing a Human-Based Multicomponent 3D Joint Model
Alexandra Damerau^1,2, Annemarie Lang^1,2, Moritz Pfeiffenberger^1,2, Timo Gaber^1,3 and Frank Buttgereit^1,2, ¹Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, ³Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Berlin, Germany
Background/Purpose: Although arthritis is a matter of research since more than 140 years, there is currently no valid 3D model available, which is able to…
Abstract Number: 2811 • 2018 ACR/ARHP Annual Meeting
Abaloparatide Effect on Bone Mineral Density and Fracture Incidence in Postmenopausal Women with Osteoporosis Aged 80 Years or Older
Susan L. Greenspan¹, Lorraine A Fitzpatrick², Bruce Mitlak², Yamei Wang², Nicholas C. Harvey³, Chad Deal⁴, Felicia Cosman⁵ and Michael McClung⁶, ¹Medicine, University of Pittsburgh, Pittsburgh, PA, ²Radius Health, Inc., Waltham, MA, ³MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom, ⁴Cleveland Clinic, Shaker Heights, OH, ⁵Columbia University College of Physicians and Surgeons, New York, NY, ⁶Oregon Osteoporosis Center, Portland, OR
Background/Purpose: The risk of fracture increases with increasing age. Thus, it is important to understand efficacy and safety of osteoporosis treatments in elderly patients. In…
Abstract Number: 1197 • 2018 ACR/ARHP Annual Meeting
The Characteristics of the Distribution of Normal Feeding Vessels between Young and Elderly Adults in Wrist Joints of Healthy Volunteers Depicted By Ultrasound (MSKUS)
Kenta Misaki¹, Kei Ikeda², Kenshi Inoue³, Moemi Miyazaki³, Naofumi Dobashi³ and Yasuhiko Imaizumi⁴, ¹Rheumatology, Kita-Harima Medical Center, Ono, Japan, ²Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, ³Kita-Harima Medical Center, Ono, Japan, ⁴kita-Harima Medical Center, Ono, Japan
Background/Purpose: Synovial vascularity as measured by power Doppler (PD) of MSKUS is correlated to rheumatoid arthritis disease activity, and PD signal reveals the prevalence of…
Abstract Number: 2812 • 2018 ACR/ARHP Annual Meeting
Evaluation of Cortical Microarchitecture, Bone Stiffness and Bone Remodeling in Patients with Atypical Femoral Fracture
Mariana O Perez¹, Diogo S Domiciano¹, Luciene M Reis², Vanda Jorgetti² and Rosa M R Pereira¹, ¹Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, ²Nephrology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Atypical femoral fractures (AFF) are low energy femoral fractures and subtrochanteric/diaphyseal localization that have been related to long-term bisphosphonate therapy. Patients with AFF exhibit…
Abstract Number: 1481 • 2018 ACR/ARHP Annual Meeting
Are ACPA Associated with More Bone Loss over Time in Patients with RA?
Emma de Moel¹, Josephine Amkreutz¹, Lotte Heimans², Cornelia F. Allaart³, Tom W.J. Huizinga⁴ and Diane van der Woude⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Internal Medicine, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, LUMC, Leiden, Netherlands, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are one of the most important serological markers for rheumatoid arthritis (RA) and have been suggested to play a pathophysiologic…
Abstract Number: 1830 • 2018 ACR/ARHP Annual Meeting
Role of BMP2 in Entheseal Bone Formation in Inflammatory Arthritis
Yukiko Maeda¹, Jozsef Karman² and Ellen M. Gravallese³, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Abbvie Bioresearch Center, Worcester, MA, ³Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Spondyloarthritis (SpA) is common, with a prevalence of ~1% in the United States. Patients with SpA suffer from pain and disability due to inflammation…
Abstract Number: 1987 • 2018 ACR/ARHP Annual Meeting
Elucidation of the Function of Dendritic Cell-Specific Transmembrane Protein (DCSTAMP) in Osteoclast Differentiation
Ananta Paine¹, Maria de la Luz Garcia-Hernandez², Dongge Li³, Minsoo Kim⁴ and Christopher T. Ritchlin², ¹Department of Medicine, Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ²Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ³Allergy, Immunology and Rheumatology, Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ⁴Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA, Rochester, NY
Background/Purpose: Osteoclasts (OC) are bone-resorbing, multinuclear cells that originate from myeloid progenitor cells through repetitive cycles of cell-cell fusion. Dendritic cell-specific transmembrane protein (DCSTAMP) is…
Abstract Number: 1989 • 2018 ACR/ARHP Annual Meeting
A Regulatory Role of ANTXR1 in RANKL-Induced Osteoclast Differentiation and Function
Myeung Su Lee¹, Changhoon Lee², Chong Hyuk Chung³, Wan-Hee Yoo⁴, Jin Jung Choi⁵, Jong Min Baek⁶ and Ju-Young Kim⁷, ¹Department of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, Iksan, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, Wonkwnag University Hospital, Division of Rheumatology, Department of Internal Medicine, Wonkwang University Hospital, IKSAN, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Research Institute of Clinical Medicine of chonbuk national university-Biomedical Research Institute of chonbuk national university hospital, Jeonju, Korea, Republic of (South), ⁵Rheumatology, CHA University Medical Center at Bundang, Sungnam, Korea, Republic of (South), ⁶Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Korea, Republic of (South), ⁷Imaging Science-based Lung and Bone Diseases Research Center, School of Medicine, Wonkwang University, IKSAN, Korea, Republic of (South)
Background/Purpose: Anthrax toxin receptor 1 (ANTXR1) has been known to have relationship with extracellular transmembrane protein deeply associated with the process of bone formation and…

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