Abstracts tagged "Biomarkers"

Abstract Number: 1723 • 2017 ACR/ARHP Annual Meeting
Nuclear Magnetic Resonance Based Metabolomics Study Identifies Highly Discriminatory Metabolites in 87 Systemic Sclerosis Patients
Sakir Ahmed¹, Mohit Kumar Rai¹, Durgesh Dubey², Atul Rawat³, Dinesh Kumar³, Durga Prasanna Misra¹ and Vikas Agarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Centre for Biomedical Research, PhD Student, Lucknow, India, ³Centre for Biomedical Research, Lucknow, India
Nuclear Magnetic Resonance based Metabolomics Study Identifies Highly Discriminatory Metabolites in 87 Systemic Sclerosis Patients Background/Purpose: Proton based Nuclear Magnetic Resonance (1H NMR) can identify…
Abstract Number: 2363 • 2017 ACR/ARHP Annual Meeting
Does Galectin-3 Have Utility As a Biomarker of Subclinical Cardiovascular Disease in RA Patients Independently of RA Disease Activity?
Amanda Nussdorf¹, Isabelle Amigues² and Joan Bathon³, ¹Columbia University Medical Center, New York, NY, ²Division of Rheumatology, Columbia University Medical Center, New York, NY, ³Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY
Background/Purpose: Galectin-3 is a beta-galactoside-binding lectin and is a marker of cardiovascular disease (CVD) in the general population. However, galectin-3 level is also elevated in…
Abstract Number: 94 • 2017 Pediatric Rheumatology Symposium
Effects of Age and Gender on Reference Levels of Biomarkers Comprising the Pediatric Renal Activity Index for Lupus Nephritis (p-RAIL)
Michael Bennett¹, Qing Ma², Jun Ying³, Prasad Devarajan¹ and Hermine Brunner⁴, ¹Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Dept of Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Center for Biostatistical Services, University of Cincinnati College of Medicine, Cincinnati, OH, ⁴Rheumatology, PRCSG, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease that disproportionately effects women and children of minorities. Renal Involvement (lupus nephritis, or LN) with…
Abstract Number: 9 • 2017 Pediatric Rheumatology Symposium
Biologically-Based Approach for Classifying Chronic Childhood Arthritis
Elham Rezaei¹, Daniel Hogan², Brett Trost², Anthony Kusalik², Susanne Benseler³, Gilles Boire⁴, David A. Cabral⁵, Bonnie Cameron⁶, Sarah Campillo⁷, Gaëlle Chédeville⁸, Paul Dancey⁹, Ciarán M. Duffy¹⁰, Karen N Watanabe Duffy¹¹, Janet Ellsworth¹², Simon Eng¹³, Brian M. Feldman¹⁴, John Gordon², Jaime Guzman¹⁵, Kristin Houghton¹⁶, Adam Huber¹⁷, Quaid Morris¹³, Bianca Lang¹⁸, Deborah M. Levy¹⁹, Loren Matheson²⁰, Kiem Oen²¹, Ross Petty²², Suzanne Ramsey²³, Johannes Roth²⁴, Dax Rumsey²⁵, Claire Saint-Cyr²⁶, Rayfel Schneider²⁷, Rosie Scuccimarri²⁸, Earl Silverman¹⁹, Lynn R. Spiegel²⁹, Elizabeth Stringer¹⁸, Shirley M.L. Tse³⁰, Lori Tucker³¹, Rae S.M. Yeung³² and Alan Rosenberg¹, ¹Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ²University of Saskatchewan, Saskatoon, SK, Canada, ³Pediatric Rheumatology, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada, ⁴Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, ⁵Pediatrics/Rm K4-121, BC Children's Hospital, Vancouver, BC, Canada, ⁶The Hospital for Sick Children, Toronto, ON, Canada, ⁷Montreal Children's Hospital, Montreal, QC, Canada, ⁸Rheumatology, McGill University, Montreal, QC, Canada, ⁹Pediatrics, Janeway Children's Hospital, St. John's, NL, Canada, ¹⁰Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ¹¹Rheumatology, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ¹²University of Alberta, Edmonton, AB, Canada, ¹³University of Toronto, Toronto, ON, Canada, ¹⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹⁵Rheumatology, BC Children's Hospital, Vancouver, BC, Canada, ¹⁶Rheumatology/Pediatrics, British Columbia Childrens Hos, Vancouver, BC, Canada, ¹⁷IWK Health Centre, Halifax, NS, Canada, ¹⁸Dalhousie University, Halifax, NS, Canada, ¹⁹Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²⁰University of Saskatchewan, Ottawa, ON, Canada, ²¹University of Manitoba, Winnipeg, MB, Canada, ²²Pediatric Rheumatology, Division of Rheumatology, BC Children's Hospital, Vancouver, BC, Canada, ²³Pediatric Rheumatology, IWK Health Centre, Halifax, NS, Canada, ²⁴Pediatric Rheumatology, Children's Hospital Eastern On, Ottawa, ON, Canada, ²⁵Stollery Children's Hospital, Edmonton, AB, Canada, ²⁶Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada, ²⁷Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, ²⁸Division of Pediatric Rheumatology, Montreal Children's Hospital/McGill University Health Centre, Montreal, QC, Canada, ²⁹Rheumatology/Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada, ³⁰Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ³¹Pediatric Rheum/Rm K4-120, BC Childrens Hospital, Vancouver, BC, Canada, ³²Paediatrics, Immunology and Medical Science, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) comprises a heterogeneous group of conditions that share chronic arthritis as a common characteristic. International uniformity in classifying JIA, based…
Abstract Number: 57 • 2017 Pediatric Rheumatology Symposium
Quantification of Dynamic MRI examinations in Juvenile Idiopathic Arthritis
Nikolay Tzaribachev¹, Romiesa Hagoug², Polymnia Louka³, Joyee Islam³, Mark Hinton³, Olga Kubassova⁴ and Mikael Boesen⁵, ¹PRI - Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany, ²Imaging, Image Analysis Group, London, United Kingdom, ³Image Analysis Group, London, United Kingdom, ⁴Image Analysis Group, Image Analysis Group, London, England, ⁵Radiology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiskberg, Denmark
Background/Purpose: In chronic inflammatory conditions, the need for a more objective measurement of disease activity has been identified, where dynamic contrast enhanced (DCE) MRI as…
Abstract Number: 32 • 2017 Pediatric Rheumatology Symposium
High Mobility Group Box 1 Protein in Children with Kawasaki Disease and Systemic Juvenile Idiopathic Arthritis
Hon Yan Ng¹, Stefan Slomp², Tracy Wilson-Gerwing³, Joan Dietz⁴, Abid Lodhi⁵, Tanya Holt⁶ and Alan Rosenberg³, ¹Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ²Pediatrics, Emergency Medicine, University of Alberta, Edmonton, AB, Canada, ³Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ⁴University of Saskatchewan, Saskatoon, SK, Canada, ⁵Regina Qu'appelle Health Region, Regina, SK, Canada, ⁶University of Saskatchewan, Sasktoon, SK, Canada
Background/Purpose: High Mobility Group Box 1 Protein (HMGB1) is a nuclear protein that stabilizes DNA and modulates gene expression. In sepsis and in certain other…
Abstract Number: 31 • 2017 Pediatric Rheumatology Symposium
Predicting therapy response to IL-1 blockade in systemic JIA: a biomarker search
Nienke M. ter Haar¹, Rianne C. Scholman¹, Wilco de Jager², Nadia Ryter³, Ariane de Ganck⁴, Dirk Foell⁵, Sytze de Roock⁶ and Bas Vastert⁷, ¹Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Dept Immunology, UMC Utrecht, Utrecht, Netherlands, ³BÜHLMANN Laboratories AG, Basel, Switzerland, ⁴Biogazelle NV, Zwijnaarde, Belgium, ⁵Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ⁶Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁷Division of Pediatric Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Systemic onset juvenile idiopathic arthritis (sJIA) is an autoinflammatory disease, characterized by fever, rash and arthritis. The IL-1 and IL-6 pathway are crucial in…
Abstract Number: 143 • 2017 Pediatric Rheumatology Symposium
Influence of Age and Sex on Collagen-Induced Arthritis
Tracy Wilson-Gerwing¹, Arash Panahifar², David M.L. Cooper² and Alan Rosenberg¹, ¹Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ²Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada
Background/Purpose: Age and sex differences are found in certain subsets of juvenile idiopathic arthritis (JIA). Collagen Induced Arthritis (CIA) in rodents has utility in assessing…
Abstract Number: 129 • 2017 Pediatric Rheumatology Symposium
Cell-bound Complement Activation Products Correlate with Disease Activity in Childhood-onset Systemic Lupus Erythematosus
Joyce Hui-Yuen¹, Derren Barken², John Conklin³, Tyler O'Malley⁴, Andrew Eichenfield⁵, Amy Starr⁶, Lisa F. Imundo⁷, Thierry Dervieux⁴ and Anca Askanase⁸, ¹Cohen Children's Medical Center of New York, Lake Success, NY, ²Exagen Diagnostics, Vista, CA, ³1261 Liberty Way Suite C, Exagen Diagnostics, Vista, CA, ⁴Research and Development, Exagen Diagnostics, Vista, CA, ⁵Columbia University Medical Center, New York, NY, ⁶Pediatric Rheumatology, Columbia University Medical Center, New York, NY, ⁷Pediatrics, Columbia University Medical Center, New York, NY, ⁸Rheumatology, Columbia University Medical Center, New York, NY
Background/Purpose: Elevated levels of cell-bound complement activation products (C4d deposition on erythrocytes [EC4d] and B lymphocytes [BC4d], CB-CAPs) have been demonstrated to be sensitive and…
Abstract Number: 130 • 2017 Pediatric Rheumatology Symposium
Validation of MRP8/14 serum levels as biomarker for the diagnosis of systemic juvenile idiopathic arthritis in fever of unknown origin
Dirk Holzinger¹, Carolin Pretzer², Maria Miranda-Garcia^2,3, Hans Huppertz⁴, Gerd Horneff⁵, Johannes Peter Haas⁶, Gerd Ganser⁷, Jasmin B. Kuemmerle-Deschner⁸, Michael Frosch⁹, Johannes Roth¹⁰ and Dirk Foell², ¹Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ²Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ³Federal Institute for Vaccines and Biomedicines, Paul-Ehrlich-Institute, Langen, Germany, ⁴Prof Hess Children’s Hospital Bremen, Bremen, Germany, ⁵Department of Pediatrics, Asklepios Clinics St. Augustin, Sankt Augustin, Germany, ⁶Centre for Pediatric Rheumatology Garmisch-Partenkirchen, Garmisch-Partenkirchen, Germany, ⁷Pediatric Rheumatology, Sankt Josef Stift Sendenhorst, Sendenhorst, Germany, ⁸Pediatrics, University Hospital Tuebingen, Tuebingen, Germany, ⁹Pediatric Pain Centre,, Children's and Adolescents' Hospital Datteln, Datteln, Germany, ¹⁰Institute of Immunology, University of Muenster, Muenster, Germany
Background/Purpose: The differential diagnosis of fever of unknown origin (FUO) is a major challenge in pediatrics especially for differentiation of systemic-onset juvenile idiopathic arthritis (SJIA)…
Abstract Number: 16 • 2017 Pediatric Rheumatology Symposium
Novel Serum Broad-Based Proteomic Discovery Analysis Identifies Proteins and Pathways Dysregulated in Juvenile Dermatomyositis (JDM) Myositis Autoantibody Groups
Hanna Kim¹, Angélique Biancotto², Foo Cheung³, Terrance P. O'Hanlon⁴, Ira N. Targoff⁵, Yan Huang⁶, Frederick Miller⁴, Raphaela Goldbach-Mansky⁶ and Lisa G. Rider⁴, ¹Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, MD, ²Center for Human Immunology, Autoimmunity and Inflammation (CHI), NHLBI, NIH, Bethesda, MD, ³Center for Human Immunology Autoimmunity and Inflammation (CHI), NHLBI, NIH, Bethesda, MD, ⁴Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁵VA Medical Center, University of Oklahoma Health Sciences Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Translational Autoinflammatory Disease Studies (TADS), NIAID, NIH, Bethesda, MD
Background/Purpose: Juvenile dermatomyositis (JDM) is a complex heterogeneous autoimmune disease. Myositis-specific autoantibodies (MSAs), present in up to 80% of JDM patients, help define distinct phenotypes…
Abstract Number: 123 • 2016 ACR/ARHP Annual Meeting
A Panel of Urinary Biomarkers to Assess Renal Involvement in Latin American Patients with Systemic Lupus Erythematosus
José A. Gómez-Puerta^1,2, Blanca L Ortiz Reyes¹, Tomás Urrego¹, Adriana L Vanegas^2,3, Carlos Horacio Muñoz^3,4, Mauricio Restrepo², Wilmer Rojas-Zuleta², Sofia Arteaga², Luis Alonso Gonzalez⁴ and Gloria Vásquez^1,4, ¹Grupo de Inmunología Celular e Inmunogenética, Universidad de Antioquia, Medellín, Colombia, ²Rheumatology Unit, Universidad de Antioquia, Medellín, Colombia, ³Hospital Universitario de San Vicente Fundación, Medellín, Colombia, ⁴Rheumatology Unit, Universidad de Antioquia, Medellin, Colombia
Background/Purpose: Some previous studies in Caucasian, Asian, and African-american patients have shown promising results for several urinary biomarkers in patients with lupus nephritis (LN). However,…
Abstract Number: 793 • 2016 ACR/ARHP Annual Meeting
Multi-Parametric Model Development for Assessing Lupus Nephritis and Disease Activity
Christopher Sjöwall¹, Chelsea Bentow², Mary Ann Aure², Gabriella Lakos², Peter Martis² and Michael Mahler², ¹Rheumatology/AIR, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, ²Research and Development, Inova Diagnostics, San Diego, CA
Multi-parametric model development for assessing lupus nephritis and disease activity Christopher Sjӧwall1, Chelsea Bentow2, Mary Ann Aure2, Gabriella Lakos2, Peter Martis2, Michael Mahler2 1AIR/Rheumatology, Department…
Abstract Number: 1380 • 2016 ACR/ARHP Annual Meeting
Multicenter Prospective Study on the Role of Urinary HER2 As a Lupus Nephritis Biomarker
Patrícia Costa Reis¹, Kelly Maurer², Emily von Scheven³, Kathleen O'Neil⁴, Jon M. Burnham⁵, Laura E. Schanberg⁶, Michelle Petri⁷ and Kathleen E. Sullivan⁸, ¹Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Division of Rheumatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, ⁴Pediatrics, Indiana University, Indianapolis, IN, ⁵Pediatric Rheumatology, Children's Hospital Philadelphia, Philadelphia, PA, ⁶Pediatrics, Duke Medical Center, Durham, NC, ⁷Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ⁸Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: HER2 (Human Epidermal Growth Factor Receptor 2) is dramatically overexpressed in the glomeruli and in the tubular compartment of patients with lupus nephritis, but…
Abstract Number: 2067 • 2016 ACR/ARHP Annual Meeting
Dermal Fibroblasts from Patients with Lupus Nephritis Express an Anti-Fibrotic Transcriptome
Robert M Clancy¹, Evan Der², Kemal Akat³, Anna R. Broder⁴, H. Michael Belmont⁵, Peter M. Izmirly⁵, Beatrice Goilav⁶, Thomas Tuschl³, Chaim Putterman⁶ and Jill P. Buyon⁷, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³Rockefeller University, New York, NY, ⁴Medicine/Rheumatology, Division of Rheumatology, Albert Einstein College of Med, Bronx, NY, ⁵New York University School of Medicine, New York, NY, ⁶Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, ⁷Medicine, New York University School of Medicine, New York, NY
Background/Purpose: The premise of this study is that the impact of renal injury in lupus nephritis is widespread with consequences to resident cells in other…

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