ACR Meeting Abstracts

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Abstracts tagged "Biomarkers"

  • Abstract Number: 0374 • ACR Convergence 2020

    Neo-epitopes of Type I Collagen Can Be Utilized as Translational Biomarkers for Skin and Joint Turnover in Patients with Psoriasis and Psoriatic Arthritis

    Solveig S. Groen1, Signe Holm Nielsen2, Conor Magee3, Anne Sofie Siebuhr4, Anne C. Bay-Jensen2, Morten A. Karsdal4, Stephen Pennington5 and Oliver FitzGerald6, 1University of Copenhagen, Copenhagen, Denmark, 2Nordic Bioscience, Herlev, Denmark, 3St Vincent's University Hospital and the UCD Conway Institute, University College Dublin, Dublin, Ireland, 4Nordic Bioscience A/S, Herlev, Denmark, 5University College Dublin, Dublin, Dublin, Ireland, 6Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland

    Background/Purpose: Psoriasis (PsO) is a chronic immune-mediated skin disease. Around 30% of patients diagnosed with PsO will develop psoriatic arthritis (PsA). Patients with PsA may…
  • Abstract Number: 0744 • ACR Convergence 2020

    Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations with Disease Characteristics, Body Composition, and Physical Functioning

    Patrick Gould1, Babette Zemel2, Elena Taratuta3 and Joshua Baker1, 1University of Pennsylvania, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, 3University of Pennsylvania, Philadelphia

    Background/Purpose: Rheumatoid arthritis (RA) can lead to changes in body composition, including muscle loss and excess adiposity, which are in turn associated with physical disability.…
  • Abstract Number: 0878 • ACR Convergence 2020

    Absolute Lymphocyte Count Is Negatively Correlated with Atherosclerotic Cardiovascular Disease Risk Score and Red Cell Distribution Width in Psoriatic Arthritis and Increases with TNF-Inhibitor Therapy

    Angela Gupta1, Sofi Damjanovska2, Alyssa Lange3, Brigid Wilson4, Taissa Bej4, Maya Mattar5, David Zidar6 and Donald Anthony7, 1(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, 2(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH, 3Case Western Reserve University, Cleveland, 4Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, 5Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH, 6Case Western Reserve University/Cleveland VA Medical Center, Cleveland, 7Case Western Reserve University/Cleveland VA Medical Center/MetroHealth Medical Center, Cleveland, OH

    Background/Purpose: Absolute lymphocyte count (ALC) is a parameter that represents the number of lymphocytes (B, T, and NK cells) in the blood, and lymphopenia often…
  • Abstract Number: 1189 • ACR Convergence 2020

    Serum High-sensitive Cardiac Troponin at Baseline Predict Cardiovascular Events in Rheumatoid Arthritis and Osteoarthritis

    M. Elaine Husni1, Daniel H Solomon2, Mingyuan Shao3, Katherine Wolski3, Steven Nissen3, Stanley Hazen4 and WH Wilson Tang4, 1Cleveland Clinic, Cleveland, OH, 2Brigham and Women's Hospital, Boston, MA, 3Cleveland Clinic Foundation, Cleveland, OH, 4Cleveland Clinic Foundation, Cleveland

    Background/Purpose: In rheumatoid arthritis (RA), excess mortality and inflammation has been attributed to cardiovascular (CV) diseases. High-sensitivity cardiac troponins (hscTnT) allow measurement of cardiac troponin…
  • Abstract Number: 1452 • ACR Convergence 2020

    Transcriptomic Meta-analysis Reveals a Core Transcriptional Program in Murine B Cell Anergy and Implicates Immunometabolic Regulation as a Central Pathway in Maintaining Non-responsiveness of Autoreactive B-cells in Both Mouse and Man

    Isaac Harley1, Bergren Crute2, Andrew Getahun2 and John Cambier3, 1University of Colorado Anschutz Medical Campus, Aurora, CO, 2University of Colorado – Anschutz Medical Campus, Aurora, 3Univ, Aurora

    Background/Purpose: The mechanisms self-tolerance loss that lead to autoantibody-mediated autoimmune disease remain underdefined. The rapid reversibility of peripheral B-cell tolerance in murine models suggests that…
  • Abstract Number: 1790 • ACR Convergence 2020

    Association of Telomere Length and the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) in Long Standing Systemic Lupus Erythematosus

    Kaitlin Lima1, Alexandra Legge2, John Hanly2, Jungwha Lee3, Jing Song3, Anh Chung3, Carly Skamra4, QiQuan Huang1, Richard Pope5 and Rosalind Ramsey-Goldman6, 1Northwestern University, Chicago, IL, 2Dalhousie University, Halifax, NS, Canada, 3Northwestern University, Chicago, 4Northwestern University, Brookfield, IL, 5McGaw Medical Center of Northwestern University, Chicago, IL, 6Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Frailty, an emerging concept in SLE, represents an individual’s ability to respond to physiologic stress. The first lupus-specific frailty index, the SLICC-FI, was recently…
  • Abstract Number: 1876 • ACR Convergence 2020

    The Role of HLA B27 in Axial Spondyloarthritis: Prevalence and Performance as a Marker in an Argentinian Cohort

    Rodrigo Garcia Salinas1, Santiago Ruta1, Einer Sanchez Prado1, Jessica Torres Chichande1, Alvaro Ruta1, Facundo Salvatori1 and Sebastian Magri1, 1Hospital Italiano La Plata, La Plata, Argentina

    Background/Purpose: HLA B27 prevalence in Latin America are heterogeneous and timeless, we propose to estimate the prevalence of HLA B27 in an Argentinian cohort of…
  • Abstract Number: 0387 • ACR Convergence 2020

    Altered Iron Homeostasis and Pulmonary Haemodynamics in Systemic Sclerosis Associated Pulmonary Arterial Hypertension

    Alper Sari1, Christopher Denton2, Svetlana Nihtyanova3, Benjamin Schreiber4 and Voon Ong3, 1Hacettepe University, Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara, Turkey, 2University College London, London, United Kingdom, 3Centre for Rheumatology, Royal Free Campus, UCL Division of Medicine, UK, London, United Kingdom, 4UCL, London, United Kingdom

    Background/Purpose: Iron deficiency (ID) is more frequent in systemic sclerosis (SSc) patients with pulmonary hypertension (PH) than those without and associated with worse prognosis. There…
  • Abstract Number: 0746 • ACR Convergence 2020

    HDL-bound yRNA-derived Small RNAs Are Altered in Patients with Rheumatoid Arthritis

    Qiong Wu1, Quanhu Sheng1, Joseph Solus1, Danielle Michell1, Kasey Vickers1, Ryan Allen1, C. Michael Stein1 and Michelle Ormseth1, 1Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Small RNAs (sRNAs), including microRNAs (miRNAs) and yRNA-derived sRNAs (yDRs), are important gene regulators and markers of disease. HDL, while known for its anti-atherogenic…
  • Abstract Number: 0936 • ACR Convergence 2020

    Urine Proteomics and Single Cell Transcriptomics Identify IL-16 as a Biomarker for Lupus Nephritis

    Andrea Fava1, Jill Buyon2, Chandra Mohan3, Ting Zhang3, H. Michael Belmont4, Peter Izmirly5, Robert Clancy6, Jose Monroy-Trujillo7, Celine Berthier8, Anne Davidson9, Nir Hacohen10, David Wofsy11, Deepak Rao12, Soumya Raychaudhuri13, The Accelerating Medicines Partnership in SLE Network14, William Apruzzese15 and Michelle Petri16, 1Johns Hopkins University, Baltimore, MD, 2Department of Medicine, NYU School of Medicine, New York, NY, 3UT Houston, Houston, 4New York University, New York, NY, 5Department of Medicine, New York University School of Medicine, New York, NY, 6NYU School of Medicine, New York, 7Johns Hopkins University, Baltimore, 8University of Michigan, Ann Arbor, 9Northwell Health, New York, 10Broad Institute, Boston, 11University of California San Francisco, San Francisco, CA, 12Brigham and Women's Hospital, Boston, MA, 13Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 14Multiple Institutions, Multiple Cities, 15., Boston, 16Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Treatment of lupus nephritis relies on renal histopathological features. However, renal biopsies do not capture patient-specific active biological pathways. Urine proteomic biomarkers could revolutionize…
  • Abstract Number: 1197 • ACR Convergence 2020

    Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Systematic Review

    Dawson Shaver1, Daniel Van Kalsbeek1, Ariadne Ebel1, Daniel Hershberger1, Cynthia Schmidt1, Jill Poole1, Geoffrey Thiele1, Dana Ascherman2, Ted Mikuls1 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: RA-associated interstitial lung disease (RA-ILD) is among the most frequent and severe extra-articular manifestations of RA, contributing significantly to the excess mortality among RA…
  • Abstract Number: 1464 • ACR Convergence 2020

    Multi-Variate Approach Including Serology and Genetics for an Improved Identification of Patients at Risk of Developing Rheumatoid Arthritis

    Céline Lamacchia1, Maresa Grundhuber2, Isabel Gehring2, Pascale Roux Lombard3, Michael John Nissen1, Andrea Rubbert Roth4, Ruediger Mueller5, Ulrich Walker6, Burkhard Moeller7, Diego Kyburz8, Adrian Ciurea9, Sascha Swiniarski10 and Axel Finckh11, 1Geneva University Hospital, Geneva - 14, Switzerland, 2Thermo Fisher Scientific Phadia GmbH, Freiburg, Germany, 3Geneva University Hospital, Geneva, Switzerland, 4Klinik für Rheumatologie, Kantonsspital St Gallen, St Gallen, Sankt Gallen, Switzerland, 5KSA: Aarau Hospital, Aarau, Switzerland, 6Basel University Hospital, Basel, Switzerland, 7Inselspital - University Hospital Bern, Bern, Switzerland, 8University Hospital Basel, Basel, Switzerland, 9University Hospital Zurich, Zurich, Switzerland, 10Phadia GmbH / Thermo Fisher Scientific, Freiburg, Germany, 11Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland

    Background/Purpose: First-degree relatives of RA patients (FDR-RA) have an increased prevalence for rheumatoid arthritis (RA) [1] and joint symptoms [2]. Identification of individuals with imminent RA…
  • Abstract Number: 1791 • ACR Convergence 2020

    Renal Tubular Complement C9 Deposition Is Associated with Renal Tubular Damage and Fibrosis in Lupus Nephritis

    Shudan Wang1, Ming Wu2, Luis Chiriboga2, Beatrice Goilav3, Shuwei Wang4, Chaim Putterman5, Daniel Schwartz6, James Pullman6, Anna Broder7 and H. Michael Belmont8, 1Montefiore Medical Center / Albert Einstein College of Medicine, Bronx, NY, 2NYU Langone Health, New York, 3The Children’s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, 4Morristown Medical Center, Morristown, NJ, 5Albert Einstein College of Medicine, Bronx, NY, 6Montefiore Medical Center, Bronx, NY, 7Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 8New York University, New York, NY

    Background/Purpose: Tubulointerstitial damage in lupus nephritis (LN) is a strong predictor of progression to chronic kidney disease (CKD) and end stage renal disease (ESRD). While…
  • Abstract Number: 1906 • ACR Convergence 2020

    Hsp90 Inhibition Effectively Prevents Progression of Dermal Fibrosis and Induces Regression of Established Bleomycin-Induced Dermal Fibrosis

    Hana Storkanova1, Lenka Storkanova2, Sabina Oreska3, Maja Spiritovic4, Barbora Hermankova5, Radim Becvar1, Karel Pavelka6, Jiří Vencovský6, Jörg HW Distler7, Ladislav Šenolt6 and Michal Tomcik1, 1Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha 2, Czech Republic, 4Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic,, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 7University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Our previous study demonstrated that Heat shock protein 90 (Hsp90) is overexpressed in the skin of patients with systemic sclerosis (SSc), in cultured SSc…
  • Abstract Number: 0399 • ACR Convergence 2020

    A Heavy Burden of Calcinosis Reflects Cumulative Disease Damage in Scleroderma

    Carrie Richardson1, Jamie Perin2, Scott Zeger3, Fredrick Wigley4, Laura Hummers5, Livia Casciola-Rosen6, Antony Rosen7 and Ami Shah8, 1Rush University Medical Center, Chicago, IL, 2JHUSPH, Baltimore, 3Johns Hopkins University, Baltimore, 4Johns Hopkins University School of Medicine, Baltimore, MD, 5Johns Hopkins Univerisity, Ellicott City, MD, 6Johns Hopkins University, Johns Hopkins University, MD, 7Johns Hopkins University, Baltimore, MD, 8Johns Hopkins University School of Medicine, Ellicott City, MD

    Background/Purpose: Ectopic calcification, or calcinosis, is a common complication of scleroderma. However, a subset of scleroderma patients has a heavy burden of calcinosis, which may…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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