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Abstracts tagged "Biomarkers"

  • Abstract Number: L13 • ACR Convergence 2022

    Fetal Cardiac Targets Identify the Autoantibodies Associated with Congenital Heart Block

    Stephanie Benjamin1, Lisa Vi2, Diptendu Chatterjee1, Edgar Jaeggi1, Marie Wahren-Herlenius3, Amelia Ruffatti4, Linda Hiraki5, Michelle Lohbihler2, Lusia Sepiashvili1, Carl Laskin6, Meena Fatah1, Daniela Dominguez5, Lawrence Ng5, Anthony Gramolini2, Vincent Christoffels7, Stephanie Protze2 and Robert Hamilton8, 1Hospital for Sick Children, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 4Universitå di Padova, Padova, Italy, 5The Hospital for Sick Children, Toronto, ON, Canada, 6Mt. Sinai Hospital/University of Toronto, Toronto, ON, Canada, 7Amsterdam UMC, Amsterdam, Zuid-Holland, Netherlands, 8Hospital for Sick Children, Markham, ON, Canada

    Background/Purpose: Autoimmune congenital heart block (CHB+) affects the fetus of mothers with anti-Ro antibodies. Anti-Ro (Ro+) antibodies (Abs) are usually present in maternal sera when…
  • Abstract Number: 0023 • ACR Convergence 2022

    New Biomarkers in Hand Osteoarthritis: The Micro-RNA Signature

    Maxime Auroux1, Marjorie Millet2, Blandine Merle2, Elisabeth Fontanges1, Florence Duvert1, Evelyne Gineyts3, Jean-Charles Rousseau3, Olivier Borel2, Alexandre Mercier1, Eric LESPESSAILLES4 and Roland Chapurlat1, 1Hospices Civils de Lyon, LYON, France, 2INSERM U1033, LYON, France, 3INSERM 1033, Lyon, France, 4Regional hospital centre of Orleans, France, ORLEANS, Centre, France

    Background/Purpose: Hand osteoarthritis (HOA) is a highly prevalent disease, associated with important disability and socio-economic burden. Erosive HOA, almost exclusively found in women, induces more…
  • Abstract Number: 0300 • ACR Convergence 2022

    Exposure-Response Analyses of Upadacitinib Effects on Plasma Biomarkers in Rheumatoid Arthritis Patients

    Yuli Qian1, Fang Cai2, Thierry Sornasse3, Jie Shen1, Heidi Camp4 and Mohamed-Eslam Mohamed1, 1AbbVie, Inc., North Chicago, IL, 2AbbVie, Redwood City, CA, 3AbbVie, South San Francisco, CA, 4Abbvie, Winnetka, IL

    Background/Purpose: Upadacitinib (UPA) is an oral Janus kinase (JAK) inhibitor approved for the treatment of moderately-to-severely active rheumatoid arthritis (RA). Previous investigations demonstrated UPA modulates…
  • Abstract Number: 0536 • ACR Convergence 2022

    Change in Urinary Biomarkers at Three Months Predicts 1-year Treatment Response of Lupus Nephritis Better Than Proteinuria

    Andrea Fava1, Laurence S Magder2, Daniel W. Goldman3, Jill Buyon4, Betty Diamond5, Joel Guthridge6, William Apruzzese7, Derek Fine1, Jose Monroy-Trujillo1, Mohamed G. Atta1, Peter Izmirly4, H Michael Belmont8, Anne Davidson5, Maria Dall'Era9, Deepak Rao7, Arnon Arazi10, Nir Hacohen11, Soumya Raychaudhuri7, the Accelerating Medicines Partnership (AMP) RA/SLE12 and Michelle Petri3, 1Johns Hopkins University, Baltimore, MD, 2University of Maryland, Department of Epidemiology and Public Health, Baltimore, MD, 3Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, 4NYU Grossman School of Medicine, New York, NY, 5Feinstein Institutes for Medical Research, Manhasset, NY, 6Oklahoma Medical Research Foundation, Oklahoma City, OK, 7Brigham and Women's Hospital, Boston, MA, 8NYU School of Medicine, New York, NY, 9University of California, San Francisco, San Francisco, 10Feinstein Institutes for Medical Research, Melrose, MA, 11Broad Institute, Cambridge, MA, 12Multiple Insitutions

    Background/Purpose: A decline of urine protein-to-creatinine ratio (UPCR) to < 0.5 is associated with better long-term preservation of kidney function in lupus nephritis (LN). UPCR…
  • Abstract Number: 0656 • ACR Convergence 2022

    Association Study Identified HLA-DQA1 as a Genetic Risk of Systemic Lupus Erythematosus-associated Pulmonary Arterial Hypertension

    Junyan Qian1, Ying Chen2, Xinzhuang Yang3, Qian Wang4, JIULIANG ZHAO5, Xiaoyue Deng1, Shengjie Li3, Yongtai Liu6, Zhuang Tian6, Juan Shen2, Qijun Liao2, Yanhong Wang7, Xianbo Zuo8, Xuejun Zhang9, MENGTAO LI1, Yong Cui8, Xueqing Yu10 and Xiaofeng Zeng11, 1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, State Key Laboratory of Complex Severe and Rare Diseases, Ministry of Science & Technology, Beijing, China, 2BGI-Shenzhen, Shenzhen, China, 3Medical Research Center, State Key laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 4Peking Union Medical College Hospital, Beijing, China, 5Beijing Union Medical College Hospital, Beijing, China, 6Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China, 7Department of Epidemiology and Bio-statistics, Institute of Basic Medical Sciences, China Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 8Department of Dermatology, China-Japan Friendship Hospital, Beijing, China, 9Institute of Dermatology, Anhui Medical University, Hefei, China, 10Division of Nephrology, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China, 11Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a rare and severe complication of systemic lupus erythematosus (SLE). Human leucocyte antigen (HLA) gene variants in the major…
  • Abstract Number: 0933 • ACR Convergence 2022

    Exploratory Study of the Usefulness of TNFAIP3 Genetic Variants in Predicting Response to Methotrexate in Early Arthritis Patients

    Ana Triguero1, JUAN BALDIVIESO ACHA2, Emilia Roy Vallejo3, Patricia Quiroga-Colina4, Irene Maria Llorente Cubas2, Rosario Garcia-Vicuña5, amaya Puig kröger6 and Isidoro Gonzalez2, 1Hospital Universitario La Princesa, Madrid, Spain, 2Hospital Universitario de La Princesa, Madrid, Spain, 3Internal Medicine Department, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain, 4Division of Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain, 5Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, 6Laboratory of Immunometabolism, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Background/Purpose: We recently described that methotrexate (MTX) could exert its immunomodulatory effect through the induction of A20 expression , a protein that negatively regulates NFkB…
  • Abstract Number: 1163 • ACR Convergence 2022

    Proteomic Investigation to Identify Urinary Biomarker for Ankylosing Spondylitis

    Ji-Hyun Lee1, Jeesoo Kim2, Sang-Hyon kim1, Jong‑Seo kim2 and Chang-Nam son1, 1Keimyung University, Dalseo-gu, Daegu, Republic of Korea, 2seoul national university, Seoul, Republic of Korea

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease that affects the spine and peripheral joints, and the exact etiology is still unknown. Diagnosis…
  • Abstract Number: 1478 • ACR Convergence 2022

    Urine ALCAM Is a Strong Predictor of Lupus Nephritis

    Dalena Chu1, Noa Schwartz2, Jeanette Ampudia1, Joel Guthridge3, Judith James3, Jill Buyon4, Stephen Connelly1, Maple Fung1, Cherie Ng1, AMP SLE/RA consortium5, Michelle Petri6, Chandra Mohan7 and Chaim Putterman8, 1Equillium, Inc., La Jolla, CA, 2Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4NYU Grossman School of Medicine, New York, NY, 5Accelerating Medicines Partnership, Los Angeles, CA, 6Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, 7University of Houston, Houston, TX, 8Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: T cells play a critical role in the pathogenicity of SLE and lupus nephritis (LN). Hence, identifying T cell co-stimulatory pathways and mediators that…
  • Abstract Number: 1650 • ACR Convergence 2022

    Systemic Immune Inflammation Index Predict All-Cause and Cardiovascular Mortality in Rheumatoid Arthritis

    Jose felix Restrepo Suarez1, Inmaculada Del Rincon1, Carlos Lorenzo2 and Agustin Escalante3, 1University of Texas Health Science center at San Antonio, San Antonio, TX, 2University of Texas Health Sciences Center San Antonio, San antonio, TX, 3University of Texas Health Science Center at San Antonio, San Antonio, TX

    Background/Purpose: The systemic immune inflammation index (SII) is an inflammation-based biomarker that is an influential prognostic factor in diseases with an inflammation-related etiology. This index…
  • Abstract Number: 1874 • ACR Convergence 2022

    Autoantibodies Are Common in Patients with Idiopathic Interstitial Lung Disease Suggesting a High Prevalence of Undiagnosed Autoimmune Connective Tissue Disease

    Sarah Tansley1, Caroline Cotton2, Fionnuala McMorrow1, Hui Lu1, Aravinthan Loganathan1, Zoe Betteridge1, Robert New3, Lisa Spencer4, Neil McHugh1 and Robert Cooper4, 1University of Bath, Bath, United Kingdom, 2Liverpool University Hospital, Liverpool, United Kingdom, 3NCA, Manchester, 4University of Liverpool, Liverpool

    Background/Purpose: In some patients, interstitial lung disease (ILD) may be the dominant or even sole overt manifestation of an otherwise unrecognised autoimmune connective tissue disease…
  • Abstract Number: 2096 • ACR Convergence 2022

    Role of Cell-Bound Complement Fragments as Biomarkers to Determine Disease Activity in Patients with Systemic Lupus Erythematosus

    Marcela Muñoz Urbano1, Diana C. Quintero-González1, Mauricio Rojas2, Joaquín Rodelo1, Alba Luz León Álvarez1, Luis Gonzalez1 and Gloria Vásquez3, 1Universidad de Antioquia, Medellín, Colombia, 2Grupo de Inmunología Celular e Inmunogenética, GICIG, and Unidad de citometría de flujo, Sede de Investigación Universitaria, Universidad de Antioquia, Medellín, Colombia, 3Grupo de Inmunología Celular e Inmunogenética, GICIG and Grupo de Reumatología, Universidad de Antioquía, Medellín, Colombia

    Background/Purpose: The prompt identification of patients with systemic lupus erythematosus (SLE) at risk of or in flare strongly influences the prognosis of the disease. Cell-bound…
  • Abstract Number: 2234 • ACR Convergence 2022

    Obesity, Adipokines, and Chronic and Persistent Pain in Rheumatoid Arthritis

    Joshua Baker1, Kristin Wipfler2, Marianna Olave3, Sofia Pedro4, Patricia Katz5 and Kaleb Michaud6, 1University of Pennsylvania, Philadelphia, PA, 2FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, 3Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, 4Forward, The National Databank for Rheumatic Diseases, Wichita, KS, 5UCSF, San Rafael, CA, 6University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Obesity has been linked to chronic pain and pain sensitization in the general population and among patients with rheumatoid arthritis (RA). The mechanism by…
  • Abstract Number: 0027 • ACR Convergence 2022

    Associations of Serum C3f with Selected Biomarkers and Radiographic and Clinical Features of Knee Osteoarthritis

    Yulia Liem1, Andrew Judge1, Khadija Ourradi1, Dominique de Seny2, Yunfei Li1 and Mohammed Sharif1, 1University of Bristol, Bristol, United Kingdom, 2University of Liège, Liège, Belgium

    Background/Purpose: C3 complement fragment (C3f) has been identified as a potential biomarker for evaluating osteoarthritis (OA). C3f is released during the catabolic degradation of C3b…
  • Abstract Number: 0304 • ACR Convergence 2022

    Rheumatoid Arthritis Patients Who Switched Treatment from Adalimumab to Upadacitinib Demonstrate a Robust Reduction of Inflammation-related Biomarkers: Proteomics Analysis from the SELECT-COMPARE Phase 3 Study

    Thierry Sornasse1, Fang Cai2, Heidi Camp3, In-Ho Song4 and Iain B McInnes5, 1AbbVie, South San Francisco, CA, 2AbbVie, Redwood City, CA, 3Abbvie, Winnetka, IL, 4AbbVie, Inc., North Chicago, IL, 5Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

    Background/Purpose: Upadacitinib 15 mg QD (UPA), an oral JAK inhibitor, showed greater efficacy compared to adalimumab (ADA) in patients (pts) with active rheumatoid arthritis (RA)…
  • Abstract Number: 0540 • ACR Convergence 2022

    Evaluation of Traditional Laboratory Markers as Predictors of Renal Flares: A Post-hoc Analysis of Four Phase III Clinical Trials of SLE

    Sandra Jägerback1, Alvaro Gomez1 and Ioannis Parodis2, 1Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: In patients with systemic lupus erythematosus (SLE), renal involvement is associated with high morbidity, and renal flare is a major contributing factor to poor…
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