Session Type: Abstract Submissions
Session Time: 5:30PM-7:00PM
Methods: : Urine was collected from 368 children from the Cincinnati Genomic Control Cohort (healthy kids presenting to Cincinnati Children’s primary care clinic for well child visits) and assayed for NGAL, KIM-1, MCP-1, APN, CP and HPX using commercially available kits or assay materials.
Results: Specimens were grouped by age (0-5 years (n=94); 5-10 (n=89); 10-15 (n=93); 15-20 (n=91)) and sex (M = 184, F=184). For age and gender comparisons, values for log transformed prior to analysis. The 95% CI for the means of each marker in the combined population were as follows: NGAL (12.9-20.1 ng/ml), KIM-1 (474.6-558.4 pg/ml), MCP-1 (240.9-293.4 pg/ml), APN (7.6-10.0 ng/ml), CP (480-589.8 ng/ml), HPX (814.3-1163.5 ng/ml). All p-RAIL biomarkers but adiponectin had weak but significant positive correlations with age, with NGAL being the strongest (r=0.33, p <0.001). Adiponectin had a weak negative correlation with age (r=-0.12, p=0.04). For gender comparisons, CP and HPX were elevated in females vs males (CP = 3% higher log transformed mean in females, p = 0.007; HPX = 5% higher log transformed mean in females, p = 0.0005). Consistent with previous findings, NGAL was greatly elevated in females vs males (86% higher log transformed mean in females, p<0.0001). No other gender differences were found.
Conclusion: We have established a reference range for the p-RAIL biomarkers and have highlighted age and gender differences. This information is essential for rational interpretation of studies and clinical trials utilizing the p-RAIL algorithm.
To cite this abstract in AMA style:Bennett M, Ma Q, Ying J, Devarajan P, Brunner H. Effects of Age and Gender on Reference Levels of Biomarkers Comprising the Pediatric Renal Activity Index for Lupus Nephritis (p-RAIL) [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 4). https://acrabstracts.org/abstract/effects-of-age-and-gender-on-reference-levels-of-biomarkers-comprising-the-pediatric-renal-activity-index-for-lupus-nephritis-p-rail/. Accessed June 6, 2020.
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